| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarah K Fritschi, Franziska Langer, Stephan A Kaeser, Luis F Maia, Erik Portelius, Dorothea Pinotsi, Clemens F Kaminski, David T Winkler, Walter Maetzler, Kathy Keyvani, Philipp Spitzer, Jens Wiltfang, Gabriele S Kaminski Schierle, Henrik Zetterberg, Matthias Staufenbiel, Mathias Jucke. Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid. Brain : a journal of neurology. vol 137. issue Pt 11. 2015-02-09. PMID:25212850. |
soluble alzheimer's disease brain extracts were serially diluted and then injected into the hippocampus of young, app transgenic mice. |
2015-02-09 |
2023-08-13 |
mouse |
| Xianhong Zheng, Weiwei Wang, Ruizhi Liu, Honglan Huang, Rihui Zhang, Liankun Su. Effect of p62 on tau hyperphosphorylation in a rat model of Alzheimer's disease. Neural regeneration research. vol 7. issue 17. 2015-02-06. PMID:25657660. |
in this study, we produced an alzheimer's disease rat model by injecting β-amyloid protein into the hippocampus and β-galactose intraperitoneally. |
2015-02-06 |
2023-08-13 |
rat |
| Alison Burgess, Sonam Dubey, Sharon Yeung, Olivia Hough, Naomi Eterman, Isabelle Aubert, Kullervo Hynyne. Alzheimer disease in a mouse model: MR imaging-guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and behavior. Radiology. vol 273. issue 3. 2015-01-28. PMID:25222068. |
alzheimer disease in a mouse model: mr imaging-guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and behavior. |
2015-01-28 |
2023-08-13 |
mouse |
| Alison Burgess, Sonam Dubey, Sharon Yeung, Olivia Hough, Naomi Eterman, Isabelle Aubert, Kullervo Hynyne. Alzheimer disease in a mouse model: MR imaging-guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and behavior. Radiology. vol 273. issue 3. 2015-01-28. PMID:25222068. |
to validate whether repeated magnetic resonance (mr) imaging-guided focused ultrasound treatments targeted to the hippocampus, a brain structure relevant for alzheimer disease ( ad alzheimer disease ), could modulate pathologic abnormalities, plasticity, and behavior in a mouse model. |
2015-01-28 |
2023-08-13 |
mouse |
| E Orta-Salazar, A Aguilar-Vázquez, H Martínez-Coria, S Luquín-De Anda, M Rivera-Cervantes, C Beas-Zarate, A Feria-Velasco, S Díaz-Cintr. REST/NRSF-induced changes of ChAT protein expression in the neocortex and hippocampus of the 3xTg-AD mouse model for Alzheimer's disease. Life sciences. vol 116. issue 2. 2015-01-28. PMID:25261598. |
rest/nrsf-induced changes of chat protein expression in the neocortex and hippocampus of the 3xtg-ad mouse model for alzheimer's disease. |
2015-01-28 |
2023-08-13 |
mouse |
| Hideomi Hamasaki, Hiroyuki Honda, Satoshi O Suzuki, Masaaki Hokama, Yutaka Kiyohara, Yusaku Nakabeppu, Toru Iwak. Down-regulation of MET in hippocampal neurons of Alzheimer's disease brains. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 34. issue 3. 2015-01-26. PMID:24444253. |
down-regulation of met in hippocampal neurons of alzheimer's disease brains. |
2015-01-26 |
2023-08-12 |
Not clear |
| Hideomi Hamasaki, Hiroyuki Honda, Satoshi O Suzuki, Masaaki Hokama, Yutaka Kiyohara, Yusaku Nakabeppu, Toru Iwak. Down-regulation of MET in hippocampal neurons of Alzheimer's disease brains. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 34. issue 3. 2015-01-26. PMID:24444253. |
we found that mrna of met, the receptor of hepatocyte growth factor (hgf), is significantly decreased in the hippocampus of alzheimer's disease (ad) patients. |
2015-01-26 |
2023-08-12 |
Not clear |
| Mohsen Taghizadeh, Sayyed Alireza Talaei, Abolghasem Djazayeri, Mahmoud Salam. Vitamin D supplementation restores suppressed synaptic plasticity in Alzheimer's disease. Nutritional neuroscience. vol 17. issue 4. 2015-01-22. PMID:23883541. |
hippocampus, an appropriate area of brain for assessment of long-term potentiation (ltp), has been found to be susceptible to neural damages caused by alzheimer's disease. |
2015-01-22 |
2023-08-12 |
Not clear |
| Craig Howard Kinsley, R Adam Franssen, Elizabeth Amory Meye. Reproductive experience may positively adjust the trajectory of senescence. Current topics in behavioral neurosciences. vol 10. 2015-01-20. PMID:21611905. |
mimicking the effects of an enriched environment, reproductive experience has been shown to: enhance/protect cognition and decrease anxiety well out to two-plus years; result in fewer hippocampal deposits of the alzheimer's disease herald, amyloid precursor protein (app); and, in general, lead to a healthier biology. |
2015-01-20 |
2023-08-12 |
rat |
| Tiffany J Mellott, Sarah M Pender, Rebecca M Burke, Erika A Langley, Jan Krzysztof Blusztaj. IGF2 ameliorates amyloidosis, increases cholinergic marker expression and raises BMP9 and neurotrophin levels in the hippocampus of the APPswePS1dE9 Alzheimer's disease model mice. PloS one. vol 9. issue 4. 2015-01-15. PMID:24732467. |
igf2 ameliorates amyloidosis, increases cholinergic marker expression and raises bmp9 and neurotrophin levels in the hippocampus of the appsweps1de9 alzheimer's disease model mice. |
2015-01-15 |
2023-08-13 |
mouse |
| Emily N Manning, Josephine Barnes, David M Cash, Jonathan W Bartlett, Kelvin K Leung, Sebastien Ourselin, Nick C Fo. APOE ε4 is associated with disproportionate progressive hippocampal atrophy in AD. PloS one. vol 9. issue 5. 2015-01-15. PMID:24878738. |
to investigate whether apoe ε4 carriers have higher hippocampal atrophy rates than non-carriers in alzheimer's disease (ad), mild cognitive impairment (mci) and controls, and if so, whether higher hippocampal atrophy rates are still observed after adjusting for concurrent whole-brain atrophy rates. |
2015-01-15 |
2023-08-13 |
Not clear |
| Mohammad Javad Fattahi, Abbas Mirshafie. Positive and negative effects of prostaglandins in Alzheimer's disease. Psychiatry and clinical neurosciences. vol 68. issue 1. 2015-01-09. PMID:23992456. |
alzheimer's disease is characterized by pathological hallmarks such as extracellular deposition of the amyloid β-peptide, the appearance of intracellular neurofibrillary tangles, extensive neuronal loss and synaptic changes in the cerebral cortex and hippocampus. |
2015-01-09 |
2023-08-12 |
Not clear |
| Yan Lin, Jianli Yao, Yaowen Chen, Li Pang, Haihong Li, Zhen Cao, Kezeng You, Haiyang Dai, Renhua W. Hippocampal neurochemical changes in senescent mice induced with chronic injection of D-galactose and NaNO₂: an in vitro high-resolution NMR spectroscopy study at 9.4T. PloS one. vol 9. issue 2. 2015-01-09. PMID:24533108. |
this d-galactose and nano₂ treated mouse model, characterized by an early-onset memory dysfunction, a robust neuronal loss, amyloid plaques and neurofibrillary tangles in hippocampal subdivision, well mimics a prodromal alzheimer's phenotype. |
2015-01-09 |
2023-08-12 |
mouse |
| Hany E S Marei, Amany Farag, Asma Althani, Nahla Afifi, Ahmed Abd-Elmaksoud, Samah Lashen, Shaymaa Rezk, Roberto Pallini, Patrizia Casalbore, Carlo Cenciarell. Human olfactory bulb neural stem cells expressing hNGF restore cognitive deficit in Alzheimer's disease rat model. Journal of cellular physiology. vol 230. issue 1. 2015-01-09. PMID:24911171. |
in this study, we aim to demonstrate the fate of allogenic adult human olfactory bulb neural stem/progenitor cells (obnsc/npcs) transplanted into the rat hippocampus treated with ibotenic acid (ibo), a neurotoxicant specific to hippocampal cholinergic neurons that are lost in alzheimer's disease. |
2015-01-09 |
2023-08-13 |
human |
| Iryna Lobanova, Adnan I Quresh. The association between cardiovascular risk factors and progressive hippocampus volume loss in persons with Alzheimer's disease. Journal of vascular and interventional neurology. vol 7. issue 5. 2015-01-08. PMID:25566342. |
the association between cardiovascular risk factors and progressive hippocampus volume loss in persons with alzheimer's disease. |
2015-01-08 |
2023-08-13 |
Not clear |
| Iryna Lobanova, Adnan I Quresh. The association between cardiovascular risk factors and progressive hippocampus volume loss in persons with Alzheimer's disease. Journal of vascular and interventional neurology. vol 7. issue 5. 2015-01-08. PMID:25566342. |
we performed the current study to test the hypothesis that the aggregation of cardiovascular risk factors in patients with alzheimer's disease (ad) was associated with a higher rate of volume loss in the hippocampus and progression of cognitive deficits. |
2015-01-08 |
2023-08-13 |
Not clear |
| Gjumrakch Aliev, Khan Shahida, Siew Hua Gan, Ck Firoz, Aziz Khan, Adel M Abuzenadah, Warda Kamal, Mohammad A Kamal, Yi Tan, Xianqin Qu, Marcella Real. Alzheimer disease and type 2 diabetes mellitus: the link to tyrosine hydroxylase and probable nutritional strategies. CNS & neurological disorders drug targets. vol 13. issue 3. 2015-01-07. PMID:24059309. |
the axons of the noradrenergic cells that project to the hippocampus appear to be affected by the β-amyloid protein, which subsequently contributes to th loss in alzheimer brain cells. |
2015-01-07 |
2023-08-12 |
Not clear |
| Sarra G Bahna, Arani Sathiyapalan, Jane A Foster, Lennard P Nile. Regional upregulation of hippocampal melatonin MT2 receptors by valproic acid: therapeutic implications for Alzheimer's disease. Neuroscience letters. vol 576. 2015-01-05. PMID:24909617. |
regional upregulation of hippocampal melatonin mt2 receptors by valproic acid: therapeutic implications for alzheimer's disease. |
2015-01-05 |
2023-08-13 |
rat |
| Sarra G Bahna, Arani Sathiyapalan, Jane A Foster, Lennard P Nile. Regional upregulation of hippocampal melatonin MT2 receptors by valproic acid: therapeutic implications for Alzheimer's disease. Neuroscience letters. vol 576. 2015-01-05. PMID:24909617. |
importantly, a significant decrease in mt2 expression has been observed in the hippocampus of alzheimer's patients. |
2015-01-05 |
2023-08-13 |
rat |
| Sarra G Bahna, Arani Sathiyapalan, Jane A Foster, Lennard P Nile. Regional upregulation of hippocampal melatonin MT2 receptors by valproic acid: therapeutic implications for Alzheimer's disease. Neuroscience letters. vol 576. 2015-01-05. PMID:24909617. |
the significant induction of melatonin mt2 receptor expression by vpa in hippocampal regions involved in learning, memory and/or neural stem cell proliferation, suggests that a combinatorial therapeutic strategy involving vpa together with melatonin or other mt2 agonists, would be beneficial in neurodegenerative disorders such as alzheimer's disease. |
2015-01-05 |
2023-08-13 |
rat |