| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ju Youn Lee, Seung Hoon Han, Min Hee Park, Im-Sook Song, Min-Koo Choi, Eunsoo Yu, Cheol-Min Park, Hee-Jin Kim, Seung Hyun Kim, Edward H Schuchman, Hee Kyung Jin, Jae-Sung Ba. N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease. Nature communications. vol 11. issue 1. 2020-08-31. PMID:32398649. |
n-as-triggered spms are direct regulators of microglia in a model of alzheimer's disease. |
2020-08-31 |
2023-08-13 |
mouse |
| José M Castellano, Silvia Garcia-Rodriguez, Juan M Espinosa, María C Millan-Linares, Mirela Rada, Javier S Peron. Oleanolic Acid Exerts a Neuroprotective Effect Against Microglial Cell Activation by Modulating Cytokine Release and Antioxidant Defense Systems. Biomolecules. vol 9. issue 11. 2020-08-25. PMID:31683841. |
these findings advocate considering oa as a novel neuroprotective agent to inhibit oxidative stress and inflammatory response in activated microglia associated with alzheimer's disease. |
2020-08-25 |
2023-08-13 |
Not clear |
| Erik C B Johnson, Eric B Dammer, Duc M Duong, Lingyan Ping, Maotian Zhou, Luming Yin, Lenora A Higginbotham, Andrew Guajardo, Bartholomew White, Juan C Troncoso, Madhav Thambisetty, Thomas J Montine, Edward B Lee, John Q Trojanowski, Thomas G Beach, Eric M Reiman, Vahram Haroutunian, Minghui Wang, Eric Schadt, Bin Zhang, Dennis W Dickson, Nilüfer Ertekin-Taner, Todd E Golde, Vladislav A Petyuk, Philip L De Jager, David A Bennett, Thomas S Wingo, Srikant Rangaraju, Ihab Hajjar, Joshua M Shulman, James J Lah, Allan I Levey, Nicholas T Seyfrie. Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation. Nature medicine. vol 26. issue 5. 2020-08-24. PMID:32284590. |
large-scale proteomic analysis of alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation. |
2020-08-24 |
2023-08-13 |
Not clear |
| Sung Hoon Baik, Seokjo Kang, Woochan Lee, Hayoung Choi, Sunwoo Chung, Jong-Il Kim, Inhee Mook-Jun. A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease. Cell metabolism. vol 30. issue 3. 2020-08-21. PMID:31257151. |
a breakdown in metabolic reprogramming causes microglia dysfunction in alzheimer's disease. |
2020-08-21 |
2023-08-13 |
mouse |
| Sung Hoon Baik, Seokjo Kang, Woochan Lee, Hayoung Choi, Sunwoo Chung, Jong-Il Kim, Inhee Mook-Jun. A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease. Cell metabolism. vol 30. issue 3. 2020-08-21. PMID:31257151. |
reactive microglia are a major pathological feature of alzheimer's disease (ad). |
2020-08-21 |
2023-08-13 |
mouse |
| D T Ohm, G Kim, T Gefen, A Rademaker, S Weintraub, E H Bigio, M-M Mesulam, E Rogalski, C Geul. Prominent microglial activation in cortical white matter is selectively associated with cortical atrophy in primary progressive aphasia. Neuropathology and applied neurobiology. vol 45. issue 3. 2020-08-19. PMID:29679378. |
ppa is associated with alzheimer's disease (ad), frontotemporal lobar degeneration (ftld) and significant accumulation of activated microglia. |
2020-08-19 |
2023-08-13 |
Not clear |
| Alejandro Carrillo-Jimenez, Özgen Deniz, Maria Victoria Niklison-Chirou, Rocio Ruiz, Karina Bezerra-Salomão, Vassilis Stratoulias, Rachel Amouroux, Ping Kei Yip, Anna Vilalta, Mathilde Cheray, Alexander Michael Scott-Egerton, Eloy Rivas, Khadija Tayara, Irene García-Domínguez, Juan Garcia-Revilla, Juan Carlos Fernandez-Martin, Ana Maria Espinosa-Oliva, Xianli Shen, Peter St George-Hyslop, Guy Charles Brown, Petra Hajkova, Bertrand Joseph, Jose Luis Venero, Miguel Ramos Branco, Miguel Angel Burguillo. TET2 Regulates the Neuroinflammatory Response in Microglia. Cell reports. vol 29. issue 3. 2020-08-18. PMID:31618637. |
we observed that microglia associated with amyloid β plaques expressed tet2 in brain tissue from individuals with alzheimer's disease (ad) and in 5xfad mice. |
2020-08-18 |
2023-08-13 |
mouse |
| Kate M Onusk. The Dual Role of Microglia in the Progression of Alzheimer's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 8. 2020-08-07. PMID:32075949. |
the dual role of microglia in the progression of alzheimer's disease. |
2020-08-07 |
2023-08-13 |
Not clear |
| Matteo Pedrazzoli, Morris Losurdo, Giovanna Paolone, Manuela Medelin, Lejdi Jaupaj, Barbara Cisterna, Anna Slanzi, Manuela Malatesta, Silvia Coco, Mario Buffell. Glucocorticoid receptors modulate dendritic spine plasticity and microglia activity in an animal model of Alzheimer's disease. Neurobiology of disease. vol 132. 2020-08-06. PMID:31394203. |
glucocorticoid receptors modulate dendritic spine plasticity and microglia activity in an animal model of alzheimer's disease. |
2020-08-06 |
2023-08-13 |
mouse |
| Malvindar K Singh-Bains, Vanessa Linke, Micah D R Austria, Adelie Y S Tan, Emma L Scotter, Nasim F Mehrabi, Richard L M Faull, Mike Draguno. Altered microglia and neurovasculature in the Alzheimer's disease cerebellum. Neurobiology of disease. vol 132. 2020-08-06. PMID:31454549. |
altered microglia and neurovasculature in the alzheimer's disease cerebellum. |
2020-08-06 |
2023-08-13 |
human |
| Michael Ewers, Nicolai Franzmeier, Marc Suárez-Calvet, Estrella Morenas-Rodriguez, Miguel Angel Araque Caballero, Gernot Kleinberger, Laura Piccio, Carlos Cruchaga, Yuetiva Deming, Martin Dichgans, John Q Trojanowski, Leslie M Shaw, Michael W Weiner, Christian Haas. Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease. Science translational medicine. vol 11. issue 507. 2020-07-27. PMID:31462511. |
loss of function of trem2, a key receptor selectively expressed by microglia in the brain, contributes to the development of alzheimer's disease (ad). |
2020-07-27 |
2023-08-13 |
human |
| Min-Fang Guo, Hui-Yu Zhang, Yan-Hua Li, Qing-Fang Gu, Wen-Yue Wei, Yu-Yin Wang, Xiao-Juan Zhang, Xiao-Qin Liu, Li-Juan Song, Zhi Chai, Jie-Zhong Yu, Cun-Gen M. Fasudil inhibits the activation of microglia and astrocytes of transgenic Alzheimer's disease mice via the downregulation of TLR4/Myd88/NF-κB pathway. Journal of neuroimmunology. vol 346. 2020-07-22. PMID:32652366. |
fasudil inhibits the activation of microglia and astrocytes of transgenic alzheimer's disease mice via the downregulation of tlr4/myd88/nf-κb pathway. |
2020-07-22 |
2023-08-13 |
mouse |
| Steven Estus, Benjamin C Shaw, Nicholas Devanney, Yuriko Katsumata, Eileen E Press, David W Fard. Evaluation of CD33 as a genetic risk factor for Alzheimer's disease. Acta neuropathologica. vol 138. issue 2. 2020-07-20. PMID:30949760. |
subsequent studies found that cd33 is expressed in microglia in the brain and then investigated the molecular mechanism underlying the cd33 genetic association with alzheimer's disease. |
2020-07-20 |
2023-08-13 |
Not clear |
| Antonio Boza-Serrano, Rocío Ruiz, Raquel Sanchez-Varo, Juan García-Revilla, Yiyi Yang, Itzia Jimenez-Ferrer, Agnes Paulus, Malin Wennström, Anna Vilalta, David Allendorf, Jose Carlos Davila, John Stegmayr, Sebastian Jiménez, Maria A Roca-Ceballos, Victoria Navarro-Garrido, Maria Swanberg, Christine L Hsieh, Luis M Real, Elisabet Englund, Sara Linse, Hakon Leffler, Ulf J Nilsson, Guy C Brown, Antonia Gutierrez, Javier Vitorica, Jose Luis Venero, Tomas Deierbor. Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease. Acta neuropathologica. vol 138. issue 2. 2020-07-20. PMID:31006066. |
gal3 was highly upregulated in the brains of ad patients and 5xfad (familial alzheimer's disease) mice and found specifically expressed in microglia associated with aβ plaques. |
2020-07-20 |
2023-08-13 |
mouse |
| Alicia A Nugent, Karin Lin, Bettina van Lengerich, Steve Lianoglou, Laralynne Przybyla, Sonnet S Davis, Ceyda Llapashtica, Junhua Wang, Do Jin Kim, Dan Xia, Anthony Lucas, Sulochanadevi Baskaran, Patrick C G Haddick, Melina Lenser, Timothy K Earr, Ju Shi, Jason C Dugas, Benjamin J Andreone, Todd Logan, Hilda O Solanoy, Hang Chen, Ankita Srivastava, Suresh B Poda, Pascal E Sanchez, Ryan J Watts, Thomas Sandmann, Giuseppe Astarita, Joseph W Lewcock, Kathryn M Monroe, Gilbert Di Paol. TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge. Neuron. vol 105. issue 5. 2020-07-07. PMID:31902528. |
loss-of-function (lof) variants of trem2, an immune receptor expressed in microglia, increase alzheimer's disease risk. |
2020-07-07 |
2023-08-13 |
human |
| Abhishek Bhattacherjee, Emily Rodrigues, Jaesoo Jung, Matthew Luzentales-Simpson, Jhon R Enterina, Danny Galleguillos, Chris D St Laurent, Maryam Nakhaei-Nejad, Felix F Fuchsberger, Laura Streith, Qian Wang, Norihito Kawasaki, Shiteng Duan, Arjun Bains, James C Paulson, Christoph Rademacher, Fabrizio Giuliani, Simonetta Sipione, Matthew S Macaule. Repression of phagocytosis by human CD33 is not conserved with mouse CD33. Communications biology. vol 2. 2020-07-06. PMID:31815204. |
cd33 is an immunomodulatory receptor linked to alzheimer's disease (ad) susceptibility via regulation of phagocytosis in microglia. |
2020-07-06 |
2023-08-13 |
mouse |
| Mai Fujikura, Naotoshi Iwahara, Shin Hisahara, Jun Kawamata, Akihiro Matsumura, Kazuki Yokokawa, Taro Saito, Tatsuo Manabe, Takashi Matsushita, Syuuichirou Suzuki, Shun Shimoham. CD14 and Toll-Like Receptor 4 Promote Fibrillar Aβ42 Uptake by Microglia Through A Clathrin-Mediated Pathway. Journal of Alzheimer's disease : JAD. vol 68. issue 1. 2020-06-18. PMID:30775984. |
we previously demonstrated that microglia play an essential role in clearance of amyloid-β (aβ) in alzheimer's disease (ad)-like pathology. |
2020-06-18 |
2023-08-13 |
mouse |
| Carlo Sala Frigerio, Leen Wolfs, Nicola Fattorelli, Nicola Thrupp, Iryna Voytyuk, Inga Schmidt, Renzo Mancuso, Wei-Ting Chen, Maya E Woodbury, Gyan Srivastava, Thomas Möller, Eloise Hudry, Sudeshna Das, Takaomi Saido, Eric Karran, Bradley Hyman, V Hugh Perry, Mark Fiers, Bart De Stroope. The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques. Cell reports. vol 27. issue 4. 2020-06-17. PMID:31018141. |
the major risk factors for alzheimer's disease: age, sex, and genes modulate the microglia response to aβ plaques. |
2020-06-17 |
2023-08-13 |
Not clear |
| Djuna von Maydell, Mehdi Jorf. The interplay between microglial states and major risk factors in Alzheimer's disease through the eyes of single-cell RNA-sequencing: beyond black and white. Journal of neurophysiology. vol 122. issue 4. 2020-06-17. PMID:31365320. |
this spectrum spans heterogeneous populations of homeostatic and neuropathology-associated microglia in both healthy and alzheimer's disease (ad) mouse brains. |
2020-06-17 |
2023-08-13 |
mouse |
| Dafina M Angelova, David R Brow. Microglia and the aging brain: are senescent microglia the key to neurodegeneration? Journal of neurochemistry. vol 151. issue 6. 2020-06-11. PMID:31478208. |
while aged microglia have been frequently identified in neurodegenerative diseases such as alzheimer's disease, there is no conclusive evidence that proves a causal role. |
2020-06-11 |
2023-08-13 |
Not clear |