| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jason Hassenstab, Rachel Chasse, Perri Grabow, Tammie L S Benzinger, Anne M Fagan, Chengjie Xiong, Mateusz Jasielec, Elizabeth Grant, John C Morri. Certified normal: Alzheimer's disease biomarkers and normative estimates of cognitive functioning. Neurobiology of aging. vol 43. 2017-09-19. PMID:27255812. |
a total of 264 cognitively normal (clinical dementia rating = 0) older adults were classified as biomarker negative ("robust normal," n = 177) or biomarker positive ("preclinical alzheimer's disease" [pcad], n = 87) based on amyloid imaging, cerebrospinal fluid biomarkers, and hippocampal volumes. |
2017-09-19 |
2023-08-13 |
human |
| Paula Abeijon, Xerardo Garcia-Mera, Olga Caamano, Matilde Yanez, Edgar Lopez-Castro, Francisco J Romero-Duran, Humberto Gonzalez-Dia. Multi-Target Mining of Alzheimer Disease Proteome with Hansch's QSBR-Perturbation Theory and Experimental-Theoretic Study of New Thiophene Isosters of Rasagiline. Current drug targets. vol 18. issue 5. 2017-09-13. PMID:26521774. |
the targets are proteins expressed by the hippocampus region of the brain of alzheimer disease (ad) patients. |
2017-09-13 |
2023-08-13 |
Not clear |
| Xike Qin, Yunling Wang, Hemant K Paude. Inhibition of Early Growth Response 1 in the Hippocampus Alleviates Neuropathology and Improves Cognition in an Alzheimer Model with Plaques and Tangles. The American journal of pathology. vol 187. issue 8. 2017-09-12. PMID:28641077. |
inhibition of early growth response 1 in the hippocampus alleviates neuropathology and improves cognition in an alzheimer model with plaques and tangles. |
2017-09-12 |
2023-08-13 |
mouse |
| Hancan Zhu, Hewei Cheng, Xuesong Yang, Yong Fa. Metric Learning for Multi-atlas based Segmentation of Hippocampus. Neuroinformatics. vol 15. issue 1. 2017-09-11. PMID:27638650. |
automatic and reliable segmentation of hippocampus from mr brain images is of great importance in studies of neurological diseases, such as epilepsy and alzheimer's disease. |
2017-09-11 |
2023-08-13 |
human |
| Xiaoliang Jiang, Zhaozhong Zhou, Xiaokang Ding, Xiaolei Deng, Ling Zou, Bailin L. Level Set Based Hippocampus Segmentation in MR Images with Improved Initialization Using Region Growing. Computational and mathematical methods in medicine. vol 2017. 2017-09-07. PMID:28191031. |
the hippocampus has been known as one of the most important structures referred to as alzheimer's disease and other neurological disorders. |
2017-09-07 |
2023-08-13 |
Not clear |
| I-Seul Joe, Jong-Hwan Kim, Hanna Kim, Jung-Hwa Hong, Mirang Kim, Mikyoung Par. Cyclin Y-mediated transcript profiling reveals several important functional pathways regulated by Cyclin Y in hippocampal neurons. PloS one. vol 12. issue 2. 2017-09-07. PMID:28241067. |
in addition, the mrna levels of some genes enriched for those annotation terms and pathways or genes reported to be altered in alzheimer's disease mouse model were further validated by quantitative real-time pcr in hippocampal neuronal cells. |
2017-09-07 |
2023-08-13 |
mouse |
| Andreas Schrötter, Andrea Oberhaus, Katharina Kolbe, Svenja Seger, Thomas Mastalski, Fouzi El Magraoui, Edeltraut Hoffmann-Posorske, Michael Bohnert, Jürgen Deckert, Christian Braun, Matthias Graw, Christoph Schmitz, Thomas Arzberger, Christina Loosse, Helmut Heinsen, Helmut E Meyer, Thorsten Mülle. LMD proteomics provides evidence for hippocampus field-specific motor protein abundance changes with relevance to Alzheimer's disease. Biochimica et biophysica acta. Proteins and proteomics. vol 1865. issue 6. 2017-09-07. PMID:28377147. |
lmd proteomics provides evidence for hippocampus field-specific motor protein abundance changes with relevance to alzheimer's disease. |
2017-09-07 |
2023-08-13 |
human |
| Andreas Schrötter, Andrea Oberhaus, Katharina Kolbe, Svenja Seger, Thomas Mastalski, Fouzi El Magraoui, Edeltraut Hoffmann-Posorske, Michael Bohnert, Jürgen Deckert, Christian Braun, Matthias Graw, Christoph Schmitz, Thomas Arzberger, Christina Loosse, Helmut Heinsen, Helmut E Meyer, Thorsten Mülle. LMD proteomics provides evidence for hippocampus field-specific motor protein abundance changes with relevance to Alzheimer's disease. Biochimica et biophysica acta. Proteins and proteomics. vol 1865. issue 6. 2017-09-07. PMID:28377147. |
human hippocampal area cornu ammonis (ca) 1 is one of the first fields in the human telencephalon showing alzheimer disease (ad)-specific neuropathological changes. |
2017-09-07 |
2023-08-13 |
human |
| Rosaliana Libro, Placido Bramanti, Emanuela Mazzo. Endogenous glucocorticoids: role in the etiopathogenesis of Alzheimer's disease. Neuro endocrinology letters. vol 38. issue 1. 2017-08-29. PMID:28456142. |
however, enhanced basal egcs levels have been observed in patients affected by alzheimer's disease (ad) and they have been correlated with dysregulation of the hypothalamic-pituitary-adrenocortical axis, hippocampal degeneration and reduced cognitive/memory performance. |
2017-08-29 |
2023-08-13 |
Not clear |
| Alice D Lam, Gina Deck, Alica Goldman, Emad N Eskandar, Jeffrey Noebels, Andrew J Col. Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease. Nature medicine. vol 23. issue 6. 2017-08-29. PMID:28459436. |
silent hippocampal seizures and spikes identified by foramen ovale electrodes in alzheimer's disease. |
2017-08-29 |
2023-08-13 |
Not clear |
| Emrin Horgusluoglu, Kelly Nudelman, Kwangsik Nho, Andrew J Sayki. Adult neurogenesis and neurodegenerative diseases: A systems biology perspective. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 174. issue 1. 2017-08-21. PMID:26879907. |
new neurons are generated throughout adulthood in two regions of the brain, the olfactory bulb and dentate gyrus of the hippocampus, and are incorporated into the hippocampal network circuitry; disruption of this process has been postulated to contribute to neurodegenerative diseases including alzheimer's disease and parkinson's disease. |
2017-08-21 |
2023-08-13 |
Not clear |
| Jeong-Yub Kim, Hee-Jin Kim, Nam Kim, Jong Hwa Kwon, Myung-Jin Par. Effects of radiofrequency field exposure on glutamate-induced oxidative stress in mouse hippocampal HT22 cells. International journal of radiation biology. vol 93. issue 2. 2017-08-17. PMID:27648632. |
to define the impact of radiofrequency (rf) under in vitro experimental alzheimer's disease conditions, we investigated the effect of rf radiation on glutamate-induced oxidative stress in mouse hippocampal neuronal ht22 cells. |
2017-08-17 |
2023-08-13 |
mouse |
| Jose L Cantero, Juan E Iglesias, Koen Van Leemput, Mercedes Atienz. Regional Hippocampal Atrophy and Higher Levels of Plasma Amyloid-Beta Are Associated With Subjective Memory Complaints in Nondemented Elderly Subjects. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 71. issue 9. 2017-08-16. PMID:26946100. |
evidence suggests a link between the presence of subjective memory complaints (smc) and lower volume of the hippocampus, one of the first regions to show neuropathological lesions in alzheimer's disease. |
2017-08-16 |
2023-08-13 |
human |
| Haoran Jing, Shaoxia Wang, Min Wang, Wenliang Fu, Chao Zhang, Donggang X. Isobavachalcone Attenuates MPTP-Induced Parkinson's Disease in Mice by Inhibition of Microglial Activation through NF-κB Pathway. PloS one. vol 12. issue 1. 2017-08-15. PMID:28060896. |
isobavachalcone is a main component of chinese herb medicine psoralea corylifolia, which function includes immunoregulation, anti-oxidation and the regulation of β-amyloid (aβ42) deposited in hippocampus in alzheimer's patients. |
2017-08-15 |
2023-08-13 |
mouse |
| Tiffany J Mellott, Olivia M Huleatt, Bethany N Shade, Sarah M Pender, Yi B Liu, Barbara E Slack, Jan K Blusztaj. Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. PloS one. vol 12. issue 1. 2017-08-14. PMID:28103298. |
perinatal choline supplementation reduces amyloidosis and increases choline acetyltransferase expression in the hippocampus of the appsweps1de9 alzheimer's disease model mice. |
2017-08-14 |
2023-08-13 |
mouse |
| Kevin N Hascup, Mary K Lynn, Patrick J Fitzgerald, Shari Randall, John J Kopchick, Heather A Boger, Andrzej Bartke, Erin R Hascu. Enhanced Cognition and Hypoglutamatergic Signaling in a Growth Hormone Receptor Knockout Mouse Model of Successful Aging. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 72. issue 3. 2017-08-10. PMID:27208894. |
glutamate plays a critical role in hippocampal learning and memory and is implicated in several neurodegenerative disorders, including alzheimer's disease. |
2017-08-10 |
2023-08-13 |
mouse |
| Xiaoying Tang, Yuanyuan Qin, Jiong Wu, Min Zhang, Wenzhen Zhu, Michael I Mille. Shape and diffusion tensor imaging based integrative analysis of the hippocampus and the amygdala in Alzheimer's disease. Magnetic resonance imaging. vol 34. issue 8. 2017-08-09. PMID:27211255. |
shape and diffusion tensor imaging based integrative analysis of the hippocampus and the amygdala in alzheimer's disease. |
2017-08-09 |
2023-08-13 |
Not clear |
| Lei Li, Li Qin, Hai-Long Lu, Ping-Jing Li, Yuan-Jian Song, Rong-Li Yan. Methylene blue improves streptozotocin-induced memory deficit by restoring mitochondrial function in rats. Brain research. vol 1657. 2017-08-07. PMID:28034723. |
the pathogenesis of alzheimer's disease (ad) is well documented to involve mitochondrial dysfunction which causes subsequent oxidative stress and energy metabolic failure in hippocampus. |
2017-08-07 |
2023-08-13 |
rat |
| Dennis Chan, Laura Marie Gallaher, Kuven Moodley, Ludovico Minati, Neil Burgess, Tom Hartle. The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease. Journal of visualized experiments : JoVE. issue 116. 2017-08-03. PMID:27768046. |
allocentric spatial memory is a key function of the hippocampus, one of the earliest brain regions to be affected in alzheimer's disease (ad) and impairment of hippocampal function predates the onset of dementia. |
2017-08-03 |
2023-08-13 |
Not clear |
| Koji Fujihara, Shin Koike, Yuki Ogasawara, Kunio Takahashi, Kiyotaka Koyama, Kaoru Kinoshit. Inhibition of amyloid β aggregation and protective effect on SH-SY5Y cells by triterpenoid saponins from the cactus Polaskia chichipe. Bioorganic & medicinal chemistry. vol 25. issue 13. 2017-08-03. PMID:28478866. |
alzheimer's disease (ad) destroys brain function, especially in the hippocampus, and is a social problem worldwide. |
2017-08-03 |
2023-08-13 |
Not clear |