| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Enrica Cavedo, Per Suppa, Catharina Lange, Roland Opfer, Simone Lista, Samantha Galluzzi, Adam J Schwarz, Lothar Spies, Ralph Buchert, Harald Hampe. Fully Automatic MRI-Based Hippocampus Volumetry Using FSL-FIRST: Intra-Scanner Test-Retest Stability, Inter-Field Strength Variability, and Performance as Enrichment Biomarker for Clinical Trials Using Prodromal Target Populations at Risk for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 60. issue 1. 2018-05-07. PMID:28777748. |
mri-based hippocampus volume is a core clinical biomarker for identification of alzheimer's disease (ad). |
2018-05-07 |
2023-08-13 |
Not clear |
| Sandro Alves, Julia Bode, Alexis-Pierre Bemelmans, Christof von Kalle, Nathalie Cartier, Björn Tew. Ultramicroscopy as a novel tool to unravel the tropism of AAV gene therapy vectors in the brain. Scientific reports. vol 6. 2018-05-03. PMID:27320056. |
um was applied to obtain high-resolution 3d analysis of aav transduction in adult mouse brains, especially in the hippocampus, a region of interest for alzheimer's disease therapy. |
2018-05-03 |
2023-08-13 |
mouse |
| Ichiro Akiguchi, Mercè Pallàs, Herbert Budka, Haruhiko Akiyama, Masaki Ueno, Jingxian Han, Hideo Yagi, Tomohumi Nishikawa, Yoichi Chiba, Hiroshi Sugiyama, Ryoya Takahashi, Keiko Unno, Keiichi Higuchi, Masanori Hosokaw. SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 37. issue 4. 2018-05-03. PMID:28261874. |
as for the hallmarks of alzheimer brains, tau morphology has not yet been confirmed regardless of the age-related increase in phosphorylated tau in samp8 mice brains, but early age-related aβ deposition in the hippocampus has recently been published. |
2018-05-03 |
2023-08-13 |
mouse |
| Paolo Bosco, Alberto Redolfi, Martina Bocchetta, Clarissa Ferrari, Anna Mega, Samantha Galluzzi, Mark Austin, Andrea Chincarini, D Louis Collins, Simon Duchesne, Bénédicte Maréchal, Alexis Roche, Francesco Sensi, Robin Wolz, Montserrat Alegret, Frederic Assal, Mircea Balasa, Christine Bastin, Anastasia Bougea, Derya Durusu Emek-Savaş, Sebastiaan Engelborghs, Timo Grimmer, Galina Grosu, Milica G Kramberger, Brian Lawlor, Gorana Mandic Stojmenovic, Mihaela Marinescu, Patrizia Mecocci, José Luis Molinuevo, Ricardo Morais, Ellis Niemantsverdriet, Flavio Nobili, Konstantinos Ntovas, Sarah O'Dwyer, George P Paraskevas, Luca Pelini, Agnese Picco, Eric Salmon, Isabel Santana, Oscar Sotolongo-Grau, Luiza Spiru, Elka Stefanova, Katarina Surlan Popovic, Magda Tsolaki, Görsev G Yener, Dina Zekry, Giovanni B Frison. The impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: A European Alzheimer's Disease Consortium study. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 13. issue 9. 2018-05-03. PMID:28263741. |
the impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected alzheimer's disease: a european alzheimer's disease consortium study. |
2018-05-03 |
2023-08-13 |
Not clear |
| Paolo Bosco, Alberto Redolfi, Martina Bocchetta, Clarissa Ferrari, Anna Mega, Samantha Galluzzi, Mark Austin, Andrea Chincarini, D Louis Collins, Simon Duchesne, Bénédicte Maréchal, Alexis Roche, Francesco Sensi, Robin Wolz, Montserrat Alegret, Frederic Assal, Mircea Balasa, Christine Bastin, Anastasia Bougea, Derya Durusu Emek-Savaş, Sebastiaan Engelborghs, Timo Grimmer, Galina Grosu, Milica G Kramberger, Brian Lawlor, Gorana Mandic Stojmenovic, Mihaela Marinescu, Patrizia Mecocci, José Luis Molinuevo, Ricardo Morais, Ellis Niemantsverdriet, Flavio Nobili, Konstantinos Ntovas, Sarah O'Dwyer, George P Paraskevas, Luca Pelini, Agnese Picco, Eric Salmon, Isabel Santana, Oscar Sotolongo-Grau, Luiza Spiru, Elka Stefanova, Katarina Surlan Popovic, Magda Tsolaki, Görsev G Yener, Dina Zekry, Giovanni B Frison. The impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: A European Alzheimer's Disease Consortium study. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 13. issue 9. 2018-05-03. PMID:28263741. |
hippocampal volume is a core biomarker of alzheimer's disease (ad). |
2018-05-03 |
2023-08-13 |
Not clear |
| Giancarlo Pepeu, Maria Grazia Giovannin. The fate of the brain cholinergic neurons in neurodegenerative diseases. Brain research. vol 1670. 2018-04-26. PMID:28652219. |
in alzheimer's disease there is an extensive loss of forebrain cholinergic neurons accompanied by a reduction of the cholinergic fiber network of the cortical mantel and hippocampus. |
2018-04-26 |
2023-08-13 |
Not clear |
| Olayemi Joseph Olajide, Nnaemeka Tobechukwu Asogwa, Blessing Oluwapelumi Moses, Christiana Bidemi Oyegbol. Multidirectional inhibition of cortico-hippocampal neurodegeneration by kolaviron treatment in rats. Metabolic brain disease. vol 32. issue 4. 2018-04-23. PMID:28405779. |
earliest signs of neurodegenerative cascades in the course of alzheimer's disease (ad) are seen within the prefrontal cortex (pfc) and hippocampus, with pathological evidences in both cortical structures correlating with manifestation of behavioural and cognitive deficits. |
2018-04-23 |
2023-08-13 |
rat |
| Azar Zandifar, Vladimir Fonov, Pierrick Coupé, Jens Pruessner, D Louis Collin. A comparison of accurate automatic hippocampal segmentation methods. NeuroImage. vol 155. 2018-04-20. PMID:28404458. |
the hippocampus is one of the first brain structures affected by alzheimer's disease (ad). |
2018-04-20 |
2023-08-13 |
Not clear |
| Catherine A Thorn, Michael Popiolek, Eda Stark, Jeremy R Edgerto. Effects of M1 and M4 activation on excitatory synaptic transmission in CA1. Hippocampus. vol 27. issue 7. 2018-04-18. PMID:28422371. |
hippocampal networks are particularly susceptible to dysfunction in many neurodegenerative diseases and neuropsychiatric disorders including alzheimer's disease, lewy body dementia, and schizophrenia. |
2018-04-18 |
2023-08-13 |
rat |
| Daniela Durand, Lila Carniglia, Juan Turati, Delia Ramírez, Julieta Saba, Carla Caruso, Mercedes Lasag. Amyloid-beta neurotoxicity and clearance are both regulated by glial group II metabotropic glutamate receptors. Neuropharmacology. vol 123. 2018-04-17. PMID:28495373. |
furthermore, mglu3r expression is reduced in hippocampal astrocytes from pdapp-j20 mice, suggesting a role for these receptors in alzheimer's disease. |
2018-04-17 |
2023-08-13 |
mouse |
| Sang Hun Lee, David Lutz, Mohanad Mossalam, Vadim Y Bolshakov, Michael Frotscher, Jie She. Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway. Molecular neurodegeneration. vol 12. issue 1. 2018-04-17. PMID:28619096. |
presenilins play a major role in the pathogenesis of alzheimer's disease, in which the hippocampus is particularly vulnerable. |
2018-04-17 |
2023-08-13 |
Not clear |
| Mathieu Verdurand, Luc Zimme. Hippocampal 5-HT Neuropharmacology. vol 123. 2018-04-17. PMID:28647411. |
hippocampal 5-ht there is increasing evidence that the serotonergic system is highly dysfunctional in alzheimer's disease (ad), and this could be related to cognitive impairments associated with dementia. |
2018-04-17 |
2023-08-13 |
Not clear |
| Qingwei Ruan, Grazia D'onofrio, Tao Wu, Antonio Greco, Daniele Sancarlo, Zhuowei Y. Sexual dimorphism of frailty and cognitive impairment: Potential underlying mechanisms (Review). Molecular medicine reports. vol 16. issue 3. 2018-04-16. PMID:28713963. |
the selection criteria of the present study included: i) sexual dimorphism of frailty, ii) sexual dimorphism of subjective memory decline (impairment) and atrophy of hippocampus during early life, iii) sexual dimorphism of late‑onset alzheimer's disease and iv) sexual dimorphism mechanisms underlying frailty and cognitive impairment. |
2018-04-16 |
2023-08-13 |
Not clear |
| Michail B Evgen'ev, George S Krasnov, Inna V Nesterova, David G Garbuz, Vadim L Karpov, Alexey V Morozov, Anastasiya V Snezhkina, Alexander N Samokhin, Alexander Sergeev, Alexei M Kulikov, Natalia V Bobkov. Molecular Mechanisms Underlying Neuroprotective Effect of Intranasal Administration of Human Hsp70 in Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 59. issue 4. 2018-04-12. PMID:28759972. |
herein, we investigated whether sub-chronic intranasal administration of exogenous hsp70 (ehsp70) exerts a neuroprotective effect on the temporal cortex and areas of the hippocampus in transgenic 5xfad mice, a model of alzheimer's disease. |
2018-04-12 |
2023-08-13 |
mouse |
| Yen Ying Lim, Jason Hassenstab, Carlos Cruchaga, Alison Goate, Anne M Fagan, Tammie L S Benzinger, Paul Maruff, Peter J Snyder, Colin L Masters, Ricardo Allegri, Jasmeer Chhatwal, Martin R Farlow, Neill R Graff-Radford, Christoph Laske, Johannes Levin, Eric McDade, John M Ringman, Martin Rossor, Stephen Salloway, Peter R Schofield, David M Holtzman, John C Morris, Randall J Batema. BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 10. 2018-04-10. PMID:27521573. |
bdnf val66met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant alzheimer's disease. |
2018-04-10 |
2023-08-13 |
Not clear |
| Yen Ying Lim, Jason Hassenstab, Carlos Cruchaga, Alison Goate, Anne M Fagan, Tammie L S Benzinger, Paul Maruff, Peter J Snyder, Colin L Masters, Ricardo Allegri, Jasmeer Chhatwal, Martin R Farlow, Neill R Graff-Radford, Christoph Laske, Johannes Levin, Eric McDade, John M Ringman, Martin Rossor, Stephen Salloway, Peter R Schofield, David M Holtzman, John C Morris, Randall J Batema. BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 10. 2018-04-10. PMID:27521573. |
see rogaeva and schmitt-ulms doi101093/aww201 for a scientific commentary on this article: the brain-derived neurotrophic factor (bdnf) val66met polymorphism is implicated in synaptic excitation and neuronal integrity, and has previously been shown to moderate amyloid-β-related memory decline and hippocampal atrophy in preclinical sporadic alzheimer's disease. |
2018-04-10 |
2023-08-13 |
Not clear |
| Yen Ying Lim, Jason Hassenstab, Carlos Cruchaga, Alison Goate, Anne M Fagan, Tammie L S Benzinger, Paul Maruff, Peter J Snyder, Colin L Masters, Ricardo Allegri, Jasmeer Chhatwal, Martin R Farlow, Neill R Graff-Radford, Christoph Laske, Johannes Levin, Eric McDade, John M Ringman, Martin Rossor, Stephen Salloway, Peter R Schofield, David M Holtzman, John C Morris, Randall J Batema. BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 10. 2018-04-10. PMID:27521573. |
we aimed to determine the effect of bdnf val66met on cognitive function, hippocampal function, tau and amyloid-β in preclinical autosomal dominant alzheimer's disease. |
2018-04-10 |
2023-08-13 |
Not clear |
| Matteo De Marco, Annamaria Vallelunga, Francesca Meneghello, Susheel Varma, Alejandro F Frangi, Annalena Venner. ApoE ε4 Allele Related Alterations in Hippocampal Connectivity in Early Alzheimer's Disease Support Memory Performance. Current Alzheimer research. vol 14. issue 7. 2018-04-10. PMID:28176662. |
apoe ε4 allele related alterations in hippocampal connectivity in early alzheimer's disease support memory performance. |
2018-04-10 |
2023-08-13 |
Not clear |
| Marcel Levy Nogueira, Dalila Samri, Stéphane Epelbaum, Simone Lista, Per Suppa, Lothar Spies, Harald Hampel, Bruno Dubois, Marc Teichman. Alzheimer's Disease Diagnosis Relies on a Twofold Clinical-Biological Algorithm: Three Memory Clinic Case Reports. Journal of Alzheimer's disease : JAD. vol 60. issue 2. 2018-04-09. PMID:28869481. |
the international working group recently provided revised criteria of alzheimer's disease (ad) proposing that the diagnosis of typical amnesic ad should be established by a clinical-biological signature, defined by the phenotype of an "amnesic syndrome of the hippocampal type" (asht) combined with positive in vivo evidence of ad pathophysiology in the cerebrospinal fluid (csf) or on amyloid pet imaging. |
2018-04-09 |
2023-08-13 |
Not clear |
| Alejandro Antón-Fernández, Jesús Merchán-Rubira, Jesús Avila, Félix Hernández, Javier DeFelipe, Alberto Muño. Phospho-Tau Accumulation and Structural Alterations of the Golgi Apparatus of Cortical Pyramidal Neurons in the P301S Tauopathy Mouse Model. Journal of Alzheimer's disease : JAD. vol 60. issue 2. 2018-04-09. PMID:28922155. |
in alzheimer's disease (ad), it has been shown to decrease in size and become fragmented in neocortical and hippocampal neuronal subpopulations. |
2018-04-09 |
2023-08-13 |
mouse |