| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Erica Balboni, Luca Nocetti, Chiara Carbone, Nicola Dinsdale, Maurilio Genovese, Gabriele Guidi, Marcella Malagoli, Annalisa Chiari, Ana I L Namburete, Mark Jenkinson, Giovanna Zambon. The impact of transfer learning on 3D deep learning convolutional neural network segmentation of the hippocampus in mild cognitive impairment and Alzheimer disease subjects. Human brain mapping. 2022-04-04. PMID:35373881. |
research on segmentation of the hippocampus in magnetic resonance images through deep learning convolutional neural networks (cnns) shows promising results, suggesting that these methods can identify small structural abnormalities of the hippocampus, which are among the earliest and most frequent brain changes associated with alzheimer disease (ad). |
2022-04-04 |
2023-08-13 |
human |
| Xiaotong Wei, Xiaotong Du, Yingying Xie, Xinjun Suo, Xiaoxi He, Hao Ding, Yu Zhang, Yi Ji, Chao Chai, Meng Liang, Chunshui Yu, Yong Liu, Wen Qi. Mapping cerebral atrophic trajectory from amnestic mild cognitive impairment to Alzheimer's disease. Cerebral cortex (New York, N.Y. : 1991). 2022-04-03. PMID:35368064. |
by mapping the region-specific nonlinear atrophic trajectory of whole cerebrum from amnestic mild cognitive impairment (amci) to ad based on longitudinal structural magnetic resonance imaging data from alzheimer's disease neuroimaging initiative (adni) database, we unraveled a quadratic accelerated atrophic trajectory of 68 cerebral regions from amci to ad, especially in the superior temporal pole, caudate, and hippocampus. |
2022-04-03 |
2023-08-13 |
Not clear |
| Seong-Hyun Kim, Sang-Seo Park, Chang-Ju Kim, Tae-Woon Ki. Exercise with 40-Hz light flicker improves hippocampal insulin signaling in Alzheimer disease mice. Journal of exercise rehabilitation. vol 18. issue 1. 2022-03-31. PMID:35356135. |
exercise with 40-hz light flicker improves hippocampal insulin signaling in alzheimer disease mice. |
2022-03-31 |
2023-08-13 |
mouse |
| Emrah Düzel, Gabriel Ziegler, David Berron, Anne Maass, Hartmut Schütze, Arturo Cardenas-Blanco, Wenzel Glanz, Coraline Metzger, Laura Dobisch, Martin Reuter, Annika Spottke, Frederic Brosseron, Klaus Fliessbach, Michael T Heneka, Christoph Laske, Oliver Peters, Josef Priller, Eike Jakob Spruth, Alfredo Ramirez, Oliver Speck, Anja Schneider, Stefan Teipel, Ingo Kilimann, Wiltfang Jens, Björn-Hendrik Schott, Lukas Preis, Daria Gref, Franziska Maier, Matthias H Munk, Nina Roy, Tomasso Ballarini, Renat Yakupov, John Dylan Haynes, Peter Dechent, Klaus Scheffler, Michael Wagner, Frank Jesse. Amyloid pathology but not APOE ε4 status is permissive for tau-related hippocampal dysfunction. Brain : a journal of neurology. 2022-03-30. PMID:35352105. |
apoe status (presence of the e4 allele), a known genetic risk factor for alzheimer's disease, did not mediate the relationship between tau pathology and hippocampal function and memory performance. |
2022-03-30 |
2023-08-13 |
human |
| Emrah Düzel, Gabriel Ziegler, David Berron, Anne Maass, Hartmut Schütze, Arturo Cardenas-Blanco, Wenzel Glanz, Coraline Metzger, Laura Dobisch, Martin Reuter, Annika Spottke, Frederic Brosseron, Klaus Fliessbach, Michael T Heneka, Christoph Laske, Oliver Peters, Josef Priller, Eike Jakob Spruth, Alfredo Ramirez, Oliver Speck, Anja Schneider, Stefan Teipel, Ingo Kilimann, Wiltfang Jens, Björn-Hendrik Schott, Lukas Preis, Daria Gref, Franziska Maier, Matthias H Munk, Nina Roy, Tomasso Ballarini, Renat Yakupov, John Dylan Haynes, Peter Dechent, Klaus Scheffler, Michael Wagner, Frank Jesse. Amyloid pathology but not APOE ε4 status is permissive for tau-related hippocampal dysfunction. Brain : a journal of neurology. 2022-03-30. PMID:35352105. |
this raises the possibility that in the predementia stage of alzheimer's disease, removing the negative impact of amyloid pathology could improve memory and hippocampal function even if the amount of tau-pathology in csf is not changed, whereas reducing increased csf tau-pathology in amyloid-negative individuals may not proportionally improve memory function. |
2022-03-30 |
2023-08-13 |
human |
| Karin Persson, Trine H Edwin, Anne-Brita Knapskog, Gro G Tangen, Geir Selbæk, Knut Engeda. Hippocampal Atrophy Subtypes of Alzheimer's Disease Using Automatic MRI in a Memory Clinic Cohort: Clinical Implications. Dementia and geriatric cognitive disorders. 2022-03-28. PMID:35344967. |
hippocampal atrophy subtypes of alzheimer's disease using automatic mri in a memory clinic cohort: clinical implications. |
2022-03-28 |
2023-08-13 |
Not clear |
| Yiming Wang, Yueqi Yang, Yiqiong Liu, Angyang Guo, Yan Zhan. Cognitive impairments in type 1 diabetes mellitus model mice are associated with synaptic protein disorders. Neuroscience letters. 2022-03-26. PMID:35337951. |
we also found decreased levels of synaptic proteins, including the n-methyl-d-aspartic acid receptor (nmdar) subunit nr2a, synaptophysin (syp), and postsynaptic density 95 (psd95), in the hippocampus and prefrontal cortex, revealing similarities in the alteration patterns of these synaptic proteins in aged alzheimer's disease (ad) app/ps1 mice and t1dm mice. |
2022-03-26 |
2023-08-13 |
mouse |
| Poornima D E Weerasinghe-Mudiyanselage, Mary Jasmin Ang, Sohi Kang, Joong-Sun Kim, Changjong Moo. Structural Plasticity of the Hippocampus in Neurodegenerative Diseases. International journal of molecular sciences. vol 23. issue 6. 2022-03-25. PMID:35328770. |
this article reviews the findings of several preclinical and clinical studies about the role of structural plasticity in the hippocampus in neurodegenerative diseases, including alzheimer's disease, parkinson's disease, huntington's disease, and multiple sclerosis. |
2022-03-25 |
2023-08-13 |
Not clear |
| Min Seok Baek, Narae Lee, Jin Woo Kim, Jin Yong Hon. Association of Hippocampal Subfield Volumes with Amyloid-Beta Deposition in Alzheimer's Disease. Journal of clinical medicine. vol 11. issue 6. 2022-03-25. PMID:35329851. |
association of hippocampal subfield volumes with amyloid-beta deposition in alzheimer's disease. |
2022-03-25 |
2023-08-13 |
human |
| Min Seok Baek, Narae Lee, Jin Woo Kim, Jin Yong Hon. Association of Hippocampal Subfield Volumes with Amyloid-Beta Deposition in Alzheimer's Disease. Journal of clinical medicine. vol 11. issue 6. 2022-03-25. PMID:35329851. |
we investigated the relationship between hippocampal subfield volumes and cortical amyloid-beta (aβ) deposition in alzheimer's disease (ad). |
2022-03-25 |
2023-08-13 |
human |
| Tatsuhiro Ayabe, Chika Takahashi, Rena Ohya, Yasuhisa An. β-Lactolin improves mitochondrial function in Aβ-treated mouse hippocampal neuronal cell line and a human iPSC-derived neuronal cell model of Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 4. 2022-03-23. PMID:35319792. |
β-lactolin improves mitochondrial function in aβ-treated mouse hippocampal neuronal cell line and a human ipsc-derived neuronal cell model of alzheimer's disease. |
2022-03-23 |
2023-08-13 |
mouse |
| Mohammed Murtza, Ayesha Bangash, Ajaz-Ur Rehman, Amjadali Pervaiz, Adeena Imra. A case of neurosyphilis with psychosis and hippocampal atrophy. General psychiatry. vol 35. issue 1. 2022-03-21. PMID:35309239. |
his brain scan showed hippocampal atrophy, a finding not often seen in neurosyphilis but more common in alzheimer's disease. |
2022-03-21 |
2023-08-13 |
Not clear |
| Sonja M Kagerer, Clemens Schroeder, Jiri M G van Bergen, Simon J Schreiner, Rafael Meyer, Stefanie C Steininger, Laetitia Vionnet, Anton F Gietl, Valerie Treyer, Alfred Buck, Klaas P Pruessmann, Christoph Hock, Paul G Unschul. Low Subicular Volume as an Indicator of Dementia-Risk Susceptibility in Old Age. Frontiers in aging neuroscience. vol 14. 2022-03-21. PMID:35309894. |
hippocampal atrophy is an established alzheimer's disease (ad) biomarker. |
2022-03-21 |
2023-08-13 |
Not clear |
| Janne J Luppi, Deborah N Schoonhoven, Anne M van Nifterick, Alida A Gouw, Arjan Hillebrand, Philip Scheltens, Cornelis J Stam, Willem de Haa. Oscillatory Activity of the Hippocampus in Prodromal Alzheimer's Disease: A Source-Space Magnetoencephalography Study. Journal of Alzheimer's disease : JAD. 2022-03-21. PMID:35311705. |
oscillatory activity of the hippocampus in prodromal alzheimer's disease: a source-space magnetoencephalography study. |
2022-03-21 |
2023-08-13 |
human |
| Ruhul Amin Hazarika, Arnab Kumar Maji, Raplang Syiem, Samarendra Nath Sur, Debdatta Kanda. Hippocampus Segmentation Using U-Net Convolutional Network from Brain Magnetic Resonance Imaging (MRI). Journal of digital imaging. 2022-03-19. PMID:35304675. |
in most of the neurological disorders related to dementia, such as, alzheimer's disease, hippocampus is one of the earliest affected regions. |
2022-03-19 |
2023-08-13 |
human |
| Nicholas F Fitz, Aaron Barchowsky, Radosveta Koldamova, Iliya Leftero. Genome-wide alteration of histone methylation profiles associated with cognitive changes in response to developmental arsenic exposure in mice. Toxicology reports. vol 9. 2022-03-18. PMID:35299870. |
increased hippocampal amyloid plaques levels of app/ps mice and cognitive decline provided evidence that arsenic exposure aggravated an existing alzheimer's disease-like phenotype. |
2022-03-18 |
2023-08-13 |
mouse |
| Guetchyn Millien, Huaixing Wang, Zongxiu Zhang, Dan L Alkon, Jarin Hongpaisa. PKCε Activation Restores Loss of PKCε, Manganese Superoxide Dismutase, Vascular Endothelial Growth Factor, and Microvessels in Aged and Alzheimer's Disease Hippocampus. Frontiers in aging neuroscience. vol 14. 2022-03-18. PMID:35299945. |
pkcε activation restores loss of pkcε, manganese superoxide dismutase, vascular endothelial growth factor, and microvessels in aged and alzheimer's disease hippocampus. |
2022-03-18 |
2023-08-13 |
mouse |
| Sonja Fixemer, Corrado Ameli, Gaël Hammer, Luis Salamanca, Oihane Uriarte Huarte, Chantal Schwartz, Jean-Jacques Gérardy, Naguib Mechawar, Alexander Skupin, Michel Mittelbronn, David S Bouvie. Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies. Acta neuropathologica communications. vol 10. issue 1. 2022-03-17. PMID:35296366. |
microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with alzheimer's disease and dementia with lewy bodies. |
2022-03-17 |
2023-08-13 |
Not clear |
| Sonja Fixemer, Corrado Ameli, Gaël Hammer, Luis Salamanca, Oihane Uriarte Huarte, Chantal Schwartz, Jean-Jacques Gérardy, Naguib Mechawar, Alexander Skupin, Michel Mittelbronn, David S Bouvie. Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies. Acta neuropathologica communications. vol 10. issue 1. 2022-03-17. PMID:35296366. |
the cellular alterations of the hippocampus lead to memory decline, a shared symptom between alzheimer's disease (ad) and dementia with lewy bodies (dlb) patients. |
2022-03-17 |
2023-08-13 |
Not clear |
| Morteza Salimi, Farhad Tabasi, Maryam Abdolsamadi, Samaneh Dehghan, Kolsoum Dehdar, Milad Nazari, Mohammad Javan, Javad Mirnajafi-Zadeh, Mohammad Reza Raouf. Disrupted connectivity in the olfactory bulb-entorhinal cortex-dorsal hippocampus circuit is associated with recognition memory deficit in Alzheimer's disease model. Scientific reports. vol 12. issue 1. 2022-03-16. PMID:35292712. |
disrupted connectivity in the olfactory bulb-entorhinal cortex-dorsal hippocampus circuit is associated with recognition memory deficit in alzheimer's disease model. |
2022-03-16 |
2023-08-13 |
rat |