| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Gerardino, P Papaleo, A Flex, E Gaetani, G Fioroni, P Pola, R Pol. Coagulation factor XIII Val34Leu gene polymorphism and Alzheimer's disease. Neurological research. vol 28. issue 8. 2007-03-21. PMID:17288735. |
fxiiia subunit was immunohistochemically detected in a subpopulation of reactive microglia in alzheimer's disease (ad). |
2007-03-21 |
2023-08-12 |
Not clear |
| Sriram Venneti, Brian J Lopresti, Clayton A Wile. The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging. Progress in neurobiology. vol 80. issue 6. 2007-03-15. PMID:17156911. |
microglia constitute the primary resident immune surveillance cell in the brain and are thought to play a significant role in the pathogenesis of several neurodegenerative disorders, such as alzheimer's disease, multiple sclerosis, parkinson's disease and hiv-associated dementia. |
2007-03-15 |
2023-08-12 |
Not clear |
| Anil Kumar, Neha Seghal, Satyanaryana Venketeshwara Padi, Pattipati Sreenivaslu Naid. Differential effects of cyclooxygenase inhibitors on intracerebroventricular colchicine-induced dysfunction and oxidative stress in rats. European journal of pharmacology. vol 551. issue 1-3. 2007-02-08. PMID:17027965. |
inflammatory cells, such as astrocytes and microglia, are activated in areas of the brain affected by amyloid plaques and inflammatory mediators including cytokines, chemokines, prostaglandins, oxygen free radicals and reactive nitrogen species may have a crucial role in alzheimer's disease pathogenesis. |
2007-02-08 |
2023-08-12 |
rat |
| James A R Nicoll, Edward Barton, Delphine Boche, Jim W Neal, Isidro Ferrer, Petrina Thompson, Christina Vlachouli, David Wilkinson, Antony Bayer, Dora Games, Peter Seubert, Dale Schenk, Clive Holme. Abeta species removal after abeta42 immunization. Journal of neuropathology and experimental neurology. vol 65. issue 11. 2006-12-27. PMID:17086100. |
neuropathologic examination of 3 patients with alzheimer disease in the elan pharmaceuticals trial using antibodies specific for different abeta species showed in one case, 4 months after the immunization, evidence of a stage of active plaque clearance with "moth-eaten" plaques and abundant abeta phagocytosis by microglia. |
2006-12-27 |
2023-08-12 |
Not clear |
| James G McLarnon, Jae K Ryu, Douglas G Walker, Hyun B Cho. Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus. Journal of neuropathology and experimental neurology. vol 65. issue 11. 2006-12-27. PMID:17086106. |
upregulated expression of purinergic p2x(7) receptor in alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus. |
2006-12-27 |
2023-08-12 |
human |
| James G McLarnon, Jae K Ryu, Douglas G Walker, Hyun B Cho. Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus. Journal of neuropathology and experimental neurology. vol 65. issue 11. 2006-12-27. PMID:17086106. |
the expression of the purinergic receptor subtype p2x(7)r, a nonselective cationic channel activated by high levels of adenosine triphosphate (atp), has been studied in adult microglia obtained from alzheimer disease (ad) and nondemented (nd) brains, in fetal human microglia exposed to abeta(1-42) peptide and in vivo in abeta(1-42)-injected rat hippocampus. |
2006-12-27 |
2023-08-12 |
human |
| Tobias Stahl, Christine Reimers, Reimar Johne, Reinhard Schliebs, Johannes Seege. Viral-induced inflammation is accompanied by beta-amyloid plaque reduction in brains of amyloid precursor protein transgenic Tg2576 mice. The European journal of neuroscience. vol 24. issue 7. 2006-12-21. PMID:17067295. |
amyloid plaques, one of the neuropathological hallmarks of alzheimer's disease, and their main constituent, the amyloid beta-peptide (abeta), are triggers of the activation of innate inflammatory mechanisms involving the activation of microglia. |
2006-12-21 |
2023-08-12 |
mouse |
| Ute Dreses-Werringloer, Hervé C Gérard, Judith A Whittum-Hudson, Alan P Hudso. Chlamydophila (Chlamydia) pneumoniae infection of human astrocytes and microglia in culture displays an active, rather than a persistent, phenotype. The American journal of the medical sciences. vol 332. issue 4. 2006-11-28. PMID:17031241. |
this bacterium was identified within astrocytes and microglia in the brain of late-onset alzheimer disease patients. |
2006-11-28 |
2023-08-12 |
human |
| Sonia Franciosi, Jae K Ryu, Hyun B Choi, Lesley Radov, Seung U Kim, James G McLarno. Broad-spectrum effects of 4-aminopyridine to modulate amyloid beta1-42-induced cell signaling and functional responses in human microglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 45. 2006-11-28. PMID:17093087. |
the overall results suggest that 4-ap modulation of an abeta(1-42)-induced i(k) (candidate channel kv3.1) and intracellular signaling pathways in human microglia could serve as a therapeutic strategy for neuroprotection in alzheimer's disease pathology. |
2006-11-28 |
2023-08-12 |
human |
| M Dragunow, J M Greenwood, R E Cameron, P J Narayan, S J O'Carroll, A G Pearson, H M Gibbon. Valproic acid induces caspase 3-mediated apoptosis in microglial cells. Neuroscience. vol 140. issue 4. 2006-10-26. PMID:16600518. |
as activated microglia secrete neurotoxins in neurodegenerative diseases such as alzheimer's, parkinson's, and hiv dementia, valproic acid may alleviate these diseases by selectively killing microglia. |
2006-10-26 |
2023-08-12 |
mouse |
| Oleg Butovsky, Maya Koronyo-Hamaoui, Gilad Kunis, Eran Ophir, Gennady Landa, Hagit Cohen, Michal Schwart. Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 31. 2006-10-25. PMID:16864778. |
glatiramer acetate fights against alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. |
2006-10-25 |
2023-08-12 |
mouse |
| Kenji Nakamura, Wakana Ohya, Hiroshi Funakoshi, Gaku Sakaguchi, Akira Kato, Masatoshi Takeda, Takashi Kudo, Toshikazu Nakamur. Possible role of scavenger receptor SRCL in the clearance of amyloid-beta in Alzheimer's disease. Journal of neuroscience research. vol 84. issue 4. 2006-10-24. PMID:16868960. |
accumulation of beta-amyloid protein (abeta) in the brain is a hallmark of alzheimer's disease (ad), and abeta-mediated pathogenesis could result from increased production of abeta or insufficient abeta clearance by microglia, astrocytes, or the vascular system. |
2006-10-24 |
2023-08-12 |
mouse |
| He Li, Zhou Gang, He Yuling, Xie Luokun, Xiong Jie, Lei Hao, Wei Li, Hu Chunsong, Liu Junyan, Jiang Mingshen, Jin Youxin, Gong Feili, Jin Boquan, Tan Jinqua. Different neurotropic pathogens elicit neurotoxic CCR9- or neurosupportive CXCR3-expressing microglia. Journal of immunology (Baltimore, Md. : 1950). vol 177. issue 6. 2006-10-24. PMID:16951324. |
these data suggest that there exist two different types of microglia, providing with a novel insight into microglial involvement in neurodegenerative and neuroinflammatory pathogenesis such as alzheimer's disease and aids dementia. |
2006-10-24 |
2023-08-12 |
mouse |
| Martina Chiappelli, Emanuela Tumini, Elisa Porcellini, Federico Licastr. Impaired regulation of immune responses in cognitive decline and Alzheimer's disease: lessons from genetic association studies. Expert review of neurotherapeutics. vol 6. issue 9. 2006-10-24. PMID:17009920. |
microglia are resident cells of the brain and metabolic upregulation of these cells may play a crucial role in the development of the neurodegeneration associated with alzheimer's disease. |
2006-10-24 |
2023-08-12 |
Not clear |
| M Sawada, K Imamura, T Nagats. Role of cytokines in inflammatory process in Parkinson's disease. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017556. |
toxic change of activated microglia may also occur in alzheimer's disease and other neurodegenerative diseases in which inflammatory process is found. |
2006-10-24 |
2023-08-12 |
mouse |
| Chie Usui, Nobuto Shibata, Tohru Ohnuma, Shinji Higashi, Taku Ohkubo, Akira Ueki, Masatsugu Nagao, Heii Ara. No genetic association between the myeloperoxidase gene -463 polymorphism and estrogen receptor-alpha gene polymorphisms and Japanese sporadic Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 21. issue 5-6. 2006-10-17. PMID:16484808. |
myeloperoxidase (mpo) presence has been demonstrated in microglia associated with senile plaques and contributes to alzheimer's disease (ad) pathology through oxidation-induced damage. |
2006-10-17 |
2023-08-12 |
Not clear |
| A Cagnin, M Kassiou, S R Meikle, R B Banat. In vivo evidence for microglial activation in neurodegenerative dementia. Acta neurologica Scandinavica. Supplementum. vol 185. 2006-10-02. PMID:16866919. |
evidence from numerous neuropathological observations and in vivo clinical imaging studies suggests a prominent role of activated microglia, the main effector cell of the brain's innate immune system, in alzheimer's disease and other neurodegenerative diseases. |
2006-10-02 |
2023-08-12 |
Not clear |
| Matt Baker, Ian R Mackenzie, Stuart M Pickering-Brown, Jennifer Gass, Rosa Rademakers, Caroline Lindholm, Julie Snowden, Jennifer Adamson, A Dessa Sadovnick, Sara Rollinson, Ashley Cannon, Emily Dwosh, David Neary, Stacey Melquist, Anna Richardson, Dennis Dickson, Zdenek Berger, Jason Eriksen, Todd Robinson, Cynthia Zehr, Chad A Dickey, Richard Crook, Eileen McGowan, David Mann, Bradley Boeve, Howard Feldman, Mike Hutto. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature. vol 442. issue 7105. 2006-09-22. PMID:16862116. |
moreover, pgrn expression is increased in activated microglia in many neurodegenerative diseases including creutzfeldt-jakob disease, motor neuron disease and alzheimer's disease. |
2006-09-22 |
2023-08-12 |
Not clear |
| Hideyuki Takeuchi, Shijie Jin, Jinyan Wang, Guiqin Zhang, Jun Kawanokuchi, Reiko Kuno, Yoshifumi Sonobe, Tetsuya Mizuno, Akio Suzumur. Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. The Journal of biological chemistry. vol 281. issue 30. 2006-09-18. PMID:16720574. |
glutamate released by activated microglia induces excitoneurotoxicity and may contribute to neuronal damage in neurodegenerative diseases, including alzheimer disease, parkinson disease, amyotrophic lateral sclerosis, and multiple sclerosis. |
2006-09-18 |
2023-08-12 |
Not clear |
| Pedro Garção, Catarina R Oliveira, Paula Agostinh. Comparative study of microglia activation induced by amyloid-beta and prion peptides: role in neurodegeneration. Journal of neuroscience research. vol 84. issue 1. 2006-09-08. PMID:16634056. |
the inflammatory responses in alzheimer's disease (ad) and prion-related encephalopathies (pre) are dominated by microglia activation. |
2006-09-08 |
2023-08-12 |
rat |