All Relations between Alzheimer Disease and microglial cell

Publication Sentence Publish Date Extraction Date Species
Lihang Zhang, Juan Xu, Jinchao Gao, Yuncheng Wu, Ming Yin, Wenjuan Zha. CD200-, CX3CL1-, and TREM2-mediated neuron-microglia interactions and their involvements in Alzheimer's disease. Reviews in the neurosciences. vol 29. issue 8. 2019-08-29. PMID:29729150. in recent years, substantial studies have focused on the interactions between neurons and microglia, revealing that microglia become reactive when the interactions are pathophysiologically interfered, usually accompanying neuronal injury, which is a common feature for alzheimer's disease (ad). 2019-08-29 2023-08-13 Not clear
Shorena Janelidze, Niklas Mattsson, Erik Stomrud, Olof Lindberg, Sebastian Palmqvist, Henrik Zetterberg, Kaj Blennow, Oskar Hansso. CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease. Neurology. vol 91. issue 9. 2019-08-19. PMID:30054439. to measure csf levels of biomarkers reflecting microglia and astrocytes activation, neuroinflammation, and cerebrovascular changes and study their associations with the core biomarkers of alzheimer disease (ad) pathology (β-amyloid [aβ] and tau), structural imaging correlates, and clinical disease progression over time. 2019-08-19 2023-08-13 Not clear
Yang Shi, David M Holtzma. Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight. Nature reviews. Immunology. vol 18. issue 12. 2019-08-15. PMID:30140051. in alzheimer disease, neuroinflammation heavily relies on innate immune responses that are primarily mediated by cns-resident microglia. 2019-08-15 2023-08-13 Not clear
Yang Shi, David M Holtzma. Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight. Nature reviews. Immunology. vol 18. issue 12. 2019-08-15. PMID:30140051. here, we review the rapidly growing literature on the role of disease-associated microglia, trem2 and apoe in the pathogenesis of alzheimer disease and present an integrated view of innate immune function in alzheimer disease. 2019-08-15 2023-08-13 Not clear
Markley Silva Oliveira-Junior, Erica Patricia Pereira, Vanessa Cristina Meira de Amorim, Luã Tainã Costa Reis, Ravena Pereira do Nascimento, Victor Diogenes Amaral da Silva, Silvia Lima Cost. Lupeol inhibits LPS-induced neuroinflammation in cerebellar cultures and induces neuroprotection associated to the modulation of astrocyte response and expression of neurotrophic and inflammatory factors. International immunopharmacology. vol 70. 2019-08-13. PMID:30852286. in the central nervous system (cns), neuroinflammation, especially that modulated by the cell response of astrocytes and microglia, is associated with damage to neurons in neurodegenerative disorders such as parkinson's disease, alzheimer's disease and, multiple sclerosis. 2019-08-13 2023-08-13 rat
Shahnawaz Ali Bhat, Anika Sood, Rakesh Shukla, Kashif Hani. AT2R Activation Prevents Microglia Pro-inflammatory Activation in a NOX-Dependent Manner: Inhibition of PKC Activation and p47 Molecular neurobiology. vol 56. issue 4. 2019-08-06. PMID:30076526. at2r activation prevents microglia pro-inflammatory activation in a nox-dependent manner: inhibition of pkc activation and p47 microglia-induced reactive oxygen species (ros) production and inflammation play an imperative role in neurodegenerative diseases like alzheimer's disease (ad) and parkinson's disease (pd). 2019-08-06 2023-08-13 Not clear
Teng Jiang, Liu-Jun Xue, Yang Yang, Qing-Guang Wang, Xiao Xue, Zhou Ou, Qing Gao, Jian-Quan Shi, Liang Wu, Ying-Dong Zhan. AVE0991, a nonpeptide analogue of Ang-(1-7), attenuates aging-related neuroinflammation. Aging. vol 10. issue 4. 2019-08-02. PMID:29667931. during the aging process, chronic neuroinflammation induced by microglia is detrimental for the brain and contributes to the etiology of several aging-related neurodegenerative diseases such as alzheimer's disease and parkinson's disease. 2019-08-02 2023-08-13 mouse
Sho Takatori, Wenbo Wang, Akihiro Iguchi, Taisuke Tomit. Genetic Risk Factors for Alzheimer Disease: Emerging Roles of Microglia in Disease Pathomechanisms. Advances in experimental medicine and biology. vol 1118. 2019-08-02. PMID:30747419. genetic risk factors for alzheimer disease: emerging roles of microglia in disease pathomechanisms. 2019-08-02 2023-08-13 Not clear
Ankita K Shukla, Laura L McIntyre, Samuel E Marsh, Christine A Schneider, Evelyn M Hoover, Craig M Walsh, Melissa B Lodoen, Mathew Blurton-Jones, Matthew A Inla. CD11a expression distinguishes infiltrating myeloid cells from plaque-associated microglia in Alzheimer's disease. Glia. vol 67. issue 5. 2019-07-29. PMID:30588668. cd11a expression distinguishes infiltrating myeloid cells from plaque-associated microglia in alzheimer's disease. 2019-07-29 2023-08-13 mouse
Michael S Unger, Julia Marschallinger, Julia Kaindl, Barbara Klein, Mary Johnson, Ahmad A Khundakar, Steffen Roßner, Michael T Heneka, Sebastien Couillard-Despres, Edward Rockenstein, Eliezer Masliah, Johannes Attems, Ludwig Aigne. Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-β plaques: A potential role in shaping plaque pathology? Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 14. issue 8. 2019-07-26. PMID:29630865. one characteristic of alzheimer's disease is the formation of amyloid-β plaques, which are typically linked to neuroinflammation and surrounded by inflammatory cells such as microglia and infiltrating immune cells. 2019-07-26 2023-08-13 Not clear
Tomoko Sao, Yuta Yoshino, Kiyohiro Yamazaki, Yuki Ozaki, Yoko Mori, Shinichiro Ochi, Taku Yoshida, Takaaki Mori, Jun-Ichi Iga, Shu-Ichi Uen. TREM1 mRNA Expression in Leukocytes and Cognitive Function in Japanese Patients with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 64. issue 4. 2019-07-26. PMID:30010135. triggering receptor expressed on myeloid cells 2 (trem2) activates the innate immune system, promotes phagocytosis by microglia, and is associated with alzheimer's disease (ad). 2019-07-26 2023-08-13 Not clear
Marc Suárez-Calvet, Anja Capell, Miguel Ángel Araque Caballero, Estrella Morenas-Rodríguez, Katrin Fellerer, Nicolai Franzmeier, Gernot Kleinberger, Erden Eren, Yuetiva Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Katrina Paumier, Randall J Bateman, Anne M Fagan, John C Morris, Johannes Levin, Adrian Danek, Mathias Jucker, Colin L Masters, Martin N Rossor, John M Ringman, Leslie M Shaw, John Q Trojanowski, Michael Weiner, Michael Ewers, Christian Haas. CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. EMBO molecular medicine. vol 10. issue 12. 2019-07-22. PMID:30482868. progranulin (pgrn) is predominantly expressed by microglia in the brain, and genetic and experimental evidence suggests a critical role in alzheimer's disease (ad). 2019-07-22 2023-08-13 Not clear
William C Kreisl, Ioline D Henter, Robert B Inni. Imaging Translocator Protein as a Biomarker of Neuroinflammation in Dementia. Advances in pharmacology (San Diego, Calif.). vol 82. 2019-07-17. PMID:29413519. accumulation of abnormal protein aggregates in alzheimer's disease, frontotemporal dementia, and dementia with lewy bodies is associated with the activation of microglia and astrocytes into proinflammatory states, and chronic low-level activation of glial cells likely contributes to the pathological changes observed in these and other neurodegenerative diseases. 2019-07-17 2023-08-13 human
C Y Daniel Lee, Anthony Daggett, Xiaofeng Gu, Lu-Lin Jiang, Peter Langfelder, Xiaoguang Li, Nan Wang, Yingjun Zhao, Chang Sin Park, Yonatan Cooper, Isabella Ferando, Istvan Mody, Giovanni Coppola, Huaxi Xu, X William Yan. Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models. Neuron. vol 97. issue 5. 2019-07-15. PMID:29518357. elevated trem2 gene dosage reprograms microglia responsivity and ameliorates pathological phenotypes in alzheimer's disease models. 2019-07-15 2023-08-13 mouse
Lisbell D Estrada, Luciana Oliveira-Cruz, Daniel Cabrer. Transforming Growth Factor Beta Type I Role in Neurodegeneration: Implications for Alzheimer´s Disease. Current protein & peptide science. vol 19. issue 12. 2019-07-11. PMID:29189146. aging and chronic inflammation reduce the canonical tgf-β1/smad signaling, facilitating cytotoxic activation of microglia and microgliamediated neurodegeneration this review gathers together evidence for a neuroprotective role of tgf-β in alzheimer's disease. 2019-07-11 2023-08-13 Not clear
Brad A Friedman, Karpagam Srinivasan, Gai Ayalon, William J Meilandt, Han Lin, Melanie A Huntley, Yi Cao, Seung-Hye Lee, Patrick C G Haddick, Hai Ngu, Zora Modrusan, Jessica L Larson, Joshua S Kaminker, Marcel P van der Brug, David V Hanse. Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer's Disease Not Evident in Mouse Models. Cell reports. vol 22. issue 3. 2019-07-09. PMID:29346778. using these modules to interpret single-cell data from an alzheimer's disease (ad) model, we identified microglial subsets-distinct from previously reported "disease-associated microglia"-expressing interferon-related or proliferation modules. 2019-07-09 2023-08-13 mouse
Lawrence Rajendran, Rosa C Paolicell. Microglia-Mediated Synapse Loss in Alzheimer's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 12. 2019-07-05. PMID:29563239. microglia are emerging as key players in neurodegenerative diseases, such as alzheimer's disease (ad). 2019-07-05 2023-08-13 Not clear
Miguel Ángel Araque Caballero, Marc Suárez-Calvet, Marco Duering, Nicolai Franzmeier, Tammie Benzinger, Anne M Fagan, Randall J Bateman, Clifford R Jack, Johannes Levin, Martin Dichgans, Mathias Jucker, Celeste Karch, Colin L Masters, John C Morris, Michael Weiner, Martin Rossor, Nick C Fox, Jae-Hong Lee, Stephen Salloway, Adrian Danek, Alison Goate, Igor Yakushev, Jason Hassenstab, Peter R Schofield, Christian Haass, Michael Ewer. White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease. Brain : a journal of neurology. vol 141. issue 10. 2019-07-05. PMID:30239611. such white matter alterations are associated with primary alzheimer's disease pathology and microglia activity in the brain. 2019-07-05 2023-08-13 human
C Gussago, M Casati, E Ferri, B Arosi. The Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) as Expression of the Relationship between Microglia and Alzheimer's Disease: A Novel Marker for a Promising Pathway to Explore. The Journal of frailty & aging. vol 8. issue 2. 2019-06-27. PMID:30997915. the triggering receptor expressed on myeloid cells-2 (trem-2) as expression of the relationship between microglia and alzheimer's disease: a novel marker for a promising pathway to explore. 2019-06-27 2023-08-13 Not clear
Srikant Rangaraju, Syed Ali Raza, Noel Xiang'An Li, Ranjita Betarbet, Eric B Dammer, Duc Duong, James J Lah, Nicholas T Seyfried, Allan I Leve. Differential Phagocytic Properties of CD45 Frontiers in immunology. vol 9. 2019-06-24. PMID:29552013. differential phagocytic properties of cd45 in the central nervous system (cns), microglia are innate immune mononuclear phagocytes (cns mps) that can phagocytose infectious particles, apoptotic cells, neurons, and pathological protein aggregates, such as aβ in alzheimer's disease (ad). 2019-06-24 2023-08-13 Not clear