| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Termpanit Chalermpalanupap, Jason P Schroeder, Jacki M Rorabaugh, L Cameron Liles, James J Lah, Allan I Levey, David Weinshenke. Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 1. 2019-02-21. PMID:29133432. |
the brainstem locus coeruleus (lc) supplies norepinephrine to the forebrain and degenerates in alzheimer's disease (ad). |
2019-02-21 |
2023-08-13 |
mouse |
| Vânia L Batalha, Diana G Ferreira, Joana E Coelho, Jorge S Valadas, Rui Gomes, Mariana Temido-Ferreira, Tatiana Shmidt, Younis Baqi, Luc Buée, Christa E Müller, Malika Hamdane, Tiago F Outeiro, Michael Bader, Sebastiaan H Meijsing, Ghazaleh Sadri-Vakili, David Blum, Luísa V Lope. The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function. Scientific reports. vol 6. 2018-05-30. PMID:27510168. |
caffeine is associated with procognitive effects in humans by counteracting overactivation of the adenosine a2a receptor (a2ar), which is upregulated in the human forebrain of aged and alzheimer's disease (ad) patients. |
2018-05-30 |
2023-08-13 |
human |
| Gerhard Rammes, Corinna Mattusch, Matthias Wulff, Franziska Seeser, Matthias Kreuzer, Kaichuan Zhu, Jan M Deussing, Jochen Herms, Chris G Parson. Involvement of GluN2B subunit containing N-methyl-d-aspartate (NMDA) receptors in mediating the acute and chronic synaptotoxic effects of oligomeric amyloid-beta (Aβ) in murine models of Alzheimer's disease (AD). Neuropharmacology. vol 123. 2018-05-09. PMID:28174113. |
to elucidate whether a permanent reduction of the glun2b subunit affects the pathology of alzheimer's disease (ad), we cross-bred mice heterozygous for glun2b receptors in the forebrain (hetglun2b) with a mouse model for ad carrying a mutated amyloid precursor protein with the swedish and arctic mutation (mapp) resulting in a hetglun2b/mapp transgenic. |
2018-05-09 |
2023-08-13 |
mouse |
| Giancarlo Pepeu, Maria Grazia Giovannin. The fate of the brain cholinergic neurons in neurodegenerative diseases. Brain research. vol 1670. 2018-04-26. PMID:28652219. |
in alzheimer's disease there is an extensive loss of forebrain cholinergic neurons accompanied by a reduction of the cholinergic fiber network of the cortical mantel and hippocampus. |
2018-04-26 |
2023-08-13 |
Not clear |
| Martin Engel, Dzung Do-Ha, Sonia Sanz Muñoz, Lezanne Oo. Common pitfalls of stem cell differentiation: a guide to improving protocols for neurodegenerative disease models and research. Cellular and molecular life sciences : CMLS. vol 73. issue 19. 2017-08-04. PMID:27154043. |
we have analyzed the literature that describes differentiation of human pluripotent stem cells into three neural cell types that are commonly used to study diseases, including forebrain cholinergic neurons for alzheimer's disease, midbrain dopaminergic neurons for parkinson's disease and cortical astrocytes for neurodegenerative and psychiatric disorders. |
2017-08-04 |
2023-08-13 |
human |
| Viviana Triaca, Valentina Sposato, Giulia Bolasco, Maria Teresa Ciotti, Piergiuseppe Pelicci, Amalia C Bruni, Chiara Cupidi, Raffaele Maletta, Marco Feligioni, Robert Nisticò, Nadia Canu, Pietro Calissan. NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease. Aging cell. vol 15. issue 4. 2017-06-05. PMID:27076121. |
ngf has been implicated in forebrain neuroprotection from amyloidogenesis and alzheimer's disease (ad). |
2017-06-05 |
2023-08-13 |
mouse |
| L Y Shields, H Kim, L Zhu, D Haddad, A Berthet, D Pathak, M Lam, R Ponnusamy, L G Diaz-Ramirez, T M Gill, H Sesaki, L Mucke, K Nakamur. Dynamin-related protein 1 is required for normal mitochondrial bioenergetic and synaptic function in CA1 hippocampal neurons. Cell death & disease. vol 6. 2016-09-29. PMID:25880092. |
to study drp1 in a neuronal population affected by alzheimer's disease (ad), stroke, and seizure disorders, we postnatally deleted drp1 from ca1 and other forebrain neurons in mice (camkii-cre, drp1lox/lox (drp1cko)). |
2016-09-29 |
2023-08-13 |
mouse |
| Sabine Hellwig, Annette Masuch, Sigrun Nestel, Natalie Katzmarski, Melanie Meyer-Luehmann, Knut Bibe. Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-β plaque formation in organotypic hippocampal slice cultures. Scientific reports. vol 5. 2016-08-08. PMID:26416689. |
the capacity to prevent aβ plaque formation was absent in forebrain microglia from young adult but not juvenile 5xfamilial alzheimer's disease (fad) mice. |
2016-08-08 |
2023-08-13 |
mouse |
| Laura K Hamilton, Martin Dufresne, Sandra E Joppé, Sarah Petryszyn, Anne Aumont, Frédéric Calon, Fanie Barnabé-Heider, Alexandra Furtos, Martin Parent, Pierre Chaurand, Karl J L Fernande. Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer's Disease. Cell stem cell. vol 17. issue 4. 2016-06-20. PMID:26321199. |
aberrant lipid metabolism in the forebrain niche suppresses adult neural stem cell proliferation in an animal model of alzheimer's disease. |
2016-06-20 |
2023-08-13 |
mouse |
| Laura K Hamilton, Martin Dufresne, Sandra E Joppé, Sarah Petryszyn, Anne Aumont, Frédéric Calon, Fanie Barnabé-Heider, Alexandra Furtos, Martin Parent, Pierre Chaurand, Karl J L Fernande. Aberrant Lipid Metabolism in the Forebrain Niche Suppresses Adult Neural Stem Cell Proliferation in an Animal Model of Alzheimer's Disease. Cell stem cell. vol 17. issue 4. 2016-06-20. PMID:26321199. |
we found that postmortem ad brains and triple-transgenic alzheimer's disease (3xtg-ad) mice accumulate neutral lipids within ependymal cells, the main support cell of the forebrain nsc niche. |
2016-06-20 |
2023-08-13 |
mouse |
| Hai-Xia Zhu, Zhi-Qin Xue, Wen-Ying Qiu, Zhao-Jun Zeng, Jia-Pei Dai, Chao Ma, Xue-Gang Luo, Xiao-Xin Ya. Age-related intraneuronal accumulation of αII-spectrin breakdown product SBDP120 in the human cerebrum is enhanced in Alzheimer's disease. Experimental gerontology. vol 69. 2016-05-31. PMID:26051930. |
in rodents, intraneuronal sbdp120 accumulation in the forebrain develops with age, which is enhanced in transgenic models of alzheimer's disease (ad). |
2016-05-31 |
2023-08-13 |
human |
| Bin Liu, Carrie H Croy, Stephen A Hitchcock, Jennifer R Allen, Zhigang Rao, David Evans, Mark G Bures, David L McKinzie, Marla Leigh Watt, G Stuart Gregory, Marvin M Hansen, Paul J Hoogestraat, James A Jamison, Fese M Okha-Mokube, Robert E Stratford, William Turner, Frank Bymaster, Christian C Felde. Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M₁ agonists. Bioorganic & medicinal chemistry letters. vol 25. issue 19. 2016-05-24. PMID:26299349. |
the observation that cholinergic deafferentation of circuits projecting from forebrain basal nuclei to frontal and hippocampal circuits occurs in alzheimer's disease has led to drug-targeting of muscarinic m1 receptors to alleviate cognitive symptoms. |
2016-05-24 |
2023-08-13 |
Not clear |
| Xia Liu, Keqiang Ye, David Weinshenke. Norepinephrine Protects against Amyloid-β Toxicity via TrkB. Journal of Alzheimer's disease : JAD. vol 44. issue 1. 2015-09-10. PMID:25208620. |
the locus coeruleus (lc), the brainstem noradrenergic nucleus that is the sole source of norepinephrine (ne) in the forebrain, is one of the first structures affected in alzheimer's disease (ad). |
2015-09-10 |
2023-08-13 |
Not clear |
| Milena Moretti, Michele Zoli, Andrew A George, Ronald J Lukas, Francesco Pistillo, Uwe Maskos, Paul Whiteaker, Cecilia Gott. The novel α7β2-nicotinic acetylcholine receptor subtype is expressed in mouse and human basal forebrain: biochemical and pharmacological characterization. Molecular pharmacology. vol 86. issue 3. 2014-09-29. PMID:25002271. |
this study represents the first direct confirmation of α7β2-nachr expression in human and mouse forebrain, supporting previous mouse studies that suggested relevance of α7β2-nachrs in alzheimer disease etiopathogenesis. |
2014-09-29 |
2023-08-13 |
mouse |
| Michel Grothe, Helmut Heinsen, Stefan Teipe. Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer's disease. Neurobiology of aging. vol 34. issue 4. 2013-08-01. PMID:23158764. |
longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to alzheimer's disease. |
2013-08-01 |
2023-08-12 |
human |
| N Iu Gerasimov, A N Goloshchapov, E B Burlakov. [Investigation of changes in fluidity of brain membranes in mice bearing experimental Alzheimer's disease using spin labeling electron paramagnetic resonance]. Biofizika. vol 58. issue 2. 2013-07-01. PMID:23755550. |
changes in fluidity of membranes isolated from the microsomal and crude synaptosomal fractions which were obtained from forebrain tissue of mice bearing experimental alzheimer's disease induced with olfactory bulbectomy were studied. |
2013-07-01 |
2023-08-12 |
mouse |
| Larry Schmued, James Raymick, William Tolleson, Sumit Sarkar, Yi-Hong Zhang, Ashlee Bell-Coh. Introducing Amylo-Glo, a novel fluorescent amyloid specific histochemical tracer especially suited for multiple labeling and large scale quantification studies. Journal of neuroscience methods. vol 209. issue 1. 2012-11-23. PMID:22705750. |
one of the hallmark pathologies associated with alzheimer's disease (ad) is the conspicuous deposition of extracellular amyloid plaques within the forebrain. |
2012-11-23 |
2023-08-12 |
Not clear |
| A Claudio Cuell. Gangliosides, NGF, brain aging and disease: a mini-review with personal reflections. Neurochemical research. vol 37. issue 6. 2012-08-31. PMID:22484968. |
furthermore, we have gathered neurochemical evidence for a compromise of this newly discovered ngf metabolic pathway in alzheimer's disease, explaining the vulnerability of ngf-dependent forebrain cholinergic neurons in this disease despite normal ngf synthesis and abundance of ngf precursor. |
2012-08-31 |
2023-08-12 |
Not clear |
| E I Chumasov, D É Korzhevskiĭ, E S Petrova, N N Kuznetsova, N S Saprono. [Glial reaction in the forebrain subventricular zone in the rat model of Alzheimer's disease]. Morfologiia (Saint Petersburg, Russia). vol 137. issue 6. 2011-05-12. PMID:21513101. |
[glial reaction in the forebrain subventricular zone in the rat model of alzheimer's disease]. |
2011-05-12 |
2023-08-12 |
rat |
| Tanja Kuczera, Roman Manuel Stilling, Hung-En Hsia, Sanaz Bahari-Javan, Stefan Irniger, Kim Nasmyth, Farahnaz Sananbenesi, Andre Fische. The anaphase promoting complex is required for memory function in mice. Learning & memory (Cold Spring Harbor, N.Y.). vol 18. issue 1. 2011-04-11. PMID:21191042. |
in our experimental setting loss of apc2 form principle forebrain neurons did not affect the course of pathology in an alzheimer's disease mouse model. |
2011-04-11 |
2023-08-12 |
mouse |