| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samaneh Zarei, Mohammad Shafiei, Maryam Firouzi, Loghman Firoozpour, Kouros Divsalar, Ali Asadipour, Tahmineh Akbarzadeh, Alireza Foroumad. Design, synthesis and biological assessment of new 1-benzyl-4-((4-oxoquinazolin-3(4 Heliyon. vol 7. issue 4. 2021-04-21. PMID:33869871. |
design, synthesis and biological assessment of new 1-benzyl-4-((4-oxoquinazolin-3(4 alzheimer's disease (ad), is among the most growing neurodegenerative diseases, which is mainly caused by the acetylcholine neurotransmitter loss in the hippocampus and cortex. |
2021-04-21 |
2023-08-13 |
Not clear |
| Zhi Ruan, Dhruba Pathak, Srinidhi Venkatesan Kalavai, Asuka Yoshii-Kitahara, Satoshi Muraoka, Nemil Bhatt, Kayo Takamatsu-Yukawa, Jianqiao Hu, Yuzhi Wang, Samuel Hersh, Maria Ericsson, Santhi Gorantla, Howard E Gendelman, Rakez Kayed, Seiko Ikezu, Jennifer I Luebke, Tsuneya Ikez. Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons. Brain : a journal of neurology. vol 144. issue 1. 2021-04-20. PMID:33246331. |
strikingly, the inoculation of alzheimer's disease or prodromal alzheimer's disease extracellular vesicles containing only 300 pg of tau into the outer molecular layer of the dentate gyrus of 18-month-old c57bl/6 mice resulted in the accumulation of abnormally phosphorylated tau throughout the hippocampus by 4.5 months, whereas inoculation of an equal amount of tau from control extracellular vesicles, isolated tau oligomers, or fibrils from the same alzheimer's disease donor showed little tau pathology. |
2021-04-20 |
2023-08-13 |
mouse |
| Zhi Ruan, Dhruba Pathak, Srinidhi Venkatesan Kalavai, Asuka Yoshii-Kitahara, Satoshi Muraoka, Nemil Bhatt, Kayo Takamatsu-Yukawa, Jianqiao Hu, Yuzhi Wang, Samuel Hersh, Maria Ericsson, Santhi Gorantla, Howard E Gendelman, Rakez Kayed, Seiko Ikezu, Jennifer I Luebke, Tsuneya Ikez. Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons. Brain : a journal of neurology. vol 144. issue 1. 2021-04-20. PMID:33246331. |
furthermore, alzheimer's disease extracellular vesicles induced misfolding of endogenous tau in both oligomeric and sarkosyl-insoluble forms in the hippocampal region. |
2021-04-20 |
2023-08-13 |
mouse |
| James W Daily, Suna Kang, Sunmin Par. Protection against Alzheimer's disease by luteolin: Role of brain glucose regulation, anti-inflammatory activity, and the gut microbiota-liver-brain axis. BioFactors (Oxford, England). vol 47. issue 2. 2021-04-20. PMID:33347668. |
alzheimer's disease (ad) is induced by the deposition of amyloid-beta (aβ) in the hippocampus and the formation of neurotoxic aβ plaques. |
2021-04-20 |
2023-08-13 |
human |
| Marta Montero-Crespo, Marta Domínguez-Álvaro, Lidia Alonso-Nanclares, Javier DeFelipe, Lidia Blazquez-Llorc. Three-dimensional analysis of synaptic organization in the hippocampal CA1 field in Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 2. 2021-04-19. PMID:33324984. |
three-dimensional analysis of synaptic organization in the hippocampal ca1 field in alzheimer's disease. |
2021-04-19 |
2023-08-13 |
human |
| Shasha Song, Jingjiong Chen, Pinpin Xiao, Hao Duan, Yajun Zhou, Feng Wang, Hongmei Wang, Yuwu Zhao, Zhi Gen. Role of Macrophages in Status Epilepticus Predisposing to Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 73. issue 1. 2021-04-19. PMID:31796682. |
continuous epileptic seizures hallmark status epilepticus, leading to preferential neuronal cell loss in the hippocampus that can progress into alzheimer's disease. |
2021-04-19 |
2023-08-13 |
rat |
| Jin-Ting He, Xin Zhao, Lei Xu, Cui-Ying Ma. Vascular Risk Factors and Alzheimer's Disease: Blood-Brain Barrier Disruption, Metabolic Syndromes, and Molecular Links. Journal of Alzheimer's disease : JAD. vol 73. issue 1. 2021-04-19. PMID:31815697. |
alzheimer's disease (ad) is a neurodegenerative disorder, marked by cortical and hippocampal deposition of amyloid-β (aβ) plaques and neurofibrillary tangles and cognitive impairment. |
2021-04-19 |
2023-08-13 |
Not clear |
| Natalie Tomaszewski, Xulei He, Victoria Solomon, Mitchell Lee, Wendy J Mack, Joseph F Quinn, Meredith N Braskie, Hussein N Yassin. Effect of APOE Genotype on Plasma Docosahexaenoic Acid (DHA), Eicosapentaenoic Acid, Arachidonic Acid, and Hippocampal Volume in the Alzheimer's Disease Cooperative Study-Sponsored DHA Clinical Trial. Journal of Alzheimer's disease : JAD. vol 74. issue 3. 2021-04-19. PMID:32116250. |
effect of apoe genotype on plasma docosahexaenoic acid (dha), eicosapentaenoic acid, arachidonic acid, and hippocampal volume in the alzheimer's disease cooperative study-sponsored dha clinical trial. |
2021-04-19 |
2023-08-13 |
Not clear |
| Francesca Rocchio, Laura Tapella, Marcello Manfredi, Mariangela Chisari, Francesca Ronco, Federico Alessandro Ruffinatti, Eleonora Conte, Pier Luigi Canonico, Maria Angela Sortino, Mariagrazia Grilli, Emilio Marengo, Armando A Genazzani, Dmitry Li. Correction: Gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an Alzheimer's disease mouse model. Cell death & disease. vol 11. issue 4. 2021-04-16. PMID:32300109. |
correction: gene expression, proteome and calcium signaling alterations in immortalized hippocampal astrocytes from an alzheimer's disease mouse model. |
2021-04-16 |
2023-08-13 |
mouse |
| Wei Ge, Chao Ren, Lei Xing, Lina Guan, Caiyi Zhang, Xuwen Sun, Guoping Wang, Haichen Niu, Sen Qu. Ginkgo biloba extract improves cognitive function and increases neurogenesis by reducing Aβ pathology in 5×FAD mice. American journal of translational research. vol 13. issue 3. 2021-04-13. PMID:33841671. |
previous studies have indicated that the generation of newborn hippocampal neurons is impaired in the early phase of alzheimer's disease (ad). |
2021-04-13 |
2023-08-13 |
mouse |
| Matthias Gralle, Simon Labrecque, Charleen Salesse, Paul De Koninc. Spatial dynamics of the insulin receptor in living neurons. Journal of neurochemistry. vol 156. issue 1. 2021-04-12. PMID:31886886. |
it has been proposed that hippocampal insulin signaling is important for memory, that brain insulin signaling is deficient in alzheimer's disease, and that intranasal insulin treatment improves cognition, but the mechanisms remain unclear and do not seem to involve increased glucose uptake by neurons. |
2021-04-12 |
2023-08-13 |
rat |
| Lauren N Woodie, Robert M Johnson, Bulbul Ahmed, Savanah Fowler, William Haynes, Beatriz Carmona, Miranda Reed, Vishnu Suppiramaniam, Michael W Green. Western diet-induced obesity disrupts the diurnal rhythmicity of hippocampal core clock gene expression in a mouse model. Brain, behavior, and immunity. vol 88. 2021-04-06. PMID:32454134. |
however, all measured core clock genes were disrupted in the hippocampus after wd feeding and the expression pattern of genes implicated in alzheimer's disease and synaptic function were altered. |
2021-04-06 |
2023-08-13 |
mouse |
| Hyeon Jeong Seo, Jung Eun Park, Seong-Min Choi, Taekyoung Kim, Soo Hyun Cho, Kyung-Hwa Lee, Woo Keun Song, Juhyun Song, Han-Seong Jeong, Dong Hyun Kim, Byeong C Ki. Inhibitory Neural Network's Impairments at Hippocampal CA1 LTP in an Aged Transgenic Mouse Model of Alzheimer's Disease. International journal of molecular sciences. vol 22. issue 2. 2021-04-02. PMID:33445678. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by a rapid accumulation of amyloid β (aβ) protein in the hippocampus, which impairs synaptic structures and neuronal signal transmission, induces neuronal loss, and diminishes memory and cognitive functions. |
2021-04-02 |
2023-08-13 |
mouse |
| Xianfeng Huang, Jinyao Yang, Xi Huang, Zaijun Zhang, Jianjun Liu, Liangyu Zou, Xifei Yan. Tetramethylpyrazine Improves Cognitive Impairment and Modifies the Hippocampal Proteome in Two Mouse Models of Alzheimer's Disease. Frontiers in cell and developmental biology. vol 9. 2021-04-02. PMID:33791294. |
tetramethylpyrazine improves cognitive impairment and modifies the hippocampal proteome in two mouse models of alzheimer's disease. |
2021-04-02 |
2023-08-13 |
mouse |
| A O Burnyasheva, N A Stefanova, E A Rudnitskay. [Adult neurogenesis: alterations with aging and Alzheimer's disease development.] Advances in gerontology = Uspekhi gerontologii. vol 33. issue 6. 2021-03-30. PMID:33774989. |
hippocampus and entorhinal cortex are the key neurogenic niches in the adult brain and one of the most vulnerable brain areas during the development of alzheimer's disease. |
2021-03-30 |
2023-08-13 |
Not clear |
| Siqi Wang, Shengwei Ke, Yueming Wu, Duo Zhang, Baowei Liu, Yao-Hui He, Wen Liu, Huawei Mu, Xiaoyuan Son. Functional Network of the Long Non-coding RNA Growth Arrest-Specific Transcript 5 and Its Interacting Proteins in Senescence. Frontiers in genetics. vol 12. 2021-03-30. PMID:33777096. |
rna pull-down assay using mouse brain hippocampus tissues showed that potential gas5 interacting proteins could be enriched into several kyoto encyclopedia of genes and genomes (kegg) pathways, and some of them are involved in senescence-associated diseases such as parkinson's and alzheimer's diseases. |
2021-03-30 |
2023-08-13 |
mouse |
| Emma Coninx, Yap Ching Chew, Xiaojing Yang, Wei Guo, Amelie Coolkens, Sarah Baatout, Lieve Moons, Mieke Verslegers, Roel Quinten. Hippocampal and cortical tissue-specific epigenetic clocks indicate an increased epigenetic age in a mouse model for Alzheimer's disease. Aging. vol 12. issue 20. 2021-03-29. PMID:33082299. |
hippocampal and cortical tissue-specific epigenetic clocks indicate an increased epigenetic age in a mouse model for alzheimer's disease. |
2021-03-29 |
2023-08-13 |
mouse |
| Doha M Beltagy, Nagat F Nawar, Tarek M Mohamed, Ehab Tousson, Mai M El-Kee. Beneficial consequences of probiotic on mitochondrial hippocampus in Alzheimer's disease. Journal of complementary & integrative medicine. 2021-03-29. PMID:33781011. |
beneficial consequences of probiotic on mitochondrial hippocampus in alzheimer's disease. |
2021-03-29 |
2023-08-13 |
Not clear |
| Marianne Chapleau, Christophe Bedetti, Gabriel A Devenyi, Signy Sheldon, Howie J Rosen, Bruce L Miller, Maria Luisa Gorno-Tempini, Mallar M Chakravarty, Simona M Brambat. Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease. NeuroImage. Clinical. vol 27. 2021-03-29. PMID:32544853. |
deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and alzheimer's disease. |
2021-03-29 |
2023-08-13 |
human |
| Marianne Chapleau, Christophe Bedetti, Gabriel A Devenyi, Signy Sheldon, Howie J Rosen, Bruce L Miller, Maria Luisa Gorno-Tempini, Mallar M Chakravarty, Simona M Brambat. Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer's disease. NeuroImage. Clinical. vol 27. 2021-03-29. PMID:32544853. |
the goal of the present study is to conduct a detailed characterization of the impact of svppa on global hippocampus volume and morphology compared with control subjects and patients with alzheimer's disease (ad). |
2021-03-29 |
2023-08-13 |
human |