| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W C Wallace, V Bragin, N K Robakis, K Sambamurti, D VanderPutten, C R Merril, K L Davis, A C Santucci, V Haroutunia. Increased biosynthesis of Alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of Meynert. Brain research. Molecular brain research. vol 10. issue 2. 1991-08-16. PMID:1649369. |
increased biosynthesis of alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of meynert. |
1991-08-16 |
2023-08-11 |
rat |
| I Iraizoz, S de Lacalle, L M Gonzal. Cell loss and nuclear hypertrophy in topographical subdivisions of the nucleus basalis of Meynert in Alzheimer's disease. Neuroscience. vol 41. issue 1. 1991-07-29. PMID:2057064. |
cell loss and nuclear hypertrophy in topographical subdivisions of the nucleus basalis of meynert in alzheimer's disease. |
1991-07-29 |
2023-08-11 |
Not clear |
| I Iraizoz, S de Lacalle, L M Gonzal. Cell loss and nuclear hypertrophy in topographical subdivisions of the nucleus basalis of Meynert in Alzheimer's disease. Neuroscience. vol 41. issue 1. 1991-07-29. PMID:2057064. |
the nucleus basalis of meynert was examined in six patients with alzheimer's disease and five age-matched controls. |
1991-07-29 |
2023-08-11 |
Not clear |
| I Iraizoz, S de Lacalle, L M Gonzal. Cell loss and nuclear hypertrophy in topographical subdivisions of the nucleus basalis of Meynert in Alzheimer's disease. Neuroscience. vol 41. issue 1. 1991-07-29. PMID:2057064. |
confirming previous neuropathological observations in alzheimer's disease, a neuronal loss of 43% in the anterior, 25% in the intermediate and 30.5% in the posterior subdivisions of the nucleus basalis of meynert was observed. |
1991-07-29 |
2023-08-11 |
Not clear |
| I Iraizoz, S de Lacalle, L M Gonzal. Cell loss and nuclear hypertrophy in topographical subdivisions of the nucleus basalis of Meynert in Alzheimer's disease. Neuroscience. vol 41. issue 1. 1991-07-29. PMID:2057064. |
the combined observation of cell loss and nuclear hypertrophy suggests that both regenerative and degenerative changes co-exist in the nucleus basalis in alzheimer's disease. |
1991-07-29 |
2023-08-11 |
Not clear |
| E Wülfer. [Pharmaceutical research strategies in Alzheimer's disease]. Journal de pharmacie de Belgique. vol 46. issue 1. 1991-07-25. PMID:2051302. |
the hypothesis that the symptomatology of alzheimer's disease is attributable to loss of cortical cholinergic innervation is supported by post-mortem studies demonstrating both reduced choline acetyltransferase (cat) activity and reduced high-affinity choline uptake (hacht) in the cortex, and neuron cell loss in the basal forebrain nucleus basalis of meynert. |
1991-07-25 |
2023-08-11 |
cat |
| T Nabeshima, S Ogawa, H Nishimura, K Fuji, T Kameyama, Y Sasak. Staurosporine facilitates recovery from the basal forebrain-lesion-induced impairment of learning and deficit of cholinergic neuron in rats. The Journal of pharmacology and experimental therapeutics. vol 257. issue 2. 1991-06-24. PMID:2033505. |
alzheimer's disease is characterized by the loss of cholinergic neurons in the nucleus basalis of meynert and by a primary loss of memory function. |
1991-06-24 |
2023-08-11 |
human |
| R Loy, D Heyer, M Clagett-Dame, P S DiStefan. Localization of NGF receptors in normal and Alzheimer's basal forebrain with monoclonal antibodies against the truncated form of the receptor. Journal of neuroscience research. vol 27. issue 4. 1991-04-26. PMID:1964180. |
the distribution of ngfr-containing neurons is similar to that previously described in normal human forebrain, as is the reduction in cell size in nucleus basalis (ch4am) in brains from patients with alzheimer's disease. |
1991-04-26 |
2023-08-11 |
human |
| M F Beal, U MacGarvey, K J Swart. Galanin immunoreactivity is increased in the nucleus basalis of Meynert in Alzheimer's disease. Annals of neurology. vol 28. issue 2. 1990-11-16. PMID:1699471. |
galanin immunoreactivity is increased in the nucleus basalis of meynert in alzheimer's disease. |
1990-11-16 |
2023-08-11 |
human |
| M F Beal, U MacGarvey, K J Swart. Galanin immunoreactivity is increased in the nucleus basalis of Meynert in Alzheimer's disease. Annals of neurology. vol 28. issue 2. 1990-11-16. PMID:1699471. |
a depletion of large cholinergic neurons in the nucleus basalis of meynert is a consistent finding in alzheimer's disease (ad). |
1990-11-16 |
2023-08-11 |
human |
| R L Neve, J Rogers, G A Higgin. The Alzheimer amyloid precursor-related transcript lacking the beta/A4 sequence is specifically increased in Alzheimer's disease brain. Neuron. vol 5. issue 3. 1990-10-19. PMID:2400606. |
in the present report, we demonstrate that a specific spliced form of mrna that is transcribed from the app gene and that lacks the beta/a4 sequence is elevated in the nucleus basalis, occipitotemporal cortex, and parahippocampal gyrus in alzheimer's disease brain relative to controls. |
1990-10-19 |
2023-08-11 |
Not clear |
| M Ruberg, W Mayo, A Brice, C Duyckaerts, J J Hauw, H Simon, M LeMoal, Y Agi. Choline acetyltransferase activity and [3H]vesamicol binding in the temporal cortex of patients with Alzheimer's disease, Parkinson's disease, and rats with basal forebrain lesions. Neuroscience. vol 35. issue 2. 1990-09-11. PMID:2166243. |
the number of binding sites was then determined in parallel with choline acetyltransferase activity in the temporal cortex of patients with alzheimer's disease, demented and non-demented patients with parkinson's disease, and in the cerebral cortex of rats with quisqualic acid lesions of the nucleus basalis magnocellularis. |
1990-09-11 |
2023-08-11 |
human |
| A M Palmer, S Gersho. Is the neuronal basis of Alzheimer's disease cholinergic or glutamatergic? FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 4. issue 10. 1990-08-30. PMID:2165009. |
the hypothesis that the symptomatology of alzheimer's disease is attributable to cholinergic dysfunction is supported by postmortem studies that have demonstrated reduced choline acetyltransferase (chat) activity across all areas of cerebral cortex and diminished numbers of perikarya in the basal forebrain nucleus basalis of meynert. |
1990-08-30 |
2023-08-11 |
Not clear |
| P Fischer, G Gatterer, M Simanyi, K Jellinger, A Marterer, K Danielczyk, W Danielczy. Memory deficits in advanced Parkinson's disease. Journal of neural transmission. Parkinson's disease and dementia section. vol 2. issue 1. 1990-08-02. PMID:2357271. |
we speculate that the isolated memory impairment in pd is associated with isolated neuronal loss in the nucleus basalis of meynert, without cortical or limbic pathology of the alzheimer's type. |
1990-08-02 |
2023-08-11 |
human |
| A M Iacopino, S Christako. Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegenerative diseases. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 11. 1990-07-12. PMID:2140897. |
comparison of diseased human brain tissue with age- and sex-matched controls yielded significant decreases (60-88%) in calbindin protein and mrna in the substantia nigra (parkinson disease), in the corpus striatum (huntington disease), in the nucleus basalis (alzheimer disease), and in the hippocampus and nucleus raphe dorsalis (parkinson, huntington, and alzheimer diseases) but not in the cerebellum, neocortex, amygdala, or locus ceruleus. |
1990-07-12 |
2023-08-11 |
human |
| O J Vogels, C A Broere, H J ter Laak, H J ten Donkelaar, R Nieuwenhuys, B P Schult. Cell loss and shrinkage in the nucleus basalis Meynert complex in Alzheimer's disease. Neurobiology of aging. vol 11. issue 1. 1990-05-15. PMID:2183081. |
cell loss and shrinkage in the nucleus basalis meynert complex in alzheimer's disease. |
1990-05-15 |
2023-08-11 |
Not clear |
| O J Vogels, C A Broere, H J ter Laak, H J ten Donkelaar, R Nieuwenhuys, B P Schult. Cell loss and shrinkage in the nucleus basalis Meynert complex in Alzheimer's disease. Neurobiology of aging. vol 11. issue 1. 1990-05-15. PMID:2183081. |
marked neuron loss in the nucleus basalis of meynert complex (nbmc) in alzheimer's disease has repeatedly been reported in the literature. |
1990-05-15 |
2023-08-11 |
Not clear |
| V Chan-Pala. Hyperinnervation of surviving neurons of the human basal nucleus of meynert by galanin in dementias of Alzheimer's and Parkinson's disease. Advances in neurology. vol 51. 1990-02-08. PMID:1688477. |
hyperinnervation of surviving neurons of the human basal nucleus of meynert by galanin in dementias of alzheimer's and parkinson's disease. |
1990-02-08 |
2023-08-11 |
human |
| K Wakabayashi, H Takahashi, F Ikuta, Y Homm. [An autopsy case of senile dementia with numerous neocortical senile plaques and preserved subcortical nuclei]. Rinsho shinkeigaku = Clinical neurology. vol 29. issue 9. 1990-02-08. PMID:2598544. |
no obvious neuronal loss was noted in the nucleus basalis of meynert, neostriatum, substantia nigra or locus ceruleus, which are well known to be involved in alzheimer's disease and sdat. |
1990-02-08 |
2023-08-11 |
Not clear |
| K Oyanagi, H Takahashi, K Wakabayashi, F Ikut. Correlative decrease of large neurons in the neostriatum and basal nucleus of Meynert in Alzheimer's disease. Brain research. vol 504. issue 2. 1990-02-06. PMID:2598036. |
correlative decrease of large neurons in the neostriatum and basal nucleus of meynert in alzheimer's disease. |
1990-02-06 |
2023-08-11 |
Not clear |