| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elena Spoleti, Livia La Barbera, Emma Cauzzi, Maria Luisa De Paolis, Luana Saba, Ramona Marino, Giuseppe Sciamanna, Vincenzo Di Lazzaro, Flavio Keller, Annalisa Nobili, Paraskevi Krashia, Marcello D'Ameli. Dopamine neuron degeneration in the Ventral Tegmental Area causes hippocampal hyperexcitability in experimental Alzheimer's Disease. Molecular psychiatry. 2024-01-16. PMID:38228889. |
dopamine neuron degeneration in the ventral tegmental area causes hippocampal hyperexcitability in experimental alzheimer's disease. |
2024-01-16 |
2024-01-19 |
mouse |
| Elena Spoleti, Livia La Barbera, Emma Cauzzi, Maria Luisa De Paolis, Luana Saba, Ramona Marino, Giuseppe Sciamanna, Vincenzo Di Lazzaro, Flavio Keller, Annalisa Nobili, Paraskevi Krashia, Marcello D'Ameli. Dopamine neuron degeneration in the Ventral Tegmental Area causes hippocampal hyperexcitability in experimental Alzheimer's Disease. Molecular psychiatry. 2024-01-16. PMID:38228889. |
early and progressive dysfunctions of the dopaminergic system from the ventral tegmental area (vta) have been described in alzheimer's disease (ad). |
2024-01-16 |
2024-01-19 |
mouse |
| Livia La Barbera, Annalisa Nobili, Emma Cauzzi, Ilaria Paoletti, Mauro Federici, Luana Saba, Cecilia Giacomet, Ramona Marino, Paraskevi Krashia, Marcello Melone, Flavio Keller, Nicola Biagio Mercuri, Maria Teresa Viscomi, Fiorenzo Conti, Marcello D'Ameli. Upregulation of Ca Molecular neurodegeneration. vol 17. issue 1. 2022-11-26. PMID:36434727. |
upregulation of ca recent clinical and experimental studies have highlighted the involvement of ventral tegmental area (vta) dopamine (da) neurons for the early pathogenesis of alzheimer's disease (ad). |
2022-11-26 |
2023-08-14 |
mouse |
| Laura Serra, Marcello D'Amelio, Sharon Esposito, Carlotta Di Domenico, Giacomo Koch, Camillo Marra, Nicola Biagio Mercuri, Carlo Caltagirone, Carlo Alberto Artusi, Leonardo Lopiano, Mara Cercignani, Marco Bozzal. Ventral Tegmental Area Disconnection Contributes Two Years Early to Correctly Classify Patients Converted to Alzheimer's Disease: Implications for Treatment. Journal of Alzheimer's disease : JAD. vol 82. issue 3. 2021-09-15. PMID:34120905. |
ventral tegmental area disconnection contributes two years early to correctly classify patients converted to alzheimer's disease: implications for treatment. |
2021-09-15 |
2023-08-13 |
Not clear |
| Laura Serra, Marcello D'Amelio, Sharon Esposito, Carlotta Di Domenico, Giacomo Koch, Camillo Marra, Nicola Biagio Mercuri, Carlo Caltagirone, Carlo Alberto Artusi, Leonardo Lopiano, Mara Cercignani, Marco Bozzal. Ventral Tegmental Area Disconnection Contributes Two Years Early to Correctly Classify Patients Converted to Alzheimer's Disease: Implications for Treatment. Journal of Alzheimer's disease : JAD. vol 82. issue 3. 2021-09-15. PMID:34120905. |
recent cross-sectional studies highlighted the loss of dopaminergic neurons in the ventral tegmental area (vta) as an early pathophysiological event in alzheimer's disease (ad). |
2021-09-15 |
2023-08-13 |
Not clear |
| Marco Bozzali, Marcello D'Amelio, Laura Serr. Ventral tegmental area disruption in Alzheimer's disease. Aging. vol 11. issue 5. 2020-05-28. PMID:30852563. |
ventral tegmental area disruption in alzheimer's disease. |
2020-05-28 |
2023-08-13 |
Not clear |
| Laura Serra, Marcello D'Amelio, Carlotta Di Domenico, Ottavia Dipasquale, Camillo Marra, Nicola Biagio Mercuri, Carlo Caltagirone, Mara Cercignani, Marco Bozzal. In vivo mapping of brainstem nuclei functional connectivity disruption in Alzheimer's disease. Neurobiology of aging. vol 72. 2019-09-16. PMID:30237073. |
we assessed here functional connectivity changes in the locus coeruleus (lc) and ventral tegmental area (vta) of patients with alzheimer's disease (ad). |
2019-09-16 |
2023-08-13 |
Not clear |
| Alberto Cordella, Paraskevi Krashia, Annalisa Nobili, Annabella Pignataro, Livia La Barbera, Maria Teresa Viscomi, Alessandro Valzania, Flavio Keller, Martine Ammassari-Teule, Nicola Biagio Mercuri, Nicola Berretta, Marcello D'Ameli. Dopamine loss alters the hippocampus-nucleus accumbens synaptic transmission in the Tg2576 mouse model of Alzheimer's disease. Neurobiology of disease. vol 116. 2019-09-06. PMID:29778899. |
in particular, the dopaminergic innervation from the vta to the hippocampus is critical for hippocampal-related memory function and alterations in the midbrain dopaminergic system are frequently reported in alzheimer's disease (ad), contributing to age-related decline in memory and non-cognitive functions. |
2019-09-06 |
2023-08-13 |
mouse |
| Matteo De Marco, Annalena Venner. Volume and Connectivity of the Ventral Tegmental Area are Linked to Neurocognitive Signatures of Alzheimer's Disease in Humans. Journal of Alzheimer's disease : JAD. vol 63. issue 1. 2019-08-26. PMID:29578486. |
volume and connectivity of the ventral tegmental area are linked to neurocognitive signatures of alzheimer's disease in humans. |
2019-08-26 |
2023-08-13 |
Not clear |
| Marcello D'Amelio, Laura Serra, Marco Bozzal. Ventral Tegmental Area in Prodromal Alzheimer's Disease: Bridging the Gap between Mice and Humans. Journal of Alzheimer's disease : JAD. vol 63. issue 1. 2019-08-26. PMID:29630556. |
ventral tegmental area in prodromal alzheimer's disease: bridging the gap between mice and humans. |
2019-08-26 |
2023-08-13 |
mouse |
| Aron S Buchman, Sukriti Nag, Joshua M Shulman, Andrew S P Lim, Veronique G J M VanderHorst, Sue E Leurgans, Julie A Schneider, David A Bennet. Locus coeruleus neuron density and parkinsonism in older adults without Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 27. issue 13. 2013-05-13. PMID:23038629. |
we measured neuron density in the substantia nigra, ventral tegmental area, locus coeruleus, and dorsal raphe, along with postmortem indices of lewy body disease, alzheimer's disease and cerebrovascular pathologies. |
2013-05-13 |
2023-08-12 |
Not clear |
| A Kastner, E C Hirsch, M T Herrero, F Javoy-Agid, Y Agi. Immunocytochemical quantification of tyrosine hydroxylase at a cellular level in the mesencephalon of control subjects and patients with Parkinson's and Alzheimer's disease. Journal of neurochemistry. vol 61. issue 3. 1993-09-27. PMID:8103078. |
in patients with alzheimer's disease, the amount of th was selectively reduced in the remaining dopaminergic neurons of the ventral tegmental area, a region characterized by a loss in dopaminergic neurons. |
1993-09-27 |
2023-08-12 |
human |
| P H van Domburg, H J ten Donkelaa. The human substantia nigra and ventral tegmental area. A neuroanatomical study with notes on aging and aging diseases. Advances in anatomy, embryology, and cell biology. vol 121. 1991-07-24. PMID:2053466. |
the present study comprises a cytoarchitectonic analysis of the human substantia nigra (sn) and ventral tegmental area (vta); a discussion of their chemoarchitecture and fiber connections (mainly based on tract-tracing studies in primates) preceded by an overview of the wealth of tract-tracing data in rodents; a discussion of the involvement of the sn/vta complex in parkinson's disease (pd) and related disorders and in alzheimer's disease (ad), including some quantitative data; and finally, some functional and pathophysiological considerations, relating nigral organization to pathophysiology and hypotheses on the etiology and distribution of ad and pd. |
1991-07-24 |
2023-08-11 |
human |
| W R Gibb, C Q Mountjoy, D M Mann, A J Lee. The substantia nigra and ventral tegmental area in Alzheimer's disease and Down's syndrome. Journal of neurology, neurosurgery, and psychiatry. vol 52. issue 2. 1989-05-15. PMID:2539435. |
mild degenerative changes accompanied by tangles in the substantia nigra and ventral tegmental area are common in alzheimer's disease, but severe cell loss is rare. |
1989-05-15 |
2023-08-11 |
Not clear |
| W R Gibb, C Q Mountjoy, D M Mann, A J Lee. The substantia nigra and ventral tegmental area in Alzheimer's disease and Down's syndrome. Journal of neurology, neurosurgery, and psychiatry. vol 52. issue 2. 1989-05-15. PMID:2539435. |
the substantia nigra and ventral tegmental area in alzheimer's disease and down's syndrome. |
1989-05-15 |
2023-08-11 |
Not clear |
| W R Gibb, C Q Mountjoy, D M Mann, A J Lee. The substantia nigra and ventral tegmental area in Alzheimer's disease and Down's syndrome. Journal of neurology, neurosurgery, and psychiatry. vol 52. issue 2. 1989-05-15. PMID:2539435. |
degenerative changes in the substantia nigra and ventral tegmental area were investigated in 104 cases of alzheimer's disease and 13 cases of down's syndrome. |
1989-05-15 |
2023-08-11 |
Not clear |
| D M Mann, P O Yates, B Marcyniu. Dopaminergic neurotransmitter systems in Alzheimer's disease and in Down's syndrome at middle age. Journal of neurology, neurosurgery, and psychiatry. vol 50. issue 3. 1987-05-18. PMID:2951499. |
in 15 patients with alzheimer's disease and in 10 with down's syndrome at middle age, there was severe atrophy, neurofibrillary degeneration and loss of pigmented dopaminergic nerve cells from ventral tegmental area (a10) whereas nerve cells in neighbouring substantia nigra (a9) were much less affected in all three respects. |
1987-05-18 |
2023-08-11 |
Not clear |