All Relations between Alzheimer Disease and microglial cell

Publication Sentence Publish Date Extraction Date Species
V Porrini, A Lanzillotta, C Branca, M Benarese, E Parrella, L Lorenzini, L Calzà, R Flaibani, P F Spano, B P Imbimbo, M Pizz. CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid. Neuroscience. vol 302. 2016-04-26. PMID:25450955. activation of microglia associated with neuroinflammation and loss of phagocytic activity is considered to play a prominent role in the pathogenesis of alzheimer's disease (ad). 2016-04-26 2023-08-13 mouse
Michael M Zeineh, Yuanxin Chen, Hagen H Kitzler, Robert Hammond, Hannes Vogel, Brian K Rut. Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease. Neurobiology of aging. vol 36. issue 9. 2016-04-25. PMID:26190634. activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in alzheimer disease. 2016-04-25 2023-08-13 human
Michael M Zeineh, Yuanxin Chen, Hagen H Kitzler, Robert Hammond, Hannes Vogel, Brian K Rut. Activated iron-containing microglia in the human hippocampus identified by magnetic resonance imaging in Alzheimer disease. Neurobiology of aging. vol 36. issue 9. 2016-04-25. PMID:26190634. although amyloid plaques and neurofibrillary pathology play important roles in alzheimer disease (ad), our understanding of ad is incomplete, and the contribution of microglia and iron to neurodegeneration is unknown. 2016-04-25 2023-08-13 human
Yue Huang, Xiu-Hua Ren, Shan-Feng Zhang, Jie-Wen Zhan. [Different doses transplanted microglia effect on β-amyloid protein in rat Alzheimer's models]. Zhonghua yi xue za zhi. vol 91. issue 33. 2016-04-23. PMID:22321752. [different doses transplanted microglia effect on β-amyloid protein in rat alzheimer's models]. 2016-04-23 2023-08-12 rat
Yue Huang, Xiu-Hua Ren, Shan-Feng Zhang, Jie-Wen Zhan. [Different doses transplanted microglia effect on β-amyloid protein in rat Alzheimer's models]. Zhonghua yi xue za zhi. vol 91. issue 33. 2016-04-23. PMID:22321752. to explore the effects of different doses of transplanted microglia (mg) on β-amyloid protein (aβ) in rat brain model of alzheimer's disease (ad). 2016-04-23 2023-08-12 rat
Alena V Savonenko, Tatiana Melnikova, Yuchuan Wang, Hayden Ravert, Yongjun Gao, Jeremy Koppel, Deidre Lee, Olga Pletnikova, Eugenia Cho, Nuzhat Sayyida, Andrew Hiatt, Juan Troncoso, Peter Davies, Robert F Dannals, Martin G Pomper, Andrew G Hort. Cannabinoid CB2 Receptors in a Mouse Model of Aβ Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of Neuroinflammation. PloS one. vol 10. issue 6. 2016-04-14. PMID:26086915. in alzheimer's disease (ad), one of the early responses to aβ amyloidosis is recruitment of microglia to areas of new plaque. 2016-04-14 2023-08-13 mouse
Wenjie Luo, Wencheng Liu, Xiaoyan Hu, Mary Hanna, April Caravaca, Steven M Pau. Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody. Scientific reports. vol 5. 2016-04-12. PMID:26057852. microglia have been shown to contribute to the clearance of brain amyloid β peptides (aβ), the major component of amyloid plaques, in alzheimer's disease (ad). 2016-04-12 2023-08-13 mouse
Eun-A Kim, Jiyoung Choi, A Reum Han, Chang Hun Cho, Soo Young Choi, Jee-Yin Ahn, Sung-Woo Ch. 2-Cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride inhibits microglial activation by suppression of nuclear factor-kappa B and mitogen-activated protein kinase signaling. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 9. issue 4. 2016-03-28. PMID:24752390. the activation of microglia is crucially associated with the neurodegeneration observed in many neuroinflammatory pathologies, including multiple sclerosis, parkinson's disease, and alzheimer's disease. 2016-03-28 2023-08-13 rat
Mario M Dorostkar, Chengyu Zou, Lidia Blazquez-Llorca, Jochen Herm. Analyzing dendritic spine pathology in Alzheimer's disease: problems and opportunities. Acta neuropathologica. vol 130. issue 1. 2016-03-22. PMID:26063233. furthermore, tau hyperphosphorylation and microglia activation, which are thought to be consequences of amyloidosis in alzheimer's disease, may also contribute to spine loss. 2016-03-22 2023-08-13 mouse
Nabil N Dagher, Allison R Najafi, Kara M Neely Kayala, Monica R P Elmore, Terra E White, Rodrigo Medeiros, Brian L West, Kim N Gree. Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice. Journal of neuroinflammation. vol 12. 2016-03-22. PMID:26232154. here, we determined the dose-dependent effects of a specific csf1r inhibitor (plx5622) on microglia in both wild-type and the 3xtg-ad mouse model of alzheimer's disease. 2016-03-22 2023-08-13 mouse
David S Bouvier, Keith K Mura. Synergistic actions of microglia and astrocytes in the progression of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 45. issue 4. 2016-03-08. PMID:25663025. synergistic actions of microglia and astrocytes in the progression of alzheimer's disease. 2016-03-08 2023-08-13 Not clear
David S Bouvier, Keith K Mura. Synergistic actions of microglia and astrocytes in the progression of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 45. issue 4. 2016-03-08. PMID:25663025. in neurodegenerative diseases such as alzheimer's disease, the reciprocal interactions between microglia and astrocytes may be particularly important for the development of neuronal pathology and disease states. 2016-03-08 2023-08-13 Not clear
Lalida Rojanathammanee, Angela M Floden, Gunjan D Manocha, Colin K Comb. Attenuation of microglial activation in a mouse model of Alzheimer's disease via NFAT inhibition. Journal of neuroinflammation. vol 12. 2016-03-07. PMID:25889879. amyloid β (aβ) peptide is hypothesized to stimulate microglia to acquire their characteristic proinflammatory phenotype in alzheimer's disease (ad) brains. 2016-03-07 2023-08-13 mouse
Christian K E Jung, Kevin Keppler, Sonja Steinbach, Lidia Blazquez-Llorca, Jochen Herm. Fibrillar amyloid plaque formation precedes microglial activation. PloS one. vol 10. issue 3. 2016-03-03. PMID:25799372. in alzheimer's disease (ad), hallmark β-amyloid deposits are characterized by the presence of activated microglia around them. 2016-03-03 2023-08-13 mouse
Zhou Wu, Hiroshi Nakanish. Lessons from Microglia Aging for the Link between Inflammatory Bone Disorders and Alzheimer's Disease. Journal of immunology research. vol 2015. 2016-03-03. PMID:26078980. lessons from microglia aging for the link between inflammatory bone disorders and alzheimer's disease. 2016-03-03 2023-08-13 Not clear
Arlan Richardson, Veronica Galvan, Ai-Ling Lin, Salvatore Odd. How longevity research can lead to therapies for Alzheimer's disease: The rapamycin story. Experimental gerontology. vol 68. 2016-02-22. PMID:25481271. rapamycin has been shown to prevent (and possibly restore in some cases) the deficit in memory observed in the mouse model of alzheimer's disease (ad-tg) as well as reduce aβ and tau aggregation, restore cerebral blood flow and vascularization, and reduce microglia activation. 2016-02-22 2023-08-13 mouse
Stefan Prokop, Kelly R Miller, Natalia Drost, Susann Handrick, Vidhu Mathur, Jian Luo, Anja Wegner, Tony Wyss-Coray, Frank L Heppne. Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer's disease-like mice. The Journal of experimental medicine. vol 212. issue 11. 2016-02-09. PMID:26458768. although central nervous system-resident microglia are believed to be ineffective at phagocytosing and clearing amyloid-β (aβ), a major pathological hallmark of alzheimer's disease (ad), it has been suggested that peripheral myeloid cells constitute a heterogeneous cell population with greater aβ-clearing capabilities. 2016-02-09 2023-08-13 mouse
Nathan G Skene, Seth G N Gran. Identification of Vulnerable Cell Types in Major Brain Disorders Using Single Cell Transcriptomes and Expression Weighted Cell Type Enrichment. Frontiers in neuroscience. vol 10. 2016-02-09. PMID:26858593. genetic susceptibility primarily affected microglia in alzheimer's and multiple sclerosis; was shared between interneurons and pyramidal neurons in autism and schizophrenia; while intellectual disabilities and epilepsy were attributable to a range of cell-types, with the strongest enrichment in interneurons. 2016-02-09 2023-08-13 mouse
Ping Gan, Li Zhang, Yanke Chen, Yu Zhang, Fali Zhang, Xiang Zhou, Xiaohu Zhang, Bo Gao, Xuechu Zhen, Jian Zhang, Long Tai Zhen. Anti-inflammatory effects of glaucocalyxin B in microglia cells. Journal of pharmacological sciences. vol 128. issue 1. 2016-02-08. PMID:26003084. over-activated microglia is involved in various kinds of neurodegenerative process including parkinson, alzheimer and hiv dementia. 2016-02-08 2023-08-13 Not clear
Julie Audoy-Rémus, Lusine Bozoyan, Aline Dumas, Mohammed Filali, Cynthia Lecours, Steve Lacroix, Serge Rivest, Marie-Eve Tremblay, Luc Vallière. GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer's disease. Brain, behavior, and immunity. vol 46. 2016-02-04. PMID:25637481. microglia surrounds the amyloid plaques that form in the brains of patients with alzheimer's disease (ad), but their role is controversial. 2016-02-04 2023-08-13 mouse