| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rikki Hullinger, Luigi Pugliell. Molecular and cellular aspects of age-related cognitive decline and Alzheimer's disease. Behavioural brain research. vol 322. issue Pt B. 2017-11-30. PMID:27163751. |
the important role of the hippocampus in age-related cognitive decline and in vulnerability to disease processes such as alzheimer's disease has prompted this review, which will focus on the complexity of changes that characterize aging, and on the molecular connections that exist between normal aging and alzheimer's disease. |
2017-11-30 |
2023-08-13 |
Not clear |
| Sarah M Neuner, Lynda A Wilmott, Brian R Hoffmann, Khyobeni Mozhui, Catherine C Kaczorowsk. Hippocampal proteomics defines pathways associated with memory decline and resilience in normal aging and Alzheimer's disease mouse models. Behavioural brain research. vol 322. issue Pt B. 2017-11-30. PMID:27265785. |
hippocampal proteomics defines pathways associated with memory decline and resilience in normal aging and alzheimer's disease mouse models. |
2017-11-30 |
2023-08-13 |
mouse |
| Ji-Xia Chai, Hui-Hui Li, Yuan-Yuan Wang, Qiang Chai, Wen-Xin He, Yan-Mei Zhou, Xiao-Dong Hu, Zhen-Huan Wan. [Effect of diallyl disulfide on learning and memory abilities and hippocampal synapses in mouse models of Alzheimer's disease]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 36. issue 10. 2017-11-27. PMID:27777209. |
[effect of diallyl disulfide on learning and memory abilities and hippocampal synapses in mouse models of alzheimer's disease]. |
2017-11-27 |
2023-08-13 |
mouse |
| Shannon L Risacher, Wesley H Anderson, Arnaud Charil, Peter F Castelluccio, Sergey Shcherbinin, Andrew J Saykin, Adam J Schwar. Alzheimer disease brain atrophy subtypes are associated with cognition and rate of decline. Neurology. vol 89. issue 21. 2017-11-27. PMID:29070667. |
to test the hypothesis that cortical and hippocampal volumes, measured in vivo from volumetric mri (vmri) scans, could be used to identify variant subtypes of alzheimer disease (ad) and to prospectively predict the rate of clinical decline. |
2017-11-27 |
2023-08-13 |
Not clear |
| Regina Biasibetti, João Paulo Almeida Dos Santos, Letícia Rodrigues, Krista Minéia Wartchow, Lucas Zingano Suardi, Patrícia Nardin, Nicholas Guerini Selistre, Dandara Vázquez, Carlos-Alberto Gonçalve. Hippocampal changes in STZ-model of Alzheimer's disease are dependent on sex. Behavioural brain research. vol 316. 2017-11-24. PMID:27585561. |
hippocampal changes in stz-model of alzheimer's disease are dependent on sex. |
2017-11-24 |
2023-08-13 |
rat |
| Hongyu Pan, Dongpi Wang, Xiaoqin Zhang, Dongming Zhou, Heng Zhang, Qi Qian, Xiao He, Zhaoling Liu, Yunjin Liu, Tingting Zheng, Ling Zhang, Mingkai Wang, Binggui Su. Amyloid β Is Not the Major Factor Accounting for Impaired Adult Hippocampal Neurogenesis in Mice Overexpressing Amyloid Precursor Protein. Stem cell reports. vol 7. issue 4. 2017-11-21. PMID:27693425. |
adult hippocampal neurogenesis was impaired in several alzheimer's disease models overexpressing mutant human amyloid precursor protein (happ). |
2017-11-21 |
2023-08-13 |
mouse |
| Yang Shen, Min Tian, Yuqiong Zheng, Fei Gong, Amy K Y Fu, Nancy Y I. Stimulation of the Hippocampal POMC/MC4R Circuit Alleviates Synaptic Plasticity Impairment in an Alzheimer's Disease Model. Cell reports. vol 17. issue 7. 2017-11-20. PMID:27829153. |
stimulation of the hippocampal pomc/mc4r circuit alleviates synaptic plasticity impairment in an alzheimer's disease model. |
2017-11-20 |
2023-08-13 |
mouse |
| Yang Shen, Min Tian, Yuqiong Zheng, Fei Gong, Amy K Y Fu, Nancy Y I. Stimulation of the Hippocampal POMC/MC4R Circuit Alleviates Synaptic Plasticity Impairment in an Alzheimer's Disease Model. Cell reports. vol 17. issue 7. 2017-11-20. PMID:27829153. |
hippocampal synaptic plasticity is modulated by neuropeptides, the disruption of which might contribute to cognitive deficits observed in alzheimer's disease (ad). |
2017-11-20 |
2023-08-13 |
mouse |
| Srinivas Ayyadevara, Meenakshisundaram Balasubramaniam, Pooja Suri, Samuel G Mackintosh, Alan J Tackett, Dennis H Sullivan, Robert J Shmookler Reis, Richard A Denni. Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Aging. vol 8. issue 12. 2017-11-20. PMID:27992858. |
proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in protein aggregation increases with age in normal tissues, and with pathology and age in alzheimer's hippocampus and mouse cardiac muscle. |
2017-11-20 |
2023-08-13 |
mouse |
| Rui Hu, Pan Wei, Lu Jin, Teng Zheng, Wen-Yu Chen, Xiao-Ya Liu, Xiao-Dong Shi, Jing-Ru Hao, Nan Sun, Can Ga. Overexpression of EphB2 in hippocampus rescues impaired NMDA receptors trafficking and cognitive dysfunction in Alzheimer model. Cell death & disease. vol 8. issue 3. 2017-11-20. PMID:28358367. |
overexpression of ephb2 in hippocampus rescues impaired nmda receptors trafficking and cognitive dysfunction in alzheimer model. |
2017-11-20 |
2023-08-13 |
mouse |
| Tammy T Tran, Caroline L Speck, Aparna Pisupati, Michela Gallagher, Arnold Bakke. Increased hippocampal activation in ApoE-4 carriers and non-carriers with amnestic mild cognitive impairment. NeuroImage. Clinical. vol 13. 2017-11-17. PMID:28070483. |
increased fmri activation in the hippocampus is recognized as a signature characteristic of the amnestic mild cognitive impairment (amci) stage of alzheimer's disease (ad). |
2017-11-17 |
2023-08-13 |
human |
| Lauge Sørensen, Christian Igel, Akshay Pai, Ioana Balas, Cecilie Anker, Martin Lillholm, Mads Nielse. Differential diagnosis of mild cognitive impairment and Alzheimer's disease using structural MRI cortical thickness, hippocampal shape, hippocampal texture, and volumetry. NeuroImage. Clinical. vol 13. 2017-11-17. PMID:28119818. |
differential diagnosis of mild cognitive impairment and alzheimer's disease using structural mri cortical thickness, hippocampal shape, hippocampal texture, and volumetry. |
2017-11-17 |
2023-08-13 |
human |
| Felix-Martin Werner, Rafael Covena. Serotonergic Drugs: Agonists/Antagonists at Specific Serotonergic Subreceptors for the Treatment of Cognitive, Depressant and Psychotic Symptoms in Alzheimer's Disease. Current pharmaceutical design. vol 22. issue 14. 2017-11-16. PMID:26818863. |
alzheimer's disease is a neurodegenerative disease showing alterations in classical neurotransmitters, above all in the hippocampus and prefrontal/temporal cortices. |
2017-11-16 |
2023-08-13 |
Not clear |
| Morten Skøtt Thomsen, Jesper Tobias Andreasen, Maria Arvaniti, Kristi Anne Kohlmeie. Nicotinic Acetylcholine Receptors in the Pathophysiology of Al zheimer's Disease: The Role of Protein-Protein Interactions in Current and Future Treatment. Current pharmaceutical design. vol 22. issue 14. 2017-11-16. PMID:26818866. |
nicotinic acetylcholine receptors (nachrs) have been pursued for decades as potential molecular targets to treat cognitive dysfunction in alzheimer's disease (ad) due to their positioning within regions of the brain critical in learning and memory, such as the prefrontal cortex and hippocampus, and their demonstrated role in processes underlying cognition such as synaptic facilitation, and theta and gamma wave activity. |
2017-11-16 |
2023-08-13 |
Not clear |
| Jesper Hagemeier, Matthew R Woodward, Usama A Rafique, Chaitanya V Amrutkar, Niels Bergsland, Michael G Dwyer, Ralph Benedict, Robert Zivadinov, Kinga Sziget. Odor identification deficit in mild cognitive impairment and Alzheimer's disease is associated with hippocampal and deep gray matter atrophy. Psychiatry research. Neuroimaging. vol 255. 2017-11-16. PMID:27567325. |
odor identification deficit in mild cognitive impairment and alzheimer's disease is associated with hippocampal and deep gray matter atrophy. |
2017-11-16 |
2023-08-13 |
human |
| Ane-Victoria Idland, Roser Sala-Llonch, Tom Borza, Leiv Otto Watne, Torgeir Bruun Wyller, Anne Brækhus, Henrik Zetterberg, Kaj Blennow, Kristine Beate Walhovd, Anders Martin Fjel. CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults. Neurobiology of aging. vol 49. 2017-11-16. PMID:27794264. |
we tested whether csf nfl levels predict hippocampal atrophy rate in cognitively healthy older adults independently of the established csf alzheimer's disease (ad) biomarkers, β-amyloid 1-42, and phosphorylated tau (p-tau). |
2017-11-16 |
2023-08-13 |
human |
| Rebecca P Haberman, Ming Teng Koh, Michela Gallaghe. Heightened cortical excitability in aged rodents with memory impairment. Neurobiology of aging. vol 54. 2017-11-16. PMID:28104309. |
elevated excitability in the hippocampus has emerged as a key contributor to reduced memory function in aging and in cognitive impairment prodromal to alzheimer's disease. |
2017-11-16 |
2023-08-13 |
rat |
| Rebecca P Haberman, Ming Teng Koh, Michela Gallaghe. Heightened cortical excitability in aged rodents with memory impairment. Neurobiology of aging. vol 54. 2017-11-16. PMID:28104309. |
elevated neural excitability extending beyond the hippocampus to interconnected posterior cortex (retrosplenial/parietal) was reduced by treatment with levetiracetam, a therapeutic with behavioral efficacy that has previously translated from rodent models of age-related impairment and alzheimer's disease to humans with amnestic mild cognitive impairment. |
2017-11-16 |
2023-08-13 |
rat |
| Adam D Bachstetter, Eseosa T Ighodaro, Yasmin Hassoun, Danah Aldeiri, Janna H Neltner, Ela Patel, Erin L Abner, Peter T Nelso. Rod-shaped microglia morphology is associated with aging in 2 human autopsy series. Neurobiology of aging. vol 52. 2017-11-16. PMID:28131016. |
alzheimer's disease-related pathology was found to influence the presence of rod-shaped microglia, but only in the parietal cortex and not in the hippocampus or temporal cortex. |
2017-11-16 |
2023-08-13 |
human |
| Tiina Annus, Liam R Wilson, Julio Acosta-Cabronero, Arturo Cardenas-Blanco, Young T Hong, Tim D Fryer, Jonathan P Coles, David K Menon, Shahid H Zaman, Anthony J Holland, Peter J Nesto. The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis. Neurobiology of aging. vol 53. 2017-11-16. PMID:28192686. |
in the presence of amyloid neuropathology, the ds brains demonstrated a strikingly similar pattern of posterior dominant cortical thinning and subcortical atrophy in the hippocampus, thalamus, and striatum, to that observed in non-ds alzheimer's disease. |
2017-11-16 |
2023-08-13 |
Not clear |