| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alcyr A Oliveira, Helen M Hodge. Alzheimer's disease and neural transplantation as prospective cell therapy. Current Alzheimer research. vol 2. issue 1. 2005-10-06. PMID:15977991. |
it has long been recognised that alzheimer's disease (ad) patients present an irreversible decline of cognitive functions as consequence of cell deterioration in the forebrain cholinergic projection system (fcps), particularly, in a structure called nucleus basalis of meynert (nbm). |
2005-10-06 |
2023-08-12 |
Not clear |
| Eugenio Mocchegiani, Carlo Bertoni-Freddari, Fiorella Marcellini, Marco Malavolt. Brain, aging and neurodegeneration: role of zinc ion availability. Progress in neurobiology. vol 75. issue 6. 2005-09-08. PMID:15927345. |
alterations in zinc homeostasis have been reported in parkinson's and alzheimer's disease as well as in transient forebrain ischemia, seizures and traumatic brain injury, but little is known regarding aged brain. |
2005-09-08 |
2023-08-12 |
Not clear |
| L Ris, M Angelo, F Plattner, B Capron, M L Errington, T V P Bliss, E Godaux, K P Gies. Sexual dimorphisms in the effect of low-level p25 expression on synaptic plasticity and memory. The European journal of neuroscience. vol 21. issue 11. 2005-08-24. PMID:15978013. |
p25, a degradation product of p35, has been reported to accumulate in the forebrain of patients with alzheimer's disease. |
2005-08-24 |
2023-08-12 |
mouse |
| H-G Bernstein, M Blazejczyk, T Rudka, E D Gundelfinger, H Dobrowolny, B Bogerts, M R Kreutz, J Kuznicki, U Wojd. The Alzheimer disease-related calcium-binding protein Calmyrin is present in human forebrain with an altered distribution in Alzheimer's as compared to normal ageing brains. Neuropathology and applied neurobiology. vol 31. issue 3. 2005-07-26. PMID:15885068. |
the alzheimer disease-related calcium-binding protein calmyrin is present in human forebrain with an altered distribution in alzheimer's as compared to normal ageing brains. |
2005-07-26 |
2023-08-12 |
human |
| Mark H Tuszynski, Leon Thal, Mary Pay, David P Salmon, Hoi Sang U, Roy Bakay, Piyush Patel, Armin Blesch, H Lee Vahlsing, Gilbert Ho, Gang Tong, Steven G Potkin, James Fallon, Lawrence Hansen, Elliott J Mufson, Jeffrey H Kordower, Christine Gall, James Conne. A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nature medicine. vol 11. issue 5. 2005-07-12. PMID:15852017. |
we performed a phase 1 trial of ex vivo ngf gene delivery in eight individuals with mild alzheimer disease, implanting autologous fibroblasts genetically modified to express human ngf into the forebrain. |
2005-07-12 |
2023-08-12 |
human |
| Gary W Arendash, Jada Lewis, Ralph E Leighty, Eileen McGowan, Jennifer R Cracchiolo, Mike Hutton, Marcos F Garci. Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain. Brain research. vol 1012. issue 1-2. 2004-08-17. PMID:15158158. |
multi-metric behavioral comparison of appsw and p301l models for alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain. |
2004-08-17 |
2023-08-12 |
mouse |
| Ruiben Feng, Huimin Wang, Jianlin Wang, David Shrom, Xuemei Zeng, Joe Z Tsie. Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 21. 2004-07-09. PMID:15148382. |
forebrain degeneration and ventricle enlargement caused by double knockout of alzheimer's presenilin-1 and presenilin-2. |
2004-07-09 |
2023-08-12 |
mouse |
| G L Wenk, K McGann, B Hauss-Wegrzyniak, S Ros. The toxicity of tumor necrosis factor-alpha upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation: implications for Alzheimer's disease. Neuroscience. vol 121. issue 3. 2004-01-09. PMID:14568031. |
inflammation and reduced forebrain norepinephrine are features of alzheimer's disease that may interact to contribute to the degeneration of specific neural systems. |
2004-01-09 |
2023-08-12 |
mouse |
| G L Wenk, K McGann, B Hauss-Wegrzyniak, S Ros. The toxicity of tumor necrosis factor-alpha upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation: implications for Alzheimer's disease. Neuroscience. vol 121. issue 3. 2004-01-09. PMID:14568031. |
the results suggest that noradrenergic cell loss in alzheimer's disease does not augment the consequences of the chronic neuroinflammation and does not enhance neurodegeneration of forebrain cholinergic neurons. |
2004-01-09 |
2023-08-12 |
mouse |
| Nicolaas I Bohnen, Daniel I Kaufer, Larry S Ivanco, Brian Lopresti, Robert A Koeppe, James G Davis, Chester A Mathis, Robert Y Moore, Steven T DeKosk. Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study. Archives of neurology. vol 60. issue 12. 2004-01-07. PMID:14676050. |
pathology reports have shown that cholinergic forebrain neuronal losses in parkinsonian dementia (pdem) are equal to or greater than those in alzheimer disease (ad). |
2004-01-07 |
2023-08-12 |
Not clear |
| Sebastian Lazareno, Angela Popham, Nigel J M Birdsal. Progress toward a high-affinity allosteric enhancer at muscarinic M1 receptors. Journal of molecular neuroscience : MN. vol 20. issue 3. 2003-12-23. PMID:14501021. |
loss of forebrain acetylcholine is an early neurochemical lesion in alzheimer's disease (ad). |
2003-12-23 |
2023-08-12 |
Not clear |
| Marco Angelo, Florian Plattner, Elaine E Irvine, K Peter Gies. Improved reversal learning and altered fear conditioning in transgenic mice with regionally restricted p25 expression. The European journal of neuroscience. vol 18. issue 2. 2003-09-24. PMID:12887424. |
cleavage of the cyclin-dependent kinase 5 activator p35 generates the protein fragment p25, which accumulates in the forebrain of patients with alzheimer's disease. |
2003-09-24 |
2023-08-12 |
mouse |
| Gary L Wenk, Susanna Rosi, Kristin McGann, Beatrice Hauss-Wegrzynia. A nitric oxide-donating flurbiprofen derivative reduces neuroinflammation without interacting with galantamine in the rat. European journal of pharmacology. vol 453. issue 2-3. 2003-07-08. PMID:12398920. |
alzheimer's disease is associated with glial activation and increased levels of the cytokines as well as impaired forebrain cholinergic function. |
2003-07-08 |
2023-08-12 |
rat |
| Sebastian Lazareno, Angela Popham, Nigel J M Birdsal. Towards a high-affinity allosteric enhancer at muscarinic M1 receptors. Journal of molecular neuroscience : MN. vol 19. issue 1-2. 2003-01-28. PMID:12212769. |
loss of forebrain acetylcholine (ach) is an early neurochemical lesion in alzheimer's disease (ad), and muscarinic receptors for ach are involved in memory and cognition, so a muscarinic agonist could provide 'replacement therapy' in this disease. |
2003-01-28 |
2023-08-12 |
Not clear |
| N V Bobkova, I V Nesterova, V V Nestero. The state of cholinergic structures in forebrain of bulbectomized mice. Bulletin of experimental biology and medicine. vol 131. issue 5. 2002-03-22. PMID:11550044. |
these findings and published data allow us to assume that pathology of the olfactory bulb can underlie memory impairment during alzheimer's disease associated with dysfunction of acetylcholine-synthesizing structures in the forebrain. |
2002-03-22 |
2023-08-12 |
mouse |
| E Vaucher, N Aumont, D Pearson, W Rowe, J Poirier, S Ka. Amyloid beta peptide levels and its effects on hippocampal acetylcholine release in aged, cognitively-impaired and -unimpaired rats. Journal of chemical neuroanatomy. vol 21. issue 4. 2001-08-23. PMID:11429273. |
excessive extracellular deposition of amyloid beta (abeta) peptide in neuritic plaques and degeneration of forebrain cholinergic neurones, which innervate the hippocampus and the neocortex, are the invariant characteristic features of alzheimer's disease (ad). |
2001-08-23 |
2023-08-12 |
rat |
| F Sohrabji, K W Peeples, O A Marroqui. Local and cortical effects of olfactory bulb lesions on trophic support and cholinergic function and their modulation by estrogen. Journal of neurobiology. vol 45. issue 2. 2000-12-07. PMID:11018768. |
collectively, these results indicate that neural injury to one limb of the forebrain cholinergic system may result in collateral damage to other limbs of this system, suggesting a mechanism for the progression of neurodegenerative diseases, such as alzheimer's disease, that involve the cholinergic system. |
2000-12-07 |
2023-08-12 |
Not clear |
| Y Yang, K Beyreuther, H P Schmit. Spatial analysis of the neuronal density of aminergic brainstem nuclei in primary neurodegenerative and vascular dementia: a comparative immunocytochemical and quantitative study using a graph method. Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology. vol 19. issue 3-4. 2000-10-26. PMID:10866275. |
a graph method was employed to analyse spatial neuronal patterns of pontine nuclei with ascending aminergic projections to the forebrain (nucleus centralis superior (ncs), raphes dorsalis (nrd) and locus coeruleus (lc)), in alzheimer disease (ad), huntington disease (hd), and vascular (vd) as well as "mixed-type" (va) dementia, compared with non-demented controls (co) and a small sample of brains from schizophrenics ("dementia praecox" (dp)). |
2000-10-26 |
2023-08-12 |
Not clear |
| G L Wenk, K McGann, A Mencarelli, B Hauss-Wegrzyniak, P Del Soldato, S Fiorucc. Mechanisms to prevent the toxicity of chronic neuroinflammation on forebrain cholinergic neurons. European journal of pharmacology. vol 402. issue 1-2. 2000-10-11. PMID:10940360. |
these results suggest that prostaglandins contribute to the degeneration of forebrain cholinergic neurons in alzheimer's disease. |
2000-10-11 |
2023-08-12 |
rat |
| F Casamenti, C Prosperi, C Scali, L Giovannelli, M A Colivicchi, M S Faussone-Pellegrini, G Pepe. Interleukin-1beta activates forebrain glial cells and increases nitric oxide production and cortical glutamate and GABA release in vivo: implications for Alzheimer's disease. Neuroscience. vol 91. issue 3. 1999-10-08. PMID:10391466. |
interleukin-1beta activates forebrain glial cells and increases nitric oxide production and cortical glutamate and gaba release in vivo: implications for alzheimer's disease. |
1999-10-08 |
2023-08-12 |
rat |