| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tiantian Guo, Xinjia Pan, Guangtong Jiang, Denghong Zhang, Jinghui Qi, Lin Shao, Zhanxiang Wang, Huaxi Xu, Yingjun Zha. Downregulating PTBP1 fails to convert astrocytes into hippocampal neurons and to alleviate symptoms in Alzheimer's mouse models. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-08-09. PMID:35944999. |
downregulating ptbp1 fails to convert astrocytes into hippocampal neurons and to alleviate symptoms in alzheimer's mouse models. |
2022-08-09 |
2023-08-14 |
mouse |
| Tiantian Guo, Xinjia Pan, Guangtong Jiang, Denghong Zhang, Jinghui Qi, Lin Shao, Zhanxiang Wang, Huaxi Xu, Yingjun Zha. Downregulating PTBP1 fails to convert astrocytes into hippocampal neurons and to alleviate symptoms in Alzheimer's mouse models. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-08-09. PMID:35944999. |
here, we demonstrate that ptbp1 downregulation using an astrocyte specific aav-mediated shrna system fails to convert hippocampal astrocytes into neurons in both male and female wt, and β-amyloid (5×fad) and tau (ps19) alzheimer's disease (ad) mouse models, and fails to reverse synaptic/cognitive deficits and ad-associated pathology in male mice. |
2022-08-09 |
2023-08-14 |
mouse |
| Huzefa Rupawala, Keshvi Shah, Caitlin Davies, Jamie Rose, Marti Colom-Cadena, Xianhui Peng, Lucy Granat, Manal Aljuhani, Keiko Mizuno, Claire Troakes, Beatriz Gomez Perez-Nievas, Alan Morgan, Po-Wah So, Tibor Hortobagyi, Tara L Spires-Jones, Wendy Noble, Karl Peter Gies. Cysteine string protein alpha accumulates with early pre-synaptic dysfunction in Alzheimer's disease. Brain communications. vol 4. issue 4. 2022-08-05. PMID:35928052. |
in the hippocampus, alterations in the level of cysteine string protein alpha, a molecular co-chaperone at the pre-synaptic terminal, occur prior to reductions in synaptophysin, suggesting that it is a very sensitive marker of synapse degeneration in alzheimer's. |
2022-08-05 |
2023-08-14 |
mouse |
| Zohreh Taghadosi, Asadollah Zarifkar, Vahid Razban, Hadi Alighol. The effect of chronic stress and its preconditioning on spatial memory as well as hippocampal LRP1 and RAGE expression in a streptozotocin-induced rat model of Alzheimer's disease. Metabolic brain disease. 2022-08-05. PMID:35930096. |
the effect of chronic stress and its preconditioning on spatial memory as well as hippocampal lrp1 and rage expression in a streptozotocin-induced rat model of alzheimer's disease. |
2022-08-05 |
2023-08-14 |
rat |
| Jingqin Luo, Folasade Agboola, Elizabeth Grant, John C Morris, Colin L Masters, Marilyn S Albert, Sterling C Johnson, Eric M McDade, Anne M Fagan, Tammie L S Benzinger, Jason Hassenstab, Randall J Bateman, Richard J Perrin, Guoqiao Wang, Yan Li, Brian Gordon, Carlos Cruchaga, Gregory S Day, Johannes Levin, Jonathan Vöglein, Takeshi Ikeuchi, Kazushi Suzuki, Ricardo F Allegri, Chengjie Xion. Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan. Brain : a journal of neurology. 2022-08-04. PMID:35925685. |
the temporal evolutions and relative orderings of alzheimer disease biomarkers, including csf amyloid-β42 (aβ42), aβ40, total tau (tau) and phosphorylated tau181 (ptau181), standardized uptake value ratio (suvr) from the molecular imaging of cerebral fibrillar amyloid-β with pet using the 11c-pittsburgh compound-b (pib), mri-based hippocampal volume and cortical thickness and cognition have been hypothesized but not yet fully tested with longitudinal data for all major biomarker modalities among cognitively normal individuals across the adult lifespan starting from 18 years. |
2022-08-04 |
2023-08-14 |
human |
| Chiara Orciani, Helene Hall, Rowan Pentz, Morgan K Foret, Sonia Do Carmo, A Claudio Cuell. Long-term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical neurons and BDNF levels without affecting the NGF synthesis. Journal of neurochemistry. 2022-08-03. PMID:35921478. |
basal forebrain cholinergic neurons (bfcns) represent the main source of cholinergic innervation to the cortex and hippocampus and degenerate early in alzheimer's disease (ad) progression. |
2022-08-03 |
2023-08-14 |
rat |
| Mengying Liu, Biyao Lian, Zhen Lan, Huan Sun, Yangang Zhao, Tao Sun, Zhaoyou Meng, Chengjun Zhao, Jiqiang Zhan. Transcriptomic Profile Identifies Hippocampal Sgk1 as the Key Mediator of Ovarian Estrogenic Regulation on Spatial Learning and Memory and Aβ Accumulation. Neurochemical research. 2022-08-01. PMID:35915371. |
previous studies have shown that ovarian estrogens are involved in the occurrence and pathology of alzheimer's disease (ad) through regulation on hippocampal synaptic plasticity and spatial memory; however, the underlying mechanisms have not yet been elucidated at the genomic scale. |
2022-08-01 |
2023-08-14 |
mouse |
| Yasuo Miki, Kunikazu Tanji, Kana Shinnai, Makoto Tanaka, Firat Altay, Sandrine C Foti, Catherine Strand, Takanori Sasaki, Tomoya Kon, Shuji Shimoyama, Tomonori Furukawa, Haruo Nishijima, Hiromi Yamazaki, Yasmine T Asi, Conceição Bettencourt, Zane Jaunmuktane, Mari Tada, Fumiaki Mori, Hiroki Mizukami, Masahiko Tomiyama, Hilal A Lashuel, Tammaryn Lashley, Akiyoshi Kakita, Helen Ling, Andrew J Lees, Janice L Holton, Thomas T Warner, Koichi Wakabayash. Pathological substrate of memory impairment in multiple system atrophy. Neuropathology and applied neurobiology. 2022-07-30. PMID:35906771. |
here, using a mouse model of adult-onset msa and human cases (msa, n = 25; parkinson's disease, n = 3, alzheimer's disease, n = 2; normal controls, n = 11), we aimed to investigate how abnormal α-synuclein in the hippocampus can lead to memory impairment. |
2022-07-30 |
2023-08-14 |
mouse |
| Ting Zhang, Xuangao Wu, Heng Yuan, Shaokai Huang, Sunmin Par. Mitigation of Memory Impairment with Fermented Fucoidan and λ-Carrageenan Supplementation through Modulating the Gut Microbiota and Their Metagenome Function in Hippocampal Amyloid-β Infused Rats. Cells. vol 11. issue 15. 2022-07-27. PMID:35892598. |
attenuating acetylcholinesterase and insulin/insulin-like growth factor-1 signaling in the hippocampus is associated with alzheimer's disease (ad) development. |
2022-07-27 |
2023-08-14 |
rat |
| Wendy Luo, Katherine J Pryzbyl, Eileen H Bigio, Sandra Weintraub, M-Marsel Mesulam, Eva E Rede. Reduced Hippocampal and Anterior Cingulate Expression of Antioxidant Enzymes and Membrane Progesterone Receptors in Alzheimer's Disease with Depression. Journal of Alzheimer's disease : JAD. 2022-07-24. PMID:35871353. |
reduced hippocampal and anterior cingulate expression of antioxidant enzymes and membrane progesterone receptors in alzheimer's disease with depression. |
2022-07-24 |
2023-08-14 |
Not clear |
| Sanaz Arezoumandan, Sharon X Xie, Katheryn A Q Cousins, Dawn J Mechanic-Hamilton, Claire S Peterson, Camille Y Huang, Daniel T Ohm, Ranjit Ittyerah, Corey T McMillan, David A Wolk, Paul Yushkevich, John Q Trojanowski, Edward B Lee, Murray Grossman, Jeffrey S Phillips, David J Irwi. Regional distribution and maturation of tau pathology among phenotypic variants of Alzheimer's disease. Acta neuropathologica. 2022-07-23. PMID:35871112. |
here, we investigated the distribution and burden of phosphorylated and c-terminally cleaved tau pathologies across hippocampal subfields and cortical regions among phenotypic variants of alzheimer's disease (ad). |
2022-07-23 |
2023-08-14 |
Not clear |
| S Mokarrami, M Jahanshahi, L Elyasi, H Badelisarkala, M Khalil. Naringin prevents the reduction of the number of neurons and the volume of CA1 in a Scopolamine-Induced animal model of Alzheimer's disease (AD): A stereological study. The International journal of neuroscience. 2022-07-21. PMID:35861379. |
naringin administration at doses of 50, 100, and 200 mg/kg for 14 consecutive days, increased neuron density and the total number of neurons in the hippocampal ca1 area.we concluded that naringin could be effective in improving scopolamine-induced inhibitory passive avoidance memory deficits and that it appeared to increase the volume and density as well as the total number of neurons in the ca1 area of the alzheimer's rat hippocampus. |
2022-07-21 |
2023-08-14 |
rat |
| Fumi Katsuki, Dmitry Gerashchenko, Ritchie E Brow. Alterations of sleep oscillations in Alzheimer's Disease: A potential role for GABAergic neurons in the cortex, hippocampus, and thalamus. Brain research bulletin. 2022-07-19. PMID:35850189. |
alterations of sleep oscillations in alzheimer's disease: a potential role for gabaergic neurons in the cortex, hippocampus, and thalamus. |
2022-07-19 |
2023-08-14 |
mouse |
| Y Qiao, Gocylen Gast, Xilin Su, Takashi Saito, Takaomi C Saido, Todd C Holmes, Xiangmin X. Hippocampal neural circuit connectivity alterations in an Alzheimer's disease mouse model revealed by monosynaptic rabies virus tracing. Neurobiology of disease. 2022-07-17. PMID:35843448. |
hippocampal neural circuit connectivity alterations in an alzheimer's disease mouse model revealed by monosynaptic rabies virus tracing. |
2022-07-17 |
2023-08-14 |
mouse |
| Ramazan Çınar, Mustafa Nazıroğl. TRPM2 Channel Inhibition Attenuates Amyloid β42-Induced Apoptosis and Oxidative Stress in the Hippocampus of Mice. Cellular and molecular neurobiology. 2022-07-15. PMID:35840808. |
alzheimer's disease (ad) is characterized by the increase of hippocampal ca |
2022-07-15 |
2023-08-14 |
mouse |
| Andra Ionescu-Tucker, Liqi Tong, Nicole C Berchtold, Carl W Cotma. Inhibiting BDNF Signaling Upregulates Hippocampal H3K9me3 in a Manner Dependent On Frontiers in aging. vol 3. 2022-07-13. PMID:35821854. |
inhibiting bdnf signaling upregulates hippocampal h3k9me3 in a manner dependent on histone modifications are key contributors to the cognitive decline that occurs in aging and alzheimer's disease. |
2022-07-13 |
2023-08-14 |
mouse |
| Balaji Kannappan, Tamil Iniyan Gunasekaran, Jan Te Nijenhuis, Muthu Gopal, Deepika Velusami, Gugan Kothandan, Kun Ho Le. Polygenic score for Alzheimer's disease identifies differential atrophy in hippocampal subfield volumes. PloS one. vol 17. issue 7. 2022-07-13. PMID:35830443. |
polygenic score for alzheimer's disease identifies differential atrophy in hippocampal subfield volumes. |
2022-07-13 |
2023-08-14 |
Not clear |
| Balaji Kannappan, Tamil Iniyan Gunasekaran, Jan Te Nijenhuis, Muthu Gopal, Deepika Velusami, Gugan Kothandan, Kun Ho Le. Polygenic score for Alzheimer's disease identifies differential atrophy in hippocampal subfield volumes. PloS one. vol 17. issue 7. 2022-07-13. PMID:35830443. |
hippocampal subfield atrophy is a prime structural change in the brain, associated with cognitive aging and neurodegenerative diseases such as alzheimer's disease. |
2022-07-13 |
2023-08-14 |
Not clear |
| Balaji Kannappan, Tamil Iniyan Gunasekaran, Jan Te Nijenhuis, Muthu Gopal, Deepika Velusami, Gugan Kothandan, Kun Ho Le. Polygenic score for Alzheimer's disease identifies differential atrophy in hippocampal subfield volumes. PloS one. vol 17. issue 7. 2022-07-13. PMID:35830443. |
in this study, we evaluated the polygenic risk of alzheimer's disease (ad pgrs) for hippocampal subfield atrophy in 1,086 individuals (319 cognitively normal (cn), 591 mild cognitively impaired (mci), and 176 alzheimer's disease dementia (add)). |
2022-07-13 |
2023-08-14 |
Not clear |
| Shan-Xue Jin, Lei Liu, Shaomin Li, Angela L Meunier, Dennis J Selko. Aβ oligomers from human brain impair mossy fiber LTP in CA3 of hippocampus, but activating cAMP-PKA and cGMP-PKG prevents this. Neurobiology of disease. 2022-07-12. PMID:35820646. |
changes in hippocampal function seem critical for cognitive impairment in early alzheimer's disease (ad). |
2022-07-12 |
2023-08-14 |
mouse |