| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emiliano Peña-Altamira, Sabrina Petralla, Francesca Massenzio, Marco Virgili, Maria L Bolognesi, Barbara Mont. Nutritional and Pharmacological Strategies to Regulate Microglial Polarization in Cognitive Aging and Alzheimer's Disease. Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:28638339. |
here we review recent data on these approaches and propose that their combination could have a synergistic effect to counteract cognitive aging impairment and alzheimer's disease (ad) through immunomodulation of microglia polarization, i.e., by driving the shift of activated microglia from the pro-inflammatory m1 to the neuroprotective m2 phenotype. |
2020-10-01 |
2023-08-13 |
human |
| Divya Raj, Zhuoran Yin, Marjolein Breur, Janine Doorduin, Inge R Holtman, Marta Olah, Ietje J Mantingh-Otter, Debby Van Dam, Peter P De Deyn, Wilfred den Dunnen, Bart J L Eggen, Sandra Amor, Erik Boddek. Increased White Matter Inflammation in Aging- and Alzheimer's Disease Brain. Frontiers in molecular neuroscience. vol 10. 2020-10-01. PMID:28713239. |
in this study, we investigated microglia activity in various brain regions upon healthy aging and alzheimer's disease (ad)-related pathology in both human and mouse samples. |
2020-10-01 |
2023-08-13 |
mouse |
| Ana I Ramirez, Rosa de Hoz, Elena Salobrar-Garcia, Juan J Salazar, Blanca Rojas, Daniel Ajoy, Inés López-Cuenca, Pilar Rojas, Alberto Triviño, José M Ramíre. The Role of Microglia in Retinal Neurodegeneration: Alzheimer's Disease, Parkinson, and Glaucoma. Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:28729832. |
the role of microglia in retinal neurodegeneration: alzheimer's disease, parkinson, and glaucoma. |
2020-10-01 |
2023-08-13 |
Not clear |
| Jun-Ichi Satoh, Yoshihiro Kino, Motoaki Yanaizu, Youhei Tosaki, Kenji Sakai, Tsuyoshi Ishida, Yuko Sait. Microglia express ABI3 in the brains of Alzheimer's disease and Nasu-Hakola disease. Intractable & rare diseases research. vol 6. issue 4. 2020-10-01. PMID:29259854. |
microglia express abi3 in the brains of alzheimer's disease and nasu-hakola disease. |
2020-10-01 |
2023-08-13 |
Not clear |
| Hu Li, Xueping Zhang, Mingfu Chen, Jianyan Chen, Tao Gao, Shanglong Ya. Dexmedetomidine inhibits inflammation in microglia cells under stimulation of LPS and ATP by c-Fos/NLRP3/caspase-1 cascades. EXCLI journal. vol 17. 2020-10-01. PMID:29743866. |
nod-like receptor 3 (nlrp3) plays critical roles in the initiation of inflammasome-mediated inflammation in microglia, thus becomes an important therapeutic target of alzheimer's disease (ad). |
2020-10-01 |
2023-08-13 |
human |
| Victoria Navarro, Elisabeth Sanchez-Mejias, Sebastian Jimenez, Clara Muñoz-Castro, Raquel Sanchez-Varo, Jose C Davila, Marisa Vizuete, Antonia Gutierrez, Javier Vitoric. Microglia in Alzheimer's Disease: Activated, Dysfunctional or Degenerative. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:29867449. |
microglia in alzheimer's disease: activated, dysfunctional or degenerative. |
2020-10-01 |
2023-08-13 |
human |
| Victoria Navarro, Elisabeth Sanchez-Mejias, Sebastian Jimenez, Clara Muñoz-Castro, Raquel Sanchez-Varo, Jose C Davila, Marisa Vizuete, Antonia Gutierrez, Javier Vitoric. Microglia in Alzheimer's Disease: Activated, Dysfunctional or Degenerative. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:29867449. |
in other degenerative processes, such as alzheimer's disease (ad), the role of microglia is far to be elucidated. |
2020-10-01 |
2023-08-13 |
human |
| Hye-Sun Lim, Yu Jin Kim, Bu-Yeo Kim, Gunhyuk Park, Soo-Jin Jeon. The Anti-neuroinflammatory Activity of Tectorigenin Pretreatment via Downregulated NF-κB and ERK/JNK Pathways in BV-2 Microglial and Microglia Inactivation in Mice With Lipopolysaccharide. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:29867470. |
the activation of microglia is decisively involved with the neurodegeneration observed in many neuroinflammatory pathologies, such as multiple sclerosis, parkinson's disease, and alzheimer's disease. |
2020-10-01 |
2023-08-13 |
mouse |
| Yingyue Zhou, Tyler K Ulland, Marco Colonn. TREM2-Dependent Effects on Microglia in Alzheimer's Disease. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:30038567. |
trem2-dependent effects on microglia in alzheimer's disease. |
2020-10-01 |
2023-08-13 |
mouse |
| Juan R Perea, María Llorens-Martín, Jesús Ávila, Marta Boló. The Role of Microglia in the Spread of Tau: Relevance for Tauopathies. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30042659. |
this review focuses on the role played by microglia in tauopathies, specifically in alzheimer's disease (ad), and how the uncoupling of activation/phagocytosis functions can have fatal consequences leading to the development of the pathology. |
2020-10-01 |
2023-08-13 |
Not clear |
| Alejandro Carrillo-Jimenez, Mar Puigdellívol, Anna Vilalta, Jose Luis Venero, Guy Charles Brown, Peter StGeorge-Hyslop, Miguel Angel Burguillo. Effective Knockdown of Gene Expression in Primary Microglia With siRNA and Magnetic Nanoparticles Without Cell Death or Inflammation. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30297984. |
microglia, the resident immune cells of the brain, have multiple functions in physiological and pathological conditions, including alzheimer's disease (ad). |
2020-10-01 |
2023-08-13 |
Not clear |
| Björn-Ole Bast, Uta Rickert, Janna Schneppenheim, François Cossais, Henrik Wilms, Philipp Arnold, Ralph Luciu. Aldosterone exerts anti-inflammatory effects on LPS stimulated microglia. Heliyon. vol 4. issue 10. 2020-10-01. PMID:30302409. |
over the last years, studies on microglia cell function in chronic neuro-inflammation and neuronal necrosis pointed towards an eminent role of these cells in multiple sclerosis, parkinson's and alzheimer's disease. |
2020-10-01 |
2023-08-13 |
Not clear |
| Camilla Thygesen, Laura Ilkjær, Stefan J Kempf, Anne Louise Hemdrup, Christian Ulrich von Linstow, Alicia A Babcock, Sultan Darvesh, Martin R Larsen, Bente Finse. Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APP Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30459560. |
diverse protein profiles in cns myeloid cells and cns tissue from lipopolysaccharide- and vehicle-injected app neuroinflammation, characterized by chronic activation of the myeloid-derived microglia, is a hallmark of alzheimer's disease (ad). |
2020-10-01 |
2023-08-13 |
Not clear |
| Israel C Nnah, Marianne Wessling-Resnic. Brain Iron Homeostasis: A Focus on Microglial Iron. Pharmaceuticals (Basel, Switzerland). vol 11. issue 4. 2020-10-01. PMID:30477086. |
increasing evidence suggests that accumulation of brain iron and chronic neuroinflammation, characterized by microglia activation and secretion of proinflammatory cytokines, are hallmarks of neurodegenerative disorders including alzheimer' s disease. |
2020-10-01 |
2023-08-13 |
Not clear |
| Atsuko Katsumoto, Hideyuki Takeuchi, Keita Takahashi, Fumiaki Tanak. Microglia in Alzheimer's Disease: Risk Factors and Inflammation. Frontiers in neurology. vol 9. 2020-10-01. PMID:30498474. |
microglia in alzheimer's disease: risk factors and inflammation. |
2020-10-01 |
2023-08-13 |
mouse |
| Jaymie R Voorhees, Matthew T Remy, Claire M Erickson, Laura M Dutca, Daniel J Brat, Andrew A Piepe. Occupational-like organophosphate exposure disrupts microglia and accelerates deficits in a rat model of Alzheimer's disease. NPJ aging and mechanisms of disease. vol 5. 2020-10-01. PMID:30701080. |
occupational-like organophosphate exposure disrupts microglia and accelerates deficits in a rat model of alzheimer's disease. |
2020-10-01 |
2023-08-13 |
rat |
| Celia G Fernandez, Mary E Hamby, Morgan L McReynolds, William J Ra. The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer's Disease. Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:30804776. |
the role of apoe4 in disrupting the homeostatic functions of astrocytes and microglia in aging and alzheimer's disease. |
2020-10-01 |
2023-08-13 |
Not clear |
| Yifei Lu, Zhongyuan Guo, Yujie Zhang, Chao Li, Yu Zhang, Qin Guo, Qinjun Chen, Xinli Chen, Xi He, Lisha Liu, Chunhui Ruan, Tao Sun, Bin Ji, Weigen Lu, Chen Jian. Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia. Advanced science (Weinheim, Baden-Wurttemberg, Germany). vol 6. issue 4. 2020-10-01. PMID:30828531. |
microenvironment remodeling micelles for alzheimer's disease therapy by early modulation of activated microglia. |
2020-10-01 |
2023-08-13 |
mouse |
| Philippa Malko, Sharifah A Syed Mortadza, Joseph McWilliam, Lin-Hua Jian. TRPM2 Channel in Microglia as a New Player in Neuroinflammation Associated With a Spectrum of Central Nervous System Pathologies. Frontiers in pharmacology. vol 10. 2020-10-01. PMID:30914955. |
however, aberrant microglial cell activation can lead to excessive generation of neurotoxic proinflammatory mediators and neuroinflammation, which represents a contributing factor in a wide spectrum of cns pathologies, including ischemic stroke, traumatic brain damage, alzheimer's disease, parkinson's disease, multiple sclerosis, psychiatric disorders, autism spectrum disorders, and chronic neuropathic pain. |
2020-10-01 |
2023-08-13 |
Not clear |
| Maria Anele Romeo, Alberto Faggioni, Mara Ciron. Could autophagy dysregulation link neurotropic viruses to Alzheimer's disease? Neural regeneration research. vol 14. issue 9. 2020-10-01. PMID:31089040. |
moreover, herpesvirus infection of central nervous system cells such as glia and microglia can increase the production of oxidant species through the alteration of mitochondrial dynamics and promote inflammation, another hallmark of alzheimer's disease. |
2020-10-01 |
2023-08-13 |
human |