| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zihao Li, Cun-Jin Zhan. Isolation and Culture of Mouse Primary Microglia and Oligodendrocyte Precursor Cells. Methods in molecular biology (Clifton, N.J.). vol 2782. 2024-04-15. PMID:38622401. |
microglia and oligodendrocyte precursor cells (opcs) are critical glia subsets in the central nervous system (cns) and are actively engaged in a body of diseases, such as stroke, alzheimer's disease, multiple sclerosis, etc. |
2024-04-15 |
2024-04-18 |
mouse |
| Sarah I Palko, Marc R Benoit, Annie Y Yao, Royce Mohan, Riqiang Ya. ER-stress response in retinal Müller glia occurs significantly earlier than amyloid pathology in the Alzheimer's mouse brain and retina. Glia. 2024-03-18. PMID:38497356. |
er-stress response in retinal müller glia occurs significantly earlier than amyloid pathology in the alzheimer's mouse brain and retina. |
2024-03-18 |
2024-03-20 |
mouse |
| Amanda Pasqualotto, Vinícius da Silva, Felipe Mateus Pellenz, Artur Francisco Schumacher Schuh, Ida Vanessa Doederlein Schwartz, Marina Sieber. Identification of metabolic pathways and key genes associated with atypical parkinsonism using a systems biology approach. Metabolic brain disease. 2024-02-02. PMID:38305999. |
the functional enrichment analyses showed that these genes are involved in several biological processes and pathways, such as the glial cell development, glial cell activation and cognition, pathways were related to alzheimer disease and parkinson disease. |
2024-02-02 |
2024-02-04 |
Not clear |
| Yang Ye, Mingzhu Gao, Wentao Shi, Yan Gao, Yilu Li, Wenhui Yang, Xiaomin Zheng, Xiaojie L. The immunomodulatory effects of mesenchymal stem cell-derived extracellular vesicles in Alzheimer's disease. Frontiers in immunology. vol 14. 2024-01-23. PMID:38259476. |
moderate glial cell activity can be neuroprotective; however, excessive glial cell activation advances the pathology of alzheimer's disease and is accompanied by structural changes in the brain interface, with peripheral immune cells entering the brain through the blood-brain barrier, creating a vicious circle. |
2024-01-23 |
2024-01-25 |
Not clear |
| Michael A Sullivan, Samuel D Lane, André D J McKenzie, Sarah R Ball, Margaret Sunde, G Gregory Neely, Cesar L Moreno, Alexandra Maximova, Eryn L Werry, Michael Kassio. iPSC-derived PSEN2 (N141I) astrocytes and microglia exhibit a primed inflammatory phenotype. Journal of neuroinflammation. vol 21. issue 1. 2024-01-04. PMID:38178159. |
widescale evidence points to the involvement of glia and immune pathways in the progression of alzheimer's disease (ad). |
2024-01-04 |
2024-01-07 |
Not clear |
| Tabea M Soelter, Timothy C Howton, Amanda D Clark, Vishal H Oza, Brittany N Lasseign. Altered Glia-Neuron Communication in Alzheimer's Disease Affects WNT, p53, and NFkB Signaling Determined by snRNA-seq. bioRxiv : the preprint server for biology. 2023-12-11. PMID:38076822. |
although neuronal loss is a primary hallmark of alzheimer's disease, it is known that non-neuronal cell populations are ultimately responsible for maintaining brain homeostasis and neuronal health through neuron-glia and glial cell crosstalk. |
2023-12-11 |
2023-12-17 |
Not clear |
| Hongyoon Choi, Eun Ji Lee, Jin Seop Shin, Hyun Kim, Sungwoo Bae, Yoori Choi, Dong Soo Le. Spatiotemporal characterization of glial cell activation in an Alzheimer's disease model by spatially resolved transcriptomics. Experimental & molecular medicine. 2023-11-30. PMID:38036733. |
spatiotemporal characterization of glial cell activation in an alzheimer's disease model by spatially resolved transcriptomics. |
2023-11-30 |
2023-12-10 |
mouse |
| Angela Gomez-Arboledas, Helene Eliane Hirbe. Editorial: Expert opinions on the relationship between microglia, glia, and Alzheimer's disease: 2022. Frontiers in aging neuroscience. vol 15. 2023-09-29. PMID:37771521. |
editorial: expert opinions on the relationship between microglia, glia, and alzheimer's disease: 2022. |
2023-09-29 |
2023-10-07 |
Not clear |
| Sarah Krupp, Isabel Hubbard, Oliver Tam, Gale M Hammell, Josh Dubna. TDP-43 pathology in Drosophila induces glial-cell type specific toxicity that can be ameliorated by knock-down of SF2/SRSF1. PLoS genetics. vol 19. issue 9. 2023-09-25. PMID:37747929. |
accumulation of cytoplasmic inclusions of tar-dna binding protein 43 (tdp-43) is seen in both neurons and glia in a range of neurodegenerative disorders, including amyotrophic lateral sclerosis (als), frontotemporal dementia (ftd) and alzheimer's disease (ad). |
2023-09-25 |
2023-10-07 |
drosophila_melanogaster |
| Amanda Amorim Mugayar, Giovanna da Silva Guimarães, Paulo Henrique Tavares de Oliveira, Renan Lyra Miranda, Aline Araujo Dos Santo. Apoptosis in the neuroprotective effect of α7 nicotinic receptor in neurodegenerative models. Journal of neuroscience research. 2023-08-24. PMID:37615647. |
studies have demonstrated the relationship between the activation of these receptors and the reduction of neuronal or glial cell injury, by controlling apoptotic processes in different models, including neurodegenerative diseases such as alzheimer's disease. |
2023-08-24 |
2023-09-07 |
Not clear |
| S Krupp, O Tam, M Gale Hammell, J Dubna. TDP-43 pathology in bioRxiv : the preprint server for biology. 2023-05-19. PMID:37205372. |
tdp-43 pathology in accumulation of cytoplasmic inclusions of tar-dna binding protein 43 (tdp-43) is seen in both neurons and glia in a range of neurodegenerative disorders, including amyotrophic lateral sclerosis (als), frontotemporal dementia (ftd) and alzheimer's disease (ad). |
2023-05-19 |
2023-08-14 |
Not clear |
| Micheli Mainardi Pillat, Ana Carolina Ayupe, Guilherme Juvenal, Carine Meinerz, Talita Glaser, Diogo Vieira da Silva Pellegrina, Daisylea Souza Paiva, Carlos Fernando Mello, Beatriz Monteiro Longo, Eduardo Moraes Reis, Henning Ulric. Differentiated Embryonic Neurospheres from Familial Alzheimer's Disease Model Show Innate Immune and Glial Cell Responses. Stem cell reviews and reports. 2023-05-02. PMID:37129730. |
differentiated embryonic neurospheres from familial alzheimer's disease model show innate immune and glial cell responses. |
2023-05-02 |
2023-08-14 |
Not clear |
| Micheli Mainardi Pillat, Ana Carolina Ayupe, Guilherme Juvenal, Carine Meinerz, Talita Glaser, Diogo Vieira da Silva Pellegrina, Daisylea Souza Paiva, Carlos Fernando Mello, Beatriz Monteiro Longo, Eduardo Moraes Reis, Henning Ulric. Differentiated Embryonic Neurospheres from Familial Alzheimer's Disease Model Show Innate Immune and Glial Cell Responses. Stem cell reviews and reports. 2023-05-02. PMID:37129730. |
proteins involved in the alzheimer's disease (ad), such as amyloid precursor protein (app) and presenilin-1 (ps1), play critical roles in early development of the central nervous system (cns), as well as in innate immune and glial cell responses. |
2023-05-02 |
2023-08-14 |
Not clear |
| Guoyan Zha. Shared and disease-specific glial gene expression changes in neurodegenerative diseases. Nature aging. vol 3. issue 3. 2023-03-30. PMID:36993868. |
we reveal similarities and differences between alzheimer's disease glia and parkinson's disease glia, as well as regional variance linked to disease pathology and neurodegeneration. |
2023-03-30 |
2023-08-14 |
Not clear |
| Amanda M Leisgang Osse, Ravi S Pandey, Ryan A Wirt, Andrew A Ortiz, Arnold Salazar, Michael Kimmich, Erin N Strom, Adrian Oblak, Bruce Lamb, James M Hyman, Gregory W Carter, Jefferson Kinne. Reduction in GABAB on glia induce Alzheimer's disease related changes. Brain, behavior, and immunity. 2023-03-11. PMID:36906075. |
reduction in gabab on glia induce alzheimer's disease related changes. |
2023-03-11 |
2023-08-14 |
Not clear |
| Weihong Yi, Dazhi Yang, Zhen Xu, Zecai Chen, Guozhi Xiao, Lei Qi. Immortalization of mouse primary astrocytes. Gene. 2023-03-04. PMID:36870428. |
astrocytes, as the most abundant glial cell type in the central nervous system, are promising therapeutical targets for many neuronal disorders, such as alzheimer's disease and parkinson's disease. |
2023-03-04 |
2023-08-14 |
mouse |
| Lihong Sheng, Emily J Shields, Janko Gospocic, Masato Sorida, Linyang Ju, China N Byrns, Faith Carranza, Shelley L Berger, Nancy Bonini, Roberto Bonasi. Ensheathing glia promote increased lifespan and healthy brain aging. Aging cell. 2023-02-25. PMID:36840361. |
furthermore, an expanded ensheathing glia population prevented amyloid-beta accumulation in a fly model of alzheimer's disease and delayed the premature death of the diseased animals. |
2023-02-25 |
2023-08-14 |
drosophila_melanogaster |
| Dasom Kong, Ki Hoon Park, Da-Hyun Kim, Nam Gyo Kim, Seung-Eun Lee, Nari Shin, Myung Geun Kook, Young Bong Kim, Kyung-Sun Kan. Cortical-blood vessel assembloids exhibit Alzheimer's disease phenotypes by activating glia after SARS-CoV-2 infection. Cell death discovery. vol 9. issue 1. 2023-01-25. PMID:36697403. |
cortical-blood vessel assembloids exhibit alzheimer's disease phenotypes by activating glia after sars-cov-2 infection. |
2023-01-25 |
2023-08-14 |
human |
| Georgina Perez-Garcia, Mesude Bicak, Jean-Vianney Haure-Mirande, Gissel M Perez, Alena Otero-Pagan, Miguel A Gama Sosa, Rita De Gasperi, Mary Sano, Carrolee Barlow, Fred H Gage, Benjamin Readhead, Michelle E Ehrlich, Sam Gandy, Gregory A Elde. BCI-838, an orally active mGluR2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the PS19 MAPT Neuroscience letters. 2023-01-19. PMID:36657633. |
bci-838, an orally active mglur2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the ps19 mapt tauopathies are a heterogeneous group of neurodegenerative disorders that are clinically and pathologically distinct from alzheimer's disease (ad) having tau inclusions in neurons and/or glia as their most prominent neuropathological feature. |
2023-01-19 |
2023-08-14 |
Not clear |
| Zhi-Bo Wang, Ya-Hui Ma, Yan Sun, Lan Tan, Hui-Fu Wang, Jin-Tai Y. Interleukin-3 is associated with sTREM2 and mediates the correlation between amyloid-β and tau pathology in Alzheimer's disease. Journal of neuroinflammation. vol 19. issue 1. 2022-12-28. PMID:36578067. |
dysfunction of glial cell communication is involved in alzheimer's disease (ad) pathogenesis, and the recent study reported that astrocytic secreted interleukin-3 (il-3) participated in astrocyte-microglia crosstalk and restricted ad pathology in mice, but the effect of il-3 on the pathological progression of ad in human is still unclear. |
2022-12-28 |
2023-08-14 |
mouse |