| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M. Galván, J.P. David, A. Delacourte, J. Luna, R. Men. Sequence of neurofibrillary changes in aging and Alzheimer's disease: A confocal study with phospho-tau antibody, AD2. Journal of Alzheimer's disease : JAD. vol 3. issue 4. 2019-11-20. PMID:12214046. |
in the present study, neurons of the entorhinal cortex, hippocampus and frontal lobe from non-demented and alzheimer's disease (ad) cases, were stained in order to study neurofibrillary changes. |
2019-11-20 |
2023-08-12 |
Not clear |
| Sheng-Zhou Wu, Angela M Bodles, Mandy M Porter, W Sue T Griffin, Anthony S Basile, Steven W Barge. Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide. Journal of neuroinflammation. vol 1. issue 1. 2019-11-20. PMID:15285800. |
the racemase mrna was also assayed in alzheimer hippocampus and age-matched controls. |
2019-11-20 |
2023-08-12 |
human |
| Sheng-Zhou Wu, Angela M Bodles, Mandy M Porter, W Sue T Griffin, Anthony S Basile, Steven W Barge. Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide. Journal of neuroinflammation. vol 1. issue 1. 2019-11-20. PMID:15285800. |
finally, the levels of serine racemase mrna were elevated in alzheimer's disease hippocampus, relative to age-matched controls. |
2019-11-20 |
2023-08-12 |
human |
| Susanna Rosi, Victor Ramirez-Amaya, Beatrice Hauss-Wegrzyniak, Gary L Wen. Chronic brain inflammation leads to a decline in hippocampal NMDA-R1 receptors. Journal of neuroinflammation. vol 1. issue 1. 2019-11-20. PMID:15285803. |
background: neuroinflammation plays a prominent role in the progression of alzheimer's disease and may be responsible for degeneration in vulnerable regions such as the hippocampus. |
2019-11-20 |
2023-08-12 |
rat |
| Zhijun Zhao, Gang Luo, Min Liu, Huining Guo, Mengzhou Xue, Xinchun Wang, Xin-Min Li, Jue H. Quetiapine reduces microglial number in the hippocampus of a transgenic mouse model of Alzheimer's disease. Neuroreport. vol 25. issue 11. 2019-11-20. PMID:24911389. |
quetiapine reduces microglial number in the hippocampus of a transgenic mouse model of alzheimer's disease. |
2019-11-20 |
2023-08-13 |
mouse |
| Zayda Lazcano, Oscar Solis, María Elena Bringas, Daniel Limón, Alfonso Diaz, Blanca Espinosa, Isabel García-Peláez, Gonzalo Flores, Jorge Guevar. Unilateral injection of Aβ Synapse (New York, N.Y.). vol 68. issue 12. 2019-11-20. PMID:25049192. |
unilateral injection of aβ alzheimer's disease (ad) is a neurodegenerative process exacerbated by several risk factors including impaired glucose metabolism in the brain that could cause molecular and neurochemical alterations in cognitive regions such as the hippocampus (hp). |
2019-11-20 |
2023-08-13 |
rat |
| Ashish Raj, Eve LoCastro, Amy Kuceyeski, Duygu Tosun, Norman Relkin, Michael Weine. Network Diffusion Model of Progression Predicts Longitudinal Patterns of Atrophy and Metabolism in Alzheimer's Disease. Cell reports. vol 10. issue 3. 2019-11-20. PMID:25600871. |
alzheimer's disease pathology (ad) originates in the hippocampus and subsequently spreads to temporal, parietal, and prefrontal association cortices in a relatively stereotyped progression. |
2019-11-20 |
2023-08-13 |
human |
| Dmitry Petrov, Ignacio Pedrós, Gonzalo Artiach, Francesc X Sureda, Emma Barroso, Mercè Pallàs, Gemma Casadesús, Carlos Beas-Zarate, Eva Carro, Isidro Ferrer, Manuel Vazquez-Carrera, Jaume Folch, Antoni Camin. High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents. Biochimica et biophysica acta. vol 1852. issue 9. 2019-11-20. PMID:26003667. |
high-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to alzheimer disease pathology in rodents. |
2019-11-20 |
2023-08-13 |
mouse |
| Sachin Suresh Tiwari, Keiko Mizuno, Anshua Ghosh, Wajeeha Aziz, Claire Troakes, Jason Daoud, Vidushi Golash, Wendy Noble, Tibor Hortobágyi, Karl Peter Gies. Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss. Brain : a journal of neurology. vol 139. issue Pt 10. 2019-11-20. PMID:27524794. |
first, in post-mortem tissue cyfip2 expression was reduced by ∼50% in severe alzheimer's hippocampus and superior temporal gyrus when normalized to expression of a neuronal or synaptic marker protein. |
2019-11-20 |
2023-08-13 |
mouse |
| Sachin Suresh Tiwari, Keiko Mizuno, Anshua Ghosh, Wajeeha Aziz, Claire Troakes, Jason Daoud, Vidushi Golash, Wendy Noble, Tibor Hortobágyi, Karl Peter Gies. Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss. Brain : a journal of neurology. vol 139. issue Pt 10. 2019-11-20. PMID:27524794. |
interestingly, there was also a trend for decreased expression in mild alzheimer's disease hippocampus. |
2019-11-20 |
2023-08-13 |
mouse |
| Ruth Sande. Exercise is associated with a delayed onset of dementia. Nursing older people. vol 18. issue 12. 2019-11-20. PMID:27732250. |
this might be because the area of the brain most susceptible to ischaemic damage, the hippocampus, which is also one of the earliest areas of the brain to be affected by alzheimer's disease, shows less tissue loss in older people with higher levels of physical activity. |
2019-11-20 |
2023-08-13 |
Not clear |
| Exercise is the best medicine. Nursing older people. vol 20. issue 7. 2019-11-20. PMID:27741713. |
researchers have shown that people with early stage alzheimer's disease suffer less shrinkage of the brain's memory centre - the hippocampus - if they take part in moderate exercise ( page 4 ). |
2019-11-20 |
2023-08-13 |
Not clear |
| Exercise slows Alzheimer's progression. Nursing older people. vol 20. issue 7. 2019-11-20. PMID:27741723. |
alzheimer's patients who exercise have less atrophy of the hippocampus structure in the brain compared with those who do not. |
2019-11-20 |
2023-08-13 |
Not clear |
| Tiffany J Mellott, Olivia M Huleatt, Bethany N Shade, Sarah M Pender, Yi B Liu, Barbara E Slack, Jan K Blusztaj. Correction: Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. PloS one. vol 12. issue 3. 2019-11-20. PMID:28334015. |
correction: perinatal choline supplementation reduces amyloidosis and increases choline acetyltransferase expression in the hippocampus of the appsweps1de9 alzheimer's disease model mice. |
2019-11-20 |
2023-08-13 |
mouse |
| Zsuzsanna Tucsek, M Noa Valcarcel-Ares, Stefano Tarantini, Andriy Yabluchanskiy, Gábor Fülöp, Tripti Gautam, Albert Orock, Anna Csiszar, Ferenc Deak, Zoltan Ungvar. Hypertension-induced synapse loss and impairment in synaptic plasticity in the mouse hippocampus mimics the aging phenotype: implications for the pathogenesis of vascular cognitive impairment. GeroScience. vol 39. issue 4. 2019-11-20. PMID:28664509. |
these hypertension-induced neuronal alterations may impair establishment of memories in the hippocampus and contribute to the pathogenesis and clinical manifestation of both vascular cognitive impairment (vci) and alzheimer's disease (ad). |
2019-11-20 |
2023-08-13 |
mouse |
| Lisa M McGinley, Osama N Kashlan, Kevin S Chen, Elizabeth S Bruno, John M Hayes, Carey Backus, Seth Feldman, Bader N Kashlan, Karl Johe, Eva L Feldma. Human neural stem cell transplantation into the corpus callosum of Alzheimer's mice. Annals of clinical and translational neurology. vol 4. issue 10. 2019-11-20. PMID:29046883. |
the hippocampus has been the target of stem cell transplantations in preclinical studies focused on alzheimer's disease, with results showing improvements in histological and behavioral outcomes. |
2019-11-20 |
2023-08-13 |
mouse |
| Yuan Zhang, Jianghao Zhao, Mingkang Yin, Yujie Cai, Shengyuan Liu, Yan Wang, Xingliang Zhang, Hao Cao, Ting Chen, Pengru Huang, Hui Mai, Zhou Liu, Hua Tao, Bin Zhao, Lili Cu. The influence of two functional genetic variants of GRK5 on tau phosphorylation and their association with Alzheimer's disease risk. Oncotarget. vol 8. issue 42. 2019-11-20. PMID:29069820. |
we confirmed that grk5 translocates from the cellular membrane to the cytosol in the hippocampus of alzheimer's disease mice and that grk5 deficiency promotes tau hyperphosphorylation, a hallmark of alzheimer's disease pathology. |
2019-11-20 |
2023-08-13 |
mouse |
| Kayla M Pate, Regina M Murph. Cerebrospinal Fluid Proteins as Regulators of Beta-amyloid Aggregation and Toxicity. Israel journal of chemistry. vol 57. issue 7-8. 2019-11-20. PMID:29129937. |
one defining diagnostic feature of alzheimer's disease is the deposition of beta-amyloid as extracellular plaques, primarily in the hippocampus. |
2019-11-20 |
2023-08-13 |
Not clear |
| S Tomaszewski, S Gauthier, A Wimo, P Rosa-Net. Combination Therapy of Anti-Tau and Anti-Amyloid Drugs for Disease Modification in Early-stage Alzheimer's Disease: Socio-economic Considerations Modeled on Treatments for Tuberculosis, HIV/AIDS and Breast Cancer. The journal of prevention of Alzheimer's disease. vol 3. issue 3. 2019-11-20. PMID:29205255. |
patients with alzheimer's disease (ad) are known to have characteristic pathology, including senile plaques with amyloid beta-protein aggregates and neurofibrillary tangles with assembled tau proteins, which start in the hippocampus and spread to neighboring areas. |
2019-11-20 |
2023-08-13 |
Not clear |
| Yu Sun, Yafei Wang, Jiaming Lu, Rengyuan Liu, Christopher G Schwarz, Hui Zhao, Yue Zhang, Lingyi Xu, Bin Zhu, Bing Zhang, Bing Liu, Suiren Wan, Yun X. Disrupted functional connectivity between perirhinal and parahippocampal cortices with hippocampal subfields in patients with mild cognitive impairment and Alzheimer's disease. Oncotarget. vol 8. issue 58. 2019-11-20. PMID:29228757. |
disrupted functional connectivity between perirhinal and parahippocampal cortices with hippocampal subfields in patients with mild cognitive impairment and alzheimer's disease. |
2019-11-20 |
2023-08-13 |
Not clear |