| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carlos Platero, María Eugenia López, María Del Carmen Tobar, Miguel Yus, Fernando Maest. Discriminating Alzheimer's disease progression using a new hippocampal marker from T1-weighted MRI: The local surface roughness. Human brain mapping. vol 40. issue 5. 2020-04-06. PMID:30451343. |
hippocampal atrophy is one of the main hallmarks of alzheimer's disease (ad). |
2020-04-06 |
2023-08-13 |
human |
| Joseph Therriault, S Wang, S Mathotaarachchi, Tharick A Pascoal, M Parent, T Beaudry, M Shin, Benedet Al, M S Kang, K P Ng, C Dansereau, M T M Park, V Fonov, F Carbonell, E Zimmer, M Mallar Chakravarty, P Bellec, S Gauthier, P Rosa-Net. Rostral-Caudal Hippocampal Functional Convergence Is Reduced Across the Alzheimer's Disease Spectrum. Molecular neurobiology. vol 56. issue 12. 2020-04-02. PMID:31230260. |
rostral-caudal hippocampal functional convergence is reduced across the alzheimer's disease spectrum. |
2020-04-02 |
2023-08-13 |
Not clear |
| Joseph Therriault, S Wang, S Mathotaarachchi, Tharick A Pascoal, M Parent, T Beaudry, M Shin, Benedet Al, M S Kang, K P Ng, C Dansereau, M T M Park, V Fonov, F Carbonell, E Zimmer, M Mallar Chakravarty, P Bellec, S Gauthier, P Rosa-Net. Rostral-Caudal Hippocampal Functional Convergence Is Reduced Across the Alzheimer's Disease Spectrum. Molecular neurobiology. vol 56. issue 12. 2020-04-02. PMID:31230260. |
beginning in the early stages of alzheimer's disease (ad), the hippocampus reduces its functional connections to other cortical regions due to synaptic depletion. |
2020-04-02 |
2023-08-13 |
Not clear |
| Joseph Therriault, S Wang, S Mathotaarachchi, Tharick A Pascoal, M Parent, T Beaudry, M Shin, Benedet Al, M S Kang, K P Ng, C Dansereau, M T M Park, V Fonov, F Carbonell, E Zimmer, M Mallar Chakravarty, P Bellec, S Gauthier, P Rosa-Net. Rostral-Caudal Hippocampal Functional Convergence Is Reduced Across the Alzheimer's Disease Spectrum. Molecular neurobiology. vol 56. issue 12. 2020-04-02. PMID:31230260. |
using fmri, we generated resting-state hippocampal functional networks across 56 controls, 48 early mci (emci), 35 late mci (lmci), and 31 ad patients from the alzheimer's disease neuroimaging initiative cohort. |
2020-04-02 |
2023-08-13 |
Not clear |
| Sarah M Neuner, Shengyuan Ding, Catherine C Kaczorowsk. Knockdown of heterochromatin protein 1 binding protein 3 recapitulates phenotypic, cellular, and molecular features of aging. Aging cell. vol 18. issue 1. 2020-03-30. PMID:30549219. |
here, we provide a mechanistic explanation for these findings and show that targeted knockdown of hp1bp3 in the hippocampus by 50%-75% is sufficient to induce cognitive deficits and transcriptional changes reminiscent of those observed in aging and alzheimer's disease brains. |
2020-03-30 |
2023-08-13 |
Not clear |
| Kyle R Christensen, Thomas G Beach, Geidy E Serrano, Nicholas M Kanaa. Pathogenic tau modifications occur in axons before the somatodendritic compartment in mossy fiber and Schaffer collateral pathways. Acta neuropathologica communications. vol 7. issue 1. 2020-03-30. PMID:30819250. |
the deposition of tau pathology in alzheimer's disease (ad) may occur first in axons of neurons and then progress back into the cell bodies to form neurofibrillary tangles, however, studies have not directly analyzed this relationship in relatively discrete circuits within the human hippocampus. |
2020-03-30 |
2023-08-13 |
human |
| Sara Chavoshinezhad, Homa Mohseni Kouchesfahani, Abolhassan Ahmadiani, Leila Dargah. Interferon beta ameliorates cognitive dysfunction in a rat model of Alzheimer's disease: Modulation of hippocampal neurogenesis and apoptosis as underlying mechanism. Progress in neuro-psychopharmacology & biological psychiatry. vol 94. 2020-03-30. PMID:31152860. |
interferon beta ameliorates cognitive dysfunction in a rat model of alzheimer's disease: modulation of hippocampal neurogenesis and apoptosis as underlying mechanism. |
2020-03-30 |
2023-08-13 |
rat |
| Sara Chavoshinezhad, Homa Mohseni Kouchesfahani, Abolhassan Ahmadiani, Leila Dargah. Interferon beta ameliorates cognitive dysfunction in a rat model of Alzheimer's disease: Modulation of hippocampal neurogenesis and apoptosis as underlying mechanism. Progress in neuro-psychopharmacology & biological psychiatry. vol 94. 2020-03-30. PMID:31152860. |
neuronal apoptosis and impaired hippocampal neurogenesis are major players in cognitive/memory dysfunctions including alzheimer's disease (ad). |
2020-03-30 |
2023-08-13 |
rat |
| Michael J Knight, Alfie Wearn, Elizabeth Coulthard, Risto A Kauppine. T2 Relaxometry and Diffusion Tensor Indices of the Hippocampus and Entorhinal Cortex Improve Sensitivity and Specificity of MRI to Detect Amnestic Mild Cognitive Impairment and Alzheimer's Disease Dementia. Journal of magnetic resonance imaging : JMRI. vol 49. issue 2. 2020-03-23. PMID:30209854. |
t2 relaxometry and diffusion tensor indices of the hippocampus and entorhinal cortex improve sensitivity and specificity of mri to detect amnestic mild cognitive impairment and alzheimer's disease dementia. |
2020-03-23 |
2023-08-13 |
Not clear |
| Lei Yu, Patricia A Boyle, Robert J Dawe, David A Bennett, Konstantinos Arfanakis, Julie A Schneide. Contribution of TDP and hippocampal sclerosis to hippocampal volume loss in older-old persons. Neurology. vol 94. issue 2. 2020-03-19. PMID:31757868. |
to investigate the contribution of alzheimer disease (ad) vs non-ad neuropathologies to hippocampal atrophy. |
2020-03-19 |
2023-08-13 |
Not clear |
| Thomas D Parker, David M Cash, Christopher A S Lane, Kirsty Lu, Ian B Malone, Jennifer M Nicholas, Sarah-Naomi James, Ashvini Keshavan, Heidi Murray-Smith, Andrew Wong, Sarah M Buchanan, Sarah E Keuss, Carole H Sudre, Marc Modat, David L Thomas, Sebastian J Crutch, Marcus Richards, Nick C Fox, Jonathan M Schot. Hippocampal subfield volumes and pre-clinical Alzheimer's disease in 408 cognitively normal adults born in 1946. PloS one. vol 14. issue 10. 2020-03-17. PMID:31622410. |
hippocampal subfield volumes and pre-clinical alzheimer's disease in 408 cognitively normal adults born in 1946. |
2020-03-17 |
2023-08-13 |
human |
| Thomas D Parker, David M Cash, Christopher A S Lane, Kirsty Lu, Ian B Malone, Jennifer M Nicholas, Sarah-Naomi James, Ashvini Keshavan, Heidi Murray-Smith, Andrew Wong, Sarah M Buchanan, Sarah E Keuss, Carole H Sudre, Marc Modat, David L Thomas, Sebastian J Crutch, Marcus Richards, Nick C Fox, Jonathan M Schot. Hippocampal subfield volumes and pre-clinical Alzheimer's disease in 408 cognitively normal adults born in 1946. PloS one. vol 14. issue 10. 2020-03-17. PMID:31622410. |
to date, research investigating the influence of cerebral β-amyloid deposition-one of the earliest hypothesised changes in the pathophysiological continuum of alzheimer's disease-on hippocampal subfield volumes in cognitively normal older individuals, has been limited. |
2020-03-17 |
2023-08-13 |
human |
| Sara Ranjbar, Stefanie N Velgos, Amylou C Dueck, Yonas E Geda, J Ross Mitchel. Brain MR Radiomics to Differentiate Cognitive Disorders. The Journal of neuropsychiatry and clinical neurosciences. vol 31. issue 3. 2020-03-16. PMID:30636564. |
the authors examined the utility of hippocampal texture analysis and volumetric features extracted from brain magnetic resonance (mr) data to differentiate between three cognitive groups (cognitively normal individuals, individuals with mild cognitive impairment, and individuals with alzheimer's disease) and neuropsychological scores on the clinical dementia rating (cdr) scale. |
2020-03-16 |
2023-08-13 |
Not clear |
| Judith A Potashkin, Virginie Bottero, Jose A Santiago, James P Quin. Computational identification of key genes that may regulate gene expression reprogramming in Alzheimer's patients. PloS one. vol 14. issue 9. 2020-03-16. PMID:31545826. |
the results indicate that switch genes are enriched in pathways involved in the proteasome, oxidative phosphorylation, parkinson's disease, huntington's disease, alzheimer's disease and metabolism in the hippocampus and posterior cingulate cortex. |
2020-03-16 |
2023-08-13 |
Not clear |
| Yubraj Gupta, Kun Ho Lee, Kyu Yeong Choi, Jang Jae Lee, Byeong Chae Kim, Goo Rak Kwo. Early diagnosis of Alzheimer's disease using combined features from voxel-based morphometry and cortical, subcortical, and hippocampus regions of MRI T1 brain images. PloS one. vol 14. issue 10. 2020-03-16. PMID:31584953. |
early diagnosis of alzheimer's disease using combined features from voxel-based morphometry and cortical, subcortical, and hippocampus regions of mri t1 brain images. |
2020-03-16 |
2023-08-13 |
human |
| Audrey Low, Heidi Foo, Ting Ting Yong, Louis C S Tan, Nagaendran Kandia. Hippocampal subfield atrophy of CA1 and subicular structures predict progression to dementia in idiopathic Parkinson's disease. Journal of neurology, neurosurgery, and psychiatry. vol 90. issue 6. 2020-03-13. PMID:30683708. |
global hippocampal atrophy is a hallmark of alzheimer's dementia and has been similarly reported in parkinson's disease dementia (pdd). |
2020-03-13 |
2023-08-13 |
Not clear |
| Eun-Young Lee, Michael R Flynn, Guangwei Du, Mechelle M Lewis, Lan Kong, Jeff D Yanosky, Richard B Mailman, Xuemei Huan. Higher Hippocampal Mean Diffusivity Values in Asymptomatic Welders. Toxicological sciences : an official journal of the Society of Toxicology. vol 168. issue 2. 2020-03-12. PMID:30629252. |
recent studies in mn-exposed animals revealed mn accumulation in the hippocampus, the presence of aβ diffuse plaques, and deficits in associative learning, the latter being hallmarks of alzheimer's disease (ad) or related disorders. |
2020-03-12 |
2023-08-13 |
human |
| P J Moore, T J Lyons, J Gallache. Using path signatures to predict a diagnosis of Alzheimer's disease. PloS one. vol 14. issue 9. 2020-03-12. PMID:31536538. |
the data used are time-ordered measurements of the whole brain, ventricles and hippocampus from the alzheimer's disease neuroimaging initiative (adni). |
2020-03-12 |
2023-08-13 |
Not clear |
| P J Moore, T J Lyons, J Gallache. Using path signatures to predict a diagnosis of Alzheimer's disease. PloS one. vol 14. issue 9. 2020-03-12. PMID:31536538. |
while hippocampal and brain volume changes are well known in alzheimer's disease, we demonstrate the power of the path signature in their identification and analysis without manual feature selection. |
2020-03-12 |
2023-08-13 |
Not clear |
| Donald J Joseph, Chunxia Liu, Jun Peng, Ge Liang, Huafeng We. Isoflurane mediated neuropathological and cognitive impairments in the triple transgenic Alzheimer's mouse model are associated with hippocampal synaptic deficits in an age-dependent manner. PloS one. vol 14. issue 10. 2020-03-12. PMID:31600350. |
isoflurane mediated neuropathological and cognitive impairments in the triple transgenic alzheimer's mouse model are associated with hippocampal synaptic deficits in an age-dependent manner. |
2020-03-12 |
2023-08-13 |
mouse |