| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sylvia E Perez, Damianka P Getova, Bin He, Scott E Counts, Changiz Geula, Laurent Desire, Severine Coutadeur, Helene Peillon, Stephen D Ginsberg, Elliott J Mufso. Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease. The American journal of pathology. vol 180. issue 2. 2012-03-25. PMID:22142809. |
rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in alzheimer's disease. |
2012-03-25 |
2023-08-12 |
Not clear |
| Sylvia E Perez, Damianka P Getova, Bin He, Scott E Counts, Changiz Geula, Laurent Desire, Severine Coutadeur, Helene Peillon, Stephen D Ginsberg, Elliott J Mufso. Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease. The American journal of pathology. vol 180. issue 2. 2012-03-25. PMID:22142809. |
cholinergic basal forebrain (cbf) nucleus basalis (nb) neurons display neurofibrillary tangles (nfts) during alzheimer's disease (ad) progression, yet the mechanisms underlying this selective vulnerability are currently unclear. |
2012-03-25 |
2023-08-12 |
Not clear |
| S George, E J Mufson, S Leurgans, R C Shah, C Ferrari, L deToledo-Morrel. MRI-based volumetric measurement of the substantia innominata in amnestic MCI and mild AD. Neurobiology of aging. vol 32. issue 10. 2011-12-15. PMID:20005600. |
the substantia innominata (si) contains the nucleus basalis of meynert, which provides the major cholinergic innervation to the entire cortical mantel and the amygdala; degeneration of nucleus basalis neurons correlates with cognitive decline in alzheimer's disease (ad). |
2011-12-15 |
2023-08-12 |
human |
| Reihaneh Hoveida, Hojjatallah Alaei, Shahrbanoo Oryan, Kazem Parivar, Parham Reis. Treadmill running improves spatial memory in an animal model of Alzheimer's disease. Behavioural brain research. vol 216. issue 1. 2011-02-18. PMID:20709113. |
alzheimer's disease (ad) is a progressive neurodegenerative disease that is characterized by a decline in cognitive function and severe neuronal loss in the cerebral cortex and certain subcortical regions of the brain including nucleus basalis magnocellularis (nbm) that play an important role in learning and memory. |
2011-02-18 |
2023-08-12 |
rat |
| J P Spencer, L J Middleton, C H Davie. Investigation into the efficacy of the acetylcholinesterase inhibitor, donepezil, and novel procognitive agents to induce gamma oscillations in rat hippocampal slices. Neuropharmacology. vol 59. issue 6. 2011-01-20. PMID:20600173. |
one of the major neuropathological hallmarks in alzheimer's disease (ad) is the loss of cholinergic neurones of the nucleus basalis of meynert (nbm). |
2011-01-20 |
2023-08-12 |
rat |
| Tong Zhang, Zhiping Mi, Nina F Scho. Role of tyrosine phosphorylation in the antioxidant effects of the p75 neurotrophin receptor. Oxidative medicine and cellular longevity. vol 2. issue 4. 2011-01-12. PMID:20716910. |
furthermore, oxidative and inflammatory injury to the cholinergic neurons of the nucleus basalis of meynert and hippocampus plays a critical role in the pathology of alzheimer's disease. |
2011-01-12 |
2023-08-12 |
rat |
| Ditte Z Christensen, Thomas A Bayer, Oliver Wirth. Intracellular Aß triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease. Neurobiology of aging. vol 31. issue 7. 2010-11-24. PMID:18771817. |
loss of cholinergic neurons in the nucleus basalis of meynert in alzheimer's disease (ad) patients was one of the first discoveries of neuron loss in ad. |
2010-11-24 |
2023-08-12 |
mouse |
| C Köhler, P Bista, J Götz, H Schröde. Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy. Brain research. vol 1347. 2010-11-02. PMID:20513372. |
to test the suitability of the pr5 model as a model of alzheimer's disease concerning the cholinergic innervation of the telencephalon, we determined the expression of the human tau transgene and the presence of neurofibrillary changes in the basal nucleus of meynert, the septal nuclei and the diagonal band of broca, sources of cholinergic innervation of the cerebral cortex and hippocampus. |
2010-11-02 |
2023-08-12 |
mouse |
| Akhlaq A Farooqu. Studies on plasmalogen-selective phospholipase A2 in brain. Molecular neurobiology. vol 41. issue 2-3. 2010-10-08. PMID:20049656. |
activities of plsetn-pla(2) are markedly increased in plasma membrane and synaptosomal plasma membrane fraction prepared from nucleus basalis and hippocampal region of brains from alzheimer disease patients compared to age-matched controls. |
2010-10-08 |
2023-08-12 |
Not clear |
| Markus Morawski, Maike Hartlage-Rübsamen, Carsten Jäger, Alexander Waniek, Stephan Schilling, Claudia Schwab, Patrick L McGeer, Thomas Arendt, Hans-Ulrich Demuth, Steffen Rossne. Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease. Acta neuropathologica. vol 120. issue 2. 2010-09-28. PMID:20383514. |
distinct glutaminyl cyclase expression in edinger-westphal nucleus, locus coeruleus and nucleus basalis meynert contributes to pglu-abeta pathology in alzheimer's disease. |
2010-09-28 |
2023-08-12 |
mouse |
| Scott E Counts, Bin He, Shaoli Che, Stephen D Ginsberg, Elliott J Mufso. Galanin fiber hyperinnervation preserves neuroprotective gene expression in cholinergic basal forebrain neurons in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 18. issue 4. 2010-09-16. PMID:19749437. |
fibers containing galanin (gal) hyperinnervate cholinergic basal forebrain (cbf) nucleus basalis neurons in late stage alzheimer's disease (ad), yet the molecular consequences of this phenomenon are unknown. |
2010-09-16 |
2023-08-12 |
human |
| Richard M van Rijn, In K Rhee, Robert Verpoort. Isolation of acetylcholinesterase inhibitory alkaloids from Nerine bowdenii. Natural product research. vol 24. issue 3. 2010-05-07. PMID:20140801. |
alzheimer's disease (ad) is associated with a steady loss of attention and memory, which has been correlated with the impairment of brain cholinergic neurotransmission, particularly a deficit of cholinergic neurons in the nucleus basalis of meynert. |
2010-05-07 |
2023-08-12 |
Not clear |
| Simona Eleuteri, Barbara Monti, Sara Brignani, Antonio Contestabil. Chronic dietary administration of valproic acid protects neurons of the rat nucleus basalis magnocellularis from ibotenic acid neurotoxicity. Neurotoxicity research. vol 15. issue 2. 2010-01-26. PMID:19384575. |
in this study, we have tested the neuroprotective potential of chronic (4 + 1 weeks) dietary administration of vpa on degeneration of cholinergic and gabaergic neurons of the rat nucleus basalis magnocellularis (nbm), injected with the excitotoxin, ibotenic acid (ibo), an animal models that is relevant for alzheimer's disease-like neurodegeneration. |
2010-01-26 |
2023-08-12 |
rat |
| Amalia M Dolga, Ivica Granic, Ingrid M Nijholt, Csaba Nyakas, Eddy A van der Zee, Paul G M Luiten, Ulrich L M Eise. Pretreatment with lovastatin prevents N-methyl-D-aspartate-induced neurodegeneration in the magnocellular nucleus basalis and behavioral dysfunction. Journal of Alzheimer's disease : JAD. vol 17. issue 2. 2009-12-16. PMID:19363269. |
we found that administration of lovastatin (20 mg/kg) significantly protects cholinergic neurons and their cortical projections against n-methyl-d-aspartate (60 nmol)-induced cell death in the magnocellular nucleus basalis, a neuronal cell group that is characteristically affected in alzheimer's disease. |
2009-12-16 |
2023-08-12 |
mouse |
| Vardan T Karamyan, Robert C Spet. Distribution of the non-AT1, non-AT2 angiotensin-binding site in the rat brain: preliminary characterization. Neuroendocrinology. vol 88. issue 4. 2009-02-19. PMID:18562784. |
very high to high binding also occurs in brain regions associated with the development of alzheimer's disease (nucleus basalis of meynert, substantia innominata). |
2009-02-19 |
2023-08-12 |
rat |
| Yan Qi Liang, Xiao Tian Huang, Xi Can Tan. Huperzine A reverses cholinergic and monoaminergic dysfunction induced by bilateral nucleus basalis magnocellularis injection of beta-amyloid peptide (1-40) in rats. Cellular and molecular neurobiology. vol 28. issue 1. 2009-01-28. PMID:17636406. |
(1) huperzine a, a promising therapeutic agent for alzheimer's disease (ad), was tested for its effects on cholinergic and monoaminergic dysfunction induced by injecting beta-amyloid peptide-(1-40) into nucleus basalis magnocellularis of the rat. |
2009-01-28 |
2023-08-12 |
rat |
| Scott E Counts, Bin He, Shaoli Che, Stephen D Ginsberg, Elliott J Mufso. Galanin hyperinnervation upregulates choline acetyltransferase expression in cholinergic basal forebrain neurons in Alzheimer's disease. Neuro-degenerative diseases. vol 5. issue 3-4. 2008-05-15. PMID:18322398. |
fibers containing galanin (gal) enlarge and hyperinnervate cholinergic basal forebrain (cbf) nucleus basalis (nb) neurons in late-stage alzheimer's disease (ad), yet the physiological consequences of this phenomenon are unclear. |
2008-05-15 |
2023-08-12 |
Not clear |
| Elliott J Mufson, Scott E Counts, Margaret Fahnestock, Stephen D Ginsber. Cholinotrophic molecular substrates of mild cognitive impairment in the elderly. Current Alzheimer research. vol 4. issue 4. 2008-02-01. PMID:17908035. |
cholinergic nucleus basalis (nb) neurons provide the major cholinergic innervation to the cortical mantle, are selectively vulnerable in late stage alzheimer's disease (ad) and require the neurotrophin, nerve growth factor (ngf) and its receptors (trka and p75(ntr)), for their survival. |
2008-02-01 |
2023-08-12 |
human |
| Scott E Counts, Bin He, Shaoli Che, Milos D Ikonomovic, Steven T DeKosky, Stephen D Ginsberg, Elliott J Mufso. Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease. Archives of neurology. vol 64. issue 12. 2008-01-02. PMID:18071042. |
dysfunction of basocortical cholinergic projection neurons of the nucleus basalis (nb) correlates with cognitive deficits in alzheimer disease (ad). |
2008-01-02 |
2023-08-12 |
Not clear |
| Hiroshige Fujishiro, Hiroyuki Umegaki, Daisuke Isojima, Hiroyasu Akatsu, Akihisa Iguchi, Kenji Kosak. Depletion of cholinergic neurons in the nucleus of the medial septum and the vertical limb of the diagonal band in dementia with Lewy bodies. Acta neuropathologica. vol 111. issue 2. 2007-10-30. PMID:16421740. |
the cholinergic basal forebrain is divided into four subregions (ch1-4), and cholinergic neuronal loss in the nucleus basalis of meynert (ch4) has been correlated with cognitive impairments in both alzheimer's disease (ad) and dementia with lewy bodies (dlb). |
2007-10-30 |
2023-08-12 |
Not clear |