| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eleonora Rossi, Eva Mracsko, Adam Papadimitropoulos, Nima Allafi, Dieter Reinhardt, Arne Mehrkens, Ivan Martin, Irene Knuesel, Arnaud Scherberic. An In Vitro Bone Model to Investigate the Role of Triggering Receptor Expressed on Myeloid Cells-2 in Bone Homeostasis. Tissue engineering. Part C, Methods. vol 24. issue 7. 2019-03-13. PMID:29897015. |
triggering receptor expressed on myeloid cells-2 (trem-2), a transmembrane receptor expressed by macrophages, microglia, and osteoclasts (ocs), plays a protective role in late-onset alzheimer disease (ad). |
2019-03-13 |
2023-08-13 |
human |
| Xiaoli Wu, Jayasankar Kosaraju, Kin Yip Ta. Anti-neuroinflammatory effects of SLOH in Aβ-induced BV-2 microglial cells and 3xTg-AD mice involve the inhibition of GSK-3β. Neuroscience letters. vol 687. 2019-03-07. PMID:30278248. |
neuroinflammation has been observed in post-mortem alzheimer's disease (ad) brains which could be due to aβ interacting with microglia and astrocytes. |
2019-03-07 |
2023-08-13 |
mouse |
| Neelima Gupta, Sukanya Shyamasundar, Radhika Patnala, Aparna Karthikeyan, Thiruma V Arumugam, Eng-Ang Ling, S Thameem Dhee. Recent progress in therapeutic strategies for microglia-mediated neuroinflammation in neuropathologies. Expert opinion on therapeutic targets. vol 22. issue 9. 2019-02-27. PMID:30138572. |
chronic activation of microglia is the hallmark of numerous neuropathologies such as alzheimer's disease, parkinson's disease, and multiple sclerosis. |
2019-02-27 |
2023-08-13 |
Not clear |
| Vahid Reza Askari, Reza Shafiee-Nic. The protective effects of β-caryophyllene on LPS-induced primary microglia M Life sciences. vol 219. 2019-02-25. PMID:30620895. |
the protective effects of β-caryophyllene on lps-induced primary microglia m neuroinflammation is observed as a routine characterization of neurodegenerative disorders such as dementia, multiple sclerosis (ms) and alzheimer's diseases (ad). |
2019-02-25 |
2023-08-13 |
Not clear |
| R A Thuraisingha. Pathogenesis of Alzheimer's Disease Examined Using a Modified Puri-Li Model that Incorporates Calcium Ion Homeostasis. Journal of molecular neuroscience : MN. vol 65. issue 2. 2019-02-18. PMID:29754213. |
the puri-li kinetic model is modified to include neuronal calcium ion homeostasis to study the effect of calcium ions on the production of amyloid-β peptides (aβ), microglia, and astroglia during the pathogenesis of alzheimer's disease (ad). |
2019-02-18 |
2023-08-13 |
Not clear |
| K E Hopperton, D Mohammad, M O Trépanier, V Giuliano, R P Bazine. Markers of microglia in post-mortem brain samples from patients with Alzheimer's disease: a systematic review. Molecular psychiatry. vol 23. issue 2. 2019-02-15. PMID:29230021. |
markers of microglia in post-mortem brain samples from patients with alzheimer's disease: a systematic review. |
2019-02-15 |
2023-08-13 |
Not clear |
| K E Hopperton, D Mohammad, M O Trépanier, V Giuliano, R P Bazine. Markers of microglia in post-mortem brain samples from patients with Alzheimer's disease: a systematic review. Molecular psychiatry. vol 23. issue 2. 2019-02-15. PMID:29230021. |
increases in the expression of markers of microglia, the main neuroinmmune cell, are widely reported in brains from patients with alzheimer's disease, but the literature has not yet been systematically reviewed to determine whether this is a consistent pathological feature. |
2019-02-15 |
2023-08-13 |
Not clear |
| K E Hopperton, D Mohammad, M O Trépanier, V Giuliano, R P Bazine. Markers of microglia in post-mortem brain samples from patients with Alzheimer's disease: a systematic review. Molecular psychiatry. vol 23. issue 2. 2019-02-15. PMID:29230021. |
papers were included if they quantitatively compared microglia markers in post-mortem brain samples from patients with alzheimer's disease and aged controls without neurological disease. |
2019-02-15 |
2023-08-13 |
Not clear |
| K E Hopperton, D Mohammad, M O Trépanier, V Giuliano, R P Bazine. Markers of microglia in post-mortem brain samples from patients with Alzheimer's disease: a systematic review. Molecular psychiatry. vol 23. issue 2. 2019-02-15. PMID:29230021. |
these results show that increased markers of microglia are a consistent feature of alzheimer's disease, though this seems to be driven primarily by increases in activation-associated markers, as opposed to markers of all microglia. |
2019-02-15 |
2023-08-13 |
Not clear |
| Qingwen Cheng, Jean Danao, Santosh Talreja, Paul Wen, Jun Yin, Ning Sun, Chi-Ming Li, Danny Chui, David Tran, Samir Koirala, Hang Chen, Ian N Foltz, Songli Wang, Shilpa Sambashiva. TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant The Journal of biological chemistry. vol 293. issue 32. 2019-02-15. PMID:29599291. |
trem2-activating antibodies abrogate the negative pleiotropic effects of the alzheimer's disease variant triggering receptor expressed on myeloid cells 2 (trem2) is an orphan immune receptor expressed on cells of myeloid lineage such as macrophages and microglia. |
2019-02-15 |
2023-08-13 |
Not clear |
| Xiao-Qun An, Wei Xi, Chen-Yun Gu, Xiao Huan. Complement protein C5a enhances the β-amyloid-induced neuro-inflammatory response in microglia in Alzheimer's disease. Medecine sciences : M/S. vol 34 Focus issue F1. 2019-02-13. PMID:30403186. |
complement protein c5a enhances the β-amyloid-induced neuro-inflammatory response in microglia in alzheimer's disease. |
2019-02-13 |
2023-08-13 |
Not clear |
| Nooshin Heshmati-Fakhr, Fattah Sotoodehnejadnematalahi, Niloufar Yousefi, Mohammad Sayyah, Sayed Masoud Hosseini, Hamid Gholami Pourbadi. Triggering microglia through toll-like receptor 2 pathway induced interferon β expression in cell and animal model of Alzheimer's disease. Neuroreport. vol 29. issue 17. 2019-02-12. PMID:30222725. |
triggering microglia through toll-like receptor 2 pathway induced interferon β expression in cell and animal model of alzheimer's disease. |
2019-02-12 |
2023-08-13 |
rat |
| Nooshin Heshmati-Fakhr, Fattah Sotoodehnejadnematalahi, Niloufar Yousefi, Mohammad Sayyah, Sayed Masoud Hosseini, Hamid Gholami Pourbadi. Triggering microglia through toll-like receptor 2 pathway induced interferon β expression in cell and animal model of Alzheimer's disease. Neuroreport. vol 29. issue 17. 2019-02-12. PMID:30222725. |
in the previous study, we found that early activation of microglia by toll-like receptor 2 (tlr2) attenuated alzheimer's disease-associated cognitive deficit. |
2019-02-12 |
2023-08-13 |
rat |
| Nooshin Heshmati-Fakhr, Fattah Sotoodehnejadnematalahi, Niloufar Yousefi, Mohammad Sayyah, Sayed Masoud Hosseini, Hamid Gholami Pourbadi. Triggering microglia through toll-like receptor 2 pathway induced interferon β expression in cell and animal model of Alzheimer's disease. Neuroreport. vol 29. issue 17. 2019-02-12. PMID:30222725. |
this study was designed to investigate whether pretreatment with the tlr2 receptor ligand can regulate microglia to produce interferon β (infβ) in a rat model of alzheimer's disease. |
2019-02-12 |
2023-08-13 |
rat |
| Mir Hilal Ahmad, Mahino Fatima, Amal Chandra Monda. Influence of microglia and astrocyte activation in the neuroinflammatory pathogenesis of Alzheimer's disease: Rational insights for the therapeutic approaches. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 59. 2019-02-12. PMID:30385170. |
influence of microglia and astrocyte activation in the neuroinflammatory pathogenesis of alzheimer's disease: rational insights for the therapeutic approaches. |
2019-02-12 |
2023-08-13 |
Not clear |
| Nisha Rathore, Sree Ranjani Ramani, Homer Pantua, Jian Payandeh, Tushar Bhangale, Arthur Wuster, Manav Kapoor, Yonglian Sun, Sharookh B Kapadia, Lino Gonzalez, Ali A Zarrin, Alison Goate, David V Hansen, Timothy W Behrens, Robert R Graha. Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease. PLoS genetics. vol 14. issue 11. 2019-02-08. PMID:30388101. |
we propose that pilra g78r protects individuals from alzheimer's disease risk via reduced inhibitory signaling in microglia and reduced microglial infection during hsv-1 recurrence. |
2019-02-08 |
2023-08-13 |
Not clear |
| Titikorn Chunchai, Nipon Chattipakorn, Siriporn C Chattipakor. The possible factors affecting microglial activation in cases of obesity with cognitive dysfunction. Metabolic brain disease. vol 33. issue 3. 2019-02-05. PMID:29164373. |
there is increasing evidence to demonstrate that microglia play a crucial role in cognitive decline in cases of obesity, alzheimer's disease and also in the aging process. |
2019-02-05 |
2023-08-13 |
Not clear |
| Tanja Blume, Carola Focke, Finn Peters, Maximilian Deussing, Nathalie L Albert, Simon Lindner, Franz-Josef Gildehaus, Barbara von Ungern-Sternberg, Laurence Ozmen, Karlheinz Baumann, Peter Bartenstein, Axel Rominger, Jochen Herms, Matthias Brende. Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study. Journal of neuroinflammation. vol 15. issue 1. 2019-01-29. PMID:30400912. |
causal associations between microglia activation and β-amyloid (aβ) accumulation during the progression of alzheimer's disease (ad) remain a matter of controversy. |
2019-01-29 |
2023-08-13 |
mouse |
| R Taipa, V Ferreira, P Brochado, A Robinson, I Reis, F Marques, D M Mann, M Melo-Pires, N Sous. Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study. Neuropathology and applied neurobiology. vol 44. issue 3. 2019-01-23. PMID:29044639. |
inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset alzheimer disease: a post mortem study. |
2019-01-23 |
2023-08-13 |
Not clear |
| Sebastián Beltrán-Castillo, Jaime Eugenín, Rommy von Bernhard. Impact of Aging in Microglia-Mediated D-Serine Balance in the CNS. Mediators of inflammation. vol 2018. 2019-01-22. PMID:30363571. |
d-serine dysregulation promoted by microglia could have a role in age-related cognitive impairment and in the induction and progression of neurodegenerative processes like alzheimer's disease. |
2019-01-22 |
2023-08-13 |
Not clear |