| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R S Dood. Clinical benefits of a new piperidine-class AChE inhibitor. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 9 Suppl 2. 1999-07-09. PMID:10332937. |
alzheimer's disease (ad) is associated with a deficiency of acetylcholine (ach) in the forebrain that correlates with brain pathology and cognitive dysfunction. |
1999-07-09 |
2023-08-12 |
Not clear |
| P R Mouton, L J Martin, M E Calhoun, G Dal Forno, D L Pric. Cognitive decline strongly correlates with cortical atrophy in Alzheimer's dementia. Neurobiology of aging. vol 19. issue 5. 1999-03-11. PMID:9880038. |
at autopsy, consortium to establish a registry for alzheimer's disease (cerad) criteria confirmed diagnoses in 33 ad cases and 19 controls, and using unbiased stereology we quantified total volumes of cortical gray matter, subcortical grey matter including white matter, and forebrain. |
1999-03-11 |
2023-08-12 |
Not clear |
| K M Cullen, G M Hallida. Neurofibrillary degeneration and cell loss in the nucleus basalis in comparison to cortical Alzheimer pathology. Neurobiology of aging. vol 19. issue 4. 1998-11-30. PMID:9733161. |
in pure alzheimer's disease, cholinergic nucleus basalis cell number, as determined from counts in serial forebrain sections, was 22-60% of control mean, with the majority of residual cells containing tangles. |
1998-11-30 |
2023-08-12 |
Not clear |
| V Haroutunian, N Greig, X F Pei, T Utsuki, R Gluck, L D Acevedo, K L Davis, W C Wallac. Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions. Brain research. Molecular brain research. vol 46. issue 1-2. 1997-08-05. PMID:9191090. |
pharmacological modulation of alzheimer's beta-amyloid precursor protein levels in the csf of rats with forebrain cholinergic system lesions. |
1997-08-05 |
2023-08-12 |
rat |
| V Haroutunian, N Greig, X F Pei, T Utsuki, R Gluck, L D Acevedo, K L Davis, W C Wallac. Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions. Brain research. Molecular brain research. vol 46. issue 1-2. 1997-08-05. PMID:9191090. |
abnormal deposition and accumulation of alzheimer's amyloid beta-protein (a beta) and degeneration of forebrain cholinergic neurons are among the principal features of alzheimer's disease. |
1997-08-05 |
2023-08-12 |
rat |
| H S Ved, M L Koenig, J R Dave, B P Docto. Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate. Neuroreport. vol 8. issue 4. 1997-07-14. PMID:9141073. |
huperzine a, a potential therapeutic agent for alzheimer's disease, inhibits acetylcholinesterase in primary cultures derived from forebrain, hippocampus, cortex and cerebellum of embryonic rat brain. |
1997-07-14 |
2023-08-12 |
rat |
| G Halliday, K Cullen, A Hardin. Neuropathological correlates of memory dysfunction in the Wernicke-Korsakoff syndrome. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 2. 1997-04-07. PMID:8974343. |
the loss of forebrain neurons containing acetylcholine in patients with alzheimer's disease has implicated this neurotransmitter in the maintenance of memory functions. |
1997-04-07 |
2023-08-12 |
Not clear |
| M Kohzuki, H Onodera, M Yasujima, Y Itoyama, M Kanazawa, T Sato, K Ab. Endothelin receptors in ischemic rat brain and Alzheimer brain. Journal of cardiovascular pharmacology. vol 26 Suppl 3. 1996-03-28. PMID:8587405. |
endothelin (et) binding sites in male wistar rat brains subjected to a 20-min four-vessel occlusion (transient forebrain ischemia model) which induces hippocampal neuron death, and in human brains with alzheimer disease, were mapped by quantitative in vitro autoradiography employing [125i]et-1 as a radioligand. |
1996-03-28 |
2023-08-12 |
human |
| J Montplaisir, D Petit, D Lorrain, S Gauthier, T Nielse. Sleep in Alzheimer's disease: further considerations on the role of brainstem and forebrain cholinergic populations in sleep-wake mechanisms. Sleep. vol 18. issue 3. 1995-08-17. PMID:7610309. |
sleep in alzheimer's disease: further considerations on the role of brainstem and forebrain cholinergic populations in sleep-wake mechanisms. |
1995-08-17 |
2023-08-12 |
Not clear |
| W Wallace, V Haroutunia. Using the subcortically lesioned rat cortex to understand the physiological role of amyloid precursor protein. Behavioural brain research. vol 57. issue 2. 1994-04-06. PMID:8117425. |
these models have been useful for the investigation of some discrete aspects of alzheimer's disease, including deficits in forebrain cholinergic activity and the resulting cognitive deficits. |
1994-04-06 |
2023-08-12 |
mouse |
| M Chaussidon, P Netter, M Kessler, H Membre, P Fener, S Delons, F Albarèd. Dialysis-associated arthropathy: secondary ion mass spectrometry evidence of aluminum silicate in beta 2-microglobulin amyloid synovial tissue and articular cartilage. Nephron. vol 65. issue 4. 1994-03-04. PMID:8302409. |
these results are similar to the abnormal al distribution recently found by sims in the forebrain of chronic renal dialysis patients and to the amorphous aluminum silicates identified in the core of senile plaques in alzheimer's disease. |
1994-03-04 |
2023-08-12 |
Not clear |
| S Aspley, K C Fon. Galanin fails to alter both acquisition of a two trial per day water maze task and neurochemical markers of cholinergic or serotonergic neurones in adult rats. Brain research. vol 622. issue 1-2. 1994-01-06. PMID:7694768. |
the co-existence of galanin with acetylcholine in ventral forebrain neurones combined with evidence that galanin attenuates cholinergic function and is present in senile plaques in alzheimer's disease all implicate this neuropeptide in the regulation of cognition. |
1994-01-06 |
2023-08-12 |
rat |
| S B Dunnett, H C Fibige. Role of forebrain cholinergic systems in learning and memory: relevance to the cognitive deficits of aging and Alzheimer's dementia. Progress in brain research. vol 98. 1994-01-06. PMID:8248529. |
role of forebrain cholinergic systems in learning and memory: relevance to the cognitive deficits of aging and alzheimer's dementia. |
1994-01-06 |
2023-08-12 |
Not clear |
| V Dubovik, M Faigon, J Feldon, D M Michaelso. Decreased density of forebrain cholinergic neurons in experimental autoimmune dementia. Neuroscience. vol 56. issue 1. 1993-12-07. PMID:8232919. |
the decrease in density of forebrain cholinergic neurons in experimental autoimmune dementia rats may mimic pathogenic processes in alzheimer's disease and supports a role for anti-cholinergic high molecular weight neurofilament subunit antibodies in the degeneration of cholinergic neurons in the disease. |
1993-12-07 |
2023-08-12 |
rat |
| J V Rosenfel. Current issues in neural transplantation. Annals of the Academy of Medicine, Singapore. vol 22. issue 3 Suppl. 1993-11-16. PMID:8215202. |
although foetal forebrain cholinergic and spinal grafts have been performed in animals, these have not yet been attempted for alzheimer's disease, or spinal cord damage respectively in humans. |
1993-11-16 |
2023-08-12 |
human |
| C Andriamampandry, J N Kanfe. Inhibition of cytosolic human forebrain choline acetyltransferase activity by phospho-L-serine: a phosphomonoester that accumulates during early stages of Alzheimer's disease. Neurobiology of aging. vol 14. issue 4. 1993-10-04. PMID:8367018. |
inhibition of cytosolic human forebrain choline acetyltransferase activity by phospho-l-serine: a phosphomonoester that accumulates during early stages of alzheimer's disease. |
1993-10-04 |
2023-08-12 |
human |
| P T Nelson, L Marton, C B Sape. Alz-50 immunohistochemistry in the normal sheep striatum: a light and electron microscope study. Brain research. vol 600. issue 2. 1993-03-23. PMID:8094642. |
alz-50 is a monoclonal antibody raised against ventral forebrain tissue from patients with alzheimer's disease (ad). |
1993-03-23 |
2023-08-12 |
human |
| M E Appleyard, B McDonal. Acetylcholinesterase and butyrylcholinesterase activities in cerebrospinal fluid from different levels of the neuraxis of patients with dementia of the Alzheimer type. Journal of neurology, neurosurgery, and psychiatry. vol 55. issue 11. 1993-01-26. PMID:1469405. |
the secretion of ache from forebrain and hindbrain regions is reduced in alzheimer's disease patients, leading to decreased ventricular and cisternal levels of the enzyme. |
1993-01-26 |
2023-08-11 |
Not clear |
| S O Ogren, T Hökfelt, K Kask, U Langel, T Bartfa. Evidence for a role of the neuropeptide galanin in spatial learning. Neuroscience. vol 51. issue 1. 1993-01-15. PMID:1281521. |
the cholinergic forebrain neurons appear to play a significant role in learning and memory, as suggested by a severe loss of these neurons in alzheimer's disease. |
1993-01-15 |
2023-08-11 |
Not clear |
| S Dunnet. Cholinergic grafts, memory and ageing. Trends in neurosciences. vol 14. issue 8. 1992-01-28. PMID:1721745. |
it is unlikely, however, that these observations will extend to a therapeutic strategy for dementia using neural transplantation, because the human diseases (at least in the case of alzheimer's disease and multi-infarct dementia) involve widespread degeneration of other populations of cortical neurones that are not so amenable to functional transplantation as the diffuse forebrain cholinergic systems. |
1992-01-28 |
2023-08-11 |
human |