| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mark L Cohen, Chae Kim, Tracy Haldiman, Mohamed ElHag, Prachi Mehndiratta, Termsarasab Pichet, Frances Lissemore, Michelle Shea, Yvonne Cohen, Wei Chen, Janis Blevins, Brian S Appleby, Krystyna Surewicz, Witold K Surewicz, Martha Sajatovic, Curtis Tatsuoka, Shulin Zhang, Ping Mayo, Mariusz Butkiewicz, Jonathan L Haines, Alan J Lerner, Jiri G Safa. Rapidly progressive Alzheimer's disease features distinct structures of amyloid-β. Brain : a journal of neurology. vol 138. issue Pt 4. 2015-06-16. PMID:25688081. |
using novel biophysical methods, we analysed levels, particle size, and conformational characteristics of amyloid-β in the posterior cingulate cortex, hippocampus and cerebellum of 48 cases of alzheimer's disease with distinctly different disease durations, and correlated the data with apoe gene polymorphism. |
2015-06-16 |
2023-08-13 |
Not clear |
| Motoyasu Honma, Takeshi Kuroda, Akinori Futamura, Azusa Sugimoto, Mitsuru Kawamur. [Mental time dysfunction in Parkinson's and Alzheimer's diseases]. Brain and nerve = Shinkei kenkyu no shinpo. vol 67. issue 3. 2015-06-16. PMID:25846444. |
it is possible that the dysfunction of mental time in parkinson's disease is caused by the abnormal striatum acting as a pacemaker, while that in alzheimer's disease is caused by abnormal hippocampal memory. |
2015-06-16 |
2023-08-13 |
Not clear |
| Sylvia E Perez, Bin He, Muhammad Nadeem, Joanne Wuu, Stephen D Ginsberg, Milos D Ikonomovic, Elliott J Mufso. Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathology. Journal of neuropathology and experimental neurology. vol 74. issue 4. 2015-06-15. PMID:25756588. |
endosomal-lysosomal and autophagic dysregulation occurs in the hippocampus in prodromal alzheimer disease (ad), but its relationship with β-amyloid (aβ) and tau pathology remains unclear. |
2015-06-15 |
2023-08-13 |
Not clear |
| K Kinugawa, V H Nguyen-Michel, J Marian. [Obstructive sleep apnea syndrome: a cause of cognitive disorders in the elderly?]. La Revue de medecine interne. vol 35. issue 10. 2015-06-08. PMID:24630586. |
the obstructive sleep apnea syndrome with cognitive impairment shares some features with alzheimer's disease, involving genetic predisposition apoe4, hippocampus and synaptic plasticity abnormalities. |
2015-06-08 |
2023-08-12 |
human |
| Melissa E Murray, Ashley Cannon, Neill R Graff-Radford, Amanda M Liesinger, Nicola J Rutherford, Owen A Ross, Ranjan Duara, Minerva M Carrasquillo, Rosa Rademakers, Dennis W Dickso. Differential clinicopathologic and genetic features of late-onset amnestic dementias. Acta neuropathologica. vol 128. issue 3. 2015-06-08. PMID:24899141. |
hippocampal sclerosis of the elderly (hpscl) and alzheimer's disease (ad), especially the limbic-predominant subtype (lp-ad), are amnestic syndromes that can be difficult to distinguish. |
2015-06-08 |
2023-08-13 |
Not clear |
| Wenjun Li, Piero G Antuono, Chunming Xie, Gang Chen, Jennifer L Jones, B Douglas Ward, Suraj P Singh, Malgorzata B Franczak, Joseph S Goveas, Shi-Jiang L. Aberrant functional connectivity in Papez circuit correlates with memory performance in cognitively intact middle-aged APOE4 carriers. Cortex; a journal devoted to the study of the nervous system and behavior. vol 57. 2015-06-04. PMID:24905971. |
the main objective of this study is to detect the early changes in resting-state papez circuit functional connectivity using the hippocampus as the seed, and to determine the associations between altered functional connectivity (fc) and the episodic memory performance in cognitively intact middle-aged apolipoprotein e4 (apoe4) carriers who are at risk of alzheimer's disease (ad). |
2015-06-04 |
2023-08-13 |
human |
| Guillaume Becker, Nathalie Streichenberger, Thierry Billard, Adrian Newman-Tancredi, Luc Zimme. A postmortem study to compare agonist and antagonist 5-HT1A receptor-binding sites in Alzheimer's disease. CNS neuroscience & therapeutics. vol 20. issue 10. 2015-06-02. PMID:25041947. |
positron emission tomography (pet) imaging using 5-ht1a receptor radioligands shows a decreased expression of this serotonin receptor in the hippocampus of patients with alzheimer's disease (ad) at advanced stages. |
2015-06-02 |
2023-08-13 |
human |
| Ryoko Ogino, Norihito Murayama, Takafumi Noshita, Naohiro Takemoto, Tetsuya Toba, Tetsushi Oka, Nobuhiro Narii, Sayaka Yoshida, Nobuhiro Ueno, Teruyoshi Inou. SUN11602 has basic fibroblast growth factor-like activity and attenuates neuronal damage and cognitive deficits in a rat model of Alzheimer's disease induced by amyloid β and excitatory amino acids. Brain research. vol 1585. 2015-06-02. PMID:25130662. |
for the in vivo study, an alzheimer's disease (ad) model with severe damage to the hippocampal tissue was constructed by injecting the hippocampi of rats with aggregated aβ1-40, followed 48 h later by an injection of ibotenate [an agonist for n-methyl-d-aspartate (nmda) receptor]. |
2015-06-02 |
2023-08-13 |
rat |
| Katherine E Davis, Sarah Fox, John Gig. Increased hippocampal excitability in the 3xTgAD mouse model for Alzheimer's disease in vivo. PloS one. vol 9. issue 3. 2015-05-29. PMID:24621690. |
increased hippocampal excitability in the 3xtgad mouse model for alzheimer's disease in vivo. |
2015-05-29 |
2023-08-12 |
mouse |
| Marlene J Végh, Céline M Heldring, Willem Kamphuis, Sara Hijazi, Arie J Timmerman, Ka Wan Li, Pim van Nierop, Huibert D Mansvelder, Elly M Hol, August B Smit, Ronald E van Kestere. Reducing hippocampal extracellular matrix reverses early memory deficits in a mouse model of Alzheimer's disease. Acta neuropathologica communications. vol 2. 2015-05-29. PMID:24974208. |
reducing hippocampal extracellular matrix reverses early memory deficits in a mouse model of alzheimer's disease. |
2015-05-29 |
2023-08-13 |
mouse |
| Andrea Fn Rosenberger, Annemieke Jm Rozemuller, Wiesje M van der Flier, Philip Scheltens, Saskia M van der Vies, Jeroen Jm Hoozeman. Altered distribution of the EphA4 kinase in hippocampal brain tissue of patients with Alzheimer's disease correlates with pathology. Acta neuropathologica communications. vol 2. 2015-05-29. PMID:25027113. |
altered distribution of the epha4 kinase in hippocampal brain tissue of patients with alzheimer's disease correlates with pathology. |
2015-05-29 |
2023-08-13 |
mouse |
| Chen Bian, Haitao Zhu, Yangang Zhao, Wenqin Cai, Jiqiang Zhan. Intriguing roles of hippocampus-synthesized 17β-estradiol in the modulation of hippocampal synaptic plasticity. Journal of molecular neuroscience : MN. vol 54. issue 2. 2015-05-28. PMID:24729128. |
the influences of gonadal and hippocampal e2 on synaptic plasticity may exist some differences, since some reports showed that gonadal (or circulating) estrogens have no obvious effects in the modulation of hippocampal synaptic proteins as evidenced in some ovariectomized animals and postmenopausal women who suffered from alzheimer's disease (ad). |
2015-05-28 |
2023-08-13 |
Not clear |
| Chen Bian, Haitao Zhu, Yangang Zhao, Wenqin Cai, Jiqiang Zhan. Intriguing roles of hippocampus-synthesized 17β-estradiol in the modulation of hippocampal synaptic plasticity. Journal of molecular neuroscience : MN. vol 54. issue 2. 2015-05-28. PMID:24729128. |
further studies about the exact roles of hippocampus-synthesized e2 and therefore src-1 are urgently needed in order to facilitate our understanding of hippocampal e2, which will be very important to the development of novel strategies of estrogen replacement therapy against neurodegenerative deficits such as alzheimer's disease (ad). |
2015-05-28 |
2023-08-13 |
Not clear |
| Taewook Kang, Jae Ho Kim, Ingie Hong, Nam Hyun Park, Nanhyun Park, Helmut Heinsen, Joo-Yong Lee, Rivka Ravid, Isidro Ferrer, Jong Shin Yoo, Kyung-Hoon Kwon, Young Mok Par. Large-scale analysis of posttranslational modifications in the hippocampus of patients with Alzheimer's disease using pI shift and label-free quantification without enrichment. Analytical and bioanalytical chemistry. vol 406. issue 22. 2015-05-26. PMID:25120180. |
large-scale analysis of posttranslational modifications in the hippocampus of patients with alzheimer's disease using pi shift and label-free quantification without enrichment. |
2015-05-26 |
2023-08-13 |
Not clear |
| Howard J Aizenstein, William E Klun. Where is hippocampal activity in the cascade of Alzheimer's disease biomarkers? Brain : a journal of neurology. vol 138. issue Pt 4. 2015-05-22. PMID:25802317. |
where is hippocampal activity in the cascade of alzheimer's disease biomarkers? |
2015-05-22 |
2023-08-13 |
Not clear |
| Xing-Hua Yue, Xiao-Jie Liu, Mei-Na Wu, Jin-Yuan Chen, Jin-Shun Q. [Amyloid β protein suppresses hippocampal theta rhythm and induces behavioral disinhibition and spatial memory deficit in rats]. Sheng li xue bao : [Acta physiologica Sinica]. vol 66. issue 2. 2015-05-16. PMID:24777399. |
the cognitive decline and behavioral disinhibition in the patients with alzheimer's disease (ad) may be relevant to amyloid β protein (aβ)-induced impairment in hippocampal neuronal cooperative activity. |
2015-05-16 |
2023-08-13 |
rat |
| Adriana Ferreir. Calpain dysregulation in Alzheimer's disease. ISRN biochemistry. vol 2012. 2015-05-13. PMID:25969760. |
alzheimer's disease (ad) is characterized by the presence of senile plaques and neurofibrillary tangles in the neocortex and hippocampus of ad patients. |
2015-05-13 |
2023-08-13 |
Not clear |
| Donald G McLaren, Reisa A Sperling, Alireza Atr. Flexible modulation of network connectivity related to cognition in Alzheimer's disease. NeuroImage. vol 100. 2015-05-12. PMID:24852459. |
to investigate the promise of characterizing context-dependent connectivity-behavior relationships, this study applies the method of generalized psychophysiological interactions (gppi) to assess the patterns of associative-memory-related fmri hippocampal functional connectivity in alzheimer's disease (ad) associated with performance on memory and other cognitively demanding neuropsychological tests and clinical measures. |
2015-05-12 |
2023-08-13 |
human |
| Kevin T Ong, Victor L Villemagne, Alex Bahar-Fuchs, Fiona Lamb, Narelle Langdon, Ana M Catafau, Andrew W Stephens, John Seibyl, Ludger M Dinkelborg, Cornelia B Reininger, Barbara Putz, Beate Rohde, Colin L Masters, Christopher C Row. Aβ imaging with 18F-florbetaben in prodromal Alzheimer's disease: a prospective outcome study. Journal of neurology, neurosurgery, and psychiatry. vol 86. issue 4. 2015-05-12. PMID:24970906. |
we assessed the clinical utility of β-amyloid (aβ) imaging with (18)f-florbetaben (fbb) in mild cognitive impairment (mci) by evaluating its prognostic accuracy for progression to alzheimer's disease (ad), comparing semiquantitative with visual scan assessment, and exploring the relationships among aβ, hippocampal volume (hv) and memory over time. |
2015-05-12 |
2023-08-13 |
Not clear |
| Edgar Dawkins, Robert Gasperini, Yanling Hu, Hao Cui, Adele J Vincent, Marta Bolós, Kaylene M Young, Lisa Foa, David H Smal. The N-terminal fragment of the β-amyloid precursor protein of Alzheimer's disease (N-APP) binds to phosphoinositide-rich domains on the surface of hippocampal neurons. Journal of neuroscience research. vol 92. issue 11. 2015-05-11. PMID:24916405. |
the n-terminal fragment of the β-amyloid precursor protein of alzheimer's disease (n-app) binds to phosphoinositide-rich domains on the surface of hippocampal neurons. |
2015-05-11 |
2023-08-13 |
Not clear |