| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J S Munger, C Haass, C A Lemere, G P Shi, W S Wong, D B Teplow, D J Selkoe, H A Chapma. Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S. The Biochemical journal. vol 311 ( Pt 1). 1995-11-09. PMID:7575468. |
immunostaining of human brain sections revealed cathepsin s in cortical neurons and glia in samples of brain from patients with alzheimer's disease. |
1995-11-09 |
2023-08-12 |
human |
| W M Purcell, C K Atterwil. Mast cells in neuroimmune function: neurotoxicological and neuropharmacological perspectives. Neurochemical research. vol 20. issue 5. 1995-09-21. PMID:7643958. |
the 'cross-talk' between mast cells, lymphocytes, neurons and glia constitutes a neuroimmune axis which is implicated in a range of neurodegenerative diseases with an inflammatory and/or autoimmune component, such as multiple sclerosis and alzheimer's disease. |
1995-09-21 |
2023-08-12 |
Not clear |
| R E Mrak, J G Sheng, W S Griffi. Glial cytokines in Alzheimer's disease: review and pathogenic implications. Human pathology. vol 26. issue 8. 1995-09-13. PMID:7635444. |
the roles of activated glia and of glial cytokines in the pathogenesis of alzheimer's disease are reviewed. |
1995-09-13 |
2023-08-12 |
Not clear |
| S H Zaidi, J S Malte. Nucleolin and heterogeneous nuclear ribonucleoprotein C proteins specifically interact with the 3'-untranslated region of amyloid protein precursor mRNA. The Journal of biological chemistry. vol 270. issue 29. 1995-08-22. PMID:7615529. |
the central nervous system deposition by neurons and glia of beta a4 amyloid protein is an important contributing factor to the development of alzheimer's disease. |
1995-08-22 |
2023-08-12 |
human |
| G Leuba, R Kraftsi. Visual cortex in Alzheimer's disease: occurrence of neuronal death and glial proliferation, and correlation with pathological hallmarks. Neurobiology of aging. vol 15. issue 1. 1994-05-13. PMID:8159261. |
visual areas 17 and 18 were studied with morphometric methods for numbers of neurons, glia, senile plaques (sp), and neurofibrillary tangles (nft) in 13 cases of alzheimer's disease (ad) as compared to 11 controls. |
1994-05-13 |
2023-08-12 |
Not clear |
| T Yamada, D B Calne, H Akiyama, E G McGeer, P L McGee. Further observations on Tau-positive glia in the brains with progressive supranuclear palsy. Acta neuropathologica. vol 85. issue 3. 1993-04-26. PMID:7681616. |
in their morphological characteristics and regionally specific appearance, these unusual glia seemed similar to the alzheimer type i glia which are commonly seen in hepatic encephalopathy or wilson's disease. |
1993-04-26 |
2023-08-12 |
Not clear |
| J H Su, B J Cummings, C W Cotma. Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease. Neuroscience. vol 51. issue 4. 1993-02-23. PMID:1488123. |
heparan sulfate glycosaminoglycan immunostaining was present within neurons, glia, neurofibrillary tangles and senile plaques in alzheimer's tissue. |
1993-02-23 |
2023-08-11 |
Not clear |
| G J Brewer, J W Ashfor. Human serum stimulates Alzheimer markers in cultured hippocampal neurons. Journal of neuroscience research. vol 33. issue 3. 1993-01-25. PMID:1335088. |
we examined neurons in culture, unprotected by glia or a blood-brain barrier, to determine if exposure to serum from alzheimer patients would affect markers for alzheimer brain lesions. |
1993-01-25 |
2023-08-11 |
human |
| J K Youn. Alzheimer's disease and metal-containing glia. Medical hypotheses. vol 38. issue 1. 1992-07-30. PMID:1614354. |
alzheimer's disease and metal-containing glia. |
1992-07-30 |
2023-08-11 |
Not clear |
| J K Youn. Alzheimer's disease and metal-containing glia. Medical hypotheses. vol 38. issue 1. 1992-07-30. PMID:1614354. |
this review proposes that all these seemingly unrelated aspects of alzheimer's disease could be related to a disturbed function of metal-containing glia. |
1992-07-30 |
2023-08-11 |
Not clear |
| B Tate-Ostroff, R E Majocha, E C Walcott, M Ventosa-Michelman, C A Marott. Colocalization of amino terminal and A4 (beta-amyloid) antigens in Alzheimer plaques: evidence for coordinated processing of the amyloid precursor protein. Journal of geriatric psychiatry and neurology. vol 3. issue 3. 1991-03-18. PMID:2126439. |
anti-n1 localized to both neurons and glia in control and alzheimer patients. |
1991-03-18 |
2023-08-11 |
Not clear |
| O S Jørgensen, B W Brooksbank, R Baláz. Neuronal plasticity and astrocytic reaction in Down syndrome and Alzheimer disease. Journal of the neurological sciences. vol 98. issue 1. 1990-12-04. PMID:1977892. |
proteins relatively enriched in neurons (neural cell adhesion molecule (ncam) and d3-protein) or in glia (glutamine synthetase, glial fibrillary acidic protein (gfap) and s100) were measured by quantitative immunochemical methods in autopsy samples of the cerebral cortex of subjects with alzheimer disease (ad) and adults with down syndrome (ds), the latter also presenting manifest signs of alzheimer type of neuropathology. |
1990-12-04 |
2023-08-11 |
human |
| N Ujihira, M Ohya, C Mabuchi, T Indo, Y Hashizum. [An autopsied case of type II citrullinemia--transient effectiveness with either citrate or benzoate to the consciousness disturbance]. Rinsho shinkeigaku = Clinical neurology. vol 29. issue 4. 1990-03-12. PMID:2692930. |
neuropathologically, characteristic findings were brain edema with cerebellar tonsilar herniation, laminar necrosis with spongy formation in cerebral cortex, and alzheimer type ii glia. |
1990-03-12 |
2023-08-11 |
Not clear |
| A Saito, N Amano, S Yokoi, M Akagi, E Izeki, N Arai, Y Ikem. [Iron deposition in the brain of a case of the special type of hepatocerebral encephalopathy]. No to shinkei = Brain and nerve. vol 41. issue 5. 1989-11-28. PMID:2803822. |
the histopathological findings of the brain showed the characteristic changes of hce, which were incomplete softening and spongy state pseudolaminarilly extending in the deep layer of the cerebral cortex, the proliferation of the severely changed alzheimer 2 type glia with or without intranuclear carmine positive substance. |
1989-11-28 |
2023-08-11 |
Not clear |
| W S Griffin, L C Stanley, C Ling, L White, V MacLeod, L J Perrot, C L White, C Arao. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. vol 86. issue 19. 1989-11-09. PMID:2529544. |
most interleukin 1-immunoreactive glia in down syndrome and alzheimer disease were classified as microglia. |
1989-11-09 |
2023-08-11 |
human |
| T Yamamoto, Y Iwasaki, Y Sato, H Yamamoto, H Konn. Astrocytic pathology of methionine sulfoximine-induced encephalopathy. Acta neuropathologica. vol 77. issue 4. 1989-05-26. PMID:2565645. |
prolonged mso-loading (every 12 h up to three times, 100-150 mg/kg body weight) brought about the appearance of astrocytes with swollen, watery nuclei reminiscent of alzheimer ii glia chiefly in the neocortex, hippocampus and lateral thalamus after 24 h. concomitantly, profound accumulation of glycogen ensued in the superficial three layers of the neocortex, hippocampus and pyriform cortex. |
1989-05-26 |
2023-08-11 |
rat |
| J C Hedreen, L S Raskin, R G Struble, D L Pric. Selective silver impregnation of senile plaques: a method useful for computer imaging. Journal of neuroscience methods. vol 25. issue 2. 1988-11-17. PMID:2459566. |
most silver methods for the demonstration of senile plaques (sp) in alzheimer's disease (ad) give variable staining of sp and often stain a variety of other structures (including normal axons, neurofibrillary tangles (nft), blood vessel reticulin, nucleoli of neurons, and nuclei of glia). |
1988-11-17 |
2023-08-11 |
Not clear |
| A Shimoji, T Miyakawa, K Watanabe, K Yamashita, S Katsuragi, K Kabashim. Wilson's disease with extensive degeneration of cerebral white matter and cortex. The Japanese journal of psychiatry and neurology. vol 41. issue 4. 1988-08-22. PMID:3453418. |
we noted the characteristic findings of alzheimer glia (types i and ii) and opalski cells and the new formation in capillaries. |
1988-08-22 |
2023-08-11 |
Not clear |
| L A Hansen, R DeTeresa, P Davies, R D Terr. Neocortical morphometry, lesion counts, and choline acetyltransferase levels in the age spectrum of Alzheimer's disease. Neurology. vol 38. issue 1. 1988-02-16. PMID:3336463. |
we studied neocortical morphometry (cortical thickness, neurons, and glia), lesion counts (plaques and tangles), and choline acetyltransferase levels in up to 113 alzheimer brains and 48 controls. |
1988-02-16 |
2023-08-11 |
Not clear |
| J G Guillemette, L Wong, D R Crapper McLachlan, P N Lewi. Characterization of messenger RNA from the cerebral cortex of control and Alzheimer-afflicted brain. Journal of neurochemistry. vol 47. issue 3. 1986-09-25. PMID:2426413. |
a detailed comparative study of rna transcripts isolated from the neocortex of control and alzheimer postmortem brains was made to determine whether morphological changes in the chromatin of alzheimer neurons and glia, which we reported earlier, are accompanied by changes in the products of transcription. |
1986-09-25 |
2023-08-11 |
human |