All Relations between Alzheimer Disease and microglial cell

Publication Sentence Publish Date Extraction Date Species
Xiao He, Bing-Gui Su. [Roles of microglia and immune receptors in Alzheimer's disease]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 49. issue 6. 2016-02-02. PMID:25212020. [roles of microglia and immune receptors in alzheimer's disease]. 2016-02-02 2023-08-13 Not clear
Carlo Condello, Peng Yuan, Aaron Schain, Jaime Grutzendle. Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques. Nature communications. vol 6. 2016-02-02. PMID:25630253. in alzheimer's disease (ad), β-amyloid (aβ) plaques are tightly enveloped by microglia processes, but the significance of this phenomenon is unknown. 2016-02-02 2023-08-13 mouse
Ying Jiang, Yingying Liu, Cansheng Zhu, Xiaomeng Ma, Lili Ma, Linli Zhou, Qiling Huang, Lei Cen, Rongbiao Pi, Xiaohong Che. Minocycline enhances hippocampal memory, neuroplasticity and synapse-associated proteins in aged C57 BL/6 mice. Neurobiology of learning and memory. vol 121. 2016-01-22. PMID:25838119. previous studies have suggested that minocycline can attenuate cognitive deficits in animal models of conditions such as alzheimer's disease and cerebral ischemia through inhibiting microglia associated anti-inflammatory actions. 2016-01-22 2023-08-13 mouse
Tarja M Malm, Taylor R Jay, Gary E Landret. The evolving biology of microglia in Alzheimer's disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 12. issue 1. 2016-01-19. PMID:25404051. the evolving biology of microglia in alzheimer's disease. 2016-01-19 2023-08-13 Not clear
Inge R Holtman, Divya D Raj, Jeremy A Miller, Wandert Schaafsma, Zhuoran Yin, Nieske Brouwer, Paul D Wes, Thomas Möller, Marie Orre, Willem Kamphuis, Elly M Hol, Erik W G M Boddeke, Bart J L Egge. Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis. Acta neuropathologica communications. vol 3. 2016-01-13. PMID:26001565. to determine the gene expression signature of priming, the transcriptomes of microglia in aging, alzheimer's disease (ad), and amyotrophic lateral sclerosis (als) mouse models were compared using weighted gene co-expression network analysis (wgcna). 2016-01-13 2023-08-13 mouse
Adam D Bachstetter, Linda J Van Eldik, Frederick A Schmitt, Janna H Neltner, Eseosa T Ighodaro, Scott J Webster, Ela Patel, Erin L Abner, Richard J Kryscio, Peter T Nelso. Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging. Acta neuropathologica communications. vol 3. 2016-01-13. PMID:26001591. disease-related microglia heterogeneity in the hippocampus of alzheimer's disease, dementia with lewy bodies, and hippocampal sclerosis of aging. 2016-01-13 2023-08-13 Not clear
Adam D Bachstetter, Linda J Van Eldik, Frederick A Schmitt, Janna H Neltner, Eseosa T Ighodaro, Scott J Webster, Ela Patel, Erin L Abner, Richard J Kryscio, Peter T Nelso. Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging. Acta neuropathologica communications. vol 3. 2016-01-13. PMID:26001591. neuropathological, genetic, and biochemical studies have provided support for the hypothesis that microglia participate in alzheimer's disease (ad) pathogenesis. 2016-01-13 2023-08-13 Not clear
Willem Kamphuis, Lieneke Kooijman, Marie Orre, Oscar Stassen, Milos Pekny, Elly M Ho. GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease. Glia. vol 63. issue 6. 2016-01-08. PMID:25731615. gfap and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for alzheimer's disease. 2016-01-08 2023-08-13 mouse
Dora Brites, Adelaide Fernande. Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation. Frontiers in cellular neuroscience. vol 9. 2016-01-06. PMID:26733805. we will overview the involvement of mirnas, exosomes, ectosomes and microglia in regulating critical pathways associated with depression and how they may contribute to other brain disorders including amyotrophic lateral sclerosis (als), alzheimer's disease (ad) and parkinson's disease (pd), which share several neuroinflammatory-associated processes. 2016-01-06 2023-08-13 Not clear
Hiroshi Hama, Hiroyuki Hioki, Kana Namiki, Tetsushi Hoshida, Hiroshi Kurokawa, Fumiyoshi Ishidate, Takeshi Kaneko, Takumi Akagi, Takashi Saito, Takaomi Saido, Atsushi Miyawak. ScaleS: an optical clearing palette for biological imaging. Nature neuroscience. vol 18. issue 10. 2015-12-22. PMID:26368944. scales permitted optical reconstructions of aged and diseased brain in alzheimer's disease models, including mapping of 3d networks of amyloid plaques, neurons and microglia, and multi-scale tracking of single plaques by successive fluorescence and electron microscopy. 2015-12-22 2023-08-13 human
M Currò, C Gangemi, A Gugliandolo, R Risitano, N Ferlazzo, R Ientile, D Caccam. Transglutaminase 2 is involved in homocysteine-induced activation of human THP-1 monocytes. Free radical research. vol 49. issue 3. 2015-12-16. PMID:25547897. aberrant transglutaminase 2 (tg2) expression and protein cross-linking activity have been associated with several chronic neurodegenerative disorders in which inflammatory processes triggered by activated microglia and monocytes play a key role, such as alzheimer's disease, parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. 2015-12-16 2023-08-13 human
Patrick L McGeer, Edith G McGee. Targeting microglia for the treatment of Alzheimer's disease. Expert opinion on therapeutic targets. vol 19. issue 4. 2015-11-23. PMID:25435348. targeting microglia for the treatment of alzheimer's disease. 2015-11-23 2023-08-13 Not clear
Patrick L McGeer, Edith G McGee. Targeting microglia for the treatment of Alzheimer's disease. Expert opinion on therapeutic targets. vol 19. issue 4. 2015-11-23. PMID:25435348. activated microglia are associated with the progression of alzheimer's disease (ad), as well as many other neurodegenerative diseases of aging. 2015-11-23 2023-08-13 Not clear
Rommy von Bernhardi, Francisca Cornejo, Guillermo E Parada, Jaime Eugení. Role of TGFβ signaling in the pathogenesis of Alzheimer's disease. Frontiers in cellular neuroscience. vol 9. 2015-11-20. PMID:26578886. aging is the main risk factor for alzheimer's disease (ad); being associated with conspicuous changes on microglia activation. 2015-11-20 2023-08-13 Not clear
Marie Orre, Willem Kamphuis, Lana M Osborn, Anne H P Jansen, Lieneke Kooijman, Koen Bossers, Elly M Ho. Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction. Neurobiology of aging. vol 35. issue 12. 2015-11-09. PMID:25002035. reactive astrocytes and microglia are associated with amyloid plaques in alzheimer's disease (ad). 2015-11-09 2023-08-13 mouse
Kendra L Puig, Brianna M Lutz, Siri A Urquhart, Andrew A Rebel, Xudong Zhou, Gunjan D Manocha, MaryAnn Sens, Ashok K Tuteja, Norman L Foster, Colin K Comb. Overexpression of mutant amyloid-β protein precursor and presenilin 1 modulates enteric nervous system. Journal of Alzheimer's disease : JAD. vol 44. issue 4. 2015-11-09. PMID:25408221. alzheimer's disease (ad) is a neurodegenerative disorder histologically characterized by amyloid-β (aβ) protein accumulation and activation of associated microglia. 2015-11-09 2023-08-13 mouse
Olena Korvatska, James B Leverenz, Suman Jayadev, Pamela McMillan, Irina Kurtz, Xindi Guo, Malia Rumbaugh, Mark Matsushita, Santhosh Girirajan, Michael O Dorschner, Kostantin Kiianitsa, Chang-En Yu, Zoran Brkanac, Gwenn A Garden, Wendy H Raskind, Thomas D Bir. R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study. JAMA neurology. vol 72. issue 8. 2015-11-05. PMID:26076170. the r47h variant in the triggering receptor expressed on myeloid cells 2 gene (trem2), a modulator of the immune response of microglia, is a strong genetic risk factor for alzheimer disease (ad) and possibly other neurodegenerative disorders. 2015-11-05 2023-08-13 Not clear
Srikant Rangaraju, Marla Gearing, Lee-Way Jin, Allan Leve. Potassium channel Kv1.3 is highly expressed by microglia in human Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 44. issue 3. 2015-10-26. PMID:25362031. potassium channel kv1.3 is highly expressed by microglia in human alzheimer's disease. 2015-10-26 2023-08-13 human
Srikant Rangaraju, Marla Gearing, Lee-Way Jin, Allan Leve. Potassium channel Kv1.3 is highly expressed by microglia in human Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 44. issue 3. 2015-10-26. PMID:25362031. recent genetic studies suggest a central role for innate immunity in alzheimer's disease (ad) pathogenesis, wherein microglia orchestrate neuroinflammation. 2015-10-26 2023-08-13 human
Ai-Guo Xuan, Xue-Bing Pan, Peng Wei, Wei-Dong Ji, Wen-Juan Zhang, Ji-Hong Liu, Le-Peng Hong, Wen-Liang Chen, Da-Hong Lon. Valproic acid alleviates memory deficits and attenuates amyloid-β deposition in transgenic mouse model of Alzheimer's disease. Molecular neurobiology. vol 51. issue 1. 2015-10-20. PMID:24854198. in the brains of patients with alzheimer's disease (ad) and transgenic ad mouse models, astrocytes and microglia activated by amyloid-β (aβ) contribute to the inflammatory process that develops around injury in the brain. 2015-10-20 2023-08-13 mouse