| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun-Ichi Satoh, Yoshihiro Kino, Motoaki Yanaizu, Tsuyoshi Ishida, Yuko Sait. Microglia express TMEM119 in the brains of Nasu-Hakola disease. Intractable & rare diseases research. vol 8. issue 4. 2020-09-28. PMID:31890453. |
tmem119 was expressed on microglia in nhd brains as well as in the brains of non-neurological controls (nc) and alzheimer's disease (ad) patients, although tmem119-immunolabeled areas exhibited great variability from case to case without significant differences among the study population. |
2020-09-28 |
2023-08-13 |
human |
| Sophie C Gray, Kerri J Kinghorn, Nathaniel S Woodlin. Shifting equilibriums in Alzheimer's disease: the complex roles of microglia in neuroinflammation, neuronal survival and neurogenesis. Neural regeneration research. vol 15. issue 7. 2020-09-28. PMID:31960800. |
shifting equilibriums in alzheimer's disease: the complex roles of microglia in neuroinflammation, neuronal survival and neurogenesis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Sophie C Gray, Kerri J Kinghorn, Nathaniel S Woodlin. Shifting equilibriums in Alzheimer's disease: the complex roles of microglia in neuroinflammation, neuronal survival and neurogenesis. Neural regeneration research. vol 15. issue 7. 2020-09-28. PMID:31960800. |
reflecting the well-established roles of microglia in reacting to pathogens and inflammatory stimuli, there is now a growing literature describing both protective and detrimental effects for individual cytokines and chemokines produced by microglia in alzheimer's disease. |
2020-09-28 |
2023-08-13 |
Not clear |
| Sophie C Gray, Kerri J Kinghorn, Nathaniel S Woodlin. Shifting equilibriums in Alzheimer's disease: the complex roles of microglia in neuroinflammation, neuronal survival and neurogenesis. Neural regeneration research. vol 15. issue 7. 2020-09-28. PMID:31960800. |
here we review recent findings on the roles played by microglia in neuroinflammation, neuronal survival and neurogenesis in alzheimer's disease. |
2020-09-28 |
2023-08-13 |
Not clear |
| Caitlín Ní Chasaide, Marina A Lync. The role of the immune system in driving neuroinflammation. Brain and neuroscience advances. vol 4. 2020-09-28. PMID:32219178. |
it is unclear what factors cause the inappropriate activation of the microglia in alzheimer's disease, but one contributor may be infiltrating peripheral immune cells and these include macrophages and t cells. |
2020-09-28 |
2023-08-13 |
Not clear |
| Caitlín Ní Chasaide, Marina A Lync. The role of the immune system in driving neuroinflammation. Brain and neuroscience advances. vol 4. 2020-09-28. PMID:32219178. |
it has been suggested that both cell types modulate the phenotype of microglia, highlighting the importance of crosstalk between the innate and adaptive immune system in alzheimer's disease. |
2020-09-28 |
2023-08-13 |
Not clear |
| Bailey A Loving, Kimberley D Bruc. Lipid and Lipoprotein Metabolism in Microglia. Frontiers in physiology. vol 11. 2020-09-28. PMID:32411016. |
this review describes our current understanding of lipid and lipoprotein metabolism in microglia, and highlights microglial lipid metabolism as a modifiable target for the treatment of neurodegenerative diseases such as alzheimer's disease and multiple sclerosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yunying Yang, Zhentao Zhan. Microglia and Wnt Pathways: Prospects for Inflammation in Alzheimer's Disease. Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32477095. |
microglia and wnt pathways: prospects for inflammation in alzheimer's disease. |
2020-09-28 |
2023-08-13 |
Not clear |
| Weigang Cui, Chunli Sun, Yuqi Ma, Songtao Wang, Xianwei Wang, Yinghua Zhan. Inhibition of TLR4 Induces M2 Microglial Polarization and Provides Neuroprotection via the NLRP3 Inflammasome in Alzheimer's Disease. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32508567. |
accumulating evidence has indicated that activation of microglia and neuroinflammation reaction play a prominent role in alzheimer's disease (ad). |
2020-09-28 |
2023-08-13 |
mouse |
| Hariharakrishnan Chidambaram, Rashmi Das, Subashchandrabose Chinnathamb. Interaction of Tau with the chemokine receptor, CX3CR1 and its effect on microglial activation, migration and proliferation. Cell & bioscience. vol 10. 2020-09-28. PMID:32944223. |
in this review, the pathophysiological roles of cx3cr1/fractalkine signalling in microglia and neurons at different stages of alzheimer's disease and the possible role of cx3cr1/tau signalling has been widely discussed. |
2020-09-28 |
2023-08-13 |
Not clear |
| Anna L Cranston, Adrianna Wysocka, Marta Steczkowska, Maciej Zadrożny, Ewelina Palasz, Charles R Harrington, Franz Theuring, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer's disease and frontotemporal lobar degeneration. Brain communications. vol 2. issue 1. 2020-09-28. PMID:32954291. |
in addition, pro-inflammatory glial cells such as astrocytes and microglia may play a key role in the neurodegenerative cascade of alzheimer's disease and tauopathies. |
2020-09-28 |
2023-08-13 |
mouse |
| Alireza Faridar, Aaron D Thome, Weihua Zhao, Jason R Thonhoff, David R Beers, Belen Pascual, Joseph C Masdeu, Stanley H Appe. Restoring regulatory T-cell dysfunction in Alzheimer's disease through Brain communications. vol 2. issue 2. 2020-09-28. PMID:32954348. |
while neuroprotective microglia are important for containment/clearance of amyloid plaques and maintaining neuronal survival, alzheimer inflammatory microglia may play a detrimental role by eliciting tau pathogenesis and accelerating neurotoxicity. |
2020-09-28 |
2023-08-13 |
Not clear |
| Rebecca Stevenson, Evgeniia Samokhina, Ilaria Rossetti, John W Morley, Yossi Buskil. Neuromodulation of Glial Function During Neurodegeneration. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32973460. |
recent advances have demonstrated that glial cells, specifically microglia and astroglia, are involved in several neurodegenerative diseases including amyotrophic lateral sclerosis (als), epilepsy, parkinson's disease (pd), alzheimer's disease (ad), and frontotemporal dementia (ftd). |
2020-09-28 |
2023-08-13 |
Not clear |
| Ishan Agrawal, Sushmita Jh. Mitochondrial Dysfunction and Alzheimer's Disease: Role of Microglia. Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32973488. |
mitochondrial dysfunction and alzheimer's disease: role of microglia. |
2020-09-28 |
2023-08-13 |
Not clear |
| Delphine Boche, Alexander Gerhard, Elena Rodriguez-Vieite. Prospects and challenges of imaging neuroinflammation beyond TSPO in Alzheimer's disease. European journal of nuclear medicine and molecular imaging. vol 46. issue 13. 2020-09-23. PMID:31396666. |
the present review describes the recent advancements in microglia and astrocyte biology in the context of health, ageing, and alzheimer's disease, the most common dementia worldwide. |
2020-09-23 |
2023-08-13 |
human |
| Lucia Batzu, Eric Westman, Joana B Pereir. Cerebrospinal fluid progranulin is associated with increased cortical thickness in early stages of Alzheimer's disease. Neurobiology of aging. vol 88. 2020-09-23. PMID:31980280. |
progranulin plays an important role in neuroinflammation in alzheimer's disease (ad) pathophysiology, being upregulated by activated microglia. |
2020-09-23 |
2023-08-13 |
human |
| James Keaney, Julien Gasser, Gaëlle Gillet, Diana Scholz, Irena Kadi. Inhibition of Bruton's Tyrosine Kinase Modulates Microglial Phagocytosis: Therapeutic Implications for Alzheimer's Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 14. issue 3. 2020-09-18. PMID:30758770. |
using potent btk inhibitors and small interfering rna (sirna) against btk, we observed that blockade of btk activity decreased activation of phospholipase gamma 2, a recently identified genetic risk factor in alzheimer's disease (ad), and reduced phagocytosis in rodent microglia and human monocyte-derived macrophages. |
2020-09-18 |
2023-08-13 |
mouse |
| Dominic M Walsh, Dennis J Selko. Amyloid β-protein and beyond: the path forward in Alzheimer's disease. Current opinion in neurobiology. vol 61. 2020-09-15. PMID:32197217. |
basic research on the biological mechanism of alzheimer's disease has focused for decades on the age-related aggregation of the amyloid β-protein and its apparent downstream effects on microglia, astrocytes and neurons, including the posttranslational modification of the tau protein that seems necessary for symptom expression. |
2020-09-15 |
2023-08-13 |
Not clear |
| Zachery Moore, Juliet M Taylor, Peter J Crac. The involvement of microglia in Alzheimer's disease: a new dog in the fight. British journal of pharmacology. vol 176. issue 18. 2020-09-14. PMID:30445661. |
the involvement of microglia in alzheimer's disease: a new dog in the fight. |
2020-09-14 |
2023-08-13 |
dog |
| Ramon Velazquez, Eric Ferreira, Sara Knowles, Chaya Fux, Alexis Rodin, Wendy Winslow, Salvatore Odd. Lifelong choline supplementation ameliorates Alzheimer's disease pathology and associated cognitive deficits by attenuating microglia activation. Aging cell. vol 18. issue 6. 2020-09-14. PMID:31560162. |
lifelong choline supplementation ameliorates alzheimer's disease pathology and associated cognitive deficits by attenuating microglia activation. |
2020-09-14 |
2023-08-13 |
mouse |