| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert A Culibrk, Katherine A Ebbert, Daniel J Yeisley, Rui Chen, Fatir A Qureshi, Juergen Hahn, Mariah S Hah. Impact of Suramin on Key Pathological Features of Sporadic Alzheimer's Disease-Derived Forebrain Neurons. Journal of Alzheimer's disease : JAD. 2024-03-01. PMID:38427475. |
impact of suramin on key pathological features of sporadic alzheimer's disease-derived forebrain neurons. |
2024-03-01 |
2024-03-04 |
Not clear |
| Savannah Lusk, Christopher S Ward, Andersen Chang, Avery Twitchell-Heyne, Shaun Fattig, Genevera Allen, Joanna L Jankowsky, Russell S Ra. An automated respiratory data pipeline for waveform characteristic analysis. The Journal of physiology. 2023-10-03. PMID:37786382. |
we demonstrate breathe easy's utility by examining a 2-year longitudinal study of an alzheimer's disease mouse model to assess contributions of forebrain pathology in disordered breathing. |
2023-10-03 |
2023-10-07 |
mouse |
| Savannah Lusk, Christopher S Ward, Andersen Chang, Avery Twitchell-Heyne, Shaun Fattig, Genevera Allen, Joanna L Jankowsky, Russell S Ra. An automated respiratory data pipeline for waveform characteristic analysis. The Journal of physiology. 2023-10-03. PMID:37786382. |
we validate breathe easy with a terabyte-scale alzheimer's dataset that examines the effects of forebrain pathology on respiratory function over 2 years of degeneration. |
2023-10-03 |
2023-10-07 |
mouse |
| Holly N Cukier, Carolina L Duarte, Mayra J Laverde-Paz, Shaina A Simon, Derek J Van Booven, Amanda T Miyares, Patrice L Whitehead, Kara L Hamilton-Nelson, Larry D Adams, Regina M Carney, Michael L Cuccaro, Jeffery M Vance, Margaret A Pericak-Vance, Anthony J Griswold, Derek M Dykxhoor. An Alzheimer's disease risk variant in TTC3 modifies the actin cytoskeleton organization and the PI3K-Akt signaling pathway in iPSC-derived forebrain neurons. Neurobiology of aging. vol 131. 2023-09-07. PMID:37677864. |
an alzheimer's disease risk variant in ttc3 modifies the actin cytoskeleton organization and the pi3k-akt signaling pathway in ipsc-derived forebrain neurons. |
2023-09-07 |
2023-10-07 |
Not clear |
| Jacob T Jackson, Stephen L Nutt, Matthew P McCormac. The Haematopoietically-expressed homeobox transcription factor: roles in development, physiology and disease. Frontiers in immunology. vol 14. 2023-07-03. PMID:37398663. |
hhex is also necessary for the developing forebrain and thyroid gland, with this reliance on hhex evident in its role in endocrine disorders later in life including a potential role in alzheimer's disease. |
2023-07-03 |
2023-08-14 |
mouse |
| Lanfang Li, Bing Zhang, Xiaomei Tang, Quntao Yu, Aodi He, Youming Lu, Xinyan L. A selective degeneration of cholinergic neurons mediated by NRADD in an Alzheimer's disease mouse model. Cell insight. vol 1. issue 6. 2023-05-16. PMID:37193353. |
cholinergic neurons in the basal forebrain constitute a major source of cholinergic inputs to the forebrain, modulate diverse functions including sensory processing, memory and attention, and are vulnerable to alzheimer's disease (ad). |
2023-05-16 |
2023-08-14 |
mouse |
| Therese C Alich, Pascal Röderer, Balint Szalontai, Kurt Golcuk, Shahan Tariq, Michael Peitz, Oliver Brüstle, Istvan Mod. Bringing to light the physiological and pathological firing patterns of human induced pluripotent stem cell-derived neurons using optical recordings. Frontiers in cellular neuroscience. vol 16. 2023-02-03. PMID:36733665. |
our system also performed well in hipsc-derived forebrain neurons where it detected spontaneous synchronous bursting behavior, thus opening the path to future applications in other cell types and disease models including parkinson's disease, alzheimer's disease, epilepsy, and schizophrenia, conditions associated with disturbances of neuronal activity and synchrony. |
2023-02-03 |
2023-08-14 |
human |
| Irene Puig-Parnau, Soleil Garcia-Brito, Laia Vila-Soles, Andrea Riberas, Laura Aldavert-Vera, Pilar Segura-Torres, Elisabet Kádár, Gemma Hugue. Intracranial self-stimulation of the medial forebrain bundle ameliorates memory disturbances and pathological hallmarks in an Alzheimer's disease model by intracerebral administration of amyloid-β in rats. Neuroscience. 2023-01-16. PMID:36646411. |
intracranial self-stimulation of the medial forebrain bundle ameliorates memory disturbances and pathological hallmarks in an alzheimer's disease model by intracerebral administration of amyloid-β in rats. |
2023-01-16 |
2023-08-14 |
rat |
| Prita R Asih, Kristie Stefanoska, Emmanuel Prikas, Arne Ittne. High level forebrain expression of active tau kinase p38γ exacerbates cognitive dysfunction in aged APP-transgenic alzheimer's mice. Neuroscience. 2022-01-15. PMID:35031398. |
high level forebrain expression of active tau kinase p38γ exacerbates cognitive dysfunction in aged app-transgenic alzheimer's mice. |
2022-01-15 |
2023-08-13 |
mouse |
| Janise N Kuehner, Junyu Chen, Emily C Bruggeman, Feng Wang, Yangping Li, Chongchong Xu, Zachary T McEachin, Ziyi Li, Li Chen, Chadwick M Hales, Zhexing Wen, Jingjing Yang, Bing Ya. 5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer's disease. Cell reports. vol 35. issue 4. 2021-12-07. PMID:33910000. |
5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in alzheimer's disease. |
2021-12-07 |
2023-08-13 |
human |
| Saravanan Subramaniam, David T Blake, Christos Constantinidi. Cholinergic Deep Brain Stimulation for Memory and Cognitive Disorders. Journal of Alzheimer's disease : JAD. vol 83. issue 2. 2021-11-18. PMID:34334401. |
high-frequency, continuous stimulation is used for movement disorders as a way of inhibiting their output; however, no overexcitation has been hypothesized in alzheimer's disease and lower stimulation frequency or intermittent patterns of stimulation (periods of stimulation interleaved with periods of no stimulation) are likely to be more effective for stimulation of the cholinergic forebrain. |
2021-11-18 |
2023-08-13 |
human |
| Julie C Lauterborn, Pietro Scaduto, Conor D Cox, Anton Schulmann, Gary Lynch, Christine M Gall, C Dirk Keene, Agenor Limo. Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer's disease. Nature communications. vol 12. issue 1. 2021-06-02. PMID:33972518. |
synaptic disturbances in excitatory to inhibitory (e/i) balance in forebrain circuits are thought to contribute to the progression of alzheimer's disease (ad) and dementia, although direct evidence for such imbalance in humans is lacking. |
2021-06-02 |
2023-08-13 |
Not clear |
| Larry W Swanson, Joel D Hahn, Olaf Sporn. Structure-function subsystem models of female and male forebrain networks integrating cognition, affect, behavior, and bodily functions. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 49. 2021-01-21. PMID:33229546. |
targeted computational (virtual) lesioning of specific regions of interest associated with alzheimer's disease, clinical depression, and other disorders may begin to clarify how the effects spread through the entire forebrain network model. |
2021-01-21 |
2023-08-13 |
rat |
| Sarah C Kelly, Erin C McKay, John S Beck, Timothy J Collier, Anne M Dorrance, Scott E Count. Locus Coeruleus Degeneration Induces Forebrain Vascular Pathology in a Transgenic Rat Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 70. issue 2. 2020-10-01. PMID:31177220. |
locus coeruleus degeneration induces forebrain vascular pathology in a transgenic rat model of alzheimer's disease. |
2020-10-01 |
2023-08-13 |
rat |
| Suji Ham, Tae K Kim, Heeok Hong, Yong S Kim, Ya-Ping Tang, Heh-In I. Big Data Analysis of Genes Associated With Neuropsychiatric Disorders in an Alzheimer's Disease Animal Model. Frontiers in neuroscience. vol 12. 2020-09-29. PMID:29962931. |
here, we explore the comprehensive changes in gene expression of genes that are associated with bipolar disorder, schizophrenia, and major depression disorder through the microarray of an alzheimer's disease animal model, the forebrain specific psen double knockout mouse. |
2020-09-29 |
2023-08-13 |
mouse |
| Suji Ham, Tae K Kim, Heeok Hong, Yong S Kim, Ya-Ping Tang, Heh-In I. Big Data Analysis of Genes Associated With Neuropsychiatric Disorders in an Alzheimer's Disease Animal Model. Frontiers in neuroscience. vol 12. 2020-09-29. PMID:29962931. |
our study revealed that the forebrain specific deletion of alzheimer's disease genes can significantly alter neuropsychiatric disorder associated genes. |
2020-09-29 |
2023-08-13 |
mouse |
| Kurt R Lehner, Harold A Silverman, Meghan E Addorisio, Ashbeel Roy, Mohammed A Al-Onaizi, Yaakov Levine, Peder S Olofsson, Sangeeta S Chavan, Robert Gros, Neil M Nathanson, Yousef Al-Abed, Christine N Metz, Vania F Prado, Marco A M Prado, Kevin J Tracey, Valentin A Pavlo. Forebrain Cholinergic Signaling Regulates Innate Immune Responses and Inflammation. Frontiers in immunology. vol 10. 2020-09-24. PMID:31024522. |
these findings reveal that forebrain cholinergic neurons regulate innate immune responses and inflammation, suggesting the possibility that in diseases associated with cholinergic dysfunction, including alzheimer's disease this anti-inflammatory regulation can be impaired. |
2020-09-24 |
2023-08-13 |
mouse |
| Balvindar Singh, Ana Covelo, Héctor Martell-Martínez, Carmen Nanclares, Mathew A Sherman, Emmanuel Okematti, Joyce Meints, Peter J Teravskis, Christopher Gallardo, Alena V Savonenko, Michael A Benneyworth, Sylvain E Lesné, Dezhi Liao, Alfonso Araque, Michael K Le. Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathy. Acta neuropathologica. vol 138. issue 4. 2020-08-04. PMID:31168644. |
however, it is currently unknown how αs abnormalities contribute to memory loss, particularly since forebrain neuronal loss in pdd and dlb is less severe than in alzheimer's disease. |
2020-08-04 |
2023-08-13 |
mouse |
| Patricia Panther, Maria Kuehne, Jürgen Voges, Sven Nullmeier, Jörn Kaufmann, Janet Hausmann, Daniel Bittner, Imke Galazky, Hans-Jochen Heinze, Andreas Kupsch, Tino Zaehl. Electric stimulation of the medial forebrain bundle influences sensorimotor gaiting in humans. BMC neuroscience. vol 20. issue 1. 2020-01-28. PMID:31035935. |
in the present study, three patients with early dementia of alzheimer type underwent dbs of the median forebrain bundle (mfb) in a compassionate use program to maintain cognitive abilities. |
2020-01-28 |
2023-08-13 |
Not clear |
| Melissa J Alldred, Helen M Chao, Sang Han Lee, Judah Beilin, Brian E Powers, Eva Petkova, Barbara J Strupp, Stephen D Ginsber. CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementation. Hippocampus. vol 28. issue 4. 2019-04-15. PMID:29394516. |
although there are changes in gene expression and alterations in neuronal density and afferent inputs in the forebrain of trisomic mouse models of down syndrome (ds) and alzheimer's disease (ad), there is a lack of systematic assessments of gene expression and encoded proteins within individual vulnerable cell populations, precluding translational investigations at the molecular and cellular level. |
2019-04-15 |
2023-08-13 |
mouse |