| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yong Cui, Yanjie Wang, Danyu Zhao, Xiaofan Feng, Lin Zhang, Chun Li. Loganin prevents BV-2 microglia cells from Aβ Cell biology international. vol 42. issue 12. 2019-01-18. PMID:30288860. |
loganin prevents bv-2 microglia cells from aβ neuroinflammation is closely related with the pathogenesis and progress of neurodegenerative diseases including alzheimer's disease (ad). |
2019-01-18 |
2023-08-13 |
Not clear |
| Katarina Krbot, Peter Hermann, Magdalena Krbot Skorić, Inga Zerr, Diego Sepulveda-Falla, Stefan Goebel, Jakob Matschke, Susanne Krasemann, Markus Glatze. Distinct microglia profile in Creutzfeldt-Jakob disease and Alzheimer's disease is independent of disease kinetics. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 38. issue 6. 2019-01-18. PMID:30318820. |
distinct microglia profile in creutzfeldt-jakob disease and alzheimer's disease is independent of disease kinetics. |
2019-01-18 |
2023-08-13 |
human |
| David V Hansen, Jesse E Hanson, Morgan Shen. Microglia in Alzheimer's disease. The Journal of cell biology. vol 217. issue 2. 2018-12-12. PMID:29196460. |
microglia in alzheimer's disease. |
2018-12-12 |
2023-08-13 |
human |
| David V Hansen, Jesse E Hanson, Morgan Shen. Microglia in Alzheimer's disease. The Journal of cell biology. vol 217. issue 2. 2018-12-12. PMID:29196460. |
proliferation and activation of microglia in the brain, concentrated around amyloid plaques, is a prominent feature of alzheimer's disease (ad). |
2018-12-12 |
2023-08-13 |
human |
| Justin Rustenhoven, Amy M Smith, Leon C Smyth, Deidre Jansson, Emma L Scotter, Molly E V Swanson, Miranda Aalderink, Natacha Coppieters, Pritika Narayan, Renee Handley, Chris Overall, Thomas I H Park, Patrick Schweder, Peter Heppner, Maurice A Curtis, Richard L M Faull, Mike Draguno. PU.1 regulates Alzheimer's disease-associated genes in primary human microglia. Molecular neurodegeneration. vol 13. issue 1. 2018-12-12. PMID:30124174. |
pu.1 regulates alzheimer's disease-associated genes in primary human microglia. |
2018-12-12 |
2023-08-13 |
human |
| Justin Rustenhoven, Amy M Smith, Leon C Smyth, Deidre Jansson, Emma L Scotter, Molly E V Swanson, Miranda Aalderink, Natacha Coppieters, Pritika Narayan, Renee Handley, Chris Overall, Thomas I H Park, Patrick Schweder, Peter Heppner, Maurice A Curtis, Richard L M Faull, Mike Draguno. PU.1 regulates Alzheimer's disease-associated genes in primary human microglia. Molecular neurodegeneration. vol 13. issue 1. 2018-12-12. PMID:30124174. |
in the brain, pu.1 is specifically expressed in microglia and recent evidence from genome-wide association studies suggests that reductions in pu.1 contribute to a delayed onset of alzheimer's disease (ad), possibly through limiting neuroinflammatory responses. |
2018-12-12 |
2023-08-13 |
human |
| Leen Janssen, Marissa L Dubbelaar, Inge R Holtman, Jelkje de Boer-Bergsma, Bart J L Eggen, Hendrikus W G M Boddeke, Peter P De Deyn, Debby Van Da. Aging, microglia and cytoskeletal regulation are key factors in the pathological evolution of the APP23 mouse model for Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 2. 2018-12-11. PMID:27838490. |
aging, microglia and cytoskeletal regulation are key factors in the pathological evolution of the app23 mouse model for alzheimer's disease. |
2018-12-11 |
2023-08-13 |
mouse |
| Nofar Torika, Keren Asraf, Ron N Apte, Sigal Fleisher-Berkovic. Candesartan ameliorates brain inflammation associated with Alzheimer's disease. CNS neuroscience & therapeutics. vol 24. issue 3. 2018-12-11. PMID:29365370. |
alzheimer's disease (ad) pathology is associated with brain inflammation involving microglia and astrocytes. |
2018-12-11 |
2023-08-13 |
Not clear |
| Sarah C Hopp, Yang Lin, Derek Oakley, Allyson D Roe, Sarah L DeVos, David Hanlon, Bradley T Hyma. The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease. Journal of neuroinflammation. vol 15. issue 1. 2018-12-11. PMID:30227881. |
the role of microglia in processing and spreading of bioactive tau seeds in alzheimer's disease. |
2018-12-11 |
2023-08-13 |
Not clear |
| Moumita Datta, Ori Staszewski, Elena Raschi, Maximilian Frosch, Nora Hagemeyer, Tuan Leng Tay, Thomas Blank, Mario Kreutzfeldt, Doron Merkler, Stephanie Ziegler-Waldkirch, Patrick Matthias, Melanie Meyer-Luehmann, Marco Prin. Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner. Immunity. vol 48. issue 3. 2018-11-27. PMID:29548672. |
in a mouse model of alzheimer's disease, deletion of hdac1 and hdac2 in microglia, but not in neuroectodermal cells, resulted in a decrease in amyloid load and improved cognitive impairment by enhancing microglial amyloid phagocytosis. |
2018-11-27 |
2023-08-13 |
mouse |
| Hai M Nguyen, Linda V Blomster, Palle Christophersen, Heike Wulf. Potassium channel expression and function in microglia: Plasticity and possible species variations. Channels (Austin, Tex.). vol 11. issue 4. 2018-11-22. PMID:28277939. |
potassium channels play important roles in microglia functions and thus constitute potential targets for the treatment of neurodegenerative diseases like alzheimer, parkinson and stroke. |
2018-11-22 |
2023-08-13 |
mouse |
| Yasunori Nishimura, Mitsuaki Moriyama, Kenji Kawabe, Hideyo Satoh, Katsura Takano, Yasu-Taka Azuma, Yoichi Nakamur. Lauric Acid Alleviates Neuroinflammatory Responses by Activated Microglia: Involvement of the GPR40-Dependent Pathway. Neurochemical research. vol 43. issue 9. 2018-11-21. PMID:29947014. |
in several neurodegenerative diseases such as alzheimer's disease (ad), microglia are hyperactivated and release nitric oxide (no) and proinflammatory cytokines, resulting its neuropathology. |
2018-11-21 |
2023-08-13 |
mouse |
| Justyna Sosna, Stephan Philipp, Ricardo Albay, Jorge Mauricio Reyes-Ruiz, David Baglietto-Vargas, Frank M LaFerla, Charles G Glab. Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease. Molecular neurodegeneration. vol 13. issue 1. 2018-11-09. PMID:29490706. |
early long-term administration of the csf1r inhibitor plx3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5xfad mouse model of alzheimer's disease. |
2018-11-09 |
2023-08-13 |
mouse |
| Srikant Rangaraju, Eric B Dammer, Syed Ali Raza, Tianwen Gao, Hailian Xiao, Ranjita Betarbet, Duc M Duong, James A Webster, Chadwick M Hales, James J Lah, Allan I Levey, Nicholas T Seyfrie. Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer's disease-related proteins. Molecular neurodegeneration. vol 13. issue 1. 2018-11-09. PMID:29954413. |
quantitative proteomics of acutely-isolated mouse microglia identifies novel immune alzheimer's disease-related proteins. |
2018-11-09 |
2023-08-13 |
mouse |
| Monika Plescher, Gerald Seifert, Jan Niklas Hansen, Peter Bedner, Christian Steinhäuser, Annett Hall. Plaque-dependent morphological and electrophysiological heterogeneity of microglia in an Alzheimer's disease mouse model. Glia. vol 66. issue 7. 2018-11-05. PMID:29493017. |
plaque-dependent morphological and electrophysiological heterogeneity of microglia in an alzheimer's disease mouse model. |
2018-11-05 |
2023-08-13 |
mouse |
| Monika Plescher, Gerald Seifert, Jan Niklas Hansen, Peter Bedner, Christian Steinhäuser, Annett Hall. Plaque-dependent morphological and electrophysiological heterogeneity of microglia in an Alzheimer's disease mouse model. Glia. vol 66. issue 7. 2018-11-05. PMID:29493017. |
microglia, the central nervous system resident innate immune cells, cluster around aβ plaques in alzheimer's disease (ad). |
2018-11-05 |
2023-08-13 |
mouse |
| Teng Jiang, Ying-Dong Zhang, Qing Gao, Zhou Ou, Peng-Yu Gong, Jian-Quan Shi, Liang Wu, Jun-Shan Zho. TREM2 Ameliorates Neuronal Tau Pathology Through Suppression of Microglial Inflammatory Response. Inflammation. vol 41. issue 3. 2018-10-10. PMID:29362997. |
as a recently identified susceptibility gene for alzheimer's disease (ad), triggering receptor expressed on myeloid cells 2 (trem2) encodes an immune receptor that is uniquely expressed on microglia, functioning as a modulator of microglial functions including phagocytosis and inflammatory response. |
2018-10-10 |
2023-08-13 |
mouse |
| Bingxu Huang, Dewei He, Guangxin Chen, Xin Ran, Wenjin Guo, Xingchi Kan, Wei Wang, Dianfeng Liu, Shoupeng Fu, Juxiong Li. α-Cyperone inhibits LPS-induced inflammation in BV-2 cells through activation of Akt/Nrf2/HO-1 and suppression of the NF-κB pathway. Food & function. vol 9. issue 5. 2018-10-03. PMID:29667667. |
accumulating evidence has shown that activated microglia cause inflammatory immune response, which could lead to neurodegenerative diseases such as parkinson's disease and alzheimer's disease. |
2018-10-03 |
2023-08-13 |
Not clear |
| Kazuyuki Takata, Takahide Amamiya, Hiroaki Mizoguchi, Shohei Kawanishi, Eriko Kuroda, Risa Kitamura, Aina Ito, Yuki Saito, Manami Tawa, Tomofumi Nagasawa, Haruka Okamoto, Yuko Sugino, Shigehiko Takegami, Tatsuya Kitade, Yuki Toda, William R Kem, Yoshihisa Kitamura, Shun Shimohama, Eishi Ashihar. Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease. Neurobiology of aging. vol 62. 2018-09-26. PMID:29175709. |
we previously demonstrated that stimulation of nicotinic acetylcholine receptors (nachrs) increases amyloid-β (aβ) phagocytosis in rat microglia and is closely associated with the decrease of brain aβ and amelioration of memory dysfunction in a transgenic mouse model of alzheimer's disease (ad). |
2018-09-26 |
2023-08-13 |
human |
| Diego Mastroeni, Jennifer Nolz, Shobana Sekar, Elaine Delvaux, Geidy Serrano, Lori Cuyugan, Winnie S Liang, Thomas G Beach, Joseph Rogers, Paul D Colema. Laser-captured microglia in the Alzheimer's and Parkinson's brain reveal unique regional expression profiles and suggest a potential role for hepatitis B in the Alzheimer's brain. Neurobiology of aging. vol 63. 2018-09-26. PMID:29207277. |
laser-captured microglia in the alzheimer's and parkinson's brain reveal unique regional expression profiles and suggest a potential role for hepatitis b in the alzheimer's brain. |
2018-09-26 |
2023-08-13 |
human |