| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicola Fattorelli, Anna Martinez-Muriana, Leen Wolfs, Ivana Geric, Bart De Strooper, Renzo Mancus. Stem-cell-derived human microglia transplanted into mouse brain to study human disease. Nature protocols. vol 16. issue 2. 2021-03-08. PMID:33424025. |
microglia are critically involved in complex neurological disorders with a strong genetic component, such as alzheimer's disease, parkinson's disease and frontotemporal dementia. |
2021-03-08 |
2023-08-13 |
mouse |
| Walter J Lukiw, Aileen I Pogu. Vesicular Transport of Encapsulated microRNA between Glial and Neuronal Cells. International journal of molecular sciences. vol 21. issue 14. 2021-03-05. PMID:32708414. |
this communication will review our current understanding of the trafficking of mirna-containing exs and emvs from astrocytes and "activated pro-inflammatory" microglia to target neurons in neurodegenerative diseases with an emphasis on alzheimer's disease wherever possible. |
2021-03-05 |
2023-08-13 |
Not clear |
| Jun Maeda, Takeharu Minamihisamatsu, Masafumi Shimojo, Xiaoyun Zhou, Maiko Ono, Yukio Matsuba, Bin Ji, Hideki Ishii, Masanao Ogawa, Hiroyasu Akatsu, Daita Kaneda, Yoshio Hashizume, John L Robinson, Virginia M-Y Lee, Takashi Saito, Takaomi C Saido, John Q Trojanowski, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi, Naruhiko Sahar. Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor. Brain communications. vol 3. issue 1. 2021-03-03. PMID:33644757. |
recent studies with single-cell rna analysis of cns cells in alzheimer's disease and diverse other neurodegenerative conditions revealed that the transition from homeostatic microglia to disease-associated microglia was defined by changes of gene expression levels, including down-regulation of the p2y12 receptor gene ( |
2021-03-03 |
2023-08-13 |
Not clear |
| Shoutang Wang, Meer Mustafa, Carla M Yuede, Santiago Viveros Salazar, Philip Kong, Hua Long, Michael Ward, Omer Siddiqui, Robert Paul, Susan Gilfillan, Adiljan Ibrahim, Hervé Rhinn, Ilaria Tassi, Arnon Rosenthal, Tina Schwabe, Marco Colonn. Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model. The Journal of experimental medicine. vol 217. issue 9. 2021-03-02. PMID:32579671. |
anti-human trem2 induces microglia proliferation and reduces pathology in an alzheimer's disease model. |
2021-03-02 |
2023-08-13 |
mouse |
| Aungkana Rachsee, Natthakarn Chiranthanut, Phraepakaporn Kunnaja, Seewaboon Sireeratawong, Parirat Khonsung, Sunee Chansakaow, Ampai Panthon. Mucuna pruriens (L.) DC. seed extract inhibits lipopolysaccharide-induced inflammatory responses in BV2 microglial cells. Journal of ethnopharmacology. vol 267. 2021-03-02. PMID:33122120. |
inflammation caused by activated microglia is known to be associated with neurodegenerative diseases, e.g., parkinson's disease (pd) and alzheimer's disease (ad). |
2021-03-02 |
2023-08-13 |
Not clear |
| Yu-Meng Wang, Wen-Zhuo Ming, Hui Liang, Ying-Jiao Wang, Yun-Hong Zhang, Da-Li Men. Isoquinolines from national herb Corydalis tomentella and neuroprotective effect against lipopolysaccharide-induced BV2 microglia cells. Bioorganic chemistry. vol 95. 2021-03-01. PMID:31862456. |
since plants from corydalis have been reported to protect against alzheimer's disease, all compounds were evaluated for their neuroprotective effect against lipopolysaccharide-induced bv2 microglia cells. |
2021-03-01 |
2023-08-13 |
Not clear |
| Mengmeng You, Zhuoning Miao, Olimpia Sienkiewicz, Xiasen Jiang, Xin Zhao, Fuliang H. 10-Hydroxydecanoic acid inhibits LPS-induced inflammation by targeting p53 in microglial cells. International immunopharmacology. vol 84. 2021-02-25. PMID:32311670. |
neuroinflammation, characterized by the activation of microglia and astrocytes, is important in the pathogenesis of many neurological disorders, such as alzheimer's disease. |
2021-02-25 |
2023-08-13 |
Not clear |
| Zhouyi Rong, Baoying Cheng, Li Zhong, Xiaowen Ye, Xin Li, Lin Jia, Yanfang Li, Francis Shue, Na Wang, Yiyun Cheng, Xiaohua Huang, Chia-Chen Liu, John D Fryer, Xin Wang, Yun-Wu Zhang, Honghua Zhen. Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 8. 2021-02-25. PMID:32613609. |
activation of fak/rac1/cdc42-gtpase signaling ameliorates impaired microglial migration response to aβ mutation of triggering receptor expressed on myeloid cells 2 (trem2) impairs the response of microglia to amyloid-β (aβ) pathology in alzheimer's disease (ad), although the mechanism governing trem2-regulated microglia recruitment to aβ plaques remains unresolved. |
2021-02-25 |
2023-08-13 |
Not clear |
| Laura Sebastian Monasor, Stephan A Müller, Alessio Vittorio Colombo, Gaye Tanrioever, Jasmin König, Stefan Roth, Arthur Liesz, Anna Berghofer, Anke Piechotta, Matthias Prestel, Takashi Saito, Takaomi C Saido, Jochen Herms, Michael Willem, Christian Haass, Stefan F Lichtenthaler, Sabina Tahirovi. Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models. eLife. vol 9. 2021-02-22. PMID:32510331. |
microglial dysfunction is a key pathological feature of alzheimer's disease (ad), but little is known about proteome-wide changes in microglia during the course of ad and their functional consequences. |
2021-02-22 |
2023-08-13 |
mouse |
| Chang Li, Yu-Hua Chen, Ke Zhan. Neuroprotective Properties and Therapeutic Potential of Bone Marrow-Derived Microglia in Alzheimer's Disease. American journal of Alzheimer's disease and other dementias. vol 35. 2021-02-22. PMID:32536247. |
neuroprotective properties and therapeutic potential of bone marrow-derived microglia in alzheimer's disease. |
2021-02-22 |
2023-08-13 |
Not clear |
| Siqiang Ren, Wen Yao, Marc D Tambini, Tao Yin, Kelly A Norris, Luciano D'Adami. Microglia eLife. vol 9. 2021-02-22. PMID:32579116. |
microglia to study the mechanisms by which the p.r47h variant of the microglia gene and alzheimer's disease (ad) risk factor trem2 increases dementia risk, we created |
2021-02-22 |
2023-08-13 |
Not clear |
| Ji-Won Lee, In-Hee Lee, Tadahiro Iimura, Sek Won Kon. Two macrophages, osteoclasts and microglia: from development to pleiotropy. Bone research. vol 9. issue 1. 2021-02-20. PMID:33568650. |
osteoclasts and microglia are distinct tissue-resident cells of the macrophage lineage in bone and brain that are responsible for pathological changes in osteoporosis and alzheimer's disease (ad), respectively. |
2021-02-20 |
2023-08-13 |
Not clear |
| Susanna R Var, Christine A Byrd-Jacob. Role of Macrophages and Microglia in Zebrafish Regeneration. International journal of molecular sciences. vol 21. issue 13. 2021-02-18. PMID:32635596. |
zebrafish are an emerging model for studying macrophages in regeneration after injury and microglia in neurodegenerative disorders such as parkinson's disease and alzheimer's disease. |
2021-02-18 |
2023-08-13 |
human |
| Carmen Lopez-Sanchez, Virginio Garcia-Martinez, Joana Poejo, Virginio Garcia-Lopez, Jairo Salazar, Carlos Gutierrez-Merin. Early Reactive A1 Astrocytes Induction by the Neurotoxin 3-Nitropropionic Acid in Rat Brain. International journal of molecular sciences. vol 21. issue 10. 2021-02-16. PMID:32443829. |
it has been shown that inflammation mediates npa-induced brain degeneration, and activated microglia secreting cytokines interleukin-1α (il-1α) and tumor necrosis factor α (tnfα) can induce a specific type of reactive neurotoxic astrocytes, named a1, which have been detected in post-mortem brain samples of huntington's, alzheimer's, and parkinson's diseases. |
2021-02-16 |
2023-08-13 |
rat |
| Noelia Geribaldi-Doldán, Cecilia Fernández-Ponce, Roberto Navarro Quiroz, Ismael Sánchez-Gomar, Lorena Gómez Escorcia, Erika Puentes Velásquez, Elkin Navarro Quiro. The Role of Microglia in Glioblastoma. Frontiers in oncology. vol 10. 2021-02-16. PMID:33585220. |
under physiological conditions, microglia, the phagocytes of the central nervous system (cns), are involved in various processes such as neurogenesis or axonal growth, and the progression of different conditions such as alzheimer's disease. |
2021-02-16 |
2023-08-13 |
Not clear |
| Wolfgang J Streit, Habibeh Khoshbouei, Ingo Bechman. Dystrophic microglia in late-onset Alzheimer's disease. Glia. vol 68. issue 4. 2021-02-02. PMID:31922322. |
dystrophic microglia in late-onset alzheimer's disease. |
2021-02-02 |
2023-08-13 |
human |
| Chuan He, Zhong-Sheng Huang, Hong-Ru Chen, Chao-Chao Yu, Xue-Song Wang, Tao Jiang, Li-Hong Kon. [Effect of pretreatment of acupuncture on learning-memory ability and related protein of NLRP3 inflammasome in hippocampus in Alzheimer's disease like rats]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 40. issue 12. 2021-02-01. PMID:33415876. |
to observe the effect of pretreatment of acupuncture on the expression of nucleotide-binding oligomerization domain-like receptor 3(nlrp3), caspase-1, interleukin1β(il-1β) and the number of activated microglia (mg) in the hippocampus in alzheimer's disease (ad) like rats, so as to explore the mechanism of pretreatment of acupuncture in preventing and treating ad. |
2021-02-01 |
2023-08-13 |
rat |
| Katherine R Giordano, Charlotte R Denman, Phoebe S Dubisch, Murtaza Akhter, Jonathan Lifshit. An update on the rod microglia variant in experimental and clinical brain injury and disease. Brain communications. vol 3. issue 1. 2021-01-30. PMID:33501429. |
rod microglia were reported frequently in the early 1900s by neuropathologists in post-mortem cases of general paresis, alzheimer's disease and encephalitis, and then remained largely ignored for almost 100 years. |
2021-01-30 |
2023-08-13 |
Not clear |
| Pavithra Suresh, Sarayut Phasuk, Ingrid Y Li. Modulation of microglia activation and Alzheimer's disease: CX3 chemokine ligand 1/CX3CR and P2X Tzu chi medical journal. vol 33. issue 1. 2021-01-30. PMID:33505871. |
modulation of microglia activation and alzheimer's disease: cx3 chemokine ligand 1/cx3cr and p2x alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by cognitive deficits. |
2021-01-30 |
2023-08-13 |
Not clear |
| Yingying He, John Bosco Ruganzu, Hui Jin, Xiaoqian Peng, Shengfeng Ji, Yanbing Ma, Liming Zheng, Weina Yan. LRP1 knockdown aggravates Aβ Experimental cell research. vol 394. issue 2. 2021-01-27. PMID:32645395. |
lrp1 knockdown aggravates aβ neuroinflammation is an important pathological feature and an early event in the pathogenesis of alzheimer's disease (ad), which is characterized by activation of microglia and astrocytes. |
2021-01-27 |
2023-08-13 |
Not clear |