| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shan Zhong, Mengdi Wang, Yaxi Zhan, Jie Zhang, Xiaoli Yang, Shumei Fu, Danlei Bi, Feng Gao, Yong Shen, Zuolong Che. Single-nucleus RNA sequencing reveals transcriptional changes of hippocampal neurons in APP23 mouse model of Alzheimer's disease. Bioscience, biotechnology, and biochemistry. vol 84. issue 5. 2021-01-07. PMID:31928331. |
single-nucleus rna sequencing reveals transcriptional changes of hippocampal neurons in app23 mouse model of alzheimer's disease. |
2021-01-07 |
2023-08-13 |
mouse |
| Azhaar A Ashraf, Melanie Dani, Po-Wah S. Low Cerebrospinal Fluid Levels of Hemopexin Are Associated With Increased Alzheimer's Pathology, Hippocampal Hypometabolism, and Cognitive Decline. Frontiers in molecular biosciences. vol 7. 2021-01-06. PMID:33392254. |
low cerebrospinal fluid levels of hemopexin are associated with increased alzheimer's pathology, hippocampal hypometabolism, and cognitive decline. |
2021-01-06 |
2023-08-13 |
human |
| Azhaar A Ashraf, Melanie Dani, Po-Wah S. Low Cerebrospinal Fluid Levels of Hemopexin Are Associated With Increased Alzheimer's Pathology, Hippocampal Hypometabolism, and Cognitive Decline. Frontiers in molecular biosciences. vol 7. 2021-01-06. PMID:33392254. |
the aim of the present study was to examine the association of cerebrospinal fluid levels (csf) hemopexin and hemoglobin subunits (α and β) to alzheimer's pathological proteins (amyloid and tau), hippocampal volume and metabolism, and cognitive performance. |
2021-01-06 |
2023-08-13 |
human |
| Bin Peng, Qiang Yang, Rachna B Joshi, Yuancai Liu, Mohammed Akbar, Byoung-Joon Song, Shuanhu Zhou, Xin Wan. Role of Alcohol Drinking in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis. International journal of molecular sciences. vol 21. issue 7. 2021-01-05. PMID:32230811. |
epidemiological studies have reported a reduction in the prevalence of alzheimer's disease in individuals who drink low amounts of alcohol; low or moderate concentrations of ethanol protect against β-amyloid (aβ) toxicity in hippocampal neurons; and excessive amounts of ethanol increase accumulation of aβ and tau phosphorylation. |
2021-01-05 |
2023-08-13 |
Not clear |
| Masako Nakano, Kenta Kubota, Eiji Kobayashi, Takako S Chikenji, Yuki Saito, Naoto Konari, Mineko Fujimiy. Bone marrow-derived mesenchymal stem cells improve cognitive impairment in an Alzheimer's disease model by increasing the expression of microRNA-146a in hippocampus. Scientific reports. vol 10. issue 1. 2021-01-05. PMID:32612165. |
bone marrow-derived mesenchymal stem cells improve cognitive impairment in an alzheimer's disease model by increasing the expression of microrna-146a in hippocampus. |
2021-01-05 |
2023-08-13 |
mouse |
| Peiliang Wu, Wenya Li, Xueding Cai, Hanhan Yan, Mayun Che. Associations of cigarette smoking with memory decline and neurodegeneration among cognitively normal older individuals. Neuroscience letters. vol 714. 2021-01-04. PMID:31678372. |
among 415 older individuals with nc from the alzheimer's disease neuroimaging initiative (adni) cohort, we examined the associations between smoking status (non-smokers vs smokers) and global cognition, verbal memory, hippocampal volumes, cerebral glucose metabolism and csf ad pathologies. |
2021-01-04 |
2023-08-13 |
human |
| Lei Zhang, Wei Tang, Feng-Lei Chao, Chun-Ni Zhou, Lin Jiang, Yi Zhang, Xin Liang, Jing Tang, Ying-Qiang Qi, Hao Yang, Qi He, Shan-Shan Zhang, Lin Zhu, Yan Peng, Yong Tan. Four-month treadmill exercise prevents the decline in spatial learning and memory abilities and the loss of spinophilin-immunoreactive puncta in the hippocampus of APP/PS1 transgenic mice. Neurobiology of disease. vol 136. 2021-01-04. PMID:31887353. |
however, the effects of exercise on synapses in the hippocampus in alzheimer's disease (ad) are not completely known. |
2021-01-04 |
2023-08-13 |
mouse |
| Kathryn M Broadhouse, Maria Fiatarone Singh, Chao Suo, Nicola Gates, Wei Wen, Henry Brodaty, Nidhi Jain, Guy C Wilson, Jacinda Meiklejohn, Nalin Singh, Bernhard T Baune, Michael Baker, Nasim Foroughi, Yi Wang, Nicole Kochan, Kevin Ashton, Matt Brown, Zhixiu Li, Yorgi Mavros, Perminder S Sachdev, Michael J Valenzuel. Hippocampal plasticity underpins long-term cognitive gains from resistance exercise in MCI. NeuroImage. Clinical. vol 25. 2021-01-04. PMID:31978826. |
for the first time we show that hippocampal subareas particularly susceptible to volume loss in alzheimer's disease (ad) are protected by resistance exercise for up to one year after training. |
2021-01-04 |
2023-08-13 |
human |
| Rehab A Hussein, Ahmed H Afifi, Ahmed A F Soliman, Zeinab A El Shahid, Khairy M A Zoheir, Khaled M Mahmou. Neuroprotective activity of Heliyon. vol 6. issue 12. 2020-12-31. PMID:33367123. |
neuroprotective activity of alzheimer's disease (ad) is one of the most prevalent neurodegenerative disorders which affects the hippocampus and cortical neurons leading to impairment of cognitive ability. |
2020-12-31 |
2023-08-13 |
Not clear |
| Yang He, Yimin Wang, Shu Liu, Zifeng Pi, Zhiqiang Liu, Junpeng Xing, Hui Zho. A metabolomic study of the urine of rats with Alzheimer's disease and the efficacy of Ding-Zhi-Xiao-Wan on the afflicted rats. Journal of separation science. vol 43. issue 8. 2020-12-29. PMID:32039552. |
to develop a better rat model of alzheimer's disease, amyloid β25-35 was injected into the bilateral hippocampus of sprague-dawley rats. |
2020-12-29 |
2023-08-13 |
rat |
| Yanshuai Tu, Liang Mi, Wen Zhang, Haomeng Zhang, Junwei Zhang, Yonghui Fan, Dhruman Goradia, Kewei Chen, Richard J Caselli, Eric M Reiman, Xianfeng Gu, Yalin Wan. Computing Univariate Neurodegenerative Biomarkers with Volumetric Optimal Transportation: A Pilot Study. Neuroinformatics. vol 18. issue 4. 2020-12-23. PMID:32253701. |
experimental results, on 314 subjects (140 aβ + ad and 174 aβ- normal controls) from the alzheimer's disease neuroimaging initiative (adni) baseline dataset, provide preliminary evidence that the proposed wi is correlated with a clinical cognitive measure (the mini-mental state examination (mmse) score), and it is able to identify group difference and achieve a good classification accuracy, outperforming two other popular univariate indices including hippocampal volume and entorhinal cortex thickness. |
2020-12-23 |
2023-08-13 |
human |
| Julien Dufort-Gervais, Chloé Provost, Laurence Charbonneau, Christopher M Norris, Frédéric Calon, Valérie Mongrain, Jonathan Brouillett. Neuroligin-1 is altered in the hippocampus of Alzheimer's disease patients and mouse models, and modulates the toxicity of amyloid-beta oligomers. Scientific reports. vol 10. issue 1. 2020-12-14. PMID:32332783. |
neuroligin-1 is altered in the hippocampus of alzheimer's disease patients and mouse models, and modulates the toxicity of amyloid-beta oligomers. |
2020-12-14 |
2023-08-13 |
mouse |
| Saeedeh Hosseinian, Ehsan Arefian, Hassan Rakhsh-Khorshid, Mehdi Eivani, Ameneh Rezayof, Hamid Pezeshk, Sayed-Amir Marash. A meta-analysis of gene expression data highlights synaptic dysfunction in the hippocampus of brains with Alzheimer's disease. Scientific reports. vol 10. issue 1. 2020-12-14. PMID:32433480. |
a meta-analysis of gene expression data highlights synaptic dysfunction in the hippocampus of brains with alzheimer's disease. |
2020-12-14 |
2023-08-13 |
rat |
| Saeedeh Hosseinian, Ehsan Arefian, Hassan Rakhsh-Khorshid, Mehdi Eivani, Ameneh Rezayof, Hamid Pezeshk, Sayed-Amir Marash. A meta-analysis of gene expression data highlights synaptic dysfunction in the hippocampus of brains with Alzheimer's disease. Scientific reports. vol 10. issue 1. 2020-12-14. PMID:32433480. |
we analysed about 2700 upregulated genes and 2200 downregulated genes from three studies on the ca1 of the hippocampus of brains with alzheimer's disease. |
2020-12-14 |
2023-08-13 |
rat |
| Saeedeh Hosseinian, Ehsan Arefian, Hassan Rakhsh-Khorshid, Mehdi Eivani, Ameneh Rezayof, Hamid Pezeshk, Sayed-Amir Marash. A meta-analysis of gene expression data highlights synaptic dysfunction in the hippocampus of brains with Alzheimer's disease. Scientific reports. vol 10. issue 1. 2020-12-14. PMID:32433480. |
finally, we confirmed the upregulation of mir-129 in the hippocampus of brains of rats with scopolamine-induced amnesia as a model of alzheimer's disease. |
2020-12-14 |
2023-08-13 |
rat |
| Susan Abushakra, Anton P Porsteinsson, Marwan Sabbagh, Luc Bracoud, Joel Schaerer, Aidan Power, John A Hey, David Scott, Joyce Suhy, Martin Tola. APOE ε4/ε4 homozygotes with early Alzheimer's disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline. Alzheimer's & dementia (New York, N. Y.). vol 6. issue 1. 2020-12-12. PMID:33304988. |
apoe ε4/ε4 homozygotes with early alzheimer's disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline. |
2020-12-12 |
2023-08-13 |
human |
| Susan Abushakra, Anton P Porsteinsson, Marwan Sabbagh, Luc Bracoud, Joel Schaerer, Aidan Power, John A Hey, David Scott, Joyce Suhy, Martin Tola. APOE ε4/ε4 homozygotes with early Alzheimer's disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline. Alzheimer's & dementia (New York, N. Y.). vol 6. issue 1. 2020-12-12. PMID:33304988. |
hippocampal volume (hv) and cortical thickness are commonly used imaging biomarkers in alzheimer's disease (ad) trials, and may have utility as selection criteria for enrichment strategies. |
2020-12-12 |
2023-08-13 |
human |
| Dariusz Świetlik, Jacek Białowąs, Janusz Moryś, Aida Kusia. Computer Model of Synapse Loss During an Alzheimer's Disease-Like Pathology in Hippocampal Subregions DG, CA3 and CA1-The Way to Chaos and Information Transfer. Entropy (Basel, Switzerland). vol 21. issue 4. 2020-12-07. PMID:33267122. |
computer model of synapse loss during an alzheimer's disease-like pathology in hippocampal subregions dg, ca3 and ca1-the way to chaos and information transfer. |
2020-12-07 |
2023-08-13 |
Not clear |
| Dariusz Świetlik, Jacek Białowąs, Janusz Moryś, Aida Kusia. Computer Model of Synapse Loss During an Alzheimer's Disease-Like Pathology in Hippocampal Subregions DG, CA3 and CA1-The Way to Chaos and Information Transfer. Entropy (Basel, Switzerland). vol 21. issue 4. 2020-12-07. PMID:33267122. |
the aim of the study was to compare the computer model of synaptic breakdown in an alzheimer's disease-like pathology in the dentate gyrus (dg), ca3 and ca1 regions of the hippocampus with a control model using neuronal parameters and methods describing the complexity of the system, such as the correlative dimension, shannon entropy and positive maximal lyapunov exponent. |
2020-12-07 |
2023-08-13 |
Not clear |
| Dariusz Świetlik, Jacek Białowąs, Janusz Moryś, Aida Kusia. Computer Model of Synapse Loss During an Alzheimer's Disease-Like Pathology in Hippocampal Subregions DG, CA3 and CA1-The Way to Chaos and Information Transfer. Entropy (Basel, Switzerland). vol 21. issue 4. 2020-12-07. PMID:33267122. |
the model of synaptic breakdown (from 13% to 50%) in the hippocampus modeling the dynamics of an alzheimer's disease-like pathology was simulated. |
2020-12-07 |
2023-08-13 |
Not clear |