| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohamed R Elnagar, Anne Byriel Walls, Gouda K Helal, Farid M Hamada, Morten Skøtt Thomsen, Anders A Jense. Probing the putative α7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue. PloS one. vol 12. issue 12. 2018-01-16. PMID:29261717. |
probing the putative α7 nachr/nmdar complex in human and murine cortex and hippocampus: different degrees of complex formation in healthy and alzheimer brain tissue. |
2018-01-16 |
2023-08-13 |
mouse |
| Holly C Hunsberger, James E Hickman, Miranda N Ree. Riluzole rescues alterations in rapid glutamate transients in the hippocampus of rTg4510 mice. Metabolic brain disease. vol 31. issue 3. 2018-01-12. PMID:26744018. |
those at risk for alzheimer's disease (ad) often exhibit hippocampal hyperexcitability in the years preceding diagnosis. |
2018-01-12 |
2023-08-13 |
mouse |
| Yun-Qi An, Chun Teng Zhang, Yong Du, Ming Zhang, Su Su Tang, Mei Hu, Yan Long, Hong Bing Sun, Hao Hon. PPARδ agonist GW0742 ameliorates Aβ1-42-induced hippocampal neurotoxicity in mice. Metabolic brain disease. vol 31. issue 3. 2018-01-12. PMID:26864581. |
these results suggest that pparδ activation ameliorates aβ1-42-induced hippocampal neurotoxicity, and it might play a crucial role in alzheimer's disease. |
2018-01-12 |
2023-08-13 |
mouse |
| Yeye Zhuo, Haibiao Guo, Yufang Cheng, Chuang Wang, Canmao Wang, Jingang Wu, Zhengqiang Zou, Danna Gan, Yiwen Li, Jiangping X. Inhibition of phosphodiesterase-4 reverses the cognitive dysfunction and oxidative stress induced by Aβ25-35 in rats. Metabolic brain disease. vol 31. issue 4. 2018-01-12. PMID:26920899. |
in this study, we explored the antioxidative effects of rolipram in alzheimer's disease (ad) by using bilateral aβ25-35 injection into the hippocampus of rats, which were used as an ad model. |
2018-01-12 |
2023-08-13 |
rat |
| Carles Bosch, Nuria Masachs, David Exposito-Alonso, Albert Martínez, Cátia M Teixeira, Isabel Fernaud, Lluís Pujadas, Fausto Ulloa, Joan X Comella, Javier DeFelipe, Angel Merchán-Pérez, Eduardo Sorian. Reelin Regulates the Maturation of Dendritic Spines, Synaptogenesis and Glial Ensheathment of Newborn Granule Cells. Cerebral cortex (New York, N.Y. : 1991). vol 26. issue 11. 2018-01-12. PMID:27624722. |
the extracellular protein reelin has an important role in neurological diseases, including epilepsy, alzheimer's disease and psychiatric diseases, targeting hippocampal circuits. |
2018-01-12 |
2023-08-13 |
Not clear |
| Hyeon-Joong Kim, Dae-Joong Kim, Eun-Ju Shin, Byung-Hwan Lee, Sun-Hye Choi, Sung-Hee Hwang, Hyewhon Rhim, Ik-Hyun Cho, Hyoung-Chun Kim, Seung-Yeol Na. Effects of gintonin-enriched fraction on hippocampal cell proliferation in wild-type mice and an APPswe/PSEN-1 double Tg mouse model of Alzheimer's disease. Neurochemistry international. vol 101. 2018-01-12. PMID:27765516. |
effects of gintonin-enriched fraction on hippocampal cell proliferation in wild-type mice and an appswe/psen-1 double tg mouse model of alzheimer's disease. |
2018-01-12 |
2023-08-13 |
mouse |
| Hyeon-Joong Kim, Dae-Joong Kim, Eun-Ju Shin, Byung-Hwan Lee, Sun-Hye Choi, Sung-Hee Hwang, Hyewhon Rhim, Ik-Hyun Cho, Hyoung-Chun Kim, Seung-Yeol Na. Effects of gintonin-enriched fraction on hippocampal cell proliferation in wild-type mice and an APPswe/PSEN-1 double Tg mouse model of Alzheimer's disease. Neurochemistry international. vol 101. 2018-01-12. PMID:27765516. |
however, little is known about whether gintonin can induce hippocampal cell proliferation in adult wild-type mice and an appswe/psen-1 double tg mouse model of alzheimer's disease (ad). |
2018-01-12 |
2023-08-13 |
mouse |
| Ana Contreras, Danila Del Rio, Ana Martínez, Carmen Gil, Lidia Morales, Mariano Ruiz-Gayo, Nuria Del Olm. Inhibition of hippocampal long-term potentiation by high-fat diets: is it related to an effect of palmitic acid involving glycogen synthase kinase-3? Neuroreport. vol 28. issue 6. 2018-01-10. PMID:28328738. |
however, glycogen synthase kinase-3 (gsk-3), a pleiotropic enzyme highly expressed in the central nervous system, modulates both hippocampal long-term potentiation (ltp) and ltd, and has been implicated in neurological disorders including alzheimer's disease. |
2018-01-10 |
2023-08-13 |
mouse |
| Cassidy M Fiford, Emily N Manning, Jonathan W Bartlett, David M Cash, Ian B Malone, Gerard R Ridgway, Manja Lehmann, Kelvin K Leung, Carole H Sudre, Sebastien Ourselin, Geert Jan Biessels, Owen T Carmichael, Nick C Fox, M Jorge Cardoso, Josephine Barne. White matter hyperintensities are associated with disproportionate progressive hippocampal atrophy. Hippocampus. vol 27. issue 3. 2018-01-09. PMID:27933676. |
this study investigates relationships between white matter hyperintensity (wmh) volume, cerebrospinal fluid (csf) alzheimer's disease (ad) pathology markers, and brain and hippocampal volume loss. |
2018-01-09 |
2023-08-13 |
human |
| Peter T Nelson, Erin L Abner, Ela Patel, Sonya Anderson, Donna M Wilcock, Richard J Kryscio, Linda J Van Eldik, Gregory A Jicha, Zsombor Gal, Ruth S Nelson, Bela G Nelson, Jozsef Gal, Md Tofial Azam, David W Fardo, Matthew D Cykowsk. The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases. Journal of neuropathology and experimental neurology. vol 77. issue 1. 2018-01-09. PMID:29186501. |
the multiplicity of pathogenic processes in human amygdalae has potentially important implications for the pathogenesis of alzheimer disease, lewy body diseases, chronic traumatic encephalopathy, primary age-related tauopathy, and hippocampal sclerosis, and for the biomarkers used to diagnose those diseases. |
2018-01-09 |
2023-08-13 |
human |
| Edmarie Guzmán-Vélez, David E Warren, Justin S Feinstein, Joel Bruss, Daniel Trane. Dissociable contributions of amygdala and hippocampus to emotion and memory in patients with Alzheimer's disease. Hippocampus. vol 26. issue 6. 2018-01-08. PMID:26606553. |
dissociable contributions of amygdala and hippocampus to emotion and memory in patients with alzheimer's disease. |
2018-01-08 |
2023-08-13 |
human |
| Edmarie Guzmán-Vélez, David E Warren, Justin S Feinstein, Joel Bruss, Daniel Trane. Dissociable contributions of amygdala and hippocampus to emotion and memory in patients with Alzheimer's disease. Hippocampus. vol 26. issue 6. 2018-01-08. PMID:26606553. |
studies have shown that patients with bilateral hippocampal damage caused by anoxia/ischemia, and patients with probable alzheimer's disease (ad), can experience emotions for prolonged periods of time, even when they cannot remember what caused the emotion in the first place (feinstein et al. |
2018-01-08 |
2023-08-13 |
human |
| Vijay R Varma, Xiaoying Tang, Michelle C Carlso. Hippocampal sub-regional shape and physical activity in older adults. Hippocampus. vol 26. issue 8. 2018-01-08. PMID:27009597. |
hippocampal atrophy is a hallmark of alzheimer's disease pathology, and a target biomarker region for testing intervention efficacy. |
2018-01-08 |
2023-08-13 |
human |
| Manuel Rodriguez-Perdigon, Rosa María Tordera, Francisco Javier Gil-Bea, Gorka Gerenu, Maria Javier Ramirez, Maite Sola. Down-regulation of glutamatergic terminals (VGLUT1) driven by Aβ in Alzheimer's disease. Hippocampus. vol 26. issue 10. 2018-01-08. PMID:27258819. |
alzheimer's disease (ad) is characterized phenotypically by memory impairment, histologically by accumulation of ptau and β-amyloid peptide and morphologically by a loss of nerve terminals in cortical and hippocampal regions. |
2018-01-08 |
2023-08-13 |
mouse |
| Catarina S Silva, Jessica Eira, Carlos A Ribeiro, Ângela Oliveira, Mónica M Sousa, Isabel Cardoso, Márcia A Li. Transthyretin neuroprotection in Alzheimer's disease is dependent on proteolysis. Neurobiology of aging. vol 59. 2018-01-08. PMID:28780366. |
the deposition of amyloid β peptide (aβ) in the hippocampus is one of the major hallmarks of alzheimer's disease, a neurodegenerative disorder characterized by memory loss and cognitive impairment. |
2018-01-08 |
2023-08-13 |
Not clear |
| Mar Cuadrado-Tejedor, Carolina Garcia-Barroso, Juan A Sánchez-Arias, Obdulia Rabal, Marta Pérez-González, Sara Mederos, Ana Ugarte, Rafael Franco, Victor Segura, Gertrudis Perea, Julen Oyarzabal, Ana Garcia-Ost. A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 2. 2018-01-05. PMID:27550730. |
a first-in-class small-molecule that acts as a dual inhibitor of hdac and pde5 and that rescues hippocampal synaptic impairment in alzheimer's disease mice. |
2018-01-05 |
2023-08-13 |
mouse |
| Ruud Zwart, Hannah Reed, Emanuele She. Oxotremorine-M potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms. Biochemical and biophysical research communications. vol 495. issue 1. 2018-01-05. PMID:29127015. |
in alzheimer's disease, the cholinergic input to the hippocampus and cortex is severely degenerated, and agonists or positive allosteric modulators of m1 receptors are therefore thought to be of potential use to treat the deficits in cognitive functions in alzheimer's disease. |
2018-01-05 |
2023-08-13 |
human |
| Kevin Richetin, Petnoi Petsophonsakul, Laurent Roybon, Bruno P Guiard, Claire Rampo. Differential alteration of hippocampal function and plasticity in females and males of the APPxPS1 mouse model of Alzheimer's disease. Neurobiology of aging. vol 57. 2018-01-03. PMID:28666707. |
differential alteration of hippocampal function and plasticity in females and males of the appxps1 mouse model of alzheimer's disease. |
2018-01-03 |
2023-08-13 |
mouse |
| Emrin Horgusluoglu-Moloch, Kwangsik Nho, Shannon L Risacher, Sungeun Kim, Tatiana Foroud, Leslie M Shaw, John Q Trojanowski, Paul S Aisen, Ronald C Petersen, Clifford R Jack, Simon Lovestone, Andrew Simmons, Michael W Weiner, Andrew J Sayki. Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease. Neurobiology of aging. vol 60. 2018-01-03. PMID:28941407. |
targeted neurogenesis pathway-based gene analysis identifies adora2a associated with hippocampal volume in mild cognitive impairment and alzheimer's disease. |
2018-01-03 |
2023-08-13 |
human |
| Emrin Horgusluoglu-Moloch, Kwangsik Nho, Shannon L Risacher, Sungeun Kim, Tatiana Foroud, Leslie M Shaw, John Q Trojanowski, Paul S Aisen, Ronald C Petersen, Clifford R Jack, Simon Lovestone, Andrew Simmons, Michael W Weiner, Andrew J Sayki. Targeted neurogenesis pathway-based gene analysis identifies ADORA2A associated with hippocampal volume in mild cognitive impairment and Alzheimer's disease. Neurobiology of aging. vol 60. 2018-01-03. PMID:28941407. |
alzheimer's disease (ad) patients display hippocampal atrophy, memory impairment, and cognitive decline. |
2018-01-03 |
2023-08-13 |
human |