| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Carlos Baldermann, Katja Hardenacke, Xiaochen Hu, Phillip Köster, Andreas Horn, Hans-Joachim Freund, Karl Zilles, Volker Sturm, Veerle Visser-Vandewalle, Frank Jessen, David Maintz, Jens Kuh. Neuroanatomical Characteristics Associated With Response to Deep Brain Stimulation of the Nucleus Basalis of Meynert for Alzheimer's Disease. Neuromodulation : journal of the International Neuromodulation Society. vol 21. issue 2. 2018-08-07. PMID:28653404. |
neuroanatomical characteristics associated with response to deep brain stimulation of the nucleus basalis of meynert for alzheimer's disease. |
2018-08-07 |
2023-08-13 |
Not clear |
| John Noel M Viaña, Merlin Bittlinger, Frederic Gilber. Ethical Considerations for Deep Brain Stimulation Trials in Patients with Early-Onset Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 58. issue 2. 2018-03-16. PMID:28436389. |
several studies of deep brain stimulation (dbs) of the fornix or the nucleus basalis of meynert have been recently conducted in people with alzheimer's disease, with several recruiting participants <65 and thus have early-onset alzheimer's disease (eoad). |
2018-03-16 |
2023-08-13 |
human |
| Bettina Maria Foidl, Patricia Do-Dinh, Bianca Hutter-Schmid, Harald R Bliem, Christian Humpe. Cholinergic neurodegeneration in an Alzheimer mouse model overexpressing amyloid-precursor protein with the Swedish-Dutch-Iowa mutations. Neurobiology of learning and memory. vol 136. 2018-02-15. PMID:27670619. |
the aim of the present study was to examine (1) anxiety and cognition, (2) aβ plaque deposition and (3) degeneration of cholinergic neurons in the nucleus basalis of meynert (nbm) and cortical cholinergic innervation in an alzheimer mouse model (app_swedi; overexpressing amyloid precursor protein (app) with the swedish k670n/m671l, dutch e693q, and iowa d694n mutations). |
2018-02-15 |
2023-08-13 |
mouse |
| Chelsea T Tiernan, Stephen D Ginsberg, Angela L Guillozet-Bongaarts, Sarah M Ward, Bin He, Nicholas M Kanaan, Elliott J Mufson, Lester I Binder, Scott E Count. Protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of Alzheimer's disease. Neurobiology of aging. vol 42. 2017-09-19. PMID:27143424. |
protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of alzheimer's disease. |
2017-09-19 |
2023-08-13 |
human |
| Chelsea T Tiernan, Stephen D Ginsberg, Angela L Guillozet-Bongaarts, Sarah M Ward, Bin He, Nicholas M Kanaan, Elliott J Mufson, Lester I Binder, Scott E Count. Protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of Alzheimer's disease. Neurobiology of aging. vol 42. 2017-09-19. PMID:27143424. |
conformational phosphorylation and cleavage events drive the tau protein from a soluble, monomeric state to a relatively insoluble, polymeric state that precipitates the formation of neurofibrillary tangles (nfts) in projection neurons in alzheimer's disease (ad), including the magnocellular perikarya located in the nucleus basalis of meynert (nbm) complex of the basal forebrain. |
2017-09-19 |
2023-08-13 |
human |
| Nasrin Hosseini, Hojjatollah Alaei, Parham Reisi, Maryam Radahmad. The effects of NBM- lesion on synaptic plasticity in rats. Brain research. vol 1655. 2017-08-08. PMID:27867034. |
the nucleus basalis magnocellularis (nbm) is a major source of cholinergic projections to the neocortex that is vulnerable to degeneration in alzheimer's disease. |
2017-08-08 |
2023-08-13 |
rat |
| Iván Manuel, Laura Lombardero, Frank M LaFerla, Lydia Giménez-Llort, Rafael Rodríguez-Puerta. Activity of muscarinic, galanin and cannabinoid receptors in the prodromal and advanced stages in the triple transgenic mice model of Alzheimer's disease. Neuroscience. vol 329. 2017-07-26. PMID:27223629. |
neurochemical alterations in alzheimer's disease (ad) include cholinergic neuronal loss in the nucleus basalis of meynert (nbm) and a decrease in densities of the m2 muscarinic receptor subtype in areas related to learning and memory. |
2017-07-26 |
2023-08-13 |
mouse |
| Brian Spencer, Paula A Desplats, Cassia R Overk, Elvira Valera-Martin, Robert A Rissman, Chengbiao Wu, Michael Mante, Anthony Adame, Jazmin Florio, Edward Rockenstein, Eliezer Maslia. Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 30. 2017-07-10. PMID:27466341. |
alzheimer's disease (ad) is characterized by the progressive accumulation of amyloid β (aβ) and microtubule associate protein tau, leading to the selective degeneration of neurons in the neocortex, limbic system, and nucleus basalis, among others. |
2017-07-10 |
2023-08-13 |
mouse |
| Talita H Ferreira-Vieira, Isabella M Guimaraes, Flavia R Silva, Fabiola M Ribeir. Alzheimer's disease: Targeting the Cholinergic System. Current neuropharmacology. vol 14. issue 1. 2016-10-19. PMID:26813123. |
cholinergic neurons located in the basal forebrain, including the neurons that form the nucleus basalis of meynert, are severely lost in alzheimer's disease (ad). |
2016-10-19 |
2023-08-13 |
Not clear |
| Qiong-Bin Zhu, Unga Unmehopa, Koen Bossers, Yu-Ting Hu, Ronald Verwer, Rawien Balesar, Juan Zhao, Ai-Min Bao, Dick Swaa. MicroRNA-132 and early growth response-1 in nucleus basalis of Meynert during the course of Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 3. 2016-07-18. PMID:26792551. |
microrna-132 and early growth response-1 in nucleus basalis of meynert during the course of alzheimer's disease. |
2016-07-18 |
2023-08-13 |
Not clear |
| Qiong-Bin Zhu, Unga Unmehopa, Koen Bossers, Yu-Ting Hu, Ronald Verwer, Rawien Balesar, Juan Zhao, Ai-Min Bao, Dick Swaa. MicroRNA-132 and early growth response-1 in nucleus basalis of Meynert during the course of Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 3. 2016-07-18. PMID:26792551. |
the cholinergic nucleus basalis of meynert, which is important for memory functions, shows neuronal activation ('up-phase') during the early stages of alzheimer's disease and neurodegeneration ('down-phase') in later stages of alzheimer's disease. |
2016-07-18 |
2023-08-13 |
Not clear |
| Qiong-Bin Zhu, Unga Unmehopa, Koen Bossers, Yu-Ting Hu, Ronald Verwer, Rawien Balesar, Juan Zhao, Ai-Min Bao, Dick Swaa. MicroRNA-132 and early growth response-1 in nucleus basalis of Meynert during the course of Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 3. 2016-07-18. PMID:26792551. |
microrna-132 (mir-132) and the transcription factor early growth response-1 (egr1) were proposed as possible candidate molecules regulating such an up-down activity pattern of the nucleus basalis of meynert during the course of alzheimer's disease, as they both show this up-down pattern of expression in the prefrontal cortex during the course of alzheimer's disease. |
2016-07-18 |
2023-08-13 |
Not clear |
| Qiong-Bin Zhu, Unga Unmehopa, Koen Bossers, Yu-Ting Hu, Ronald Verwer, Rawien Balesar, Juan Zhao, Ai-Min Bao, Dick Swaa. MicroRNA-132 and early growth response-1 in nucleus basalis of Meynert during the course of Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 3. 2016-07-18. PMID:26792551. |
in the nucleus basalis of meynert, we investigated the expression of mir-132 and egr1 along the entire course of alzheimer's disease. |
2016-07-18 |
2023-08-13 |
Not clear |
| Qiong-Bin Zhu, Unga Unmehopa, Koen Bossers, Yu-Ting Hu, Ronald Verwer, Rawien Balesar, Juan Zhao, Ai-Min Bao, Dick Swaa. MicroRNA-132 and early growth response-1 in nucleus basalis of Meynert during the course of Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 3. 2016-07-18. PMID:26792551. |
forty-nine post-mortem nucleus basalis of meynert samples were studied, ranging from non-demented controls (braak stage = 0) to late alzheimer's disease patients (braak stage = vi), and from clinical reisberg scale 1 to 7. |
2016-07-18 |
2023-08-13 |
Not clear |
| Qiong-Bin Zhu, Unga Unmehopa, Koen Bossers, Yu-Ting Hu, Ronald Verwer, Rawien Balesar, Juan Zhao, Ai-Min Bao, Dick Swaa. MicroRNA-132 and early growth response-1 in nucleus basalis of Meynert during the course of Alzheimer's disease. Brain : a journal of neurology. vol 139. issue Pt 3. 2016-07-18. PMID:26792551. |
we found that the expression of mir-132 and egr1 in the nucleus basalis of meynert was quite stable during the early stages of alzheimer's disease and decreased significantly only during late alzheimer's disease stages. |
2016-07-18 |
2023-08-13 |
Not clear |
| Athanasios Alexandris, Alan King Lun Liu, Raymond Chuen-Chung Chang, Ronald K B Pearce, Steve M Gentlema. Differential expression of galanin in the cholinergic basal forebrain of patients with Lewy body disorders. Acta neuropathologica communications. vol 3. 2016-05-27. PMID:26621352. |
depletion of cholinergic neurons within the nucleus basalis of meynert (nbm) is thought to contribute to the development of cognitive impairments in both alzheimer's disease (ad) and lewy body disorders (lbd). |
2016-05-27 |
2023-08-13 |
Not clear |
| M Noreik, J Kuhn, K Hardenacke, D Lenartz, A Bauer, C P Bührle, P Häussermann, M Hellmich, J Klosterkötter, J Wiltfang, M Maarouf, H-J Freund, V Visser-Vandewalle, V Sturm, R-J Schul. Changes in Nutritional Status after Deep Brain Stimulation of the Nucleus Basalis of Meynert in Alzheimer's Disease--Results of a Phase I Study. The journal of nutrition, health & aging. vol 19. issue 8. 2016-04-25. PMID:26412285. |
changes in nutritional status after deep brain stimulation of the nucleus basalis of meynert in alzheimer's disease--results of a phase i study. |
2016-04-25 |
2023-08-13 |
Not clear |
| Yasumasa Yoshiyama, Ayako Kojima, Kimiko Itoh, Sagiri Isose, Mizuho Koide, Koji Hori, Kimihito Ara. Does Anticholinergic Activity Affect Neuropathology? Implication of Neuroinflammation in Alzheimer's Disease. Neuro-degenerative diseases. vol 15. issue 3. 2016-03-22. PMID:26138491. |
one characteristic neuropathological feature of alzheimer's disease (ad) is profound neuronal loss in the nucleus basalis of meynert, the major source of cholinergic innervation of the cerebral cortex. |
2016-03-22 |
2023-08-13 |
mouse |
| Jens Kuhn, Katja Hardenacke, Elena Shubina, Doris Lenartz, Veerle Visser-Vandewalle, Karl Zilles, Volker Sturm, Hans-Joachim Freun. Deep Brain Stimulation of the Nucleus Basalis of Meynert in Early Stage of Alzheimer's Dementia. Brain stimulation. vol 8. issue 4. 2016-03-04. PMID:25991080. |
deep brain stimulation of the nucleus basalis of meynert in early stage of alzheimer's dementia. |
2016-03-04 |
2023-08-13 |
Not clear |
| J Kuhn, K Hardenacke, D Lenartz, T Gruendler, M Ullsperger, C Bartsch, J K Mai, K Zilles, A Bauer, A Matusch, R-J Schulz, M Noreik, C P Bührle, D Maintz, C Woopen, P Häussermann, M Hellmich, J Klosterkötter, J Wiltfang, M Maarouf, H-J Freund, V Stur. Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer's dementia. Molecular psychiatry. vol 20. issue 3. 2016-03-03. PMID:24798585. |
deep brain stimulation of the nucleus basalis of meynert in alzheimer's dementia. |
2016-03-03 |
2023-08-13 |
Not clear |