| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shun-Fat Lau, Congping Chen, Wing-Yu Fu, Jianan Y Qu, Tom H Cheung, Amy K Y Fu, Nancy Y I. IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer's Disease. Cell reports. vol 31. issue 3. 2021-05-14. PMID:32320664. |
il-33-pu.1 transcriptome reprogramming drives functional state transition and clearance activity of microglia in alzheimer's disease. |
2021-05-14 |
2023-08-13 |
mouse |
| Hongjun Fu, Bin Liu, Liangping Li, Cynthia A Lemer. Microglia Do Not Take Up Soluble Amyloid-beta Peptides, But Partially Degrade Them by Secreting Insulin-degrading Enzyme. Neuroscience. vol 443. 2021-05-14. PMID:32697980. |
microglia play important roles in the pathogenesis of alzheimer's disease (ad), in part, by affecting the clearance of amyloid-β (aβ) peptides. |
2021-05-14 |
2023-08-13 |
mouse |
| Qiu-Lan Ma, Cansheng Zhu, Marco Morselli, Trent Su, Matteo Pelligrini, Zhengqi Lu, Mychica Jones, Paul Denver, Daniel Castro, Xuelin Gu, Frances Relampagos, Kaitlin Caoili, Bruce Teter, Sally A Frautschy, Gregory M Col. The Novel Omega-6 Fatty Acid Docosapentaenoic Acid Positively Modulates Brain Innate Immune Response for Resolving Neuroinflammation at Early and Late Stages of Humanized APOE-Based Alzheimer's Disease Models. Frontiers in immunology. vol 11. 2021-05-14. PMID:33178186. |
neuroinflammation plays a crucial role in the development and progression of alzheimer's disease (ad), in which activated microglia are found to be associated with neurodegeneration. |
2021-05-14 |
2023-08-13 |
Not clear |
| Alexei Verkhratsky, Robert Zore. Large-Scale Proteomics Highlights Glial Role in Neurodegeneration. Cell metabolism. vol 32. issue 1. 2021-05-13. PMID:32640242. |
recent quantitative mass spectrometry and coexpression network analysis of postmortem human brain samples identified protein networks responsible for sugar metabolism and function of astrocytes and microglia are altered in alzheimer's disease and other types of neurodegenerative disorders. |
2021-05-13 |
2023-08-13 |
human |
| Daniel C Ellwanger, Shoutang Wang, Simone Brioschi, Zhifei Shao, Lydia Green, Ryan Case, Daniel Yoo, Dawn Weishuhn, Palaniswami Rathanaswami, Jodi Bradley, Sara Rao, Diana Cha, Peng Luan, Shilpa Sambashivan, Susan Gilfillan, Samuel A Hasson, Ian N Foltz, Menno van Lookeren Campagne, Marco Colonn. Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 3. 2021-05-12. PMID:33446504. |
prior activation state shapes the microglia response to antihuman trem2 in a mouse model of alzheimer's disease. |
2021-05-12 |
2023-08-13 |
mouse |
| Rashmi Das, Subashchandrabose Chinnathamb. Microglial remodeling of actin network by Tau oligomers, via G protein-coupled purinergic receptor, P2Y12R-driven chemotaxis. Traffic (Copenhagen, Denmark). vol 22. issue 5. 2021-05-10. PMID:33527700. |
alzheimer's disease (ad) is associated with age-related neurodegeneration, synaptic deformation and chronic inflammation mediated by microglia and infiltrated macrophages in the brain. |
2021-05-10 |
2023-08-13 |
Not clear |
| Ada Ndoja, Rohit Reja, Seung-Hye Lee, Joshua D Webster, Hai Ngu, Christopher M Rose, Donald S Kirkpatrick, Zora Modrusan, Ying-Jiun Jasmine Chen, Debra L Dugger, Vineela Gandham, Luke Xie, Kim Newton, Vishva M Dixi. Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia. Cell. vol 182. issue 5. 2021-05-07. PMID:32795415. |
dysregulated microglia are intimately involved in neurodegeneration, including alzheimer's disease (ad) pathogenesis, but the mechanisms controlling pathogenic microglial gene expression remain poorly understood. |
2021-05-07 |
2023-08-13 |
mouse |
| Shashank Kumar Maurya, Neetu Bhattacharya, Suman Mishra, Amit Bhattacharya, Pratibha Banerjee, Sabyasachi Senapati, Rajnikant Mishr. Microglia Specific Drug Targeting Using Natural Products for the Regulation of Redox Imbalance in Neurodegeneration. Frontiers in pharmacology. vol 12. 2021-05-02. PMID:33927630. |
microglia, a type of innate immune cell of the brain, regulates neurogenesis, immunological surveillance, redox imbalance, cognitive and behavioral changes under normal and pathological conditions like alzheimer's, parkinson's, multiple sclerosis and traumatic brain injury. |
2021-05-02 |
2023-08-13 |
Not clear |
| Shashank Kumar Maurya, Neetu Bhattacharya, Suman Mishra, Amit Bhattacharya, Pratibha Banerjee, Sabyasachi Senapati, Rajnikant Mishr. Microglia Specific Drug Targeting Using Natural Products for the Regulation of Redox Imbalance in Neurodegeneration. Frontiers in pharmacology. vol 12. 2021-05-02. PMID:33927630. |
the possible interventions by curcumin, resveratrol, cannabidiol, ginsenosides, flavonoids and sulforaphane on microglia specific protein iba1 suggest possibility of natural products mediated regulation of microglia phenotypes and its functions to control redox imbalance and neuroinflammation in management of alzheimer's, parkinson's and multiple sclerosis for microglia-mediated therapeutics. |
2021-05-02 |
2023-08-13 |
Not clear |
| Edward S Wickstead, Murray A Irving, Stephen J Getting, Simon McArthu. Exploiting formyl peptide receptor 2 to promote microglial resolution: a new approach to Alzheimer's disease treatment. The FEBS journal. 2021-05-01. PMID:33811735. |
inflammatory activation of the primary brain immune cells, the microglia, has been implicated in alzheimer's pathogenesis through genetic, preclinical, imaging and postmortem human studies, and strategies to regulate microglial activity may hold great promise for disease modification. |
2021-05-01 |
2023-08-13 |
human |
| Renato Socodato, Camila C Portugal, Teresa Canedo, Artur Rodrigues, Tiago O Almeida, Joana F Henriques, Sandra H Vaz, João Magalhães, Cátia M Silva, Filipa I Baptista, Renata L Alves, Vanessa Coelho-Santos, Ana Paula Silva, Roberto Paes-de-Carvalho, Ana Magalhães, Cord Brakebusch, Ana M Sebastião, Teresa Summavielle, António F Ambrósio, João B Relva. Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration. Cell reports. vol 31. issue 12. 2021-04-28. PMID:32579923. |
we also find that the rhoa/src signaling pathway is disrupted in microglia of the app/ps1 mouse model of alzheimer disease and that low doses of aβ oligomers trigger microglia neurotoxic polarization through the disruption of rhoa-to-src signaling. |
2021-04-28 |
2023-08-13 |
mouse |
| Karpagam Srinivasan, Brad A Friedman, Ainhoa Etxeberria, Melanie A Huntley, Marcel P van der Brug, Oded Foreman, Jonathan S Paw, Zora Modrusan, Thomas G Beach, Geidy E Serrano, David V Hanse. Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation. Cell reports. vol 31. issue 13. 2021-04-28. PMID:32610143. |
alzheimer's patient microglia exhibit enhanced aging and unique transcriptional activation. |
2021-04-28 |
2023-08-13 |
mouse |
| Karpagam Srinivasan, Brad A Friedman, Ainhoa Etxeberria, Melanie A Huntley, Marcel P van der Brug, Oded Foreman, Jonathan S Paw, Zora Modrusan, Thomas G Beach, Geidy E Serrano, David V Hanse. Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation. Cell reports. vol 31. issue 13. 2021-04-28. PMID:32610143. |
damage-associated microglia (dam) profiles observed in alzheimer's disease (ad)-related mouse models reflect an activation state that could modulate ad risk or progression. |
2021-04-28 |
2023-08-13 |
mouse |
| Yanting Chen, Tingting Hong, Feng Chen, Yuanhong Sun, Yan Wang, Lili Cu. Interplay Between Microglia and Alzheimer's Disease-Focus on the Most Relevant Risks: APOE Genotype, Sex and Age. Frontiers in aging neuroscience. vol 13. 2021-04-28. PMID:33897406. |
interplay between microglia and alzheimer's disease-focus on the most relevant risks: apoe genotype, sex and age. |
2021-04-28 |
2023-08-13 |
Not clear |
| Yanting Chen, Tingting Hong, Feng Chen, Yuanhong Sun, Yan Wang, Lili Cu. Interplay Between Microglia and Alzheimer's Disease-Focus on the Most Relevant Risks: APOE Genotype, Sex and Age. Frontiers in aging neuroscience. vol 13. 2021-04-28. PMID:33897406. |
uncontrolled activation of microglia is related to the course of neurodegenerative diseases such as alzheimer's disease. |
2021-04-28 |
2023-08-13 |
Not clear |
| M S Unger, E Li, L Scharnagl, R Poupardin, B Altendorfer, H Mrowetz, B Hutter-Paier, T M Weiger, M T Heneka, J Attems, L Aigne. CD8 Brain, behavior, and immunity. vol 89. 2021-04-27. PMID:32479993. |
cd8 neuroinflammation is a major contributor to disease progression in alzheimer's disease (ad) and is characterized by the activity of brain resident glial cells, in particular microglia cells. |
2021-04-27 |
2023-08-13 |
Not clear |
| Shima Safaiyan, Simon Besson-Girard, Tuğberk Kaya, Ludovico Cantuti-Castelvetri, Lu Liu, Hao Ji, Martina Schifferer, Garyfallia Gouna, Fumere Usifo, Nirmal Kannaiyan, Dirk Fitzner, Xianyuan Xiang, Moritz J Rossner, Matthias Brendel, Ozgun Gokce, Mikael Simon. White matter aging drives microglial diversity. Neuron. vol 109. issue 7. 2021-04-27. PMID:33606969. |
in the aged brain, wams form independent of apolipoprotein e (apoe), in contrast to mouse models of alzheimer's disease, in which microglia with the wam gene signature are generated prematurely and in an apoe-dependent pathway similar to dams. |
2021-04-27 |
2023-08-13 |
mouse |
| Duraisamy Kempuraj, Ramasamy Thangavel, Deepak D Kempuraj, Mohammad Ejaz Ahmed, Govindhasamy Pushpavathi Selvakumar, Sudhanshu P Raikwar, Smita A Zaheer, Shankar S Iyer, Raghav Govindarajan, Premkumar Nattanmai Chandrasekaran, Asgar Zahee. Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma. BioFactors (Oxford, England). vol 47. issue 2. 2021-04-26. PMID:33098588. |
in addition, luteolin can suppress neuroinflammatory response, activation of microglia and astrocytes, oxidative stress, neuroinflammation, and the severity of neuroinflammatory diseases such as alzheimer's disease, parkinson's disease, multiple sclerosis, and tbi pathogenesis. |
2021-04-26 |
2023-08-13 |
Not clear |
| b' Gaia Piccioni, Dalila Mango, Amira Saidi, Massimo Corbo, Robert Nistic\\xc3\\xb. Targeting Microglia-Synapse Interactions in Alzheimer\'s Disease. International journal of molecular sciences. vol 22. issue 5. 2021-04-19. PMID:33652870.' |
on the other hand, inflammatory signals associated with alzheimer's disease are able to modify the ramified morphology of microglia, thus leading to synapse loss and dysfunction, as well as cognitive impairment. |
2021-04-19 |
2023-08-13 |
Not clear |
| Thomas Ernest James Phillips, Emily Maguir. Phosphoinositides: Roles in the Development of Microglial-Mediated Neuroinflammation and Neurodegeneration. Frontiers in cellular neuroscience. vol 15. 2021-04-13. PMID:33841102. |
microglia are increasingly recognized as vital players in the pathology of a variety of neurodegenerative conditions including alzheimer's (ad) and parkinson's (pd) disease. |
2021-04-13 |
2023-08-13 |
Not clear |