| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohammad R Khazaei, Mostafa Bakhti, Mehran Habibi-Rezae. Nicotine reduces the cytotoxic effect of glycated proteins on microglial cells. Neurochemical research. vol 35. issue 4. 2010-08-02. PMID:19946744. |
glycated proteins can induce activation of microglia, which exacerbate the pathology of alzheimer's disease by causing chronic inflammation. |
2010-08-02 |
2023-08-12 |
cattle |
| Karthikeyan Veeraraghavalu, Se Hoon Choi, Sangram S Sisodi. Expression of familial Alzheimer's disease-linked human presenilin 1 variants impair enrichment-induced adult hippocampal neurogenesis. Neuro-degenerative diseases. vol 7. issue 1-3. 2010-07-21. PMID:20160458. |
the impairments in proliferation and neurogenesis are, at least in part, due to alterations in the levels of specific chemokines and growth factors secreted from microglia expressing familial alzheimer's disease-linked ps1 variants. |
2010-07-21 |
2023-08-12 |
mouse |
| Shweta Mandrekar-Colucci, Gary E Landret. Microglia and inflammation in Alzheimer's disease. CNS & neurological disorders drug targets. vol 9. issue 2. 2010-07-12. PMID:20205644. |
microglia and inflammation in alzheimer's disease. |
2010-07-12 |
2023-08-12 |
Not clear |
| V Hugh Perry, James A R Nicoll, Clive Holme. Microglia in neurodegenerative disease. Nature reviews. Neurology. vol 6. issue 4. 2010-07-12. PMID:20234358. |
the fact that diseases with a chronic systemic inflammatory component are risk factors for alzheimer disease implies that crosstalk occurs between systemic inflammation and microglia in the cns. |
2010-07-12 |
2023-08-12 |
Not clear |
| Wei-Chao Huang, Feng-Chang Yen, Feng-Shiun Shie, Chih-Ming Pan, Young-Ji Shiao, Cheng-Ning Yang, Fong-Lee Huang, Yen-Jen Sung, Huey-Jen Tsa. TGF-beta1 blockade of microglial chemotaxis toward Abeta aggregates involves SMAD signaling and down-regulation of CCL5. Journal of neuroinflammation. vol 7. 2010-07-01. PMID:20429874. |
overactivated microglia that cluster at neuritic plaques constantly release neurotoxins, which actively contribute to progressive neurodegeneration in alzheimer's disease (ad). |
2010-07-01 |
2023-08-12 |
Not clear |
| Robert E Mra. Neuropathology and the neuroinflammation idea. Journal of Alzheimer's disease : JAD. vol 18. issue 3. 2010-06-30. PMID:19584454. |
the idea that microglia and cytokines are important in neurodegeneration arose from neuropathological observations, especially in alzheimer's disease. |
2010-06-30 |
2023-08-12 |
Not clear |
| Robert E Mra. Neuropathology and the neuroinflammation idea. Journal of Alzheimer's disease : JAD. vol 18. issue 3. 2010-06-30. PMID:19584454. |
microglia are invariant components of the abeta plaques of alzheimer's disease, where they show a waxing and waning of numbers, activation state, and cytokine expression during plaque progression. |
2010-06-30 |
2023-08-12 |
Not clear |
| Robert E Mra. Neuropathology and the neuroinflammation idea. Journal of Alzheimer's disease : JAD. vol 18. issue 3. 2010-06-30. PMID:19584454. |
in alzheimer's disease, plaque-associated astrocytes, which also produce paracrine mediators, show a pattern similar to that of microglia; and the associated plaque progression is accompanied by progressive damage to and loss of adjacent neurons. |
2010-06-30 |
2023-08-12 |
Not clear |
| Amanda McRae, Eng Ang Lin. Cerebrospinal fluid and serum antimicroglial antibodies: prospects for early diagnosis of Alzheimer's disease. Expert review of neurotherapeutics. vol 3. issue 2. 2010-06-28. PMID:19810841. |
activated microglia, now considered as the immune cell of the cns, have gained recognition as participating in the cascade of early events leading to alzheimer's disease pathology. |
2010-06-28 |
2023-08-12 |
Not clear |
| Amanda McRae, Eng Ang Lin. Cerebrospinal fluid and serum antimicroglial antibodies: prospects for early diagnosis of Alzheimer's disease. Expert review of neurotherapeutics. vol 3. issue 2. 2010-06-28. PMID:19810841. |
the serendipitous findings of microglia antibodies in the serum and cerebrospinal fluid of alzheimer's disease patients could be a means to distinguish alzheimer's disease patients from other dementias. |
2010-06-28 |
2023-08-12 |
Not clear |
| T N Griffith, L Varela-Nallar, M C Dinamarca, N C Inestros. Neurobiological effects of Hyperforin and its potential in Alzheimer's disease therapy. Current medicinal chemistry. vol 17. issue 5. 2010-06-15. PMID:20015041. |
importantly, it has been shown to have neuroprotective effects against alzheimer's disease (ad) neuropathology, including the ability to disassemble amyloid-beta (abeta) aggregates in vitro, decrease astrogliosis and microglia activation, as well as improve spatial memory in vivo. |
2010-06-15 |
2023-08-12 |
Not clear |
| Inelia Morales, Gonzalo Farías, Ricardo B Maccion. Neuroimmunomodulation in the pathogenesis of Alzheimer's disease. Neuroimmunomodulation. vol 17. issue 3. 2010-06-14. PMID:20134203. |
evidence has been cumulated on the role of microglia cells deregulation and alterations in their interaction patterns with brain neurons, in the pathway towards neurodegeneration in alzheimer's disease (ad). |
2010-06-14 |
2023-08-12 |
Not clear |
| John C Ashton, Michelle Glas. The cannabinoid CB2 receptor as a target for inflammation-dependent neurodegeneration. Current neuropharmacology. vol 5. issue 2. 2010-06-10. PMID:18615177. |
the presence of cb2 receptors in microglia in the human alzheimer's diseased brain suggests that cb2 may provide a novel target for a range of neuropathologies. |
2010-06-10 |
2023-08-12 |
human |
| Douglas Walker, Lih-Fen Lu. Anti-inflammatory and immune therapy for Alzheimer's disease: current status and future directions. Current neuropharmacology. vol 5. issue 4. 2010-06-10. PMID:19305740. |
from the initial characterizations of inflammatory responses in alzheimer's disease (ad) affected brains, namely the demonstration of activated microglia and reactive astrocytes, complement system activation, increased production of proinflammatory cytokines, and evidence for microglial-produced neurotoxins, there was hope that reducing inflammation might be a feasible treatment for this memory-robbing disease. |
2010-06-10 |
2023-08-12 |
Not clear |
| Brent Cameron, Gary E Landret. Inflammation, microglia, and Alzheimer's disease. Neurobiology of disease. vol 37. issue 3. 2010-06-08. PMID:19833208. |
inflammation, microglia, and alzheimer's disease. |
2010-06-08 |
2023-08-12 |
Not clear |
| Brent Cameron, Gary E Landret. Inflammation, microglia, and Alzheimer's disease. Neurobiology of disease. vol 37. issue 3. 2010-06-08. PMID:19833208. |
in the alzheimer's disease brain, amyloid deposition provokes the phenotypic activation of microglia and their elaboration of proinflammatory molecules. |
2010-06-08 |
2023-08-12 |
Not clear |
| Jack Rocky-Jay Rivers, John Clive Ashto. The development of cannabinoid CBII receptor agonists for the treatment of central neuropathies. Central nervous system agents in medicinal chemistry. vol 10. issue 1. 2010-06-07. PMID:20236042. |
we first discuss the role of microglia in the healthy brain, and then the role of microglia in chronic neuroinflammatory disorders, including alzheimer's disease and parkinson's disease, as well as in neuroinflammation following acute brain injury such as stroke and global hypoxia. |
2010-06-07 |
2023-08-12 |
Not clear |
| Takato Takenouchi, Kazunari Sekiyama, Akio Sekigawa, Masayo Fujita, Masaaki Waragai, Shuei Sugama, Yoshifumi Iwamaru, Hiroshi Kitani, Makoto Hashimot. P2X7 receptor signaling pathway as a therapeutic target for neurodegenerative diseases. Archivum immunologiae et therapiae experimentalis. vol 58. issue 2. 2010-05-28. PMID:20143170. |
the expression and function of the p2x7 receptor (p2x7r), an atp-gated ion channel abundantly expressed in microglia in the brain, is significantly up-regulated in the postmortem brain of alzheimer's disease patients and various neurodegenerative disease animal models. |
2010-05-28 |
2023-08-12 |
Not clear |
| Shuei Sugama, Takato Takenouchi, Byung P Cho, Tong H Joh, Makoto Hashimoto, Hiroshi Kitan. Possible roles of microglial cells for neurotoxicity in clinical neurodegenerative diseases and experimental animal models. Inflammation & allergy drug targets. vol 8. issue 4. 2010-05-13. PMID:19754411. |
microglia has been demonstrated to play critical roles in various neurodegenerative disorders, such as parkinson's disease (pd), alzheimer's disease (ad), huntington's disease (hd) as well as neuroinflammatory disorders including aids encephalitis, multiple sclerosis. |
2010-05-13 |
2023-08-12 |
human |
| Mark F McCarty, Jorge Barroso-Aranda, Francisco Contrera. Oral phycocyanobilin may diminish the pathogenicity of activated brain microglia in neurodegenerative disorders. Medical hypotheses. vol 74. issue 3. 2010-05-07. PMID:19576698. |
there is considerable evidence that activated microglia play a central role in the pathogenesis of many prominent neurodegenerative disorders, including parkinson's and alzheimer's diseases. |
2010-05-07 |
2023-08-12 |
mouse |