| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eun-A Kim, A Reum Han, Jiyoung Choi, Jee-Yin Ahn, Soo Young Choi, Sung-Woo Ch. Anti-inflammatory mechanisms of N-adamantyl-4-methylthiazol-2-amine in lipopolysaccharide-stimulated BV-2 microglial cells. International immunopharmacology. vol 22. issue 1. 2015-05-11. PMID:24975832. |
the activation of microglia is crucially associated with the neurodegeneration observed in many neuroinflammatory pathologies, such as multiple sclerosis, parkinson's disease, and alzheimer's disease. |
2015-05-11 |
2023-08-13 |
Not clear |
| Michael W Marlatt, Jan Bauer, Eleonora Aronica, Elise S van Haastert, Jeroen J M Hoozemans, Marian Joels, Paul J Lucasse. Proliferation in the Alzheimer hippocampus is due to microglia, not astroglia, and occurs at sites of amyloid deposition. Neural plasticity. vol 2014. 2015-05-11. PMID:25215243. |
proliferation in the alzheimer hippocampus is due to microglia, not astroglia, and occurs at sites of amyloid deposition. |
2015-05-11 |
2023-08-13 |
Not clear |
| Michael W Marlatt, Jan Bauer, Eleonora Aronica, Elise S van Haastert, Jeroen J M Hoozemans, Marian Joels, Paul J Lucasse. Proliferation in the Alzheimer hippocampus is due to microglia, not astroglia, and occurs at sites of amyloid deposition. Neural plasticity. vol 2014. 2015-05-11. PMID:25215243. |
microglia and astrocytes contribute to alzheimer's disease (ad) etiology and may mediate early neuroinflammatory responses. |
2015-05-11 |
2023-08-13 |
Not clear |
| Peter Thériault, Ayman ElAli, Serge Rives. The dynamics of monocytes and microglia in Alzheimer's disease. Alzheimer's research & therapy. vol 7. issue 1. 2015-04-16. PMID:25878730. |
the dynamics of monocytes and microglia in alzheimer's disease. |
2015-04-16 |
2023-08-13 |
Not clear |
| Xiang Zhou, Ping Gan, Lili Hao, Li Tao, Jia Jia, Bo Gao, Jiang-yun Liu, Long Tai Zheng, Xuechu Zhe. Antiinflammatory effects of orientin-2"-O-galactopyranoside on lipopolysaccharide-stimulated microglia. Biological & pharmaceutical bulletin. vol 37. issue 8. 2015-04-06. PMID:25087950. |
microglia activation-mediated neuroinflammation plays an important role in the pathogenesis of neurodegenerative diseases such as alzheimer's disease, parkinson's disease, multiple sclerosis, and human immunodeficiency virus (hiv)-associated dementia. |
2015-04-06 |
2023-08-13 |
human |
| Li Tao, Fali Zhang, Lili Hao, Jing Wu, Jia Jia, Jiang-yun Liu, Long Tai Zheng, Xuechu Zhe. 1-O-tigloyl-1-O-deacetyl-nimbolinin B inhibits LPS-stimulated inflammatory responses by suppressing NF-κB and JNK activation in microglia cells. Journal of pharmacological sciences. vol 125. issue 4. 2015-03-30. PMID:25018136. |
overactivation of microglia may contribute to the pathogenesis of neurodegenerative diseases such as parkinson's disease, alzheimer's disease, and hiv dementia. |
2015-03-30 |
2023-08-13 |
Not clear |
| Zhen-Yi Hong, Xue-Ru Shi, Kai Zhu, Ting-Ting Wu, Yi-Zhun Zh. SCM-198 inhibits microglial overactivation and attenuates Aβ(1-40)-induced cognitive impairments in rats via JNK and NF-кB pathways. Journal of neuroinflammation. vol 11. 2015-03-30. PMID:25134526. |
neuroinflammation mediated by overactivated microglia plays a key role in many neurodegenerative diseases, including alzheimer's disease (ad). |
2015-03-30 |
2023-08-13 |
rat |
| Zhou Wu, Hiroshi Nakanish. Connection between periodontitis and Alzheimer's disease: possible roles of microglia and leptomeningeal cells. Journal of pharmacological sciences. vol 126. issue 1. 2015-03-30. PMID:25168594. |
connection between periodontitis and alzheimer's disease: possible roles of microglia and leptomeningeal cells. |
2015-03-30 |
2023-08-13 |
Not clear |
| Cui Lv, Lei Wang, Xiaoli Liu, Xiao Cong, Shirley ShiDu Yan, Yongyan Wang, Wensheng Zhan. Geniposide attenuates oligomeric Aβ(1-42)-induced inflammatory response by targeting RAGE-dependent signaling in BV2 cells. Current Alzheimer research. vol 11. issue 5. 2015-02-02. PMID:24801214. |
the neuroinflammation induced by amyloid-β (aβ) is one of the key events in alzheimer's disease (ad) progress in which microglia are the main cells involved. |
2015-02-02 |
2023-08-13 |
Not clear |
| Caitlin E O'Brien, Tony Wyss-Cora. Sorting through the roles of beclin 1 in microglia and neurodegeneration. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 9. issue 3. 2015-01-26. PMID:24385262. |
microglia lacking beclin 1 have a reduced phagocytic capacity, which impairs clearance of amyloid β (aβ) in a mouse model of alzheimer's disease (ad). |
2015-01-26 |
2023-08-12 |
mouse |
| Ruying Fu, Qingyu Shen, Pengfei Xu, Jin Jun Luo, Yamei Tan. Phagocytosis of microglia in the central nervous system diseases. Molecular neurobiology. vol 49. issue 3. 2015-01-26. PMID:24395130. |
this review focuses on phagocytic phenotype of microglia in neurological diseases such as alzheimer's disease, multiple sclerosis, parkinson's disease, traumatic brain injury, ischemic and other brain diseases. |
2015-01-26 |
2023-08-12 |
Not clear |
| Federica Agosta, Dacia Dalla Libera, Edoardo Gioele Spinelli, Annamaria Finardi, Elisa Canu, Alessandra Bergami, Luisella Bocchio Chiavetto, Manuela Baronio, Giancarlo Comi, Gianvito Martino, Michela Matteoli, Giuseppe Magnani, Claudia Verderio, Roberto Furla. Myeloid microvesicles in cerebrospinal fluid are associated with myelin damage and neuronal loss in mild cognitive impairment and Alzheimer disease. Annals of neurology. vol 76. issue 6. 2015-01-26. PMID:25087695. |
we have described cerebrospinal fluid (csf) myeloid microvesicles (mvs) as a marker of microglia activation during neuroinflammation in alzheimer disease (ad), and characterized their ability to produce toxic amyloid β1-42 (aβ1-42 ) oligomers from aggregated or soluble substrate. |
2015-01-26 |
2023-08-13 |
Not clear |
| Zhao Yang, Tian-Zhi Zhao, Yong-Jie Zou, John H Zhang, Hua Fen. Hypoxia Induces autophagic cell death through hypoxia-inducible factor 1α in microglia. PloS one. vol 9. issue 5. 2015-01-23. PMID:24818601. |
as phagocytic cells of central nervous system, excessive activation or cell death of microglia is involved in a lot of nervous system injury and degenerative disease, such as stroke, epilepsy, parkinson's disease, alzheimer's disease. |
2015-01-23 |
2023-08-13 |
Not clear |
| Huayan Liu, Jun Wang, Takeshi Tabir. Juzen-Taiho-to, an herbal medicine, promotes the differentiation of transplanted bone marrow cells into microglia in the mouse brain injected with fibrillar amyloid β. The Tohoku journal of experimental medicine. vol 233. issue 2. 2015-01-09. PMID:24869594. |
microglia are the main immunocompetent and phagocytic cells in alzheimer's disease (ad). |
2015-01-09 |
2023-08-13 |
mouse |
| Jun-Ichi Satoh, Naohiro Asahina, Shouta Kitano, Yoshihiro Kin. A Comprehensive Profile of ChIP-Seq-Based PU.1/Spi1 Target Genes in Microglia. Gene regulation and systems biology. vol 8. 2015-01-09. PMID:25574134. |
microglia, rapidly activated in response to proinflammatory stimuli, are accumulated in brain lesions of neurodegenerative diseases, such as alzheimer's disease and parkinson's disease. |
2015-01-09 |
2023-08-13 |
mouse |
| Sungho Lee, Guixiang Xu, Taylor R Jay, Sabina Bhatta, Ki-Wook Kim, Steffen Jung, Gary E Landreth, Richard M Ransohoff, Bruce T Lam. Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 37. 2015-01-07. PMID:25209291. |
several alzheimer's disease (ad) risk genes are specifically expressed by microglia within the cns. |
2015-01-07 |
2023-08-13 |
mouse |
| James G McLarno. Correlated inflammatory responses and neurodegeneration in peptide-injected animal models of Alzheimer's disease. BioMed research international. vol 2014. 2015-01-05. PMID:24822221. |
animal models of alzheimer's disease (ad) which emphasize activation of microglia may have particular utility in correlating proinflammatory activity with neurodegeneration. |
2015-01-05 |
2023-08-13 |
rat |
| Wolfgang J Streit, Qing-Shan Xu. Human CNS immune senescence and neurodegeneration. Current opinion in immunology. vol 29. 2014-12-04. PMID:24908174. |
on the basis of histopathological observations in human brain, we believe that the ability of microglia to provide neuroprotection deteriorates as our brains get older and that such cns immune senescence is a major factor contributing to the development of aging-related neurodegenerative diseases, notably alzheimer's disease. |
2014-12-04 |
2023-08-13 |
human |
| Victoria Ingham, Alun Williams, Clive Bat. Glimepiride reduces CD14 expression and cytokine secretion from macrophages. Journal of neuroinflammation. vol 11. 2014-12-01. PMID:24952384. |
activated microglia are associated with deposits of aggregated proteins within the brains of patients with alzheimer's disease (ad), parkinson's disease (pd) and prion diseases. |
2014-12-01 |
2023-08-13 |
Not clear |
| Deepa Ajit, Lucas T Woods, Jean M Camden, Christina N Thebeau, Farid G El-Sayed, Glen W Greeson, Laurie Erb, Michael J Petris, Douglas C Miller, Grace Y Sun, Gary A Weisma. Loss of P2Y₂ nucleotide receptors enhances early pathology in the TgCRND8 mouse model of Alzheimer's disease. Molecular neurobiology. vol 49. issue 2. 2014-11-21. PMID:24193664. |
neuroinflammation is a prominent feature in alzheimer's disease (ad) and activation of the brain's innate immune system, particularly microglia, has been postulated to both retard and accelerate ad progression. |
2014-11-21 |
2023-08-12 |
mouse |