| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sang Keun Ha, Eunjung Moon, Pyeongjae Lee, Jong Hoon Ryu, Myung Sook Oh, Sun Yeou Ki. Acacetin attenuates neuroinflammation via regulation the response to LPS stimuli in vitro and in vivo. Neurochemical research. vol 37. issue 7. 2013-10-31. PMID:22447574. |
however, over-activated microglia secrete proinflammatory and cytotoxic factors that can induce progressive brain disorders, including alzheimer's disease, parkinson's disease and ischemia. |
2013-10-31 |
2023-08-12 |
mouse |
| Grietje Krabbe, Annett Halle, Vitali Matyash, Jan L Rinnenthal, Gina D Eom, Ulrike Bernhardt, Kelly R Miller, Stefan Prokop, Helmut Kettenmann, Frank L Heppne. Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology. PloS one. vol 8. issue 4. 2013-10-22. PMID:23577177. |
to uncover and characterize putative changes in the functionality of microglia during alzheimer's disease, we directly assessed microglial behavior in two mouse models of alzheimer's disease. |
2013-10-22 |
2023-08-12 |
mouse |
| Yan Chen Shang, Zhao Zhong Chong, Shaohui Wang, Kenneth Maies. Wnt1 inducible signaling pathway protein 1 (WISP1) targets PRAS40 to govern β-amyloid apoptotic injury of microglia. Current neurovascular research. vol 9. issue 4. 2013-10-17. PMID:22873724. |
given the present challenges to attain effective treatment for β-amyloid (aβ) toxicity in neurodegenerative disorders such as alzheimer's disease, development of novel cytoprotective pathways that can assist immune mediated therapies through the preservation of central nervous system microglia could offer significant promise. |
2013-10-17 |
2023-08-12 |
Not clear |
| Juan Li, Jing Yu Yang, Xue Chun Yao, Xue Xue, Qing Chun Zhang, Xiao Xiao Wang, Ling Ling Ding, Chun Fu W. Oligomeric Aβ-induced microglial activation is possibly mediated by NADPH oxidase. Neurochemical research. vol 38. issue 2. 2013-10-17. PMID:23229789. |
in conclusion, microglial activation induced by oaβ is possibly mediated by nadph oxidase, suggesting that oaβ, which is normally considered a neurotoxin, may also lead to indirect neuronal damage through the pro-inflammation activation of microglia in alzheimer's disease and that nadph oxidase could be a potential target to prevent oaβ-induced inflammatory neurodegeneration. |
2013-10-17 |
2023-08-12 |
Not clear |
| Bob Olsson, Joakim Hertze, Ronald Lautner, Henrik Zetterberg, Katarina Nägga, Kina Höglund, Hans Basun, Peter Annas, Lars Lannfelt, Niels Andreasen, Lennart Minthon, Kaj Blennow, Oskar Hansso. Microglial markers are elevated in the prodromal phase of Alzheimer's disease and vascular dementia. Journal of Alzheimer's disease : JAD. vol 33. issue 1. 2013-09-24. PMID:22890100. |
microglia manage immunosurveillance and mediate inflammation, both suggested to be important in alzheimer's disease (ad). |
2013-09-24 |
2023-08-12 |
Not clear |
| A M Duffy, C Hölsche. The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer's disease. Neuroscience. vol 228. 2013-09-23. PMID:23103794. |
we have shown previously that the long-lasting incretin hormone analogue d-ala(2)gip protects memory formation and synaptic plasticity, reduces plaques, normalises the proliferation of stem cells, reduces the activation of microglia, and prevents the loss of synapses in the cortex of the appswe/ps1deltae9 mouse model of alzheimer's disease. |
2013-09-23 |
2023-08-12 |
mouse |
| Roberta Cascella, Simona Conti, Francesca Tatini, Elisa Evangelisti, Tania Scartabelli, Fiorella Casamenti, Mark R Wilson, Fabrizio Chiti, Cristina Cecch. Extracellular chaperones prevent Aβ42-induced toxicity in rat brains. Biochimica et biophysica acta. vol 1832. issue 8. 2013-09-19. PMID:23602994. |
alzheimer's disease (ad) is a progressive neurodegenerative disorder characterised by cognitive decline, formation of the extracellular amyloid β (aβ42) plaques, neuronal and synapse loss, and activated microglia and astrocytes. |
2013-09-19 |
2023-08-12 |
rat |
| Carina Halleskog, Gunnar Schult. Pertussis toxin-sensitive heterotrimeric G(αi/o) proteins mediate WNT/β-catenin and WNT/ERK1/2 signaling in mouse primary microglia stimulated with purified WNT-3A. Cellular signalling. vol 25. issue 4. 2013-09-17. PMID:23266471. |
we have previously shown that β-catenin levels are elevated in proinflammatory microglia of alzheimer's disease patients and that wnt-3a can evoke a strong proinflammatory response in primary microglia. |
2013-09-17 |
2023-08-12 |
mouse |
| Ji-Youn Lim, Donggeun Sul, Bang Yeon Hwang, Kwang Woo Hwang, Ki-Yeol Yoo, So-Young Par. Suppression of LPS-induced inflammatory responses by inflexanin B in BV2 microglial cells. Canadian journal of physiology and pharmacology. vol 91. issue 2. 2013-08-30. PMID:23458198. |
over-activation of microglia by a range of stimuli disrupts the physiological homeostasis of the brain, and induces inflammatory response and degenerative processes, such as those implicated in neurodegenerative diseases, including alzheimer's disease and parkinson's disease. |
2013-08-30 |
2023-08-12 |
Not clear |
| Amrita Madhusudan, Prisca Vogel, Irene Knuese. Impact of prenatal immune system disturbances on brain development. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 8. issue 1. 2013-08-16. PMID:22580757. |
here, we discuss how a prenatal immune challenge can affect the developing brain-with a selective focus on the impact on microglia, the brain's immune cells-and the implications for brain aging and its associated risk of developing alzheimer's disease. |
2013-08-16 |
2023-08-12 |
Not clear |
| Holly F Green, Yvonne M Nola. GSK-3 mediates the release of IL-1β, TNF-α and IL-10 from cortical glia. Neurochemistry international. vol 61. issue 5. 2013-07-29. PMID:22796213. |
neuroinflammation has been shown to contribute to neurodegenerative and psychiatric disorders such as alzheimer's disease and major depression due to the inappropriate release of pro-inflammatory cytokines from activated microglia. |
2013-07-29 |
2023-08-12 |
rat |
| Hao Fan, Yu Guo, Xiaoyan Liang, Yibiao Yuan, Xiaohong Qi, Min Wang, Jianhua Ma, Hong Zho. Hydrogen sulfide protects against amyloid beta-peptide induced neuronal injury via attenuating inflammatory responses in a rat model. Journal of biomedical research. vol 27. issue 4. 2013-07-25. PMID:23885269. |
neuroinflammation has been recognized to play a critical role in the pathogenesis of alzheimer's disease (ad), which is pathologically characterized by the accumulation of senile plaques containing activated microglia and amyloid β-peptides (aβ). |
2013-07-25 |
2023-08-12 |
rat |
| D C Lee, J Rizer, J B Hunt, M-L B Selenica, M N Gordon, D Morga. Review: experimental manipulations of microglia in mouse models of Alzheimer's pathology: activation reduces amyloid but hastens tau pathology. Neuropathology and applied neurobiology. vol 39. issue 1. 2013-07-24. PMID:23171029. |
review: experimental manipulations of microglia in mouse models of alzheimer's pathology: activation reduces amyloid but hastens tau pathology. |
2013-07-24 |
2023-08-12 |
mouse |
| D Boche, V H Perry, J A R Nicol. Review: activation patterns of microglia and their identification in the human brain. Neuropathology and applied neurobiology. vol 39. issue 1. 2013-07-24. PMID:23252647. |
in this review, we consider translational aspects of our knowledge of microglia: specifically, we discuss the question as to what extent different activation states of microglia exist in the human central nervous system, which tools can be used to identify them and emerging evidence for such changes in ageing and in alzheimer's disease. |
2013-07-24 |
2023-08-12 |
human |
| S M Gentlema. Review: microglia in protein aggregation disorders: friend or foe? Neuropathology and applied neurobiology. vol 39. issue 1. 2013-07-24. PMID:23339288. |
microglia cells have been implicated, to some extent, in the pathogenesis of all of the common neurodegenerative disorders involving protein aggregation such as alzheimer's disease, parkinson's disease and amyotrophic lateral sclerosis. |
2013-07-24 |
2023-08-12 |
Not clear |
| Alberto Serrano-Pozo, Alona Muzikansky, Teresa Gómez-Isla, John H Growdon, Rebecca A Betensky, Matthew P Frosch, Bradley T Hyma. Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 72. issue 6. 2013-07-19. PMID:23656989. |
differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in alzheimer disease. |
2013-07-19 |
2023-08-12 |
Not clear |
| Alberto Serrano-Pozo, Alona Muzikansky, Teresa Gómez-Isla, John H Growdon, Rebecca A Betensky, Matthew P Frosch, Bradley T Hyma. Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 72. issue 6. 2013-07-19. PMID:23656989. |
although it is clear that astrocytes and microglia cluster around dense-core amyloid plaques in alzheimer disease (ad), whether they are primarily attracted to amyloid deposits or are just reacting to plaque-associated neuritic damage remains elusive. |
2013-07-19 |
2023-08-12 |
Not clear |
| Bijay Parajuli, Yoshifumi Sonobe, Jun Kawanokuchi, Yukiko Doi, Mariko Noda, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumur. GM-CSF increases LPS-induced production of proinflammatory mediators via upregulation of TLR4 and CD14 in murine microglia. Journal of neuroinflammation. vol 9. 2013-07-01. PMID:23234315. |
microglia are resident macrophage-like cells in the central nervous system (cns) and cause innate immune responses via the lps receptors, toll-like receptor (tlr) 4 and cd14, in a variety of neuroinflammatory disorders including bacterial infection, alzheimer's disease, and amyotrophic lateral sclerosis. |
2013-07-01 |
2023-08-12 |
Not clear |
| Rachael L Terry, Daniel R Getts, Celine Deffrasnes, Caryn van Vreden, Iain L Campbell, Nicholas J C Kin. Inflammatory monocytes and the pathogenesis of viral encephalitis. Journal of neuroinflammation. vol 9. 2013-07-01. PMID:23244217. |
ly6chi/ccr2(hi) inflammatory monocytes have been identified as the circulating precursors of brain macrophages, dendritic cells and arguably microglia in experimental autoimmune encephalomyelitis; alzheimer's disease; stroke; and more recently in cns infection caused by herpes simplex virus, murine hepatitis virus, theiler's murine encephalomyelitis virus, japanese encephalitis virus and west nile virus. |
2013-07-01 |
2023-08-12 |
human |
| Jiong Ni, Peijun Wang, Jingfa Zhang, Wei Chen, Limin G. Silencing of the P2X(7) receptor enhances amyloid-β phagocytosis by microglia. Biochemical and biophysical research communications. vol 434. issue 2. 2013-06-28. PMID:23562658. |
p2x7 receptor (p2x7r) is an atp-gated cation channel that promotes microglia activation and plays a critical role in the pathogenesis of alzheimer's disease. |
2013-06-28 |
2023-08-12 |
Not clear |