| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marc Fakhour. Microglia and Astrocytes in Alzheimer's Disease: Implications for Therapy. Current neuropharmacology. vol 16. issue 5. 2018-09-14. PMID:28730967. |
microglia and astrocytes in alzheimer's disease: implications for therapy. |
2018-09-14 |
2023-08-13 |
Not clear |
| Stephanie Ziegler-Waldkirch, Paolo d'Errico, Jonas-Frederic Sauer, Daniel Erny, Shakuntala Savanthrapadian, Desirée Loreth, Natalie Katzmarski, Thomas Blank, Marlene Bartos, Marco Prinz, Melanie Meyer-Luehman. Seed-induced Aβ deposition is modulated by microglia under environmental enrichment in a mouse model of Alzheimer's disease. The EMBO journal. vol 37. issue 2. 2018-09-11. PMID:29229786. |
seed-induced aβ deposition is modulated by microglia under environmental enrichment in a mouse model of alzheimer's disease. |
2018-09-11 |
2023-08-13 |
mouse |
| Hua Bai, Bo Yang, Wenfeng Yu, Yan Xiao, Dejun Yu, Qifang Zhan. Cathepsin B links oxidative stress to the activation of NLRP3 inflammasome. Experimental cell research. vol 362. issue 1. 2018-09-07. PMID:29196167. |
oxidative stress-mediated activation of nlrp3 inflammasome in microglia is critical in the development of neurodegerative diseases such as alzheimer's disease (ad), parkinson disease (pd). |
2018-09-07 |
2023-08-13 |
Not clear |
| Namkwon Kim, Jimin Do, Jae-Sung Bae, Hee Kyung Jin, Jong-Ho Kim, Kyung-Soo Inn, Myung Sook Oh, Jong Kil Le. Piperlongumine inhibits neuroinflammation via regulating NF-κB signaling pathways in lipopolysaccharide-stimulated BV2 microglia cells. Journal of pharmacological sciences. vol 137. issue 2. 2018-09-07. PMID:29970291. |
however, the activation of abnormal microglia can be detrimental to neurons, even resulting in neurodegenerative diseases such as alzheimer's disease, parkinson's disease and huntington's disease. |
2018-09-07 |
2023-08-13 |
Not clear |
| Do Hee Kim, Hua Li, Yeong Eun Han, Ji Hye Jeong, Hwa Jin Lee, Jae-Ha Ry. Modulation of Inducible Nitric Oxide Synthase Expression in LPS-Stimulated BV-2 Microglia by Prenylated Chalcones from Cullen corylifolium (L.) Medik. through Inhibition of I-κBα Degradation. Molecules (Basel, Switzerland). vol 23. issue 1. 2018-09-03. PMID:29300354. |
the overproduction of nitric oxide (no) and prostaglandin e₂ (pge₂) by microglia may cause neurodegenerative diseases, such as alzheimer's disease and parkinson's disease. |
2018-09-03 |
2023-08-13 |
Not clear |
| Lalita Subedi, Oh Wook Kwon, Chaeho Pak, Goeun Lee, Kangwoo Lee, Hakwon Kim, Sun Yeou Ki. N,N-disubstituted azines attenuate LPS-mediated neuroinflammation in microglia and neuronal apoptosis via inhibiting MAPK signaling pathways. BMC neuroscience. vol 18. issue 1. 2018-08-13. PMID:29281977. |
activated microglia interact with astrocytes and neuronal cells to induce neuroinflammation, which can contribute to the pathogenesis and progression of alzheimer's and parkinson's disease. |
2018-08-13 |
2023-08-13 |
Not clear |
| Jiezhong Yu, Qingfang Gu, Yuqing Yan, Hongqiang Yu, Minfang Guo, Chunyun Liu, Guobin Song, Zhi Chai, Qing Wang, Baoguo Xiao, Hanting Zhang, Yuqiang Jiang, Cungen M. [Fasudil improves cognition of APP/PS1 transgenic mice via inhibiting the activation of microglia and shifting microglia phenotypes from M1 to M2]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 33. issue 12. 2018-08-09. PMID:29382415. |
objective to examine the regulatory effects of rho kinase inhibitor fasudil on cognition and microglia polarization in app/ps1 transgenic (app/ps1 tg) mice, a widely used model of alzheimer's disease (ad). |
2018-08-09 |
2023-08-13 |
mouse |
| Tatsuhiro Akaishi, Kazuho Ab. CNB-001, a synthetic pyrazole derivative of curcumin, suppresses lipopolysaccharide-induced nitric oxide production through the inhibition of NF-κB and p38 MAPK pathways in microglia. European journal of pharmacology. vol 819. 2018-08-06. PMID:29221948. |
since aberrant activation of microglia is involved in the pathogenesis of alzheimer's disease, the present study was undertaken to investigate the effect of cnb-001 on microglia-mediated inflammatory responses. |
2018-08-06 |
2023-08-13 |
rat |
| Carmen Mecca, Ileana Giambanco, Rosario Donato, Cataldo Arcur. Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes. International journal of molecular sciences. vol 19. issue 1. 2018-08-03. PMID:29361745. |
moreover, microglia contribute to some neurodevelopmental disorders such as nasu-hakola disease (nhd), and to aged-associated neurodegenerative diseases, such as alzheimer's disease (ad), parkinson's disease (pd), and others. |
2018-08-03 |
2023-08-13 |
human |
| Gizelle M McCarthy, Sean P Farris, Yuri A Blednov, R Adron Harris, R Dayne Mayfiel. Microglial-specific transcriptome changes following chronic alcohol consumption. Neuropharmacology. vol 128. 2018-07-17. PMID:29101021. |
alterations in steady-state cellular function and over-activation of microglia can facilitate the initiation and progression of neuropathological conditions such as alzheimer's disease, multiple sclerosis, and major depressive disorder. |
2018-07-17 |
2023-08-13 |
Not clear |
| Ashley McDonough, Richard V Lee, Jonathan R Weinstei. Microglial Interferon Signaling and White Matter. Neurochemical research. vol 42. issue 9. 2018-07-09. PMID:28540600. |
other recent studies implicate "microgliopathies" more broadly in neurological disorders including alzheimer's disease (ad) and ms, suggesting that microglia are a potential therapeutic target for disease prevention and/or treatment, with interferon signaling playing a key role in regulating the microglial phenotype. |
2018-07-09 |
2023-08-13 |
mouse |
| Nareshwaran Gnanasegaran, Vijayendran Govindasamy, Vasudevan Mani, Noor Hayaty Abu Kasi. Neuroimmunomodulatory properties of DPSCs in an in vitro model of Parkinson's disease. IUBMB life. vol 69. issue 9. 2018-06-26. PMID:28685937. |
in neurodegenerative diseases, such as alzheimer's and parkinson's, microglial cell activation is thought to contribute to their degeneration by producing neurotoxic compounds. |
2018-06-26 |
2023-08-13 |
human |
| Dimitry Ofengeim, Sonia Mazzitelli, Yasushi Ito, Judy Park DeWitt, Lauren Mifflin, Chengyu Zou, Sudeshna Das, Xian Adiconis, Hongbo Chen, Hong Zhu, Michelle A Kelliher, Joshua Z Levin, Junying Yua. RIPK1 mediates a disease-associated microglial response in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 41. 2018-06-26. PMID:28904096. |
dysfunction of microglia is known to play an important role in alzheimer's disease (ad). |
2018-06-26 |
2023-08-13 |
mouse |
| Hansruedi Mathys, Chinnakkaruppan Adaikkan, Fan Gao, Jennie Z Young, Elodie Manet, Martin Hemberg, Philip L De Jager, Richard M Ransohoff, Aviv Regev, Li-Huei Tsa. Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution. Cell reports. vol 21. issue 2. 2018-06-13. PMID:29020624. |
microglia, the tissue-resident macrophages in the brain, are damage sensors that react to nearly any perturbation, including neurodegenerative diseases such as alzheimer's disease (ad). |
2018-06-13 |
2023-08-13 |
mouse |
| Atsushi Sasak. Microglia and brain macrophages: An update. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 37. issue 5. 2018-06-11. PMID:27859676. |
activated microglia often secrete inflammatory cytokines in various diseases, including alzheimer's disease, but microglial activation is not always associated with inflammation. |
2018-06-11 |
2023-08-13 |
human |
| Wen Fu, Vlatka Vukojevic, Aarti Patel, Rania Soudy, David MacTavish, David Westaway, Kamaljit Kaur, Valeri Goncharuk, Jack Jhamanda. Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation. Journal of neuroinflammation. vol 14. issue 1. 2018-06-06. PMID:28985759. |
neuroinflammation in the brain consequent to activation of microglia is viewed as an important component of alzheimer's disease (ad) pathology. |
2018-06-06 |
2023-08-13 |
human |
| Francesca Regen, Julian Hellmann-Regen, Erica Costantini, Marcella Real. Neuroinflammation and Alzheimer's Disease: Implications for Microglial Activation. Current Alzheimer research. vol 14. issue 11. 2018-06-04. PMID:28164764. |
with growing knowledge about microglia functions in surveying the brain for alterations, microglial activation is increasingly discussed in the context of disease progression and pathogenesis of alzheimer's disease (ad). |
2018-06-04 |
2023-08-13 |
Not clear |
| Marcelo N N Vieira, Danielle Beckma. Training Microglia to Resist Alzheimer's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 3. 2018-05-30. PMID:28100733. |
training microglia to resist alzheimer's disease. |
2018-05-30 |
2023-08-13 |
Not clear |
| Dibyadeep Datt. APP Modulates Aβ-Induced Activation of Microglia in Mouse Model of Alzheimer's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 2. 2018-05-28. PMID:28077703. |
app modulates aβ-induced activation of microglia in mouse model of alzheimer's disease. |
2018-05-28 |
2023-08-13 |
mouse |
| Kai Schlepckow, Gernot Kleinberger, Akio Fukumori, Regina Feederle, Stefan F Lichtenthaler, Harald Steiner, Christian Haas. An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function. EMBO molecular medicine. vol 9. issue 10. 2018-05-24. PMID:28855300. |
sequence variations occurring in the gene encoding the triggering receptor expressed on myeloid cells 2 (trem2) support an essential function of microglia and innate immunity in the pathogenesis of alzheimer's disease (ad) and other neurodegenerative disorders. |
2018-05-24 |
2023-08-13 |
Not clear |