| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masoud Tahmasian, Lorenzo Pasquini, Martin Scherr, Chun Meng, Stefan Förster, Satja Mulej Bratec, Kuangyu Shi, Igor Yakushev, Markus Schwaiger, Timo Grimmer, Janine Diehl-Schmid, Valentin Riedl, Christian Sorg, Alexander Drzezg. The lower hippocampus global connectivity, the higher its local metabolism in Alzheimer disease. Neurology. vol 84. issue 19. 2015-07-23. PMID:25878180. |
the lower hippocampus global connectivity, the higher its local metabolism in alzheimer disease. |
2015-07-23 |
2023-08-13 |
Not clear |
| Masoud Tahmasian, Lorenzo Pasquini, Martin Scherr, Chun Meng, Stefan Förster, Satja Mulej Bratec, Kuangyu Shi, Igor Yakushev, Markus Schwaiger, Timo Grimmer, Janine Diehl-Schmid, Valentin Riedl, Christian Sorg, Alexander Drzezg. The lower hippocampus global connectivity, the higher its local metabolism in Alzheimer disease. Neurology. vol 84. issue 19. 2015-07-23. PMID:25878180. |
based on the hippocampus disconnection hypothesis in alzheimer disease (ad), which postulates that uncoupling from cortical inputs contributes to disinhibition-like changes in hippocampus activity, we suggested that in patients with ad, the more the intrinsic functional connectivity between hippocampus and precuneus is decreased, the higher hippocampal glucose metabolism will be. |
2015-07-23 |
2023-08-13 |
Not clear |
| Melissa J Alldred, Sang Han Lee, Eva Petkova, Stephen D Ginsber. Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice. The Journal of comparative neurology. vol 523. issue 1. 2015-07-21. PMID:25131634. |
individuals with ds show a variety of cognitive deficits, most notably in hippocampal learning and memory, and display pathological hallmarks of alzheimer's disease (ad), with neurodegeneration of cholinergic basal forebrain (cbf) neurons. |
2015-07-21 |
2023-08-13 |
mouse |
| Li Tian, Ke Zhang, Zhi-Ying Tian, Tao Wang, De-Shu Shang, Bo Li, Dong-Xin Liu, Wen-Gang Fang, Zhan-You Wang, Yu-Hua Che. Decreased expression of cathepsin D in monocytes is related to the defective degradation of amyloid-β in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 42. issue 2. 2015-07-20. PMID:24898658. |
alzheimer's disease (ad) is a progressive neurodegenerative dementia characterized by pathological senile plaques composed of amyloid-β (aβ) in the cerebral cortex and hippocampus. |
2015-07-20 |
2023-08-13 |
mouse |
| Julia Elisa Sepulveda-Diaz, Seyedeh Maryam Alavi Naini, Minh Bao Huynh, Mohand Ouidir Ouidja, Constantin Yanicostas, Sandrine Chantepie, Joao Villares, Foudil Lamari, Estelle Jospin, Toin H van Kuppevelt, Ayikoe Guy Mensah-Nyagan, Rita Raisman-Vozari, Nadia Soussi-Yanicostas, Dulce Papy-Garci. HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology. Brain : a journal of neurology. vol 138. issue Pt 5. 2015-07-17. PMID:25842390. |
here, we first measured the transcript levels of all human heparan sulphate sulphotransferases in hippocampus of alzheimer's disease (n = 8; 76.8 ± 3.5 years old) and found increased expression of hs3st2 (p < 0.001) compared with control brain (n = 8; 67.8 ± 2.9 years old). |
2015-07-17 |
2023-08-13 |
human |
| Andrea D Thompson, K Matthew Scaglione, John Prensner, Anne T Gillies, Arul Chinnaiyan, Henry L Paulson, Umesh K Jinwal, Chad A Dickey, Jason E Gestwick. Analysis of the tau-associated proteome reveals that exchange of Hsp70 for Hsp90 is involved in tau degradation. ACS chemical biology. vol 7. issue 10. 2015-07-15. PMID:22769591. |
consistent with this model, analysis of reported microarray expression data from alzheimer's disease patients and age-matched controls showed that the levels of hsp90 are reduced in the diseased hippocampus. |
2015-07-15 |
2023-08-12 |
Not clear |
| Fehmida Bibi, Muhammad Yasir, Sayed S Sohrab, Esam I Azhar, Mohammed H Al-Qahtani, Adel M Abuzenadah, Mohammad A Kamal, Muhammad I Nasee. Link between chronic bacterial inflammation and Alzheimer disease. CNS & neurological disorders drug targets. vol 13. issue 7. 2015-07-13. PMID:25230225. |
alzheimer's disease (ad) is a degenerative disease of brain that is associated with dementia, brain atrophy, accumulation of hyperphosphorylated tau protein and amyloid-beta peptide in hippocampus and cortex region of the brain. |
2015-07-13 |
2023-08-13 |
Not clear |
| Fang Yu, Ulf G Bronas, Suma Konety, Nathaniel W Nelson, Maurice Dysken, Clifford Jack, Jean F Wyman, David Vock, Glenn Smit. Effects of aerobic exercise on cognition and hippocampal volume in Alzheimer's disease: study protocol of a randomized controlled trial (The FIT-AD trial). Trials. vol 15. 2015-07-09. PMID:25304364. |
effects of aerobic exercise on cognition and hippocampal volume in alzheimer's disease: study protocol of a randomized controlled trial (the fit-ad trial). |
2015-07-09 |
2023-08-13 |
Not clear |
| X Chen, J Hu, L Jiang, S Xu, B Zheng, C Wang, J Zhang, X Wei, L Chang, Q Wan. Brilliant Blue G improves cognition in an animal model of Alzheimer's disease and inhibits amyloid-β-induced loss of filopodia and dendrite spines in hippocampal neurons. Neuroscience. vol 279. 2015-07-08. PMID:25193238. |
brilliant blue g improves cognition in an animal model of alzheimer's disease and inhibits amyloid-β-induced loss of filopodia and dendrite spines in hippocampal neurons. |
2015-07-08 |
2023-08-13 |
mouse |
| Amina Chaalal, Roseline Poirier, David Blum, Brigitte Gillet, Pascale Le Blanc, Marie Basquin, Luc Buée, Serge Laroche, Valérie Enderli. PTU-induced hypothyroidism in rats leads to several early neuropathological signs of Alzheimer's disease in the hippocampus and spatial memory impairments. Hippocampus. vol 24. issue 11. 2015-07-07. PMID:24978200. |
ptu-induced hypothyroidism in rats leads to several early neuropathological signs of alzheimer's disease in the hippocampus and spatial memory impairments. |
2015-07-07 |
2023-08-13 |
rat |
| Guangyu Chen, B Douglas Ward, Gang Chen, Shi-Jiang L. Decreased effective connectivity from cortices to the right parahippocampal gyrus in Alzheimer's disease subjects. Brain connectivity. vol 4. issue 9. 2015-07-06. PMID:25132215. |
the purpose of this study was to detect effective connectivity (ec) changes in the default mode network and hippocampus network in 20 patients with alzheimer's disease (ad) and 20 cognitively normal (cn) subjects, using multivariate granger causality. |
2015-07-06 |
2023-08-13 |
human |
| Shunjiang Xu, Rui Zhang, Jingya Niu, Dongsheng Cui, Bing Xie, Binggui Zhang, Kang Lu, Wenjun Yu, Xueyi Wang, Qingfu Zhan. Oxidative stress mediated-alterations of the microRNA expression profile in mouse hippocampal neurons. International journal of molecular sciences. vol 13. issue 12. 2015-07-03. PMID:23443129. |
these results demonstrated that oxidative stress alters the mirna expression profile of hippocampal neurons, and the deregulated mirnas might play a potential role in the pathogenesis of neurodegenerative diseases, such as alzheimer's disease (ad). |
2015-07-03 |
2023-08-12 |
mouse |
| K An, J H Jung, A Y Jeong, H G Kim, S Y Jung, K Lee, H J Kim, S-J Kim, T-Y Jeong, Y Son, H-S Kim, J-H Ki. Neuritin can normalize neural deficits of Alzheimer's disease. Cell death & disease. vol 5. 2015-07-02. PMID:25393479. |
reductions in hippocampal neurite complexity and synaptic plasticity are believed to contribute to the progressive impairment in episodic memory and the mild cognitive decline that occur particularly in the early stages of alzheimer's disease (ad). |
2015-07-02 |
2023-08-13 |
mouse |
| Mina Eftekharzadeh, Maliheh Nobakht, Akram Alizadeh, Mansooreh Soleimani, Mahmood Hajghasem, Bahareh Kordestani Shargh, Nushin Karkuki Osguei, Babak Behnam, Ali Samadikuchaksarae. The effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of Alzheimer's disease. Iranian journal of basic medical sciences. vol 18. issue 5. 2015-06-30. PMID:26124940. |
the effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of alzheimer's disease. |
2015-06-30 |
2023-08-13 |
rat |
| Martin Vyhnalek, Tomas Nikolai, Ross Andel, Zuzana Nedelska, Eva Rubínová, Hana Marková, Jan Laczó, Ondrej Bezdicek, Katerina Sheardova, Jakub Hor. Neuropsychological correlates of hippocampal atrophy in memory testing in nondemented older adults. Journal of Alzheimer's disease : JAD. vol 42 Suppl 3. 2015-06-29. PMID:24670399. |
cognitive deficits in older adults attributable to alzheimer's disease (ad) pathology are featured early on by hippocampal impairment. |
2015-06-29 |
2023-08-12 |
Not clear |
| Costas A Anastasiou, Mary Yannakoulia, Nikolaos Scarmea. Vitamin D and cognition: an update of the current evidence. Journal of Alzheimer's disease : JAD. vol 42 Suppl 3. 2015-06-29. PMID:24820017. |
on the other hand, vitamin d has been found to be protective against biological processes associated with alzheimer's disease and cognition, including amyloid-β deposition, inflammation, calcium homeostasis, and corticosteroid-induced perturbations in cortical areas and the hippocampus. |
2015-06-29 |
2023-08-13 |
human |
| Ze Wan. Characterizing early Alzheimer's disease and disease progression using hippocampal volume and arterial spin labeling perfusion MRI. Journal of Alzheimer's disease : JAD. vol 42 Suppl 4. 2015-06-29. PMID:25182742. |
characterizing early alzheimer's disease and disease progression using hippocampal volume and arterial spin labeling perfusion mri. |
2015-06-29 |
2023-08-13 |
Not clear |
| Ya-Ting Chang, Chi-Wei Huang, Yen-Hsiang Chang, Nai-Ching Chen, Kun-Ju Lin, Tzu-Chen Yan, Wen-Neng Chang, Sz-Fan Chen, Chun-Chung Lui, Pin-Hsuan Lin, Chiung-Chih Chan. Amyloid burden in the hippocampus and default mode network: relationships with gray matter volume and cognitive performance in mild stage Alzheimer disease. Medicine. vol 94. issue 16. 2015-06-26. PMID:25906109. |
amyloid burden in the hippocampus and default mode network: relationships with gray matter volume and cognitive performance in mild stage alzheimer disease. |
2015-06-26 |
2023-08-13 |
Not clear |
| Maria Pascual-Lucas, Silvia Viana da Silva, Marianna Di Scala, Carolina Garcia-Barroso, Gloria González-Aseguinolaza, Christophe Mulle, Cristina M Alberini, Mar Cuadrado-Tejedor, Ana Garcia-Ost. Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice. EMBO molecular medicine. vol 6. issue 10. 2015-06-22. PMID:25100745. |
furthermore, we report that igf2 expression decreases in the hippocampus of patients with alzheimer's disease, and this leads us to hypothesize that increased igf2 levels may be beneficial for treating the disease. |
2015-06-22 |
2023-08-13 |
mouse |
| Julie Davies, Elena Zachariades, Karly-Rai Rogers-Broadway, Emmanouil Karteri. Elucidating the role of DEPTOR in Alzheimer's disease. International journal of molecular medicine. vol 34. issue 5. 2015-06-17. PMID:25119265. |
it has also been implicated in alzheimer's disease (ad) with neuronal cells and hippocampal slices of ad transgenic mice experiencing dysregulated mtor and synaptic plasticity in response to treatment with the toxic amyloid β (aβ(1-42)) peptide, which has been implicated in ad. |
2015-06-17 |
2023-08-13 |
mouse |