| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carlos Cruchaga, Celeste M Karch, Sheng Chih Jin, Bruno A Benitez, Yefei Cai, Rita Guerreiro, Oscar Harari, Joanne Norton, John Budde, Sarah Bertelsen, Amanda T Jeng, Breanna Cooper, Tara Skorupa, David Carrell, Denise Levitch, Simon Hsu, Jiyoon Choi, Mina Ryten, Celeste Sassi, Jose Bras, Raphael J Gibbs, Dena G Hernandez, Michelle K Lupton, John Powell, Paola Forabosco, Perry G Ridge, Christopher D Corcoran, JoAnn T Tschanz, Maria C Norton, Ronald G Munger, Cameron Schmutz, Maegan Leary, F Yesim Demirci, Mikhil N Bamne, Xingbin Wang, Oscar L Lopez, Mary Ganguli, Christopher Medway, James Turton, Jenny Lord, Anne Braae, Imelda Barber, Kristelle Brown, Pau Pastor, Oswaldo Lorenzo-Betancor, Zoran Brkanac, Erick Scott, Eric Topol, Kevin Morgan, Ekaterina Rogaeva, Andy Singleton, John Hardy, M Ilyas Kamboh, Peter St George-Hyslop, Nigel Cairns, John C Morris, John S K Kauwe, Alison M Goat. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature. vol 505. issue 7484. 2014-02-04. PMID:24336208. |
pld3 is highly expressed in brain regions that are vulnerable to alzheimer's disease pathology, including hippocampus and cortex, and is expressed at significantly lower levels in neurons from alzheimer's disease brains compared to control brains. |
2014-02-04 |
2023-08-12 |
Not clear |
| Panagiota Mistridis, Kirsten I Taylor, Johanna M Kissler, Andreas U Monsch, Reto W Kressig, Sasa L Kivisaar. Distinct neural systems underlying reduced emotional enhancement for positive and negative stimuli in early Alzheimer's disease. Frontiers in human neuroscience. vol 7. 2014-01-30. PMID:24478669. |
we investigated these questions in a group of patients with alzheimer's disease (ad), which affects the amygdala, hippocampus and neocortical regions. |
2014-01-30 |
2023-08-12 |
Not clear |
| Heng Meng, Duo Zhang, Haishan Yan. Effects of amyloid precursor protein 17 peptide on the protection of diabetic encephalopathy and improvement of glycol metabolism in the diabetic rat. Journal of diabetes research. vol 2013. 2014-01-28. PMID:23844373. |
no amyloid plaques in the cortex and the hippocampus were detected in either group, indicating that the experimental animals in the current study were not suffering from alzheimer's disease. |
2014-01-28 |
2023-08-12 |
rat |
| Chelsea Cavanagh, Jessica Colby-Milley, David Bouvier, Mark Farso, Jean-Guy Chabot, Rémi Quirion, Slavica Kranti. βCTF-correlated burst of hippocampal TNFα occurs at a very early, pre-plaque stage in the TgCRND8 mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 36. issue 2. 2014-01-27. PMID:23579326. |
βctf-correlated burst of hippocampal tnfα occurs at a very early, pre-plaque stage in the tgcrnd8 mouse model of alzheimer's disease. |
2014-01-27 |
2023-08-12 |
mouse |
| Chelsea Cavanagh, Jessica Colby-Milley, David Bouvier, Mark Farso, Jean-Guy Chabot, Rémi Quirion, Slavica Kranti. βCTF-correlated burst of hippocampal TNFα occurs at a very early, pre-plaque stage in the TgCRND8 mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 36. issue 2. 2014-01-27. PMID:23579326. |
we investigated whether alterations in the level of tnfα occur at a time point that precedes the reported seizure-associated hyperexcitability of hippocampal networks in pre-plaque models of alzheimer's disease (ad). |
2014-01-27 |
2023-08-12 |
mouse |
| Ingie Hong, Taewook Kang, Yongcheol Yoo, Royun Park, Junuk Lee, Sukwon Lee, Jeongyeon Kim, Boemjong Song, Se-Young Kim, Minho Moon, Ki Na Yun, Jin Young Kim, Inhee Mook-Jung, Young Mok Park, Sukwoo Cho. Quantitative proteomic analysis of the hippocampus in the 5XFAD mouse model at early stages of Alzheimer's disease pathology. Journal of Alzheimer's disease : JAD. vol 36. issue 2. 2014-01-27. PMID:23603400. |
quantitative proteomic analysis of the hippocampus in the 5xfad mouse model at early stages of alzheimer's disease pathology. |
2014-01-27 |
2023-08-12 |
mouse |
| Rita Selvatici, Luca Marani, Silvia Marino, Anna Siniscalch. In vitro mitochondrial failure and oxidative stress mimic biochemical features of Alzheimer disease. Neurochemistry international. vol 63. issue 2. 2014-01-27. PMID:23722080. |
since it is well known that hippocampal cholinergic neurons are particularly affected in alzheimer disease, the effects of nan3 and h2o2 were also studied in electrically stimulated rat hippocampal slices, evaluating the (3)h-choline efflux, as an index of acetylcholine release. |
2014-01-27 |
2023-08-12 |
rat |
| Nadezhda A Kapay, Olga V Popova, Nikolay K Isaev, Elena V Stelmashook, Rodion V Kondratenko, Dmitry B Zorov, Vladimir G Skrebitsky, Vladimir P Skulache. Mitochondria-targeted plastoquinone antioxidant SkQ1 prevents amyloid-β-induced impairment of long-term potentiation in rat hippocampal slices. Journal of Alzheimer's disease : JAD. vol 36. issue 2. 2014-01-27. PMID:23735258. |
to summarize, in vivo and in vitro injection of skq1 compensates for aβ-induced oxidative damage of long-term synaptic plasticity in the hippocampus, which is considered to be the main reason of memory loss and impairment of other cognitive functions associated with alzheimer's disease. |
2014-01-27 |
2023-08-12 |
rat |
| Lei Luo, Guo-Jie Sun, Yan-Jun D. [Effects of acupuncture and moxibustion on energy metabolism-related protein of hippocampal neuron mitochondria in Alzheimer's disease rats]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 33. issue 10. 2014-01-23. PMID:24377225. |
[effects of acupuncture and moxibustion on energy metabolism-related protein of hippocampal neuron mitochondria in alzheimer's disease rats]. |
2014-01-23 |
2023-08-12 |
rat |
| Zhongyang Liu, Xiaoling Gao, Ting Kang, Mengyin Jiang, Deyu Miao, Guangzhi Gu, Quanyin Hu, Qingxiang Song, Lei Yao, Yifan Tu, Hongzhuan Chen, Xinguo Jiang, Jun Che. B6 peptide-modified PEG-PLA nanoparticles for enhanced brain delivery of neuroprotective peptide. Bioconjugate chemistry. vol 24. issue 6. 2014-01-20. PMID:23718945. |
administration of b6-np encapsulated neuroprotective peptide-napvsipq (nap)-to alzheimer's disease mouse models showed excellent amelioration in learning impairments, cholinergic disruption, and loss of hippocampal neurons even at lower dose. |
2014-01-20 |
2023-08-12 |
mouse |
| Leonidas Chouliaras, Diego Mastroeni, Elaine Delvaux, Andrew Grover, Gunter Kenis, Patrick R Hof, Harry W M Steinbusch, Paul D Coleman, Bart P F Rutten, Daniel L A van den Hov. Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients. Neurobiology of aging. vol 34. issue 9. 2014-01-17. PMID:23582657. |
consistent decrease in global dna methylation and hydroxymethylation in the hippocampus of alzheimer's disease patients. |
2014-01-17 |
2023-08-12 |
human |
| Ina Tesseur, Anna A Pimenova, Adrian C Lo, Marta Ciesielska, Stefan F Lichtenthaler, Joris H De Maeyer, Jan A J Schuurkes, Rudi D'Hooge, Bart De Stroope. Chronic 5-HT4 receptor activation decreases Aβ production and deposition in hAPP/PS1 mice. Neurobiology of aging. vol 34. issue 7. 2014-01-16. PMID:23474291. |
chronic administration of this compound in a happ/ps1 mouse model of alzheimer's disease decreased soluble and insoluble aβ in hippocampus, but the potential mechanisms underlying these observations seem to be complex. |
2014-01-16 |
2023-08-12 |
mouse |
| Ipek Baysal, Samiye Yabanoglu-Ciftci, Yeliz Tunc-Sarisozen, Kezban Ulubayram, Gulberk Uca. Interaction of selegiline-loaded PLGA-b-PEG nanoparticles with beta-amyloid fibrils. Journal of neural transmission (Vienna, Austria : 1996). vol 120. issue 6. 2014-01-10. PMID:23420173. |
alzheimer's disease (ad) is an irreversible and progressive neurodegenerative disease that is caused by the irreversible loss of neurons in the hippocampus and cortex regions of the brain. |
2014-01-10 |
2023-08-12 |
Not clear |
| M Ryazantseva, K Skobeleva, E Kaznacheyev. Familial Alzheimer's disease-linked presenilin-1 mutation M146V affects store-operated calcium entry: does gain look like loss? Biochimie. vol 95. issue 7. 2014-01-09. PMID:23624206. |
alzheimer's disease (ad) is a neurodegenerative disorder that leads to neuron death and synapse loss in the hippocampus and cortex, with consequent cognitive disability and dementia. |
2014-01-09 |
2023-08-12 |
human |
| Robert Vassa. ADAM10 prodomain mutations cause late-onset Alzheimer's disease: not just the latest FAD. Neuron. vol 80. issue 2. 2014-01-09. PMID:24139026. |
(2013) describe two rare adam10 prodomain mutations that cause late-onset alzheimer's disease by impairing prodomain chaperone function, attenuating α-secretase activity, and reducing adult hippocampal neurogenesis. |
2014-01-09 |
2023-08-12 |
Not clear |
| M Jorge Cardoso, Kelvin Leung, Marc Modat, Shiva Keihaninejad, David Cash, Josephine Barnes, Nick C Fox, Sebastien Ourseli. STEPS: Similarity and Truth Estimation for Propagated Segmentations and its application to hippocampal segmentation and brain parcelation. Medical image analysis. vol 17. issue 6. 2014-01-08. PMID:23510558. |
mean±sd hippocampal volume (mm(3)) was 5195 ± 656 for controls; 4786 ± 781 for mci; and 4427 ± 903 for alzheimer's disease patients and hippocampal atrophy rates (%/year) of 1.09 ± 3.0, 2.74 ± 3.5 and 4.04 ± 3.6 respectively. |
2014-01-08 |
2023-08-12 |
Not clear |
| Fan Ding, Jia Yao, Liqin Zhao, Zisu Mao, Shuhua Chen, Roberta Diaz Brinto. Ovariectomy induces a shift in fuel availability and metabolism in the hippocampus of the female transgenic model of familial Alzheimer's. PloS one. vol 8. issue 3. 2014-01-07. PMID:23555795. |
ovariectomy induces a shift in fuel availability and metabolism in the hippocampus of the female transgenic model of familial alzheimer's. |
2014-01-07 |
2023-08-12 |
mouse |
| Yue-Feng Zhang, Jian-Chun Yu, Xue-Zhu Zhang, Jing-Xian Ha. [Effect of acupuncture intervention on hippocampal neuron loss and astrocytosis in SAMP 8 mice]. Zhen ci yan jiu = Acupuncture research. vol 38. issue 5. 2014-01-07. PMID:24308181. |
to observe the effect of "sanjiao acupuncture therapy" on hippocampal selective neuron loss and astrocytosis in senile accelerated mice (sam) so as to reveal its mechanism underlying improvement of alzheimer's disease (ad). |
2014-01-07 |
2023-08-12 |
mouse |
| Jie Shi, Paul M Thompson, Boris Gutman, Yalin Wan. Surface fluid registration of conformal representation: application to detect disease burden and genetic influence on hippocampus. NeuroImage. vol 78. 2014-01-06. PMID:23587689. |
we tested the system on alzheimer's disease neuroimaging initiative (adni) baseline dataset to study ad symptoms on hippocampus. |
2014-01-06 |
2023-08-12 |
human |
| Chang-An Liu, Yuan-Jin Wang, Sha N. [Effects of soybean isoflavones on RAGE mediated signal transduction in the hippocampus of rats with Alzheimer's disease]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 32. issue 6. 2014-01-02. PMID:22978107. |
[effects of soybean isoflavones on rage mediated signal transduction in the hippocampus of rats with alzheimer's disease]. |
2014-01-02 |
2023-08-12 |
rat |