All Relations between Alzheimer Disease and microglial cell

Publication Sentence Publish Date Extraction Date Species
Simon Beggs, Michael W Salte. SnapShot: Microglia in Disease. Cell. vol 165. issue 5. 2016-11-09. PMID:27203115. by contrast, dysregulation of microglia contributes to the pathology of neurodevelopmental disorders such as autism spectrum disorders; neurodegenerative disorders such as alzheimer's disease; and schizophrenia and chronic neuropathic pain. 2016-11-09 2023-08-13 Not clear
Nevenka Dudvarski Stankovic, Marcin Teodorczyk, Robert Ploen, Frauke Zipp, Mirko H H Schmid. Microglia-blood vessel interactions: a double-edged sword in brain pathologies. Acta neuropathologica. vol 131. issue 3. 2016-11-08. PMID:26711460. such reactive microglia have been reported to even escalate the damage of the brain parenchyma as is the case in ischemic injuries, brain tumors, multiple sclerosis, alzheimer's and parkinson's disease. 2016-11-08 2023-08-13 Not clear
Marie Christine Pardo. Lipopolysaccharide hyporesponsiveness: protective or damaging response to the brain? Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 56. issue 3. 2016-11-07. PMID:26662122. and while reduced tlr4 signaling reduces the risk of neurodegenerative diseases, up-regulation of anti-inflammatory cytokines associated with lps hyporesponsiveness can have deleterious consequences to the brain by inhibiting the protective phenotype of microglia, aggravating the progression of some neurodegenerative conditions such as alzheimer's disease. 2016-11-07 2023-08-13 Not clear
Soumitra Ghosh, Robert L Geahle. Stress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer's Disease. EBioMedicine. vol 2. issue 11. 2016-11-04. PMID:26870803. stress granules modulate syk to cause microglial cell dysfunction in alzheimer's disease. 2016-11-04 2023-08-13 Not clear
Claudio Villegas-Llerena, Alexandra Phillips, Pablo Garcia-Reitboeck, John Hardy, Jennifer M Pococ. Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease. Current opinion in neurobiology. vol 36. 2016-11-01. PMID:26517285. neuroinflammation is a pathological hallmark of alzheimer's disease (ad), and microglia, the brain's resident phagocyte, are pivotal for the immune response observed in ad. 2016-11-01 2023-08-13 Not clear
Soyon Hong, Lasse Dissing-Olesen, Beth Steven. New insights on the role of microglia in synaptic pruning in health and disease. Current opinion in neurobiology. vol 36. 2016-11-01. PMID:26745839. recent genome-wide association studies implicate microglia in alzheimer's disease (ad) pathogenesis; however, their biological significance remains poorly understood. 2016-11-01 2023-08-13 Not clear
Kelsey E Melah, Sharon Yuan-Fu Lu, Siobhan M Hoscheidt, Andrew L Alexander, Nagesh Adluru, Daniel J Destiche, Cynthia M Carlsson, Henrik Zetterberg, Kaj Blennow, Ozioma C Okonkwo, Carey E Gleason, N Maritza Dowling, Lisa C Bratzke, Howard A Rowley, Mark A Sager, Sanjay Asthana, Sterling C Johnson, Barbara B Bendli. Cerebrospinal Fluid Markers of Alzheimer's Disease Pathology and Microglial Activation are Associated with Altered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 50. issue 3. 2016-10-31. PMID:26836182. the immune response in alzheimer's disease (ad) involves activation of microglia which may remove amyloid-β (aβ). 2016-10-31 2023-08-13 Not clear
Jun-ichi Satoh, Yoshihiro Kino, Naohiro Asahina, Mika Takitani, Junko Miyoshi, Tsuyoshi Ishida, Yuko Sait. TMEM119 marks a subset of microglia in the human brain. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 36. issue 1. 2016-10-19. PMID:26250788. notably, tmem119 immunoreactivity was expressed exclusively on a subset of iba1(+) cd68(+) microglia with ramified and amoeboid morphologies in the brains of neurodegenerative diseases, such as alzheimer's disease (ad), whereas iba1(+) cd68(+) infiltrating macrophages do not express tmem119 in demyelinating lesions of multiple sclerosis and necrotic lesions of cerebral infarction. 2016-10-19 2023-08-13 human
Richard M Ransohoff, Joseph El Khour. Microglia in Health and Disease. Cold Spring Harbor perspectives in biology. vol 8. issue 1. 2016-10-13. PMID:26354893. here, we review recent advances in our understanding of the role of microglia in physiological and pathological processes of the cns with a focus on multiple sclerosis and alzheimer's disease. 2016-10-13 2023-08-13 Not clear
Marta Bolós, María Llorens-Martín, Jerónimo Jurado-Arjona, Félix Hernández, Alberto Rábano, Jesús Avil. Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo. Journal of Alzheimer's disease : JAD. vol 50. issue 1. 2016-10-07. PMID:26638867. in addition, we demonstrate, for the first time, that microglia colocalize with various forms of tau in postmortem brain tissue of patients with alzheimer's disease and non-demented control subjects. 2016-10-07 2023-08-13 mouse
Ryan C McCarthy, Dah-Yuu Lu, Ahmed Alkhateeb, Andrew M Gardeck, Chih-Hao Lee, Marianne Wessling-Resnic. Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta. Journal of neuroinflammation. vol 13. 2016-10-05. PMID:26819091. alzheimer's disease is associated with amyloid-beta (aβ)-induced microglia activation. 2016-10-05 2023-08-13 Not clear
Adele Salemme, Anna Rita Togna, Arianna Mastrofrancesco, Vittoria Cammisotto, Monica Ottaviani, Armandodoriano Bianco, Alessandro Venditt. Anti-inflammatory effects and antioxidant activity of dihydroasparagusic acid in lipopolysaccharide-activated microglial cells. Brain research bulletin. vol 120. 2016-09-30. PMID:26592472. the activation of microglia and subsequent release of toxic pro-inflammatory factors are crucially associated with neurodegenerative disease, characterized by increased oxidative stress and neuroinflammation, including alzheimer and parkinson diseases and multiple sclerosis. 2016-09-30 2023-08-13 rat
P Rangarajan, A Karthikeyan, J Lu, E-A Ling, S T Dhee. Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia. Neuroscience. vol 311. 2016-09-14. PMID:26523980. chronic activation of microglia has been linked to aging-associated neurodegenerative diseases such as alzheimer's disease (ad) and parkinson's disease (pd) since they produce excessive amounts of ros for a prolonged duration leading to oxidative stress. 2016-09-14 2023-08-13 rat
Yan Wang, Jizong Lin, Qing-Zhuang Chen, Ning Zhu, De-Qi Jiang, Ming-Xing Li, Yong Wan. Overexpression of mitochondrial Hsp75 protects neural stem cells against microglia-derived soluble factor-induced neurotoxicity by regulating mitochondrial permeability transition pore opening in vitro. International journal of molecular medicine. vol 36. issue 6. 2016-09-12. PMID:26500047. microglia (mg)-induced neurotoxicity, a major determinant of alzheimer's disease, is closely related to the survival of neural stem cells (nscs). 2016-09-12 2023-08-13 human
Lianne Hoeijmakers, Yvonne Heinen, Anne-Marie van Dam, Paul J Lucassen, Aniko Koros. Microglial Priming and Alzheimer's Disease: A Possible Role for (Early) Immune Challenges and Epigenetics? Frontiers in human neuroscience. vol 10. 2016-08-24. PMID:27555812. neuroinflammation is thought to contribute to alzheimer's disease (ad) pathogenesis that is, to a large extent, mediated by microglia. 2016-08-24 2023-08-13 Not clear
Elizabeth E Spangenberg, Rafael J Lee, Allison R Najafi, Rachel A Rice, Monica R P Elmore, Mathew Blurton-Jones, Brian L West, Kim N Gree. Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology. Brain : a journal of neurology. vol 139. issue Pt 4. 2016-08-18. PMID:26921617. eliminating microglia in alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology. 2016-08-18 2023-08-13 mouse
Elizabeth E Spangenberg, Rafael J Lee, Allison R Najafi, Rachel A Rice, Monica R P Elmore, Mathew Blurton-Jones, Brian L West, Kim N Gree. Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology. Brain : a journal of neurology. vol 139. issue Pt 4. 2016-08-18. PMID:26921617. inflammation in alzheimer's disease is characterized by the presence of reactive astrocytes and activated microglia surrounding amyloid plaques, implicating their role in disease pathogenesis. 2016-08-18 2023-08-13 mouse
Elizabeth E Spangenberg, Rafael J Lee, Allison R Najafi, Rachel A Rice, Monica R P Elmore, Mathew Blurton-Jones, Brian L West, Kim N Gree. Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology. Brain : a journal of neurology. vol 139. issue Pt 4. 2016-08-18. PMID:26921617. in this study, we set out to determine if chronically activated microglia in the alzheimer's disease brain are also dependent on csf1r signalling, and if so, how these cells contribute to disease pathogenesis. 2016-08-18 2023-08-13 mouse
Lorraine Hamelin, Julien Lagarde, Guillaume Dorothée, Claire Leroy, Mickael Labit, Robert A Comley, Leonardo Cruz de Souza, Helene Corne, Luce Dauphinot, Maxime Bertoux, Bruno Dubois, Philippe Gervais, Olivier Colliot, Marie Claude Potier, Michel Bottlaender, Marie Sarazi. Early and protective microglial activation in Alzheimer's disease: a prospective study using 18F-DPA-714 PET imaging. Brain : a journal of neurology. vol 139. issue Pt 4. 2016-08-18. PMID:26984188. while emerging evidence suggests that neuroinflammation plays a crucial role in alzheimer's disease, the impact of the microglia response in alzheimer's disease remains a matter of debate. 2016-08-18 2023-08-13 human
Chin Wai Hui, Yang Zhang, Karl Herru. Non-Neuronal Cells Are Required to Mediate the Effects of Neuroinflammation: Results from a Neuron-Enriched Culture System. PloS one. vol 11. issue 1. 2016-08-11. PMID:26788729. chronic inflammation is associated with activated microglia and reactive astrocytes and plays an important role in the pathogenesis of neurodegenerative diseases such as alzheimer's. 2016-08-11 2023-08-13 mouse