| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junling Yang, Jinghong Kou, Robert Lalonde, Ken-Ichiro Fukuch. Intracranial IL-17A overexpression decreases cerebral amyloid angiopathy by upregulation of ABCA1 in an animal model of Alzheimer's disease. Brain, behavior, and immunity. vol 65. 2018-04-10. PMID:28526436. |
neuroinflammation is a pervasive feature of alzheimer's disease (ad) and characterized by activated microglia, increased proinflammatory cytokines and/or infiltrating immune cells. |
2018-04-10 |
2023-08-13 |
mouse |
| Parakalan Rangarajan, Aparna Karthikeyan, S T Dhee. Role of dietary phenols in mitigating microglia-mediated neuroinflammation. Neuromolecular medicine. vol 18. issue 3. 2018-04-03. PMID:27465151. |
studies show that these natural phenols inhibit key signaling pathways in activated microglia such as the nfκb, mapk and jak-stat that trigger microglia-mediated inflammation in various neuropathological conditions such as injury, infection, stroke, autism and neurodegenerative diseases, i.e., alzheimer's disease and parkinson's disease. |
2018-04-03 |
2023-08-13 |
Not clear |
| b' Qian Xiao, Weihua Yu, Qi Tian, Xue Fu, Xia Wang, Min Gu, Yang L\\xc3\\xb. Chitinase1 contributed to a potential protection via microglia polarization and A\\xce\\xb2 oligomer reduction in D-galactose and aluminum-induced rat model with cognitive impairments. Neuroscience. vol 355. 2018-03-28. PMID:28499970.' |
we investigated the effects of chitinase1 on alzheimer's pathology and microglia function. |
2018-03-28 |
2023-08-13 |
rat |
| Gunjan D Manocha, Atreyi Ghatak, Kendra L Puig, Susan D Kraner, Christopher M Norris, Colin K Comb. NFATc2 Modulates Microglial Activation in the AβPP/PS1 Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 58. issue 3. 2018-03-21. PMID:28505967. |
alzheimer's disease (ad) brains are characterized by fibrillar amyloid-β (aβ) peptide containing plaques and associated reactive microglia. |
2018-03-21 |
2023-08-13 |
mouse |
| Ulrika Wilhelmsson, Daniel Andersson, Yolanda de Pablo, Roy Pekny, Anders Ståhlberg, Jan Mulder, Nicholas Mitsios, Tibor Hortobágyi, Milos Pekny, Marcela Pekn. Injury Leads to the Appearance of Cells with Characteristics of Both Microglia and Astrocytes in Mouse and Human Brain. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 6. 2018-03-19. PMID:28398520. |
cells co-expressing astrocyte and microglia markers were also detected in the in vitro lps activation/injury model and in sections from human brain affected by stroke, alzheimer's disease, and lewy body dementia. |
2018-03-19 |
2023-08-13 |
mouse |
| Qiaoqiao Shi, Saba Chowdhury, Rong Ma, Kevin X Le, Soyon Hong, Barbara J Caldarone, Beth Stevens, Cynthia A Lemer. Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice. Science translational medicine. vol 9. issue 392. 2018-03-19. PMID:28566429. |
complement c3 is elevated in alzheimer's disease (ad), colocalizing with neuritic plaques, and appears to contribute to clearance of aβ by microglia in the brain. |
2018-03-19 |
2023-08-13 |
mouse |
| Kelly S Kirkley, Katriana A Popichak, Maryam F Afzali, Marie E Legare, Ronald B Tjalken. Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity. Journal of neuroinflammation. vol 14. issue 1. 2018-03-02. PMID:28476157. |
in diseases such as parkinson's disease, alzheimer's disease, multiple sclerosis, and human immunodeficiency virus-induced dementia, activation of microglia precedes astrogliosis and overt neuronal loss. |
2018-03-02 |
2023-08-13 |
human |
| Yi-Ling Liu, Wei-Ting Chen, Yu-Yi Lin, Po-Hung Lu, Shie-Liang Hsieh, Irene Han-Juo Chen. Amelioration of amyloid-β-induced deficits by DcR3 in an Alzheimer's disease model. Molecular neurodegeneration. vol 12. issue 1. 2018-02-22. PMID:28438208. |
microglia mediate amyloid-beta peptide (aβ)-induced neuroinflammation, which is one of the key events in the pathogenesis of alzheimer's disease (ad). |
2018-02-22 |
2023-08-13 |
Not clear |
| Patrick C G Haddick, Jessica L Larson, Nisha Rathore, Tushar R Bhangale, Qui T Phung, Karpagam Srinivasan, David V Hansen, Jennie R Lill, Margaret A Pericak-Vance, Jonathan Haines, Lindsay A Farrer, John S Kauwe, Gerard D Schellenberg, Carlos Cruchaga, Alison M Goate, Timothy W Behrens, Ryan J Watts, Robert R Graham, Joshua S Kaminker, Marcel van der Bru. A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains. Journal of Alzheimer's disease : JAD. vol 56. issue 3. 2018-02-21. PMID:28106546. |
il-6 responsive genes were identified in primary astrocytes and microglia and an il-6 gene signature was increased in the cns of late onset alzheimer's disease subjects in an il6r allele dependent manner. |
2018-02-21 |
2023-08-13 |
human |
| Stefan Wendt, Meron Maricos, Natascha Vana, Niklas Meyer, Dilansu Guneykaya, Marcus Semtner, Helmut Kettenman. Changes in phagocytosis and potassium channel activity in microglia of 5xFAD mice indicate alterations in purinergic signaling in a mouse model of Alzheimer's disease. Neurobiology of aging. vol 58. 2018-02-14. PMID:28697378. |
changes in phagocytosis and potassium channel activity in microglia of 5xfad mice indicate alterations in purinergic signaling in a mouse model of alzheimer's disease. |
2018-02-14 |
2023-08-13 |
mouse |
| Stefan Wendt, Meron Maricos, Natascha Vana, Niklas Meyer, Dilansu Guneykaya, Marcus Semtner, Helmut Kettenman. Changes in phagocytosis and potassium channel activity in microglia of 5xFAD mice indicate alterations in purinergic signaling in a mouse model of Alzheimer's disease. Neurobiology of aging. vol 58. 2018-02-14. PMID:28697378. |
as the immunocompetent cells of the central nervous system, microglia accumulate at amyloid beta plaques in alzheimer's disease (ad) and acquire a morphological phenotype of activated microglia. |
2018-02-14 |
2023-08-13 |
mouse |
| Hai M Nguyen, Eva M Grössinger, Makoto Horiuchi, Kyle W Davis, Lee-Way Jin, Izumi Maezawa, Heike Wulf. Differential Kv1.3, KCa3.1, and Kir2.1 expression in "classically" and "alternatively" activated microglia. Glia. vol 65. issue 1. 2018-02-01. PMID:27696527. |
lipopolysaccharide (lps) and interferon-γ (ifn-γ) promote differentiation into classically activated m1-like microglia, which produce high levels of pro-inflammatory cytokines and nitric oxide and are thought to contribute to neurological damage in ischemic stroke and alzheimer's disease. |
2018-02-01 |
2023-08-13 |
Not clear |
| Thais F Galatro, Ilia D Vainchtein, Nieske Brouwer, Erik W G M Boddeke, Bart J L Egge. Isolation of Microglia and Immune Infiltrates from Mouse and Primate Central Nervous System. Methods in molecular biology (Clifton, N.J.). vol 1559. 2018-01-31. PMID:28063055. |
microglia are increasingly implicated in neuropathological and neurodegenerative conditions, such as alzheimer's disease, parkinson's disease, and glioma progression. |
2018-01-31 |
2023-08-13 |
mouse |
| Golo Kronenberg, Ria Uhlemann, Johanna Schöner, Stephanie Wegner, Valérie Boujon, Nikolas Deigendesch, Matthias Endres, Karen Gert. Repression of telomere-associated genes by microglia activation in neuropsychiatric disease. European archives of psychiatry and clinical neuroscience. vol 267. issue 5. 2018-01-30. PMID:27896432. |
a panel of candidate genes associated with telomere maintenance, mitochondrial biogenesis, and cell-cycle regulation were investigated in m1- and m2-polarized microglia in vitro as well as in macs-purified cd11b+ microglia/brain macrophages from models of stroke, alzheimer's disease, and chronic stress. |
2018-01-30 |
2023-08-13 |
Not clear |
| Walther Haenseler, Stephen N Sansom, Julian Buchrieser, Sarah E Newey, Craig S Moore, Francesca J Nicholls, Satyan Chintawar, Christian Schnell, Jack P Antel, Nicholas D Allen, M Zameel Cader, Richard Wade-Martins, William S James, Sally A Cowle. A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response. Stem cell reports. vol 8. issue 6. 2018-01-29. PMID:28591653. |
microglia are increasingly implicated in brain pathology, particularly neurodegenerative disease, with many genes implicated in alzheimer's, parkinson's, and motor neuron disease expressed in microglia. |
2018-01-29 |
2023-08-13 |
human |
| Jaime Eugenín, Andrea Vecchiola, Paola Murgas, Pablo Arroyo, Francisca Cornejo, Rommy von Bernhard. Expression Pattern of Scavenger Receptors and Amyloid-β Phagocytosis of Astrocytes and Microglia in Culture are Modified by Acidosis: Implications for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 53. issue 3. 2018-01-26. PMID:27258416. |
expression pattern of scavenger receptors and amyloid-β phagocytosis of astrocytes and microglia in culture are modified by acidosis: implications for alzheimer's disease. |
2018-01-26 |
2023-08-13 |
Not clear |
| Ling Guo, Aras Rezvanian, Lokesh Kukreja, Ramez Hoveydai, Eileen H Bigio, M-Marsel Mesulam, Joseph El Khoury, Changiz Geul. Postmortem Adult Human Microglia Proliferate in Culture to High Passage and Maintain Their Response to Amyloid-β. Journal of Alzheimer's disease : JAD. vol 54. issue 3. 2018-01-26. PMID:27567845. |
significantly, microglia cultured from brains with pathologically confirmed alzheimer's disease displayed the same characteristics as microglia cultured from normal aged brains. |
2018-01-26 |
2023-08-13 |
human |
| Danielle S Davies, Jolande Ma, Thuvarahan Jegathees, Claire Goldsbur. Microglia show altered morphology and reduced arborization in human brain during aging and Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 27. issue 6. 2018-01-26. PMID:27862631. |
microglia show altered morphology and reduced arborization in human brain during aging and alzheimer's disease. |
2018-01-26 |
2023-08-13 |
human |
| Danielle S Davies, Jolande Ma, Thuvarahan Jegathees, Claire Goldsbur. Microglia show altered morphology and reduced arborization in human brain during aging and Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 27. issue 6. 2018-01-26. PMID:27862631. |
changes in microglia function are involved in alzheimer's disease (ad) for which ageing is the major risk factor. |
2018-01-26 |
2023-08-13 |
human |
| Souvarish Sarkar, Emir Malovic, Brandon Plante, Gary Zenitsky, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasam. Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility. Journal of visualized experiments : JoVE. issue 122. 2018-01-18. PMID:28447995. |
the classical (m1-type) and alternative (m2-type) activations of macrophages have also been extended to microglia in an effort to better understand the underlying interplay these phenotypes have in neuroinflammatory conditions such as parkinson's, alzheimer's, and huntington's diseases. |
2018-01-18 |
2023-08-13 |
Not clear |