| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yaghoub Pourshojaei, Khalil Eskandari, Ali Asadipou. Highly Significant Scaffolds to Design and Synthesis Cholinesterase Inhibitors as Anti-Alzheimer Agents. Mini reviews in medicinal chemistry. vol 19. issue 19. 2019-12-26. PMID:31538893. |
based on the cholinergic hypothesis, and xray crystallographic determination of the structure of acetylcholinesterase (ache) enzyme, the level of acetylcholine (ach, an important neurotransmitter associated with memory) in the hippocampus and cortex area of the brain has a direct effect on alzheimer. |
2019-12-26 |
2023-08-13 |
Not clear |
| Lucia Leone, Claudia Colussi, Katia Gironi, Valentina Longo, Salvatore Fusco, Domenica Donatella Li Puma, Marcello D'Ascenzo, Claudio Grass. Altered Nup153 Expression Impairs the Function of Cultured Hippocampal Neural Stem Cells Isolated from a Mouse Model of Alzheimer's Disease. Molecular neurobiology. vol 56. issue 8. 2019-12-17. PMID:30689197. |
altered nup153 expression impairs the function of cultured hippocampal neural stem cells isolated from a mouse model of alzheimer's disease. |
2019-12-17 |
2023-08-13 |
mouse |
| Lucia Leone, Claudia Colussi, Katia Gironi, Valentina Longo, Salvatore Fusco, Domenica Donatella Li Puma, Marcello D'Ascenzo, Claudio Grass. Altered Nup153 Expression Impairs the Function of Cultured Hippocampal Neural Stem Cells Isolated from a Mouse Model of Alzheimer's Disease. Molecular neurobiology. vol 56. issue 8. 2019-12-17. PMID:30689197. |
impairment of adult hippocampal neurogenesis is an early event in alzheimer's disease (ad), playing a crucial role in cognitive dysfunction associated with this pathology. |
2019-12-17 |
2023-08-13 |
mouse |
| Fumiko Shigiyama, Makoto Hamanoue, Masaaki Kobayashi, Ken Takamats. Cell-permeable p38 MAP kinase protects adult hippocampal neurons from cell death. Neuroscience letters. vol 699. 2019-12-17. PMID:30735722. |
our findings indicate that cell-permeable p38 protein may be useful in preventing the degeneration of higher brain function occurring through hippocampal neuronal cell death, and furthermore, that the maintenance of intracellular p38 levels could be another therapeutic target for neurodegenerative diseases such as alzheimer's disease (ad). |
2019-12-17 |
2023-08-13 |
Not clear |
| Yu-Xiang Wang, Zhen-Hong Xia, Xue Jiang, Li-Xia Li, Di An, Hong-Gang Wang, Bin Heng, Yan-Qiang Li. Genistein Inhibits Aβ Cellular and molecular neurobiology. vol 39. issue 6. 2019-12-17. PMID:31037516. |
genistein inhibits aβ we established a model of alzheimer's disease in vitro by exposing primary hippocampal neurons of neonatal wistar rats to the β-amyloid peptide fragment 25-35, aβ |
2019-12-17 |
2023-08-13 |
rat |
| Margarete Delazer, Laura Zamarian, Thomas Benke, Michaela Wagner, Elke R Gizewski, Christoph Scherfle. Is an intact hippocampus necessary for answering 3 × 3? - Evidence from Alzheimer's disease. Brain and cognition. vol 134. 2019-12-17. PMID:31054405. |
in this study, we assessed whether patients with hippocampal atrophy due to alzheimer's disease (ad) are still able to retrieve overlearned arithmetic facts from memory. |
2019-12-17 |
2023-08-13 |
Not clear |
| Thomas D Parker, Catherine F Slattery, Keir X X Yong, Jennifer M Nicholas, Ross W Paterson, Alexander J M Foulkes, Ian B Malone, David L Thomas, David M Cash, Sebastian J Crutch, Nick C Fox, Jonathan M Schot. Differences in hippocampal subfield volume are seen in phenotypic variants of early onset Alzheimer's disease. NeuroImage. Clinical. vol 21. 2019-12-16. PMID:30558867. |
differences in hippocampal subfield volume are seen in phenotypic variants of early onset alzheimer's disease. |
2019-12-16 |
2023-08-13 |
human |
| Thomas D Parker, Catherine F Slattery, Keir X X Yong, Jennifer M Nicholas, Ross W Paterson, Alexander J M Foulkes, Ian B Malone, David L Thomas, David M Cash, Sebastian J Crutch, Nick C Fox, Jonathan M Schot. Differences in hippocampal subfield volume are seen in phenotypic variants of early onset Alzheimer's disease. NeuroImage. Clinical. vol 21. 2019-12-16. PMID:30558867. |
the hippocampus, which comprises a number of interconnected anatomically and functionally distinct subfields, is centrally involved in alzheimer's disease and is a crucial mediator of episodic memory. |
2019-12-16 |
2023-08-13 |
human |
| Grazia Daniela Femminella, Melanie Dani, Melanie Wood, Zhen Fan, Valeria Calsolaro, Rebecca Atkinson, Trudi Edginton, Rainer Hinz, David J Brooks, Paul Ediso. Microglial activation in early Alzheimer trajectory is associated with higher gray matter volume. Neurology. vol 92. issue 12. 2019-12-12. PMID:30796139. |
to investigate the influence of microglial activation in the early stages of alzheimer's disease trajectory, we assessed the relationship between microglial activation and gray matter volume and hippocampal volume in patients with mild cognitive impairment (mci). |
2019-12-12 |
2023-08-13 |
Not clear |
| Mostafa Mehdipour Ghazi, Mads Nielsen, Akshay Pai, M Jorge Cardoso, Marc Modat, Sébastien Ourselin, Lauge Sørense. Training recurrent neural networks robust to incomplete data: Application to Alzheimer's disease progression modeling. Medical image analysis. vol 53. 2019-12-11. PMID:30682584. |
the proposed lstm algorithm is applied to model the progression of alzheimer's disease (ad) using six volumetric magnetic resonance imaging (mri) biomarkers, i.e., volumes of ventricles, hippocampus, whole brain, fusiform, middle temporal gyrus, and entorhinal cortex, and it is compared to standard lstm networks with data imputation and a parametric, regression-based dpm method. |
2019-12-11 |
2023-08-13 |
human |
| Veronika Hanko, Alexandra C Apple, Kathryn I Alpert, Kristen N Warren, Julie A Schneider, Konstantinos Arfanakis, David A Bennett, Lei Wan. In vivo hippocampal subfield shape related to TDP-43, amyloid beta, and tau pathologies. Neurobiology of aging. vol 74. 2019-11-26. PMID:30453234. |
we used hippocampal shape analysis of ante-mortem t1-weighted structural magnetic resonance imaging images of 42 participants from two longitudinal cohort studies conducted by the rush alzheimer's disease center. |
2019-11-26 |
2023-08-13 |
human |
| Jeroen G J van Rooij, Lieke H H Meeter, Shami Melhem, Diana A T Nijholt, Tsz Hang Wong, Annemieke Rozemuller, Andre G Uitterlinden, Joyce G van Meurs, John C van Swiete. Hippocampal transcriptome profiling combined with protein-protein interaction analysis elucidates Alzheimer's disease pathways and genes. Neurobiology of aging. vol 74. 2019-11-26. PMID:30497016. |
hippocampal transcriptome profiling combined with protein-protein interaction analysis elucidates alzheimer's disease pathways and genes. |
2019-11-26 |
2023-08-13 |
Not clear |
| Yiming Chen, Huimin Fan, Chen Xu, Wenli Hu, Bingran Y. Efficient Cholera Toxin B Subunit-Based Nanoparticles with MRI Capability for Drug Delivery to the Brain Following Intranasal Administration. Macromolecular bioscience. vol 19. issue 2. 2019-11-26. PMID:30536989. |
alzheimer's disease (ad) is an incurable neurodegenerative brain disorder that exhibits clear pathologic changes in the hippocampus. |
2019-11-26 |
2023-08-13 |
Not clear |
| Yoko Eguchi, Yoshihiro Noda, Shinichiro Nakajima, Sakiko Tsugawa, Hisashi Kida, Eric Plitman, Ariel Graff-Guerrero, Mallar M Chakravarty, Midori Takayama, Yasumichi Arai, Hiroshi Matsuda, Masaru Mimura, Hidehito Niimur. Subiculum volumes associated with memory function in the oldest-old individuals aged 95 years and older. Geriatrics & gerontology international. vol 19. issue 4. 2019-11-26. PMID:30803149. |
the subiculum in the hippocampus is thought to be related to memory function, and atrophy of this structure might result in the conversion from amnestic mild cognitive impairment to alzheimer's disease. |
2019-11-26 |
2023-08-13 |
Not clear |
| Benjamin B Tournier, Stergios Tsartsalis, Daphney Rigaud, Christine Fossey, Thomas Cailly, Frédéric Fabis, Tien Pham, Marie-Claude Grégoire, Eniko Kövari, Marcelle Moulin-Sallanon, Armand Savioz, Philippe Mille. TSPO and amyloid deposits in sub-regions of the hippocampus in the 3xTgAD mouse model of Alzheimer's disease. Neurobiology of disease. vol 121. 2019-11-21. PMID:30261283. |
tspo and amyloid deposits in sub-regions of the hippocampus in the 3xtgad mouse model of alzheimer's disease. |
2019-11-21 |
2023-08-13 |
mouse |
| Tsugu, Ojika, Matsukawa, Iwase, Otsuka, Katada, Mitak. High levels of hippocampal cholinergic neurostimulating peptide (HCNP) in the CSF of some patients with Alzheimer's disease. European journal of neurology. vol 5. issue 6. 2019-11-20. PMID:10210891. |
high levels of hippocampal cholinergic neurostimulating peptide (hcnp) in the csf of some patients with alzheimer's disease. |
2019-11-20 |
2023-08-12 |
rat |
| McEwen, de Leon MJ, Lupien, Meane. Corticosteroids, the Aging Brain and Cognition. Trends in endocrinology and metabolism: TEM. vol 10. issue 3. 2019-11-20. PMID:10322401. |
for human brain aging, there are new non-invasive imaging tools to relate to the animal models, and these can help to assess the vulnerability of the aging hippocampus in relation to stress and alzheimer's disease. |
2019-11-20 |
2023-08-12 |
human |
| Gottwald, Rozansk. Rivastigmine, a brain-region selective acetylcholinesterase inhibitor for treating Alzheimer's disease: review and current status. Expert opinion on investigational drugs. vol 8. issue 10. 2019-11-20. PMID:11139819. |
alzheimer's disease is, in part, characterised by the loss of neurones in the basal forebrain cholinergic cells that project to the cerebral cortex and hippocampus. |
2019-11-20 |
2023-08-12 |
Not clear |
| W.J. McEntee, T.H. Croo. Cholinergic function in the aged brain: implications for treatment of memory impairments associated with aging. Behavioural pharmacology. vol 3. issue 4. 2019-11-20. PMID:11224135. |
unlike alzheimer's disease, it is not clear whether normal aging results in a loss of cholinergic innervation to cerebral cortex and hippocampus, but prevailing evidence suggests that certain aspects of brain cholinergic function are diminished with advancing age. |
2019-11-20 |
2023-08-12 |
human |
| G.A. Grigoryan, J.A. Gray, T. Rashid, A. Chadwick, H. Hodge. Conditionally immortal neuroepithelial stem cell grafts restore spatial learning in rats with lesions at the source of cholinergic forebrain projections cholinergic forebrain projections Conditionally immortal neuroepithelial stem cell grafts restore spatial leaming in rats with lesions at the source of cholinergic forebrain projections. Restorative neurology and neuroscience. vol 17. issue 4. 2019-11-20. PMID:11490086. |
purpose: loss of cholinergic projections from the basal forebrain (bf) to the cortex and from the medial septal area (msa) to tbe hippocampus is a reliable correlate of cognitive deficits in aging and alzheimer's disease (ad). |
2019-11-20 |
2023-08-12 |
human |