All Relations between Alzheimer Disease and neuroglial cell

Publication Sentence Publish Date Extraction Date Species
Robert E Mrak, W Sue T Griffi. Common inflammatory mechanisms in Lewy body disease and Alzheimer disease. Journal of neuropathology and experimental neurology. vol 66. issue 8. 2007-10-26. PMID:17882012. activated microglia are found in association with alpha-synuclein-containing neurons and glia in parkinson disease, in dementia with lewy bodies, and in multiple system atrophy, and these associations are reminiscent of microglial associations with neurofibrillary tangle-containing neurons in alzheimer disease. 2007-10-26 2023-08-12 Not clear
Yongbae Kim, Luisa Olivi, Jae Hoon Cheong, Alex Maertens, Joseph P Bressle. Aluminum stimulates uptake of non-transferrin bound iron and transferrin bound iron in human glial cells. Toxicology and applied pharmacology. vol 220. issue 3. 2007-08-13. PMID:17376497. because of the association between aluminum and alzheimer's disease, and findings of higher levels of iron in alzheimer's disease brains, the effects of aluminum on iron homeostasis were examined in a human glial cell line. 2007-08-13 2023-08-12 human
Izumi Maezawa, Nobuyo Maeda, Thomas J Montine, Kathleen S Montin. Apolipoprotein E-specific innate immune response in astrocytes from targeted replacement mice. Journal of neuroinflammation. vol 3. 2007-07-20. PMID:16603079. apoe isoform-specific modulation of several pathogenic processes, in addition to amyloid beta metabolism in alzheimer's disease, have been proposed: one of these is innate immune response by glia. 2007-07-20 2023-08-12 mouse
Caleb E Finch, Todd E Morga. Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: a position paper. Current Alzheimer research. vol 4. issue 2. 2007-07-10. PMID:17430245. alzheimer disease (ad) includes inflammatory processes in the senile plaques and surrounding glia, with increased expression of acute phase proteins such as c-reactive protein (crp) and il-6. 2007-07-10 2023-08-12 human
Yuxian Shen, Guihong Zhang, Lihua Liu, Shuyun X. Suppressive effects of melatonin on amyloid-beta-induced glial activation in rat hippocampus. Archives of medical research. vol 38. issue 3. 2007-06-05. PMID:17350477. growing evidence indicates that activated glia, as a result of chronic inflammation, are associated with amyloid-beta peptide (abeta) deposits in the brain of alzheimer's disease (ad) patients. 2007-06-05 2023-08-12 rat
Kurt A Jellinge. Challenges in neuronal apoptosis. Current Alzheimer research. vol 3. issue 4. 2006-11-03. PMID:17017868. given the short duration required for the completion of apoptosis and the chronic progressive course of neurodegeneration in alzheimer disease and related disorders, the detection of rare neurons displaying morphological signs of apoptosis and expression of the activated key-executing enzyme csp-3 is realistic, although there is significantly increased incidence of cells with dna fragmentation, mainly glia, and markers for a "proapoptotic" environment in the aged human brain indicate increased susceptibility of neurons to metabolic and other noxious factors. 2006-11-03 2023-08-12 human
Nobuyuki Kimura, Masaki Takahashi, Tomoko Tashiro, Keiji Tera. Amyloid beta up-regulates brain-derived neurotrophic factor production from astrocytes: rescue from amyloid beta-related neuritic degeneration. Journal of neuroscience research. vol 84. issue 4. 2006-10-24. PMID:16862545. astrocytes, the most abundant type of glia in the brain, are considered to play a key role in alzheimer's disease (ad) pathologies. 2006-10-24 2023-08-12 human
Paul D Drew, Jihong Xu, Paul D Storer, Janet A Chavis, Michael K Rack. Peroxisome proliferator-activated receptor agonist regulation of glial activation: relevance to CNS inflammatory disorders. Neurochemistry international. vol 49. issue 2. 2006-09-14. PMID:16753239. under such conditions, glia can become chronically activated and may contribute to the neuropathology associated with a variety of neuroinflammatory disorders including multiple sclerosis (ms), alzheimer's disease (ad), parkinson's disease (pd), amyotrophic lateral sclerosis (als), and stroke. 2006-09-14 2023-08-12 Not clear
A-M Nilselid, Pia Davidsson, Katarina Nägga, Niels Andreasen, Pam Fredman, Kaj Blenno. Clusterin in cerebrospinal fluid: analysis of carbohydrates and quantification of native and glycosylated forms. Neurochemistry international. vol 48. issue 8. 2006-07-25. PMID:16490286. clusterin expression is increased in brain tissue in affected regions of alzheimer patients, and intense clusterin staining is found in both senile plaques and in neuronal and glia cells. 2006-07-25 2023-08-12 Not clear
Seung U Kim, Jean de Velli. Microglia in health and disease. Journal of neuroscience research. vol 81. issue 3. 2005-11-07. PMID:15954124. it was del rio hortega in 1927 who determined that microglia belong a distinct glial cell type apart from astrocytes and oligodendrocytes, and since 1970s there has been wide recognition that microglia are immune effectors in the cns that respond to pathological conditions and participate in initiation and progression of neurological disorders including alzheimer's disease, parkinson's disease, multiple sclerosis, and acquired immune deficiency syndrome dementia complex by releasing potentially cytotoxic molecules such as proinflammatory cytokines, reactive oxygen intermediates, proteinases and complement proteins. 2005-11-07 2023-08-12 Not clear
Diana Dominguez, Jos Tournoy, Dieter Hartmann, Tobias Huth, Kim Cryns, Siska Deforce, Lutgarde Serneels, Ira Espuny Camacho, Els Marjaux, Katleen Craessaerts, Anton J M Roebroek, Michael Schwake, Rudi D'Hooge, Patricia Bach, Ulrich Kalinke, Dieder Moechars, Christian Alzheimer, Karina Reiss, Paul Saftig, Bart De Stroope. Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. The Journal of biological chemistry. vol 280. issue 35. 2005-10-25. PMID:15987683. as glia are 10 times more abundant in brain compared with neurons, our data indicate that bace2 could indeed contribute to abeta generation in the brains of alzheimer disease and, in particular, down syndrome patients. 2005-10-25 2023-08-12 mouse
Piotr Alexandrov, Jian-Guo Cui, Yuhai Zhao, Walter J Luki. 24S-hydroxycholesterol induces inflammatory gene expression in primary human neural cells. Neuroreport. vol 16. issue 9. 2005-09-30. PMID:15931060. in this study, we examined the effects of 24s-hydroxycholesterol on gene expression in human neural cells, a primary coculture of neurons and glia useful for studying pathogenic mechanisms in alzheimer's disease. 2005-09-30 2023-08-12 human
Ya-Ting Yang, Tzyh-Chwen Ju, Ding-I Yan. Induction of hypoxia inducible factor-1 attenuates metabolic insults induced by 3-nitropropionic acid in rat C6 glioma cells. Journal of neurochemistry. vol 93. issue 3. 2005-06-03. PMID:15836611. compromised mitochondrial function in neurons and glia has been observed in several neurodegenerative disorders, including huntington's disease and alzheimer's disease. 2005-06-03 2023-08-12 rat
Jill A White, Arlene M Manelli, Kristina H Holmberg, Linda J Van Eldik, Mary Jo Lad. Differential effects of oligomeric and fibrillar amyloid-beta 1-42 on astrocyte-mediated inflammation. Neurobiology of disease. vol 18. issue 3. 2005-05-17. PMID:15755672. activated glia, as a result of chronic inflammation, are associated with amyloid-beta peptide (abeta) deposits in the brain of alzheimer's disease (ad) patients. 2005-05-17 2023-08-12 rat
Yann Verdier, Márta Zarándi, Botond Penk. Amyloid beta-peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's disease. Journal of peptide science : an official publication of the European Peptide Society. vol 10. issue 5. 2005-03-10. PMID:15160835. amyloid beta-peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for alzheimer's disease. 2005-03-10 2023-08-12 Not clear
T Estefanía Saez, Mariana Pehar, Marcelo Vargas, Luis Barbeito, Ricardo B Maccion. Astrocytic nitric oxide triggers tau hyperphosphorylation in hippocampal neurons. In vivo (Athens, Greece). vol 18. issue 3. 2005-03-07. PMID:15341183. although extensive genetic data implicate the beta amyloid peptide (abeta) in the neurodegenerative cascade of alzheimer's disease (ad), the molecular mechanisms underlying its effects on neurons and glia and the relationship between glial activation and neuronal death are not well understood. 2005-03-07 2023-08-12 rat
M R Pazos, E Núñez, C Benito, R M Tolón, J Romer. Role of the endocannabinoid system in Alzheimer's disease: new perspectives. Life sciences. vol 75. issue 16. 2004-09-30. PMID:15306158. we have recently reported the existence of profound changes in the location and density of several elements of this system in alzheimer's disease tissue samples, indicating that a non-neuronal endocannabinoid system is up-regulated in activated glia. 2004-09-30 2023-08-12 Not clear
M M Ahmed, H Hoshino, T Chikuma, M Yamada, T Kat. Effect of memantine on the levels of glial cells, neuropeptides, and peptide-degrading enzymes in rat brain regions of ibotenic acid-treated alzheimer's disease model. Neuroscience. vol 126. issue 3. 2004-09-14. PMID:15183513. it has been implicated that glia activation plays a critical role in the progression of alzheimer's disease (ad). 2004-09-14 2023-08-12 rat
Ling Guo, Mary Jo LaDu, Linda J Van Eldi. A dual role for apolipoprotein e in neuroinflammation: anti- and pro-inflammatory activity. Journal of molecular neuroscience : MN. vol 23. issue 3. 2004-08-26. PMID:15181248. chronically activated glia associated with amyloid plaques might contribute to neuronal dysfunction in alzheimer's disease (ad) through generation of neuroinflammatory molecules. 2004-08-26 2023-08-12 human
Seon H Kim, Carolyn J Smith, Linda J Van Eldi. Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1 beta production. Neurobiology of aging. vol 25. issue 4. 2004-05-11. PMID:15013563. in alzheimer's disease (ad), chronically activated glia contribute to neuronal dysfunction through production of neuroinflammatory molecules like interleukin (il)-1beta. 2004-05-11 2023-08-12 Not clear