| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Hu, S L Côté, A C Cuell. Differential modulation of the cholinergic phenotype of the nucleus basalis magnocellularis neurons by applying NGF at the cell body or cortical terminal fields. Experimental neurology. vol 143. issue 1. 1997-02-28. PMID:9000455. |
more recently, it was further demonstrated that in alzheimer's disease (ad), the ngf peptide increased throughout the brain but decreased in the nucleus basalis magnocellularis (nbm), suggesting that there is an impaired retrograde transport of ngf from the cortex to the nbm. |
1997-02-28 |
2023-08-12 |
mouse |
| F Boissière, S Lehéricy, O Strada, Y Agid, E C Hirsc. Neurotrophin receptors and selective loss of cholinergic neurons in Alzheimer disease. Molecular and chemical neuropathology. vol 28. issue 1-3. 1997-01-23. PMID:8871962. |
the most consistent neuropathological finding in alzheimer disease (ad) is the loss of cholinergic neurons of the nucleus basalis of meynert (nbm). |
1997-01-23 |
2023-08-12 |
human |
| T Irie, K Fukushi, H Namba, M Iyo, H Tamagami, S Nagatsuka, N Ikot. Brain acetylcholinesterase activity: validation of a PET tracer in a rat model of Alzheimer's disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 37. issue 4. 1996-08-26. PMID:8691261. |
the purpose of this study was to examine whether the tracers would have the sensitivity needed for early diagnosis of alzheimer' disease using rats with a unilateral lesion in the nucleus basalis magnocellularis (nbm), an animal model of the cholinergic deficit in alzheimer's disease. |
1996-08-26 |
2023-08-12 |
rat |
| J N Crawle. Minireview. Galanin-acetylcholine interactions: relevance to memory and Alzheimer's disease. Life sciences. vol 58. issue 24. 1996-07-22. PMID:8649205. |
in alzheimer's disease, galanin is overexpressed in terminals innervating the nucleus basalis of meynert cell bodies. |
1996-07-22 |
2023-08-12 |
rat |
| P Riekkinen, M Riekkine. Effects of tetrahydroaminoacridine and nicotine in nucleus basalis and serotonin-lesioned rats. European journal of pharmacology. vol 279. issue 1. 1995-11-21. PMID:7556384. |
the present results suggest that, in alzheimer's disease, combined degeneration of nucleus basalis cholinergic and brainstem serotonergic cells decreases the therapeutic effect of nicotine, but not that of tetrahydroaminoacridine. |
1995-11-21 |
2023-08-12 |
rat |
| S A Scott, E J Mufson, J A Weingartner, K A Skau, K A Crutche. Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 15. issue 9. 1995-10-12. PMID:7666203. |
nerve growth factor in alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis. |
1995-10-12 |
2023-08-12 |
Not clear |
| E J Mufson, J M Conner, J H Kordowe. Nerve growth factor in Alzheimer's disease: defective retrograde transport to nucleus basalis. Neuroreport. vol 6. issue 7. 1995-09-12. PMID:7632896. |
nerve growth factor in alzheimer's disease: defective retrograde transport to nucleus basalis. |
1995-09-12 |
2023-08-12 |
Not clear |
| W C Benzing, E J Mufso. Apolipoprotein E immunoreactivity within neurofibrillary tangles: relationship to Tau and PHF in Alzheimer's disease. Experimental neurology. vol 132. issue 2. 1995-07-26. PMID:7540552. |
the present immunohistochemical study determined the relationship between apoe and the expression of the cytoskeletal protein tau (tau2) and paired helical filaments (phf), within the magnocellular neurons of the nucleus basalis of meynert and layer ii stellate neurons of the entorhinal cortex in alzheimer's disease (ad). |
1995-07-26 |
2023-08-12 |
human |
| G Pepeu, I Marconcini Pepe. Dysfunction of the brain cholinergic system during aging and after lesions of the nucleus basalis of Meynert. Journal of neural transmission. Supplementum. vol 44. 1995-04-27. PMID:7897390. |
in order to establish how closely the models mimic aging and alzheimer's disease, a comparison was made, using the extensive literature available, between brain cholinergic dysfunction in aging animals and man, and between that in animals with lesions of the nucleus basalis of meynert and in subjects affected by alzheimer's disease. |
1995-04-27 |
2023-08-12 |
human |
| G Pepeu, I Marconcini Pepe. Dysfunction of the brain cholinergic system during aging and after lesions of the nucleus basalis of Meynert. Journal of neural transmission. Supplementum. vol 44. 1995-04-27. PMID:7897390. |
a similarity can also be found between the cortical dysfunction induced by lesions of the nucleus basalis and that occurring in patients with alzheimer's disease. |
1995-04-27 |
2023-08-12 |
human |
| M Holzer, H P Holzapfel, D Zedlick, M K Brückner, T Arend. Abnormally phosphorylated tau protein in Alzheimer's disease: heterogeneity of individual regional distribution and relationship to clinical severity. Neuroscience. vol 63. issue 2. 1995-04-18. PMID:7891861. |
the distribution of abnormally phosphorylated tau proteins was investigated in a number of cortical areas and in the basal nucleus of meynert of 12 patients with alzheimer's disease. |
1995-04-18 |
2023-08-12 |
Not clear |
| W Wallace, D Brane, N Hsu, N Khowong, C R Merril, V Haroutunia. Characterization of gene expression in the cerebral cortices of rat brains containing subcortical lesions. Applied and theoretical electrophoresis : the official journal of the International Electrophoresis Society. vol 4. issue 1. 1995-02-03. PMID:7811765. |
neurotoxic lesion of the nucleus basalis of meynert in the rat brain, which results in the loss of subcortical cholinergic innervation to the cerebral cortex, is an animal model for the cortical cholinergic deficits that are characteristic of alzheimer's disease. |
1995-02-03 |
2023-08-12 |
rat |
| J W Unger, Y Schmid. Neuropeptide Y and somatostatin in the neocortex of young and aging rats: response to nucleus basalis lesions. Journal of chemical neuroanatomy. vol 7. issue 1-2. 1995-01-31. PMID:7802968. |
lesions of the nucleus basalis of meynert (nbm) have been used to mimic, in part, cholinergic deficits occurring in age-related neurodegenerative disorders, i.e., alzheimer's disease. |
1995-01-31 |
2023-08-12 |
rat |
| K Oyanagi, T Makifuchi, T Ohtoh, K M Chen, D C Gajdusek, T N Chase, F Ikut. The neostriatum and nucleus accumbens in parkinsonism-dementia complex of Guam: a pathological comparison with Alzheimer's disease and progressive supranuclear palsy. Acta neuropathologica. vol 88. issue 2. 1995-01-04. PMID:7985492. |
the neostriatum, nucleus accumbens and basal nucleus of meynert (bnm) in the parkinsonism-dementia complex of guam (guam pdc) were examined immunohistologically, ultrastructurally, quantitatively and topographically, and the results were compared with those in alzheimer's disease (ad) and progressive supranuclear palsy (psp). |
1995-01-04 |
2023-08-12 |
Not clear |
| J Blin, M F Piercey, M E Giuffra, M M Mouradian, T N Chas. Metabolic effects of scopolamine and physostigmine in human brain measured by positron emission tomography. Journal of the neurological sciences. vol 123. issue 1-2. 1994-09-19. PMID:8064320. |
two of the more consistent findings in alzheimer's disease are depressions in frontal and temporoparietal glucose metabolism and a loss of cholinergic neurons in the nucleus basalis of meynert. |
1994-09-19 |
2023-08-12 |
human |
| A Salehi, P J Lucassen, C W Pool, N K Gonatas, R Ravid, D F Swaa. Decreased neuronal activity in the nucleus basalis of Meynert in Alzheimer's disease as suggested by the size of the Golgi apparatus. Neuroscience. vol 59. issue 4. 1994-09-12. PMID:8058125. |
decreased neuronal activity in the nucleus basalis of meynert in alzheimer's disease as suggested by the size of the golgi apparatus. |
1994-09-12 |
2023-08-12 |
Not clear |
| A Salehi, P J Lucassen, C W Pool, N K Gonatas, R Ravid, D F Swaa. Decreased neuronal activity in the nucleus basalis of Meynert in Alzheimer's disease as suggested by the size of the Golgi apparatus. Neuroscience. vol 59. issue 4. 1994-09-12. PMID:8058125. |
in order to study changes in neuronal activity in the nucleus basalis of meynert in aging and alzheimer's disease, we applied a polyclonal antibody directed against the golgi apparatus on formalin-fixed, paraffin-embedded material. |
1994-09-12 |
2023-08-12 |
Not clear |
| A Salehi, P J Lucassen, C W Pool, N K Gonatas, R Ravid, D F Swaa. Decreased neuronal activity in the nucleus basalis of Meynert in Alzheimer's disease as suggested by the size of the Golgi apparatus. Neuroscience. vol 59. issue 4. 1994-09-12. PMID:8058125. |
a significant reduction of 49% in the size of the golgi apparatus was found in the entire population of nucleus basalis neurons in alzheimer's disease. |
1994-09-12 |
2023-08-12 |
Not clear |
| A Salehi, P J Lucassen, C W Pool, N K Gonatas, R Ravid, D F Swaa. Decreased neuronal activity in the nucleus basalis of Meynert in Alzheimer's disease as suggested by the size of the Golgi apparatus. Neuroscience. vol 59. issue 4. 1994-09-12. PMID:8058125. |
furthermore, although there was no significant decrease in the size of the persisting large neurons in the nucleus basalis of meynert, a significantly decreased size of the golgi apparatus was found in these neurons in alzheimer's disease. |
1994-09-12 |
2023-08-12 |
Not clear |
| A Salehi, P J Lucassen, C W Pool, N K Gonatas, R Ravid, D F Swaa. Decreased neuronal activity in the nucleus basalis of Meynert in Alzheimer's disease as suggested by the size of the Golgi apparatus. Neuroscience. vol 59. issue 4. 1994-09-12. PMID:8058125. |
these results suggest that the overall activity of nucleus basalis neurons is severely decreased in alzheimer's disease. |
1994-09-12 |
2023-08-12 |
Not clear |