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Reference Sentence Publish Date Extraction Date Species
Bin Wang, Cong Gu. Concentration-Dependent Effects of Cholesterol on the Dimerization of Amyloid-\\xce\\xb2 Peptides in Lipid Bilayers. ACS chemical neuroscience vol issue 2022 36082607 membrane disruption mediated by the accumulation of amyloid-\xce\xb2 (a\xce\xb2) on cell membranes is central to the pathogenesis of alzheimer's disease (ad). 2022-09-09 2022-09-14 Not clear
Jia Wang, Si-Fei Ma, Qi Yun, Wen-Jun Liu, Hong-Ru Zhai, Hou-Zhen Shi, Lan-Gui Xie, Jin-Jun Qian, Chun-Jie Zhao, Wei-Ning Zhan. FOXG1 as a Potential Therapeutic Target for Alzheimer's Disease with a Particular Focus on Cell Cycle Regulation. Journal of Alzheimer's disease : JAD vol issue 2022 35180113 foxg1 as a potential therapeutic target for alzheimer's disease with a particular focus on cell cycle regulation. 2022-02-18 2022-02-23 Not clear
Jelena Osmanovic Barilar, Ana Knezovic, Jan Homolak, Ana Babic Perhoc, Melita Salkovic-Petrisi. Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer's Disease. International journal of molecular sciences vol 23 issue 1 2022 35008973 this study aimed to explore the roles of central glucagon-like peptide-1 (glp-1) and gastric inhibitory polypeptide (gip) on cell metabolism and energy in the brain, as well as on the levels of these incretins, insulin, and glucose via inhibition of the central incretin receptors following intracerebroventricular administration of the respective antagonists in healthy rats and a streptozotocin-induced rat model of sporadic alzheimer's disease (sad). 2022-01-11 2022-01-13 Not clear
Jingcong Zhuang, Zhongjie Chen, Pingping Cai, Rong Wang, Qingwei Yang, Longling Li, Huili Yang, Renjing Zh. Targeting MicroRNA-125b Promotes Neurite Outgrowth but Represses Cell Apoptosis and Inflammation via Blocking PTGS2 and CDK5 in a FOXQ1-Dependent Way in Alzheimer Disease. Frontiers in cellular neuroscience vol 14 issue 2021 33408612 this study aimed to explore the molecular regulatory network among microrna-125b (mir-125b), forkhead box q1 (foxq1), prostaglandin-endoperoxide synthase 2 (ptgs2), and cyclin-dependent kinase 5 (cdk5), as well as their effects on cell apoptosis, neurite outgrowth, and inflammation in alzheimer disease (ad). 2021-01-11 2022-01-13 Not clear
Weiwei Yang, Sheng Zhang, Biao Li, Yao Zhan. [MALAT1 inhibits proliferation and promotes apoptosis of SH-SY5Y cells induced by A\\xce\\xb2 Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology vol 34 issue 5 2019 30043735 [malat1 inhibits proliferation and promotes apoptosis of sh-sy5y cells induced by a\xce\xb2 objective to investigate the effects of long non-coding rna (lncrna) metastasis-associated lung adenocarcinoma transcript 1 (malat1) on cell cycle, proliferation and apoptosis in sh-sy5y model cells of alzheimer's disease (ad). 2019-07-08 2022-01-13 Not clear
Francesco Angelucci, Francesca Gelfo, Marco Fiore, Nicoletta Croce, Aleksander A Math\\xc3\\xa9, Sergio Bernardini, Carlo Caltagiron. The effect of neuropeptide Y on cell survival and neurotrophin expression in in-vitro models of Alzheimer's disease. Canadian journal of physiology and pharmacology vol 92 issue 8 2015 25026432 the effect of neuropeptide y on cell survival and neurotrophin expression in in-vitro models of alzheimer's disease. 2015-05-11 2022-01-12 Not clear
Daniela Puzzo, Carla Loreto, Salvatore Giunta, Giuseppe Musumeci, Giuseppina Frasca, Maria Vittoria Podda, Ottavio Arancio, Agostino Palmer. Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice. Neurobiology of aging vol 35 issue 3 2014 24112792 because it has been previously demonstrated that phosphodiesterase-5 inhibitors (pde5-is) protect against hippocampal synaptic dysfunction and memory deficits in mouse models of alzheimer's disease and physiological aging, we investigated the effect of a treatment with the pde5-i, sildenafil, on cell death, pro- and antiapoptotic molecules, and a\xce\xb2 production. 2014-09-29 2022-01-12 Not clear
Carolina Adura, Simon Guerrero, Edison Salas, Luis Medel, Ana Riveros, Juan Mena, Jordi Arbiol, Fernando Albericio, Ernest Giralt, Marcelo J Koga. Stable conjugates of peptides with gold nanorods for biomedical applications with reduced effects on cell viability. ACS applied materials & interfaces vol 5 issue 10 2013 23597259 in this study, we produced a conjugate of gold nanorods with the peptide clpffd that recognizes toxic \xce\xb2-amyloid aggregates present in alzheimer's disease, demonstrates colloidal stability, maintains plasmonic properties, and shows no effects on cell viability in the sh-sy5y cell line. 2013-10-17 2022-01-12 Not clear
Shuke Cui, Yan Sun, Chengzang Li. Effect of bushenyisui formula on brain tissue apoptosis and Bcl-2 in beta-amyloid protein-induced Alzheimer's disease rat models. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan vol 32 issue 4 2013 23427404 to investigate the effect of bushenyisui formula on cell apoptosis and positive b cell lymphoma (bcl-2) in the brain of rat models of alzheimer's disease (ad) induced by beta-amyloid protein (abeta) and the mechanism underlying the effect. 2013-04-04 2022-01-12 Not clear
Willem Kamphuis, Marie Orre, Lieneke Kooijman, Maurice Dahmen, Elly M Ho. Differential cell proliferation in the cortex of the APPswePS1dE9 Alzheimer's disease mouse model. Glia vol 60 issue 4 2012 22262260 plaque deposition in alzheimer's disease (ad) is known to decrease proliferation in neurogenic niches in ad mouse models, but the effects on cell proliferation and differentiation in other brain areas have not been studied in detail. 2012-06-12 2022-01-12 Not clear
Xiaoguang Yang, Wenwen Sheng, Grace Y Sun, James C-M Le. Effects of fatty acid unsaturation numbers on membrane fluidity and \\xce\\xb1-secretase-dependent amyloid precursor protein processing. Neurochemistry international vol 58 issue 3 2011 21184792 to address the roles of fatty acid unsaturation numbers in cellular pathways of alzheimer's disease (ad), we systematically investigated the effects of fatty acids on cell membrane fluidity and \xce\xb1-secretase-cleaved soluble amyloid precursor protein (sapp(\xce\xb1)) secretion in relation to unsaturation numbers using stearic acid (sa, 18:0), oleic acid (oa, 18:1), linoleic acid (la, 18:2), \xce\xb1-linolenic acid (ala, 18:3), arachidonic acid (aa, 20:4), eicosapentaenoic acid (epa, 20:5), and docosahexaenoic acid (dha, 22:6). 2011-12-27 2022-01-12 Not clear
Steven S-S Wang, Ming-Shen Lin, Shen-Liang Chen, Yung Chang, Rouch-Chyu Ruaan, Wen-Yih Che. Using isothermal titration calorimetry to real-time monitor the heat of metabolism: a case study using PC12 cells and A\\xce\\xb2(1-40). Colloids and surfaces. B, Biointerfaces vol 83 issue 2 2011 21190816 the deposition and aggregation of \xce\xb2-amyloid (a\xce\xb2) on cell membranes was considered as one of the primary factors in having alzheimer's disease (ad). 2011-04-25 2022-01-12 Not clear
Suman Nag, Jiji Chen, J Irudayaraj, S Mait. Measurement of the attachment and assembly of small amyloid-\\xce\\xb2 oligomers on live cell membranes at physiological concentrations using single-molecule tools. Biophysical journal vol 99 issue 6 2011 20858443 it is thought that the pathological cascade in alzheimer's disease is initiated by the formation of amyloid-\xce\xb2 (a\xce\xb2) peptide complexes on cell membranes. 2011-01-04 2022-01-12 Not clear
Zhi-qiang Xu, Jing Li, Juan Deng, Xiao-jiang Jiang, Hua-dong Zho. [Effects of proBDNF on cell proliferation and differentiation in hippocampal dentate gyrus in Alzheimer' disease rat model]. Zhonghua yi xue za zhi vol 90 issue 19 2010 20646587 to explore the effects of probdnf on cell proliferation and differentiation in hippocampal dentate gyrus in alzheimer' disease (ad) rat model. 2010-09-09 2022-01-12 Not clear
Zhi-qiang Xu, Jing Li, Juan Deng, Xiao-jiang Jiang, Hua-dong Zho. [Effects of proBDNF on cell proliferation and differentiation in hippocampal dentate gyrus in Alzheimer' disease rat model]. Zhonghua yi xue za zhi vol 90 issue 19 2010 20646587 [effects of probdnf on cell proliferation and differentiation in hippocampal dentate gyrus in alzheimer' disease rat model]. 2010-09-09 2022-01-12 Not clear
Alex Per\\xc3\\xa1lvarez-Mar\\xc3\\xadn, Laura Mateos, Ce Zhang, Shalini Singh, Angel Cedazo-M\\xc3\\xadnguez, Neus Visa, Ludmilla Morozova-Roche, Astrid Gr\\xc3\\xa4slund, Andreas Bart. Influence of residue 22 on the folding, aggregation profile, and toxicity of the Alzheimer's amyloid beta peptide. Biophysical journal vol 97 issue 1 2009 19580765 several biophysical techniques have been used to determine differences in the aggregation profile (i.e., the secondary structure, aggregation propensity, dynamics, and morphology of amyloid structures) and the effects on cell viability of three variants of the amyloid beta peptide involved in alzheimer's disease. 2009-10-13 2022-01-12 Not clear
Yuichi Hashimoto, Megumi Kurita, Sadakazu Aiso, Ikuo Nishimoto, Masaaki Matsuok. Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130. Molecular biology of the cell vol 20 issue 12 2009 19386761 humanin (hn) inhibits neuronal death induced by various alzheimer's disease (ad)-related insults via an unknown receptor on cell membranes. 2009-09-21 2022-01-12 Not clear
Ming-Shen Lin, Liang-Yu Chen, Steven S S Wang, Yung Chang, Wen-Yih Che. Examining the levels of ganglioside and cholesterol in cell membrane on attenuation the cytotoxicity of beta-amyloid peptide. Colloids and surfaces. B, Biointerfaces vol 65 issue 2 2008 18514493 the deposition of beta-amyloid (abeta) on cell membranes is considered as one of the primary factors in having alzheimer's disease (ad). 2008-09-30 2022-01-12 Not clear
Esperanza Arias, Sonia Gallego-Sand\\xc3\\xadn, Mercedes Villarroya, Antonio G Garc\\xc3\\xada, Manuela G L\\xc3\\xb3pe. Unequal neuroprotection afforded by the acetylcholinesterase inhibitors galantamine, donepezil, and rivastigmine in SH-SY5Y neuroblastoma cells: role of nicotinic receptors. The Journal of pharmacology and experimental therapeutics vol 315 issue 3 2006 16144975 we have studied the neuroprotective effects of these drugs, in comparison with nicotine, on cell death caused by beta-amyloid (abeta) and okadaic acid, two models that are relevant to alzheimer's pathology, in the human neuroblastoma cell line sh-sy5y. 2006-01-23 2022-01-13 Not clear
D Aguado-Llera, E Arilla-Ferreiro, A Campos-Barros, L Puebla-Jim\\xc3\\xa9nez, V Barrio. Protective effects of insulin-like growth factor-I on the somatostatinergic system in the temporal cortex of beta-amyloid-treated rats. Journal of neurochemistry vol 92 issue 3 2005 15659230 because alterations of the somatostatinergic system have been described in alzheimer's disease, we investigated the effects of the abeta peptide and the possible protective role of igf-i on the somatostatinergic system of the rat temporal cortex and on cell death and phosphorylated (p)-akt levels in this area. 2005-06-24 2022-01-12 Not clear
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