| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simona Bussini, Lucia Meda, Elio Scarpini, Emilio Clementi, Giancarlo Conti, Marco Tiriticco, Nereo Bresolin, Pierluigi Baro. Heparan sulfate proteoglycan induces the production of NO and TNF-alpha by murine microglia. Immunity & ageing : I & A. vol 2. 2005-10-21. PMID:16022734. |
a common feature of alzheimer's disease (ad) pathology is the abundance of activated microglia in neuritic plaques containing amyloid-beta protein (abeta) and associated molecules including heparan sulfate proteoglycan (hspg). |
2005-10-21 |
2023-08-12 |
Not clear |
| Catharina Lindberg, Maj-Linda Bardyl Selenica, Anita Westlind-Danielsson, Marianne Schultzber. Beta-amyloid protein structure determines the nature of cytokine release from rat microglia. Journal of molecular neuroscience : MN. vol 27. issue 1. 2005-10-13. PMID:16055942. |
activated microglia represent a major source of inflammatory factors in alzheimer's disease and a possible source of cytotoxic factors. |
2005-10-13 |
2023-08-12 |
rat |
| Dave Morgan, Marcia N Gordon, Jun Tan, Donna Wilcock, Amyn M Rojian. Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics. Journal of neuropathology and experimental neurology. vol 64. issue 9. 2005-10-12. PMID:16141783. |
the presence of activated microglia in postmortem alzheimer disease specimens is used to support the argument that inflammation contributes to alzheimer pathogenesis. |
2005-10-12 |
2023-08-12 |
mouse |
| Rodrigo Alarcón, Carolina Fuenzalida, Marcos Santibáñez, Rommy von Bernhard. Expression of scavenger receptors in glial cells. Comparing the adhesion of astrocytes and microglia from neonatal rats to surface-bound beta-amyloid. The Journal of biological chemistry. vol 280. issue 34. 2005-10-03. PMID:15987691. |
astrocytes and microglia associate to amyloid plaques, a pathological hallmark of alzheimer disease. |
2005-10-03 |
2023-08-12 |
rat |
| Fabrizio Giuliani, Walter Hader, V Wee Yon. Minocycline attenuates T cell and microglia activity to impair cytokine production in T cell-microglia interaction. Journal of leukocyte biology. vol 78. issue 1. 2005-09-08. PMID:15817702. |
minocycline, a tetracycline with anti-inflammatory properties, has been reported to down-regulate the activity of microglia, whose activation occurs in inflammatory and degenerative diseases of the central nervous system, such as multiple sclerosis and alzheimer's disease. |
2005-09-08 |
2023-08-12 |
human |
| Susanna Rosi, Victor Ramirez-Amaya, Almira Vazdarjanova, Paul F Worley, Carol A Barnes, Gary L Wen. Neuroinflammation alters the hippocampal pattern of behaviorally induced Arc expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 3. 2005-08-18. PMID:15659610. |
neuroinflammation is associated with a variety of neurological and pathological diseases, such as alzheimer's disease (ad), and is reliably detected by the presence of activated microglia. |
2005-08-18 |
2023-08-12 |
rat |
| Yang Liu, Silke Walter, Massimiliano Stagi, Dmitry Cherny, Maryse Letiembre, Walter Schulz-Schaeffer, Holger Heine, Botond Penke, Harald Neumann, Klaus Fassbende. LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide. Brain : a journal of neurology. vol 128. issue Pt 8. 2005-08-16. PMID:15857927. |
in complementary clinical experiments, we detected a pronounced cd14 immunoreactivity on parenchymal microglia spatially correlated to characteristic alzheimer's disease lesion sites in brain sections of alzheimer's disease patients but not in brain sections of control subjects. |
2005-08-16 |
2023-08-12 |
human |
| Shuang Chen, Natale T Averett, Arlene Manelli, Mary Jo Ladu, Warren May, March D Ar. Isoform-specific effects of apolipoprotein E on secretion of inflammatory mediators in adult rat microglia. Journal of Alzheimer's disease : JAD. vol 7. issue 1. 2005-08-02. PMID:15750212. |
inflammation mediated by activated microglia cells has been shown to contribute to the pathogenesis of alzheimer disease (ad) [1]. |
2005-08-02 |
2023-08-12 |
rat |
| Andis Klegeris, Patrick L McGee. Chymotrypsin-like proteases contribute to human monocytic THP-1 cell as well as human microglial neurotoxicity. Glia. vol 51. issue 1. 2005-07-27. PMID:15779083. |
activated microglia have been observed in various neurodegenerative diseases, including alzheimer's disease (ad), parkinson's disease (pd), amyotrophic lateral sclerosis, and multiple sclerosis. |
2005-07-27 |
2023-08-12 |
human |
| Wolfgang J Strei. Microglia and neuroprotection: implications for Alzheimer's disease. Brain research. Brain research reviews. vol 48. issue 2. 2005-07-15. PMID:15850662. |
microglia and neuroprotection: implications for alzheimer's disease. |
2005-07-15 |
2023-08-12 |
Not clear |
| Rosario Luna-Medina, Marta Cortes-Canteli, Mercedes Alonso, Angel Santos, Ana Martínez, Ana Perez-Castill. Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation. The Journal of biological chemistry. vol 280. issue 22. 2005-07-12. PMID:15817469. |
in most neurodegenerative disorders, including multiple sclerosis, parkinson disease, and alzheimer disease, a massive neuronal cell death occurs as a consequence of an uncontrolled inflammatory response, where activated astrocytes and microglia and their cytotoxic agents play a crucial pathological role. |
2005-07-12 |
2023-08-12 |
Not clear |
| Z Xie, M E Harris-White, P A Wals, S A Frautschy, C E Finch, T E Morga. Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro. Journal of neurochemistry. vol 93. issue 4. 2005-07-05. PMID:15857407. |
apolipoprotein j (apoj; also known as clusterin and sulfated glycoprotein (sgp)-2) is associated with senile plaques in degenerating regions of alzheimer's disease brains, where activated microglia are also prominent. |
2005-07-05 |
2023-08-12 |
human |
| Masaru Yamamoto, Masahide Horiba, James L Buescher, DeReng Huang, Howard E Gendelman, Richard M Ransohoff, Tsuneya Ikez. Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition. The American journal of pathology. vol 166. issue 5. 2005-06-21. PMID:15855647. |
microglia accumulation at the site of amyloid plaques is a strong indication that microglia play a major role in alzheimer's disease pathogenesis. |
2005-06-21 |
2023-08-12 |
mouse |
| S Thameem Dheen, Yan Jun, Zhou Yan, Samuel S W Tay, Eng Ang Lin. Retinoic acid inhibits expression of TNF-alpha and iNOS in activated rat microglia. Glia. vol 50. issue 1. 2005-06-16. PMID:15602748. |
the release of proinflammatory mediators such as tumor necrosis factor-alpha (tnf-alpha) and nitric oxide by microglia has been implicated in neurotoxicity in chronic neurodegenerative diseases such as alzheimer's disease. |
2005-06-16 |
2023-08-12 |
rat |
| Tatyana Tchaikovskaya, Vadim Fraifeld, Tinatin Urphanishvili, John H Andorfer, Peter Davies, Irving Listowsk. Glutathione S-transferase hGSTM3 and ageing-associated neurodegeneration: relationship to Alzheimer's disease. Mechanisms of ageing and development. vol 126. issue 2. 2005-06-13. PMID:15621212. |
immunocytochemistry performed with hgstm3-specific antisera, showed prominent staining of neuritic plaques, neurofibrillary tangles and microglia in sections of hippocampus obtained from patients with alzheimer's disease. |
2005-06-13 |
2023-08-12 |
human |
| Tarja M Malm, Milla Koistinaho, Maria Pärepalo, Tero Vatanen, Andreas Ooka, Stefan Karlsson, Jari Koistinah. Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice. Neurobiology of disease. vol 18. issue 1. 2005-05-16. PMID:15649704. |
the role of microglia recruited from bone marrow (bm) into the cns during the progression of alzheimer's disease (ad) is poorly understood. |
2005-05-16 |
2023-08-12 |
mouse |
| Sachiko Ito, Makoto Sawada, Masataka Haneda, Satoshi Fujii, Kentaro Oh-Hashi, Kazutoshi Kiuchi, Masahide Takahashi, Ken-Ichi Isob. Amyloid-beta peptides induce cell proliferation and macrophage colony-stimulating factor expression via the PI3-kinase/Akt pathway in cultured Ra2 microglial cells. FEBS letters. vol 579. issue 9. 2005-05-11. PMID:15792809. |
alzheimer's disease is characterized by numerous amyloid-beta peptide (abeta) plaques surrounded by microglia. |
2005-05-11 |
2023-08-12 |
mouse |
| Nahed S Elsisi, Selina Darling-Reed, Eunsook Y Lee, Ebenezer T Oriaku, Karam F Solima. Ibuprofen and apigenin induce apoptosis and cell cycle arrest in activated microglia. Neuroscience letters. vol 375. issue 2. 2005-04-22. PMID:15670648. |
evidence suggests that microglia proliferate by cell division to create gliosis at the site of pathological conditions such as the amyloid plaques in alzheimer's disease and the substantia nigra of parkinson's disease patients. |
2005-04-22 |
2023-08-12 |
Not clear |
| Robert E Mrak, W Sue T Griffi. Glia and their cytokines in progression of neurodegeneration. Neurobiology of aging. vol 26. issue 3. 2005-04-19. PMID:15639313. |
all of these conditions are associated with early and often dramatic activation of, and cytokine overexpression in, microglia and astrocytes, sometimes decades before pathological changes consistent with a diagnosis of alzheimer's disease are apparent, as in patients with down's syndrome or head injury. |
2005-04-19 |
2023-08-12 |
Not clear |
| Kirk P Townsend, Terrence Town, Takashi Mori, Lih-Fen Lue, Doug Shytle, Paul R Sanberg, David Morgan, Francisco Fernandez, Richard A Flavell, Jun Ta. CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide. European journal of immunology. vol 35. issue 3. 2005-04-19. PMID:15688347. |
although deposition of amyloid beta-peptide (abeta) as abeta plaques involves activation of microglia-mediated inflammatory responses, activated microglia ultimately fail to clear abeta plaques in the brains of either alzheimer's disease (ad) patients or ad mouse models. |
2005-04-19 |
2023-08-12 |
mouse |