| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seon H Kim, Carolyn J Smith, Linda J Van Eldi. Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1 beta production. Neurobiology of aging. vol 25. issue 4. 2004-05-11. PMID:15013563. |
in alzheimer's disease (ad), chronically activated glia contribute to neuronal dysfunction through production of neuroinflammatory molecules like interleukin (il)-1beta. |
2004-05-11 |
2023-08-12 |
Not clear |
| Simona Vuletic, Lee-Way Jin, Santica M Marcovina, Elaine R Peskind, Thomas Moller, John J Alber. Widespread distribution of PLTP in human CNS: evidence for PLTP synthesis by glia and neurons, and increased levels in Alzheimer's disease. Journal of lipid research. vol 44. issue 6. 2004-02-11. PMID:12671035. |
widespread distribution of pltp in human cns: evidence for pltp synthesis by glia and neurons, and increased levels in alzheimer's disease. |
2004-02-11 |
2023-08-12 |
human |
| D Martin Watterson, Anastasia V Velentza, Magdalena Zasadzki, Jeffrey M Craft, Jacques Haiech, Linda J Van Eldi. Discovery of a new class of synthetic protein kinase inhibitors that suppress selective aspects of glial activation and protect against beta-amyloid induced injury: a foundation for future medicinal chemistry efforts focused on targeting Alzheimer's disease progression. Journal of molecular neuroscience : MN. vol 20. issue 3. 2003-12-23. PMID:14501026. |
a prevailing hypothesis in alzheimer's disease (ad) research is that chronically activated glia may contribute to neuronal dysfunction, through generation of a detrimental state of neuroinflammation. |
2003-12-23 |
2023-08-12 |
Not clear |
| Cristina Benito, Estefanía Núñez, Rosa M Tolón, Erica J Carrier, Alberto Rábano, Cecilia J Hillard, Julián Romer. Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 35. 2003-12-23. PMID:14657172. |
cannabinoid cb2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in alzheimer's disease brains. |
2003-12-23 |
2023-08-12 |
human |
| Dorte P Pelvig, Henning Pakkenberg, Lisbeth Regeur, Solveig Oster, Bente Pakkenber. Neocortical glial cell numbers in Alzheimer's disease. A stereological study. Dementia and geriatric cognitive disorders. vol 16. issue 4. 2003-11-06. PMID:14512716. |
neocortical glial cell numbers in alzheimer's disease. |
2003-11-06 |
2023-08-12 |
Not clear |
| B P Kennedy, M G Ziegler, M Alford, L A Hansen, L J Thal, E Maslia. Early and persistent alterations in prefrontal cortex MAO A and B in Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 110. issue 7. 2003-10-14. PMID:12811639. |
mao b is elevated in plaque-associated glia in alzheimer brain. |
2003-10-14 |
2023-08-12 |
human |
| Zhong Xie, Todd E Morgan, Irina Rozovsky, Caleb E Finc. Aging and glial responses to lipopolysaccharide in vitro: greater induction of IL-1 and IL-6, but smaller induction of neurotoxicity. Experimental neurology. vol 182. issue 1. 2003-08-06. PMID:12821383. |
mixed glia from f344 male rats, aged 3 and 24 months, cultured from cerebral cortex (cx), hippocampus (hc), and striatum (st), were assayed for cytokines implicated in alzheimer's disease: il-1alpha, il-1beta, il-6, and tnf-alpha. |
2003-08-06 |
2023-08-12 |
rat |
| Katsuji Kobayashi, Hiroyuki Nakano, Masahiro Hayashi, Masao Shimazaki, Yuken Fukutani, Kazuo Sasaki, Kaoru Sugimori, Yoshifumi Koshin. Association of phosphorylation site of tau protein with neuronal apoptosis in Alzheimer's disease. Journal of the neurological sciences. vol 208. issue 1-2. 2003-04-28. PMID:12639720. |
in addition to neuritic changes and amyloid deposits, neuronal and glial cell apoptosis is an important pathological feature of alzheimer's disease (ad). |
2003-04-28 |
2023-08-12 |
Not clear |
| Jaewon Lee, Sic L Chan, Mark P Mattso. Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain. Neuromolecular medicine. vol 2. issue 1. 2003-02-06. PMID:12230303. |
inflammatory processes involving glial cell activation are associated with amyloid plaques and neurofibrillary tangles, the cardinal neuropathological lesions in the brains of alzheimer's disease (ad) patients, however, it is unclear whether these inflammatory processes occur as a response to neuronal degeneration or might represent more seminal events in the disease process. |
2003-02-06 |
2023-08-12 |
mouse |
| Y Nakamura, M Yamamoto, E Kumamar. Significance of the variant and full-length forms of the very low density lipoprotein receptor in brain. Brain research. vol 922. issue 2. 2002-03-18. PMID:11743951. |
the expression of a full length form of vldlr was detected in senile plaques and some neurons and satellite glia in aged and alzheimer brains. |
2002-03-18 |
2023-08-12 |
human |
| L Guo, A Sawkar, M Zasadzki, D M Watterson, L J Van Eldi. Similar activation of glial cultures from different rat brain regions by neuroinflammatory stimuli and downregulation of the activation by a new class of small molecule ligands. Neurobiology of aging. vol 22. issue 6. 2002-02-28. PMID:11755006. |
activated glia (astrocytes and microglia) surrounding neuritic plaques in alzheimer's disease (ad) overexpress an array of detrimental inflammatory molecules. |
2002-02-28 |
2023-08-12 |
rat |
| D O Slosman, C Ludwig, S Zerarka, L Pellerin, C Chicherio, A de Ribaupierre, J M Annoni, C Bouras, F Herrmann, J P Michel, E Giacobini, P J Magistrett. Brain energy metabolism in Alzheimer's disease: 99mTc-HMPAO SPECT imaging during verbal fluency and role of astrocytes in the cellular mechanism of 99mTc-HMPAO retention. Brain research. Brain research reviews. vol 36. issue 2-3. 2002-02-08. PMID:11690620. |
in addition, they also suggest that specific alterations in glial cell metabolism could explain flow-independent changes in 99mtc-hmpao retention in the brain as observed by spect in certain pathologies (including alzheimer's disease). |
2002-02-08 |
2023-08-12 |
human |
| E A Thomas, L N Sautkulis, J R Criado, D Games, J G Sutcliff. Apolipoprotein D mRNA expression is elevated in PDAPP transgenic mice. Journal of neurochemistry. vol 79. issue 5. 2002-01-17. PMID:11739619. |
these findings suggest that, although increases in apod expression are a normal feature of brain aging, super-increases may represent a glial cell compensatory response to beta-amyloid deposition in alzheimer's disease. |
2002-01-17 |
2023-08-12 |
mouse |
| P Schubert, T Ogata, C Marchini, S Ferron. Glia-related pathomechanisms in Alzheimer's disease: a therapeutic target? Mechanisms of ageing and development. vol 123. issue 1. 2002-01-04. PMID:11640951. |
reactive glial cell properties could contribute to pathomechanisms underlying alzheimer's disease by favoring oxidative neuronal damage and beta-amyloid toxicity. |
2002-01-04 |
2023-08-12 |
rat |
| A G Lam, T Koppal, K T Akama, L Guo, J M Craft, B Samy, J P Schavocky, D M Watterson, L J Van Eldi. Mechanism of glial activation by S100B: involvement of the transcription factor NFkappaB. Neurobiology of aging. vol 22. issue 5. 2002-01-03. PMID:11705636. |
compelling evidence links chronic activation of glia and the subsequent cycle of neuroinflammation and neuronal dysfunction to the progression of neurodegeneration in disorders such as alzheimer's disease (ad). |
2002-01-03 |
2023-08-12 |
rat |
| L J Van Eldi. Glia and Alzheimer's disease. Neurochemistry international. vol 39. issue 5-6. 2001-12-28. PMID:11578767. |
glia and alzheimer's disease. |
2001-12-28 |
2023-08-12 |
Not clear |
| M J LaDu, J A Shah, C A Reardon, G S Getz, G Bu, J Hu, L Guo, L J Van Eldi. Apolipoprotein E and apolipoprotein E receptors modulate A beta-induced glial neuroinflammatory responses. Neurochemistry international. vol 39. issue 5-6. 2001-12-28. PMID:11578778. |
large numbers of activated glia are a common pathological feature of many neurodegenerative disorders, including alzheimer's disease (ad). |
2001-12-28 |
2023-08-12 |
mouse |
| D M Watterson, S Mirzoeva, L Guo, A Whyte, J J Bourguignon, M Hibert, J Haiech, L J Van Eldi. Ligand modulation of glial activation: cell permeable, small molecule inhibitors of serine-threonine protein kinases can block induction of interleukin 1 beta and nitric oxide synthase II. Neurochemistry international. vol 39. issue 5-6. 2001-12-28. PMID:11578781. |
activated glia (astrocytes and microglia) and their associated neuroinflammatory sequelae have been linked to the disease progression of several neurodegenerative disorders, including alzheimer's disease. |
2001-12-28 |
2023-08-12 |
Not clear |
| M T Heneka, H Wiesinger, L Dumitrescu-Ozimek, P Riederer, D L Feinstein, T Klockgethe. Neuronal and glial coexpression of argininosuccinate synthetase and inducible nitric oxide synthase in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 60. issue 9. 2001-09-27. PMID:11556547. |
ass and inducible nos (inos) expression in neurons and glia was investigated by immunohistochemistry in brains of alzheimer disease (ad) patients and nondemented, age-matched controls. |
2001-09-27 |
2023-08-12 |
human |
| P J Yao, J M Weimer, T M O'Herron, P D Colema. Clathrin assembly protein AP-2 is detected in both neurons and glia, and its reduction is prominent in layer II of frontal cortex in Alzheimer's disease. Neurobiology of aging. vol 21. issue 6. 2001-02-15. PMID:11124443. |
clathrin assembly protein ap-2 is detected in both neurons and glia, and its reduction is prominent in layer ii of frontal cortex in alzheimer's disease. |
2001-02-15 |
2023-08-12 |
Not clear |