All Relations between Alzheimer Disease and microglial cell

Publication Sentence Publish Date Extraction Date Species
R Thangavel, D Stolmeier, X Yang, P Anantharam, A Zahee. Expression of glia maturation factor in neuropathological lesions of Alzheimer's disease. Neuropathology and applied neurobiology. vol 38. issue 6. 2013-02-22. PMID:22035352. the pathology of alzheimer's disease (ad) is characterized by the presence of amyloid plaques (aps), neurofibrillary tangles (nfts), degenerating neurones, and an abundance of reactive astrocytes and microglia. 2013-02-22 2023-08-12 Not clear
Johannes Vom Berg, Stefan Prokop, Kelly R Miller, Juliane Obst, Roland E Kälin, Ileana Lopategui-Cabezas, Anja Wegner, Florian Mair, Carola G Schipke, Oliver Peters, York Winter, Burkhard Becher, Frank L Heppne. Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline. Nature medicine. vol 18. issue 12. 2013-02-11. PMID:23178247. using the appps1 alzheimer's disease mouse model, we found increased production of the common interleukin-12 (il-12) and il-23 subunit p40 by microglia. 2013-02-11 2023-08-12 mouse
Amanda Sierra, Oihane Abiega, Anahita Shahraz, Harald Neuman. Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis. Frontiers in cellular neuroscience. vol 7. 2013-02-07. PMID:23386811. in addition, microglia phagocytoses brain-specific cargo, such as axonal and myelin debris in spinal cord injury or multiple sclerosis, amyloid-β deposits in alzheimer's disease, and supernumerary synapses in postnatal development. 2013-02-07 2023-08-12 Not clear
Liyun Jia, Jing Liu, Zhen Song, Xiaohua Pan, Liang Chen, Xing Cui, Molin Wan. Berberine suppresses amyloid-beta-induced inflammatory response in microglia by inhibiting nuclear factor-kappaB and mitogen-activated protein kinase signalling pathways. The Journal of pharmacy and pharmacology. vol 64. issue 10. 2013-02-01. PMID:22943182. the neuroinflammation induced by amyloid-beta peptide (aβ) is one of the key events in alzheimer's disease (ad) progress in which microglia are the main cells involved. 2013-02-01 2023-08-12 Not clear
Jonas Hannestad, Jean-Dominique Gallezot, Thomas Schafbauer, Keunpoong Lim, Tracy Kloczynski, Evan D Morris, Richard E Carson, Yu-Shin Ding, Kelly P Cosgrov. Endotoxin-induced systemic inflammation activates microglia: [¹¹C]PBR28 positron emission tomography in nonhuman primates. NeuroImage. vol 63. issue 1. 2013-01-29. PMID:22776451. an important clinical question is whether the effects of systemic inflammation on microglia mediate the deleterious effects of systemic inflammation in diseases such as alzheimer's dementia, multiple sclerosis, and stroke. 2013-01-29 2023-08-12 Not clear
Gunjan Dhawan, Angela M Floden, Colin K Comb. Amyloid-β oligomers stimulate microglia through a tyrosine kinase dependent mechanism. Neurobiology of aging. vol 33. issue 10. 2013-01-21. PMID:22133278. alzheimer's disease (ad) has been well characterized by the presence of reactive microglia, often associated with β-amyloid (aβ) plaque deposition. 2013-01-21 2023-08-12 mouse
Branden Stansley, Jan Post, Kenneth Hensle. A comparative review of cell culture systems for the study of microglial biology in Alzheimer's disease. Journal of neuroinflammation. vol 9. 2013-01-17. PMID:22651808. over the past two decades, it has become increasingly apparent that alzheimer's disease neuropathology is characterized by activated microglia (brain resident macrophages) as well as the classic features of amyloid plaques and neurofibrillary tangles. 2013-01-17 2023-08-12 human
Branden Stansley, Jan Post, Kenneth Hensle. A comparative review of cell culture systems for the study of microglial biology in Alzheimer's disease. Journal of neuroinflammation. vol 9. 2013-01-17. PMID:22651808. this review summarizes several of the most common microglial cell culture systems currently being employed in alzheimer's research including primary microglia; bv2 and n9 retroviral immortalized microglia; human immortalized microglia (hmo6); and spontaneously immortalized rodent microglial lines (eoc lines and hapi cells). 2013-01-17 2023-08-12 human
Andressa Bernardi, Rudimar L Frozza, André Meneghetti, Juliana B Hoppe, Ana Maria O Battastini, Adriana R Pohlmann, Sílvia S Guterres, Christianne G Salbeg. Indomethacin-loaded lipid-core nanocapsules reduce the damage triggered by Aβ1-42 in Alzheimer's disease models. International journal of nanomedicine. vol 7. 2013-01-17. PMID:23028221. neuroinflammation, characterized by the accumulation of activated microglia and reactive astrocytes, is believed to modulate the development and/or progression of alzheimer's disease (ad). 2013-01-17 2023-08-12 Not clear
Lee-Way Ji. Microglia in Alzheimer's disease. International journal of Alzheimer's disease. vol 2012. 2012-12-20. PMID:23251825. microglia in alzheimer's disease. 2012-12-20 2023-08-12 Not clear
Banafsheh Amiraslani, Farzaneh Sabouni, Shahsanam Abbasi, Habiballah Nazem, Mohammadsadegh Sabe. Recognition of betaine as an inhibitor of lipopolysaccharide-induced nitric oxide production in activated microglial cells. Iranian biomedical journal. vol 16. issue 2. 2012-11-13. PMID:22801281. neuroinflammation, as a major outcome of microglia activation, is an important factor for progression of neurodegenerative disorders including alzheimer's disease and parkinson's disease. 2012-11-13 2023-08-12 Not clear
Tatiana Veremeyko, Sarah-Christine Starossom, Howard L Weiner, Eugene D Ponomare. Detection of microRNAs in microglia by real-time PCR in normal CNS and during neuroinflammation. Journal of visualized experiments : JoVE. issue 65. 2012-11-02. PMID:22872097. the described method will be useful to measure the level of expression of micrornas in microglia in normal cns or during neuroinflammation associated with various pathologies including ms, stroke, traumatic injury, alzheimer's disease and brain tumors. 2012-11-02 2023-08-12 mouse
Barbara Biscaro, Olle Lindvall, Giuseppina Tesco, Christine T Ekdahl, Roger M Nitsc. Inhibition of microglial activation protects hippocampal neurogenesis and improves cognitive deficits in a transgenic mouse model for Alzheimer's disease. Neuro-degenerative diseases. vol 9. issue 4. 2012-10-23. PMID:22584394. activated microglia with macrophage-like functions invade and surround β-amyloid (aβ) plaques in alzheimer's disease (ad), possibly contributing to the turnover of aβ, but they can also secrete proinflammatory factors that may be involved in the pathogenesis of ad. 2012-10-23 2023-08-12 mouse
Jong Kil Lee, Edward H Schuchman, Hee Kyung Jin, Jae-sung Ba. Soluble CCL5 derived from bone marrow-derived mesenchymal stem cells and activated by amyloid β ameliorates Alzheimer's disease in mice by recruiting bone marrow-induced microglia immune responses. Stem cells (Dayton, Ohio). vol 30. issue 7. 2012-10-19. PMID:22570192. soluble ccl5 derived from bone marrow-derived mesenchymal stem cells and activated by amyloid β ameliorates alzheimer's disease in mice by recruiting bone marrow-induced microglia immune responses. 2012-10-19 2023-08-12 mouse
Jong Kil Lee, Edward H Schuchman, Hee Kyung Jin, Jae-sung Ba. Soluble CCL5 derived from bone marrow-derived mesenchymal stem cells and activated by amyloid β ameliorates Alzheimer's disease in mice by recruiting bone marrow-induced microglia immune responses. Stem cells (Dayton, Ohio). vol 30. issue 7. 2012-10-19. PMID:22570192. microglia have the ability to eliminate amyloid β (aβ) by a cell-specific phagocytic mechanism, and bone marrow (bm) stem cells have shown a beneficial effect through endogenous microglia activation in the brains of alzheimer's disease (ad) mice. 2012-10-19 2023-08-12 mouse
b' Zorica Jovanovi\\xc4\\x8. [Mechanisms of neurodegeneration in Alzheimer\'s disease]. Medicinski pregled. vol 65. issue 7-8. 2012-10-05. PMID:22924250.' microglial activation and nicotinamide adenine dinucleotide phosphate oxidase in alzheimer's disease: there is a wealth of evidence demonstrating that microglia, the resident innate immune cells in the brain, can become deleterious and damage neurons. 2012-10-05 2023-08-12 Not clear
Egle Solito, Magdalena Sastr. Microglia function in Alzheimer's disease. Frontiers in pharmacology. vol 3. 2012-10-02. PMID:22363284. microglia function in alzheimer's disease. 2012-10-02 2023-08-12 Not clear
Egle Solito, Magdalena Sastr. Microglia function in Alzheimer's disease. Frontiers in pharmacology. vol 3. 2012-10-02. PMID:22363284. it is known that inflammation has an essential role in the progression of alzheimer's disease (ad), since amyloid-β (aβ) is able to activate microglia, initiating an inflammatory response, which could have different consequences for neuronal survival. 2012-10-02 2023-08-12 Not clear
P Sozio, M Rapino, V Di Valerio, S Laserra, S Pacella, A Di Stefano, A Catald. pPKCα-mediated effect on in vitro Aβ production in response to gamma secretase inhibitor LY411575 in rat CTXTNA2 astrocytes. Journal of biological regulators and homeostatic agents. vol 26. issue 2. 2012-09-21. PMID:22824752. alzheimer's disease implies memory and cognitive impairment due to beta amyloid accumulation, presence of reactive microglia and astrocytes, loss of synapses, neural network dysfunctions and modifications of neuronal signalling. 2012-09-21 2023-08-12 rat
Shai Abutbul, Jenny Shapiro, Irit Szaingurten-Solodkin, Nitzan Levy, Yaron Carmy, Rona Baron, Steffen Jung, Alon Monsoneg. TGF-β signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment. Glia. vol 60. issue 7. 2012-09-20. PMID:22511296. our study suggests that the abundant expression of tgf-β within the cns during development and various inflammatory processes plays a key role in promoting the quiescent phenotype of microglia and may thus serve as a target for therapeutic strategies aimed at modulating the function of microglia in neurodegenerative diseases such as alzheimer's and prion. 2012-09-20 2023-08-12 Not clear