All Relations between Alzheimer Disease and microglial cell

Publication Sentence Publish Date Extraction Date Species
Sabine Hellwig, Annette Masuch, Sigrun Nestel, Natalie Katzmarski, Melanie Meyer-Luehmann, Knut Bibe. Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-β plaque formation in organotypic hippocampal slice cultures. Scientific reports. vol 5. 2016-08-08. PMID:26416689. the capacity to prevent aβ plaque formation was absent in forebrain microglia from young adult but not juvenile 5xfamilial alzheimer's disease (fad) mice. 2016-08-08 2023-08-13 mouse
Shi Shi, Dongli Liang, Yi Chen, Yilin Xie, Yingchao Wang, Lianyun Wang, Zhaoxia Wang, Zhongdong Qia. Gx-50 reduces β-amyloid-induced TNF-α, IL-1β, NO, and PGE2 expression and inhibits NF-κB signaling in a mouse model of Alzheimer's disease. European journal of immunology. vol 46. issue 3. 2016-08-04. PMID:26643273. chronic inflammation, which is regulated by overactivated microglia in the brain, accelerates the occurrence and development of alzheimer's disease (ad). 2016-08-04 2023-08-13 mouse
Roger F Butterwort. Hepatic encephalopathy in alcoholic cirrhosis. Handbook of clinical neurology. vol 125. 2016-07-28. PMID:25307598. neuropathologically, he in cirrhosis is principally a disorder of neuroglia characterized by alzheimer type ii astrocytosis and activation of microglia. 2016-07-28 2023-08-13 Not clear
Gen-Lin He, Zhen Luo, Ju Yang, Ting-Ting Shen, Yi Chen, Xue-Sen Yan. Curcumin Ameliorates the Reduction Effect of PGE2 on Fibrillar β-Amyloid Peptide (1-42)-Induced Microglial Phagocytosis through the Inhibition of EP2-PKA Signaling in N9 Microglial Cells. PloS one. vol 11. issue 1. 2016-07-26. PMID:26824354. inflammatory activation of microglia and β amyloid (aβ) deposition are considered to work both independently and synergistically to contribute to the increased risk of alzheimer's disease (ad). 2016-07-26 2023-08-13 Not clear
Marco Colonna, Yaming Wan. TREM2 variants: new keys to decipher Alzheimer disease pathogenesis. Nature reviews. Neuroscience. vol 17. issue 4. 2016-07-21. PMID:26911435. genome-wide association studies have identified rare variants of the gene that encodes triggering receptor expressed on myeloid cells 2 (trem2) - an immune receptor that is found in brain microglia - as risk factors for non-familial alzheimer disease (ad). 2016-07-21 2023-08-13 Not clear
Joseph Jebelli, Thomas Piers, Jennifer Pococ. Selective Depletion of Microglia from Cerebellar Granule Cell Cultures Using L-leucine Methyl Ester. Journal of visualized experiments : JoVE. issue 101. 2016-07-06. PMID:26275019. this approach allows one to assess the relative impact of microglia on experimental data, as well as determine whether microglia are playing a neuroprotective or neurotoxic role in culture models of neurological conditions, such as stroke, alzheimer's or parkinson's disease. 2016-07-06 2023-08-13 Not clear
Raz Yirmiya, Neta Rimmerman, Ronen Reshe. Depression as a microglial disease. Trends in neurosciences. vol 38. issue 10. 2016-07-06. PMID:26442697. recent studies indicate that impairment of the normal structure and function of microglia, caused by either intense inflammatory activation (e.g., following infections, trauma, stroke, short-term stress, autoimmune or neurodegenerative diseases) or by decline and senescence of these cells (e.g., during aging, alzheimer's disease, or chronic unpredictable stress exposure), can lead to depression and associated impairments in neuroplasticity and neurogenesis. 2016-07-06 2023-08-13 Not clear
Melanie Meyer-Luehmann, Marco Prin. Myeloid cells in Alzheimer's disease: culprits, victims or innocent bystanders? Trends in neurosciences. vol 38. issue 10. 2016-07-06. PMID:26442698. mononuclear phagocytes are blatantly involved in alzheimer's disease (ad) of the central nervous system (cns), but the specific functions of resident microglia, perivascular or meningeal macrophages, and circulating myeloid cells have not yet been fully resolved. 2016-07-06 2023-08-13 Not clear
Lei Zhu, Jing-yu Yang, Xue Xue, Ying-xu Dong, Yang Liu, Feng-rong Miao, Yong-feng Wang, Hong Xue, Chun-fu W. A novel phosphodiesterase-5 Inhibitor: Yonkenafil modulates neurogenesis, gliosis to improve cognitive function and ameliorates amyloid burden in an APP/PS1 transgenic mice model. Mechanisms of ageing and development. vol 150. 2016-06-30. PMID:26200391. in alzheimer's disease (ad), activated microglia invade and surround β-amyloid plaques, possibly contributing to the aggregation of amyloid β (aβ), which affect the survival of neurons and lead to memory loss. 2016-06-30 2023-08-13 mouse
Miho Shukuri, Aya Mawatari, Masahiro Ohno, Masaaki Suzuki, Hisashi Doi, Yasuyoshi Watanabe, Hirotaka Ono. Detection of Cyclooxygenase-1 in Activated Microglia During Amyloid Plaque Progression: PET Studies in Alzheimer's Disease Model Mice. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 57. issue 2. 2016-06-14. PMID:26585055. detection of cyclooxygenase-1 in activated microglia during amyloid plaque progression: pet studies in alzheimer's disease model mice. 2016-06-14 2023-08-13 mouse
Soyon Hong, Victoria F Beja-Glasser, Bianca M Nfonoyim, Arnaud Frouin, Shaomin Li, Saranya Ramakrishnan, Katherine M Merry, Qiaoqiao Shi, Arnon Rosenthal, Ben A Barres, Cynthia A Lemere, Dennis J Selkoe, Beth Steven. Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science (New York, N.Y.). vol 352. issue 6286. 2016-06-07. PMID:27033548. complement and microglia mediate early synapse loss in alzheimer mouse models. 2016-06-07 2023-08-13 mouse
Yu Young Lee, Jin-Sun Park, Ji-Sun Jung, Dong-Hyun Kim, Hee-Sun Ki. Anti-inflammatory effect of ginsenoside Rg5 in lipopolysaccharide-stimulated BV2 microglial cells. International journal of molecular sciences. vol 14. issue 5. 2016-05-26. PMID:23698769. however, overactivation of microglia causes neuronal death, which is associated with neurodegenerative diseases, such as parkinson's disease and alzheimer's disease. 2016-05-26 2023-08-12 rat
Zhihong Chen, Bruce D Trap. Microglia and neuroprotection. Journal of neurochemistry. vol 136 Suppl 1. 2016-05-26. PMID:25693054. microglia can also protect the cns by promoting neurogenesis, clearing debris, and suppressing inflammation in diseases such as stroke, autism, and alzheimer's. 2016-05-26 2023-08-13 Not clear
In-Uk Song, Sung-Woo Chung, Young-Do Kim, Lee-So Maen. Relationship between the hs-CRP as non-specific biomarker and Alzheimer's disease according to aging process. International journal of medical sciences. vol 12. issue 8. 2016-05-24. PMID:26283879. the clinical effect of microglia in patients with alzheimer's disease (ad) is poorly defined. 2016-05-24 2023-08-13 Not clear
Arnaud François, Adrien Julian, Stéphanie Ragot, Emilie Dugast, Ludovic Blanchard, Sonia Brishoual, Faraj Terro, Damien Chassaing, Guylène Page, Marc Paccali. Inflammatory Stress on Autophagy in Peripheral Blood Mononuclear Cells from Patients with Alzheimer's Disease during 24 Months of Follow-Up. PloS one. vol 10. issue 9. 2016-05-24. PMID:26393801. recent findings indicate that microglia in alzheimer's disease (ad) is senescent whereas peripheral blood mononuclear cells (pbmcs) could infiltrate the brain to phagocyte amyloid deposits. 2016-05-24 2023-08-13 Not clear
Maike Gold, Joseph El Khour. β-amyloid, microglia, and the inflammasome in Alzheimer's disease. Seminars in immunopathology. vol 37. issue 6. 2016-05-17. PMID:26251237. β-amyloid, microglia, and the inflammasome in alzheimer's disease. 2016-05-17 2023-08-13 Not clear
Douglas G Walker, Lih-Fen Lu. Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains. Alzheimer's research & therapy. vol 7. issue 1. 2016-05-03. PMID:26286145. available markers for identifying microglial phenotypes in human brains are still limited; those available provide incomplete information on the functions or polarization states of microglia observed in tissues from diseases such as alzheimer's disease, parkinson's disease and multiple sclerosis. 2016-05-03 2023-08-13 human
L-F Lue, C Schmitz, D G Walke. What happens to microglial TREM2 in Alzheimer's disease: Immunoregulatory turned into immunopathogenic? Neuroscience. vol 302. 2016-04-26. PMID:25281879. this review provides a summary of current literature in trem2 and dap12 from several aspects, and proposes a theory that loss of trem2 functions might contribute to the immunopathogenic role of microglia in alzheimer's disease. 2016-04-26 2023-08-13 human
C H Latta, H M Brothers, D M Wilcoc. Neuroinflammation in Alzheimer's disease; A source of heterogeneity and target for personalized therapy. Neuroscience. vol 302. 2016-04-26. PMID:25286385. microglia surrounding amyloid plaques in the brain of auguste d were described in the original publication of alois alzheimer. 2016-04-26 2023-08-13 Not clear
D G Walker, A M Whetzel, L-F Lu. Expression of suppressor of cytokine signaling genes in human elderly and Alzheimer's disease brains and human microglia. Neuroscience. vol 302. 2016-04-26. PMID:25286386. expression of suppressor of cytokine signaling genes in human elderly and alzheimer's disease brains and human microglia. 2016-04-26 2023-08-13 human