| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M G Caporali, E Bronzetti, E Ciriaco, T Niglio, A Ricci, A Scotti de Carolis, F Ament. Changes in the intensity of sulfide staining in fronto-parietal cortex of the rat following nucleus basalis magnocellularis lesions: possible relevance to Alzheimer's disease. Archives of gerontology and geriatrics. vol 13. issue 2. 2005-03-10. PMID:15374428. |
changes in the intensity of sulfide staining in fronto-parietal cortex of the rat following nucleus basalis magnocellularis lesions: possible relevance to alzheimer's disease. |
2005-03-10 |
2023-08-12 |
rat |
| Scott E Counts, Muhammad Nadeem, Joanne Wuu, Stephen D Ginsberg, H Uri Saragovi, Elliott J Mufso. Reduction of cortical TrkA but not p75(NTR) protein in early-stage Alzheimer's disease. Annals of neurology. vol 56. issue 4. 2004-12-02. PMID:15455399. |
degeneration of cholinergic nucleus basalis (nb) cortical projection neurons is associated with cognitive decline in late-stage alzheimer's disease (ad). |
2004-12-02 |
2023-08-12 |
Not clear |
| Hiroyuki Ara. [Current therapies in dementia]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics. vol 41. issue 3. 2004-09-03. PMID:15237749. |
currently, cholinergic therapies for alzheimer's disease (ad) have been developed and widely accepted based upon an observation that presynaptic cholinergic neurons in the basal nucleus of meynert that widely project to the cerebral cortices are consistently damaged in ad brains. |
2004-09-03 |
2023-08-12 |
Not clear |
| K Herholz, S Weisenbach, G Zündorf, O Lenz, H Schröder, B Bauer, E Kalbe, W-D Heis. In vivo study of acetylcholine esterase in basal forebrain, amygdala, and cortex in mild to moderate Alzheimer disease. NeuroImage. vol 21. issue 1. 2004-03-26. PMID:14741650. |
it is currently unclear whether impairment of the cholinergic system is present in alzheimer disease (ad) already at an early stage and to what extent it depends on degeneration of the nucleus basalis of meynert (nbm). |
2004-03-26 |
2023-08-12 |
Not clear |
| E J G Dubelaar, R W H Verwer, M A Hofman, J J Van Heerikhuize, R Ravid, D E Swaa. ApoE epsilon4 genotype is accompanied by lower metabolic activity in nucleus basalis of Meynert neurons in Alzheimer patients and controls as indicated by the size of the Golgi apparatus. Journal of neuropathology and experimental neurology. vol 63. issue 2. 2004-03-24. PMID:14989602. |
apoe epsilon4 genotype is accompanied by lower metabolic activity in nucleus basalis of meynert neurons in alzheimer patients and controls as indicated by the size of the golgi apparatus. |
2004-03-24 |
2023-08-12 |
human |
| E J G Dubelaar, R W H Verwer, M A Hofman, J J Van Heerikhuize, R Ravid, D E Swaa. ApoE epsilon4 genotype is accompanied by lower metabolic activity in nucleus basalis of Meynert neurons in Alzheimer patients and controls as indicated by the size of the Golgi apparatus. Journal of neuropathology and experimental neurology. vol 63. issue 2. 2004-03-24. PMID:14989602. |
we previously found apolipoprotein (apoe) epsilon4-dependent lower metabolic activity in nucleus basalis of meynert (nbm) neurons in alzheimer disease (ad). |
2004-03-24 |
2023-08-12 |
human |
| Willy Mayo, Olivier George, Sonia Darbra, Jean-Jacques Bouyer, Monique Vallée, Muriel Darnaudéry, Marc Pallarès, Valérie Lemaire-Mayo, Michel Le Moal, Pier-Vincenzo Piazza, Nora Abrou. Individual differences in cognitive aging: implication of pregnenolone sulfate. Progress in neurobiology. vol 71. issue 1. 2004-01-16. PMID:14611866. |
preg-s infused at the level of ach cell bodies (nucleus basalis magnocellularis, nbm, or pedunculopontine nucleus, ppt) increases paradoxical sleep in young animals.finally, aging related cognitive dysfunctions, particularly those observed in alzheimer's disease, have also been related to alterations of mechanisms underlying cerebral plasticity. |
2004-01-16 |
2023-08-12 |
human |
| G L Wenk, K McGann, B Hauss-Wegrzyniak, S Ros. The toxicity of tumor necrosis factor-alpha upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation: implications for Alzheimer's disease. Neuroscience. vol 121. issue 3. 2004-01-09. PMID:14568031. |
the toxicity of tumor necrosis factor-alpha upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation: implications for alzheimer's disease. |
2004-01-09 |
2023-08-12 |
mouse |
| Yuriko Tanaka, Haruo Hanyu, Hirofumi Sakurai, Masaru Takasaki, Kimihiko Ab. Atrophy of the substantia innominata on magnetic resonance imaging predicts response to donepezil treatment in Alzheimer's disease patients. Dementia and geriatric cognitive disorders. vol 16. issue 3. 2003-11-05. PMID:12826736. |
to investigate whether atrophy of the substantia innominata as shown on magnetic resonance imaging (mri), reflecting degeneration of cholinergic neurons in the nucleus basalis of meynert, predicts response to donepezil treatment in patients with alzheimer's disease (ad), we studied correlations between the thickness of the substantia innominata and clinical efficacy. |
2003-11-05 |
2023-08-12 |
Not clear |
| H Shinotoh, K Fukushi, S Nagatsuka, N Tanaka, A Aotsuka, T Ota, H Namba, S Tanada, T Iri. The amygdala and Alzheimer's disease: positron emission tomographic study of the cholinergic system. Annals of the New York Academy of Sciences. vol 985. 2003-06-17. PMID:12724174. |
the primary transmitter deficit is cholinergic in alzheimer's disease (ad), and the amygdala receives a major cholinergic projection from the nucleus basalis of meynert (ch4), which may play an important role in the retention of affective conditioning and/or memory consolidation. |
2003-06-17 |
2023-08-12 |
Not clear |
| Chris Zarow, Scott A Lyness, James A Mortimer, Helena C Chu. Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases. Archives of neurology. vol 60. issue 3. 2003-04-03. PMID:12633144. |
neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in alzheimer and parkinson diseases. |
2003-04-03 |
2023-08-12 |
Not clear |
| Scott A Lyness, Chris Zarow, Helena C Chu. Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysis. Neurobiology of aging. vol 24. issue 1. 2003-03-26. PMID:12493547. |
cell counts in the cholinergic nucleus basalis (nb), noradrenergic locus coeruleus (lc), dopaminergic substantia nigra (sn), and the serotonergic dorsal raphe nucleus (drn) were assessed from primary-level reports in patients with alzheimer disease (ad) and in controls. |
2003-03-26 |
2023-08-12 |
Not clear |
| Elliott J Mufson, Scott E Counts, Stephen D Ginsber. Gene expression profiles of cholinergic nucleus basalis neurons in Alzheimer's disease. Neurochemical research. vol 27. issue 10. 2003-01-27. PMID:12462403. |
gene expression profiles of cholinergic nucleus basalis neurons in alzheimer's disease. |
2003-01-27 |
2023-08-12 |
human |
| Elliott J Mufson, Scott E Counts, Stephen D Ginsber. Gene expression profiles of cholinergic nucleus basalis neurons in Alzheimer's disease. Neurochemical research. vol 27. issue 10. 2003-01-27. PMID:12462403. |
cholinergic neurons of the nucleus basalis (nb) are selectively vulnerable in alzheimer's disease (ad), yet the molecular mechanisms associated with their dysfunction remain unknown. |
2003-01-27 |
2023-08-12 |
human |
| Tatjana A Ishunina, Bart Fisser, Dick F Swaa. Sex differences in androgen receptor immunoreactivity in basal forebrain nuclei of elderly and Alzheimer patients. Experimental neurology. vol 176. issue 1. 2002-08-16. PMID:12093089. |
the vertical limb of the diagonal band of broca (vdb or ch2) and the nucleus basalis of meynert (nbm or ch4) are major cholinergic nuclei of the human basal forebrain, a complex that is affected in alzheimer's disease (ad). |
2002-08-16 |
2023-08-12 |
human |
| Y Chu, E J Cochran, D A Bennett, E J Mufson, J H Kordowe. Down-regulation of trkA mRNA within nucleus basalis neurons in individuals with mild cognitive impairment and Alzheimer's disease. The Journal of comparative neurology. vol 437. issue 3. 2001-09-27. PMID:11494257. |
down-regulation of trka mrna within nucleus basalis neurons in individuals with mild cognitive impairment and alzheimer's disease. |
2001-09-27 |
2023-08-12 |
Not clear |
| T A Ishunina, D F Swaa. Increased expression of estrogen receptor alpha and beta in the nucleus basalis of Meynert in Alzheimer's disease. Neurobiology of aging. vol 22. issue 3. 2001-07-26. PMID:11378248. |
increased expression of estrogen receptor alpha and beta in the nucleus basalis of meynert in alzheimer's disease. |
2001-07-26 |
2023-08-12 |
human |
| T A Ishunina, D F Swaa. Increased expression of estrogen receptor alpha and beta in the nucleus basalis of Meynert in Alzheimer's disease. Neurobiology of aging. vol 22. issue 3. 2001-07-26. PMID:11378248. |
the human nucleus basalis of meynert (nbm) is severely affected in alzheimer's disease (ad). |
2001-07-26 |
2023-08-12 |
human |
| F Kagitani, S Uchida, H Hotta, A Sat. Effects of nicotine on blood flow and delayed neuronal death following intermittent transient ischemia in rat hippocampus. The Japanese journal of physiology. vol 50. issue 6. 2001-07-12. PMID:11173554. |
a cholinergic neural vasodilative response in the cerebral cortex and hippocampus, independent of metabolic vasodilation, was recently demonstrated by activating the nicotinic acetylcholine receptors (nachrs) via activation of cholinergic neurons originating in the nucleus basalis of meynert and septal complex in the basal forebrain and projecting to the cortex and hippocampus (see reviews by sato a and sato y: neurosci res 14: 242--274, 1992; sato a and sato y: alzheimer dis assoc disord 9: 28--38, 1995). |
2001-07-12 |
2023-08-12 |
rat |
| L Burghaus, U Schütz, K Simonnet, U Krempel, J Lindstrom, H Schröde. Nucleus basalis Meynert lesions and the expression of nicotinic acetylcholine receptor proteins in the rat frontal cerebral cortex. Neuroscience letters. vol 301. issue 2. 2001-05-24. PMID:11248435. |
an important feature of cholinergic dysfunction in alzheimer's disease (ad) is the degenerative loss of magnocellular cholinergic neurons in the basal nucleus of meynert. |
2001-05-24 |
2023-08-12 |
rat |